Search Results (57)

In the complex and high-risk underground environment of coal mining, ensuring occupational health and safety is a fundamental pillar of social sustainability. Traditional safety compliance is insufficient to prevent unpredictable accidents and sustain long-term enterprise resilience. Thus, fostering proactive safety citizenship behavior is essential for enhancing organizational resilience. Drawing on the cognitive appraisal theory of stress, this study constructs a double-edged sword model of felt accountability on miners’ safety citizenship behavior. A three-wave time-lagged survey was conducted among 375 frontline coal miners in China, with data analyzed using SPSS 26.0 and AMOS 24.0. The findings show that felt accountability can increase work engagement and promote employee safety citizenship behavior, while also enhancing psychological strain and inhibiting employee safety citizenship behavior. In addition, safety-specific transformational leadership amplifies the positive impact of felt accountability on work engagement and mitigates its effects on psychological strain. These findings enrich our understanding of the impact of felt accountability, and provide practical insights for coal enterprise managers to improve sustainable safety performance and foster a socially sustainable work environment. Full article

The remarkable evolution of oncological therapies has dramatically improved cancer survival rates but has simultaneously introduced a significant burden of cardiovascular complications. Cardio-oncology has emerged as a critical multidisciplinary field focused on mitigating the “collateral damage” of life-saving anticancer treatments, ranging from traditional chemotherapeutics to novel immunotherapies. This review provides a comprehensive analysis of the pathophysiological mechanisms, clinical phenotypes, and evolving management strategies for cancer therapy-related cardiac dysfunction (CTRCD). An extensive synthesis of the current literature was conducted, focusing on the molecular pathways of cardiotoxicity, including Topoisomerase IIβ inhibition by anthracyclines, HER2 signaling disruption by targeted agents, and immune-mediated myocarditis triggered by checkpoint inhibitors (ICIs). Cardiotoxicity is increasingly recognized as a spectrum of phenotypes. Heart failure with reduced ejection fraction (HFrEF) remains a primary concern with cytotoxic agents, while heart failure with preserved ejection fraction (HFpEF) is emerging as a critical complication of radiation therapy and tyrosine kinase inhibitors (TKIs). The integration of advanced diagnostic tools—specifically Global Longitudinal Strain (GLS) and Cardiac Magnetic Resonance (CMR) mapping—has shifted the clinical focus toward subclinical detection. Furthermore, pivotal clinical trials such as PRADA and SUCCOUR have validated early pharmacological prophylaxis and strain-guided interventions. Emerging challenges, including the management of CAR-T cell-induced cytokine release syndrome and the specific cardiovascular needs of pediatric and geriatric populations, are also explored. The future of cardio-oncology lies in precision medicine, leveraging genomic profiling and artificial intelligence to identify high-risk individuals. A proactive, multidisciplinary approach is essential to ensure that the success of modern oncology is not compromised by irreversible cardiovascular morbidity. Full article

Personality traits are well-established predictors of safety behavior in construction, yet the cognitive mechanisms through which these traits influence such behavior remain poorly understood. In particular, hazard recognition and risk perception are underexamined cognitive mediators that elucidate how personality traits shape safety behavior. Moreover, the mediating effects of these cognitive processes are likely to vary across individuals, reflecting heterogeneity in background characteristics. Neglecting these mediating processes and their differentiated effects not only limits theoretical understanding of the pathways linking personality traits to safety behavior but also undermines the effectiveness of safety interventions. To address this gap, this study develops a framework incorporating cognitive mediators to examine how personality traits influence safety behavior (safety compliance and participation). The hypothesized cognitive-mediation pathways were tested using structural equation modeling based on offline questionnaire data collected from 213 site managers and workers. The findings reveal distinct cognitive pathways through which personality traits shape safety behavior. Extraversion and openness indirectly reduced safety compliance and safety participation by weakening hazard recognition and risk perception, either independently or sequentially. In contrast, agreeableness and conscientiousness enhanced safety behavior by strengthening these same cognitive processes. Higher education levels positively moderated certain mediating effects, whereas extensive work experience exerted mixed influences on specific pathways, facilitating some and inhibiting others depending on context. These findings deepen understanding of the internal mechanisms through which personality traits influence safety behavior via risk cognition. By identifying differentiated pathways across groups, this study further refines the theoretical framework explaining construction workers’ safety behavior. In addition, the theoretical insights generated by this study offer proactive and effective directions for safety practice, including improving person–job fit, designing targeted risk cognition training, and implementing stratified safety management strategies. Full article

