The microwave assisted reaction between heterocyclic
o-aminonitriles
1 and cyclic ketones
2 catalyzed by zinc chloride led to new series of pyrazolo[3,4-
b] [1,8]naphthyridin-5-amines
3 in good yields. This procedure provides several advantages such as being environmentally friendly, high yields, simple
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The microwave assisted reaction between heterocyclic
o-aminonitriles
1 and cyclic ketones
2 catalyzed by zinc chloride led to new series of pyrazolo[3,4-
b] [1,8]naphthyridin-5-amines
3 in good yields. This procedure provides several advantages such as being environmentally friendly, high yields, simple work-up procedure, broad scope of applicability and the protocol provides an alternative for the synthesis of pyrazolonaphthyridines. The whole series showed antifungal activities against
Candida albicans and
Cryptococcus neoformans standardized strains, being compounds with a 4-
p-tolyl substituent of the naphthyridin scheleton (
3a,
3d and
3g), the most active ones mainly against
C. albicans, which appear to be related to their comparative hydrophobicity. Among them,
3d, containing a cyclohexyl fused ring, showed the best activity. The anti-
Candida activity was corroborated by testing the three most active compounds against clinical isolates of
albicans and non-
albicans Candida strains. These compounds were also screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines. Compounds
3a and
3e showed remarkable antitumor activity against cancer cell lines, with the most important GI
50 values ranging from 0.62 to 2.18 μM
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