Excitable neurons are intrinsically capable of firing action potentials (AP), yet a state of hyperexcitability is prevented in the central nervous system by powerful GABAergic inhibition. For this inhibition to be effective, it must occur before excitatory signals can initiate runaway activity, implying the existence of a proactive control system. To test for such proactive inhibition, we used Ca²⁺ imaging and patch-clamp recording to measure how hippocampal neurons respond to depolarization and glutamatergic agonists. In mature hippocampal cultures (14 days in vitro (DIV)) and acute brain slices from two-month-old rats, neurons exhibited non-simultaneous responses to various excitatory stimuli, including KCl, NH₄Cl, forskolin, domoic acid, and glutamate. We observed that the Ca²⁺ rise occurred significantly earlier in GABAergic neurons than in glutamatergic neurons. This delay in glutamatergic neurons was abolished by GABA(A) receptor inhibitors, suggesting a mechanism of preliminary γ-aminobutyric acid (GABA) release. We further found that these early-responding GABAergic neurons express calcium-permeable kainate and AMPA receptors (CP-KARs and CP-AMPARs). Application of domoic acid induced an immediate Ca²⁺ increase in neurons expressing these receptors, but a delayed response in others. Crucially, when domoic acid was applied in the presence of the AMPA receptor inhibitors NBQX or GYKI-52466, the response delay in glutamatergic neurons was significantly prolonged. This confirms that CP-KARs on GABAergic neurons are responsible for the delayed excitation of glutamatergic neurons. In hippocampal slices from two-month-old rats, depolarization with 50 mM KCl revealed two distinct neuronal populations based on their calcium dynamics: a majority group (presumably glutamatergic) exhibited fluctuating Ca²⁺ signals, while a minority (presumably GABAergic) showed a steady, advancing increase in [Ca²⁺]i. This distinction was reinforced by the application of domoic acid. The “advancing-response” neurons reacted to domoic acid with a similar prompt increase, whereas the “fluctuating-response” neurons displayed an even more delayed and fluctuating reaction (80 s delay). Therefore, we identify a subgroup of hippocampal neurons—in both slices and cultures—that respond to depolarization and domoic acid with an early [Ca²⁺]_i signal. Consistent with our data from cultures, we conclude these early-responding neurons are GABAergic. Their early GABA release directly explains the delayed Ca²⁺ response observed in glutamatergic neurons. We propose that this proactive mechanism, mediated by CP-KARs on GABAergic neurons, is a primary means of protecting the network from hyperexcitation. Furthermore, the activity of these CP-KAR-expressing neurons is itself regulated by GABAergic neurons containing CP-AMPARs. Full article

Background: Tyrosine kinase inhibitors (TKIs) are crucial to treating endocrine-related malignancies, including advanced thyroid cancers and neuroendocrine tumors, but their benefit is tempered by cutaneous adverse events (CAEs) that impair adherence and quality of life. Objective: To summarize the dermatologic toxicities of TKIs used in endocrine oncology and provide practical, multidisciplinary guidance for prevention and management. Methods: Narrative synthesis of clinical trial reports, post-marketing studies, and specialty guidelines pertinent to lenvatinib, vandetanib, cabozantinib, and other commonly used TKIs, integrating dermatologic and endocrine perspectives on mechanisms and care pathways. Results: VEGFR-targeted TKIs frequently cause hand–foot skin reaction, xerosis, fissuring, paronychia, and impaired wound healing; multikinase inhibition also produces alopecia, pigmentary changes, and mucositis. Epidermal growth factor receptor (EGFR) and rearranged during transfection (RET) inhibition with vandetanib is associated with acneiform eruption, photosensitivity, and nail fragility. Pathogenesis reflects on-target inhibition of VEGF/EGFR signaling leading to keratinocyte dysfunction, vascular fragility, and altered eccrine mechanics. Early risk stratification, patient education, and bundle-based prophylaxis (emollients, keratolytics, urea-based creams, sun protection) reduce incidence and severity. Grade-based algorithms combining topical corticosteroids/antibiotics, dose interruptions or reductions, and short systemic courses (e.g., doxycycline, antihistamines) enable symptom control while maintaining anticancer intensity. Close coordination around procedures minimizes wound-healing complications. Conclusions: Dermatologic toxicities are predictable, mechanism-linked, and manageable with proactive, multidisciplinary care. Standardized prevention and treatment pathways tailored to specific TKIs—particularly lenvatinib, vandetanib, and cabozantinib—can preserve dose intensity, optimize quality of life, and sustain antineoplastic efficacy. Full article

Coral reefs are facing a catastrophic decline due to climate-induced bleaching, threatening critical marine biodiversity. Automated, large-scale monitoring is essential; however, modern object detectors are hindered by two fundamental limitations in complex underwater scenes: a spatial reasoning deficit in their decoupled heads, which inhibits robust multi-scale feature integration, and a feature robustness deficit, which renders deterministic networks vulnerable to stochastic visual variations. To address these limitations, we propose Coral-YOLO, a novel framework for detection and forecasting. We introduce the Holistic Attention Block Head (HAB-Head), which enables deep cross-scale reasoning through explicit feature interaction, and MCAttention, a randomized training mechanism that enables the network to learn scale-invariant features with inherent robustness. Evaluated on our newly curated, multi-year CR-Mix dataset, Coral-YOLO achieves a state-of-the-art 50.3% AP (average precision at IoU threshold 0.5:0.95, following COCO metrics), representing a +1.8 percentage point improvement over the YOLOv12-m baseline, with particularly pronounced gains on small objects (+2.6 percentage points in $A{P}_S$). Crucially, its integrated temporal forecasting module achieves 82.7% accuracy in predicting future coral health, substantially outperforming conventional methods. Coral-YOLO sets a new performance benchmark and enables proactive reef conservation. It provides a powerful tool to identify at-risk corals long before severe bleaching becomes visually apparent. Full article

Biofilms are structured microbial communities that adhere to biotic and abiotic surfaces embedded in an autonomous extracellular matrix. These structures contribute to persistent infections, especially in patients with indwelling medical devices, due to their resistance to antimicrobial agents; they have evolved to evade host immune responses. Despite advances in antimicrobial therapies, biofilm-associated infections remain a major challenge in clinical infectious diseases. This perspective explores the underlying mechanisms of biofilm resilience and immune evasion, emphasizing the limitations of conventional treatments and the need to develop pre-emptive measures that focus on preventing biofilm formation rather than implementing a treatment. This work discusses emerging strategies, such as quorum-sensing inhibition, hormonal modulation, matrix-degrading enzymes, anti-adhesive surface modifications, and nanotechnology-based drug delivery, that offer promising avenues to disrupt biofilm formation and maturation. Also offers a shift from the paradigm, looking into proactive prevention rather than treatment, emphasizing clinical translation, scalability, and biocompatibility. Embedding these strategies into routine care could significantly reduce healthcare-associated infections, improve patient outcomes, and mitigate the development of antimicrobial resistance. Our analysis highlights biofilm prevention as a critical frontier in the future of infectious disease management. Full article

This comprehensive narrative review of bioactive plant compounds, pro-resolving anti-inflammatory lipids, and statins shows their potential in the inhibition of intervertebral disc degeneration (IVDD), pain resolution, tissue repair, and disc regeneration. IVDD is a multifactorial disease involving a multitude of signaling pathways, leading to the loss of normal disc function. An influx of nociceptive mechanoreceptors generate low back pain (LBP). IL6 and IL8 levels are elevated in patients undergoing spinal fusion to alleviate LBP, indicating these pro-inflammatory mediators may be major contributors to the generation of LBP. Apoptosis of disc cells leads to the depletion of key extracellular matrix components that equip the disc with its weight-bearing properties. A biomechanically incompetent degenerated IVD stimulates nociceptor mechanoreceptor activity, generating pain. Myo-tendinous, vertebral body, muscle, and facet joint tissues also contain pain receptors. Disturbance of the normal architecture of the IVD also generates pain in these tissues. Plant compounds have been used in folkloric medicine for centuries. This review attempts to provide a scientific basis for their purported health benefits; however, further studies are still required to substantiate this. Until this evidence is available, it would be prudent to be cautious in the use of such compounds. A diverse range of plant compounds (flavonoids, terpenoids, glycosides, alkaloids, and polyphenolics) inhibit inflammation and apoptosis, reduce spinal pain, and stimulate tissue repair by targeting cell signaling pathways in IVDD. Pro-resolving lipid mediators (lipoxin A4, resolvin D1, protectins, and maresins) also reduce inflammation, maintaining disc health and function. Cholesterol lowering statins disrupt phosphorylation in cell signaling pathways inhibiting IVDD, promoting tissue repair and regeneration. Full article

Population aging is increasingly recognized as a challenge to sustainable economic development, raising concerns about its impact on innovation and productivity. This study examines how population aging affects “new quality productivity” in China, using a balanced panel dataset of 30 provinces from 2011 to 2022. The analysis employs panel regression models with fixed effects and incorporates mediation and moderation approaches to explore underlying pathways. Land productivity is identified as a significant channel through which aging influences productivity, while the level of urbanization is examined as a moderating factor in this relationship. The results indicate that population aging significantly inhibits new quality productivity. Specifically, an aging population leads to lower land productivity, which hinders the growth of new quality productivity. However, higher urbanization is found to mitigate the adverse effect of aging on productivity. These findings are robust under various model specifications and statistical checks. In conclusion, the study underscores the necessity for proactive measures to mitigate the adverse effects of demographic aging. The findings provide policy insights, suggesting that boosting technological innovation, improving agricultural efficiency, and leveraging urbanization can help sustain high-quality development in the face of an aging population. Full article

This study analyzed the use of a toolbox to evaluate the impact of agricultural activity on the water quality/status classification of a hydro-agricultural reservoir (Lage reservoir, Southern Portugal). The framework integrated the quantification of a group of 51 pesticides and ecotoxicological endpoints with organisms from different trophic categories (the bacterium Aliivibrio fischeri, the microalga Pseudokirchneriella subcapitata, and the crustaceans Daphnia magna and Thamnocephalus platyurus) at two sampling points in the reservoir (Lage (L) and Lage S (LS)) between 2018 and 2020. Over the three-year study, we quantified 36 of the 51 pesticides analyzed in the Lage reservoir. Total concentrations increased successively from 0.95 µg L⁻¹ to 1.99 and 2.66 µg L⁻¹. Among these, the pesticides most frequently detected were terbuthylazine (100% of detection) and metolachlor (83% of detection), with maximum concentrations of 115.6 and 85.5 µg L⁻¹, respectively. Samples from the LS site showed higher toxicity, where A. fischeri presented 30 min EC₅₀ values of 39–51%. Microalgae growth was consistently inhibited, correlating with agricultural activity, mainly the application of herbicides and insecticides, while D. magna feeding rates revealed no inhibitory effects in the Lage samples. The results highlight that although the detected pesticide levels were below regulatory limits, they still induced toxic effects in the tested organisms. The potential ecological status of the reservoir was classified as moderate, and the integration of the proposal toolbox allowed refinement of the classification of water status. The results demonstrated that this integrated approach, combining multiple assessment methods, establishes a more robust water quality evaluation methodology, allowing it to be used as a tool complementary to the WFD methodology. This proposal not only identified existing pollution impacts but also enabled (1) early detection of the toxic effects of emerging contaminants to prevent ecological damage; (2) proactive management through specific actions to restore water status; and (3) improved sustainable water use. Full article

Cognitive control impairments contribute to the onset and maintenance of both substance and behavioral addictions. Guided by the Dual Mechanisms of Control framework, this study examined cognitive control deficits in methamphetamine-dependent individuals and those who overuse social media, each compared to a matched control group. Across two experiments, participants completed an operational working memory span task (Experiment 1) to assess their cognitive control resources, and a modified AX-Continuous Performance Test (AX-CPT, Experiment 2) to evaluate their inhibition-based proactive and reactive control. The results indicated that while both methamphetamine-dependent individuals and social media overusers demonstrated cognitive control impairments, the severity, affected components, and overall patterns differed. Methamphetamine-dependent individuals were characterized by more pronounced, pervasive deficits and a maladaptive reliance on compromised reactive control. In contrast, social media overuse was associated with milder impairments, maintaining relatively intact proactive versus reactive control patterns. These findings underscore the distinct cognitive control profiles underlying substance versus behavioral addictions and highlight the necessity of developing tailored intervention strategies to address the specific cognitive vulnerabilities of each population. Full article

The mechanisms underlying the disruption of bone balance are well known. To date, several possible treatments exist for osteoporosis, mostly based on inhibition of bone resorption. However, as osteoporosis is a disease that causes significant fragility, it merits a proactive prevention-based approach, which identifies risk factors, such as nutritional deficiencies, during the preosteoporotic stage. In this context, nutraceuticals may find application in delaying the onset of osteoporosis and prior to the need for pharmaceutical invention. The beneficial effects of inositol supplementation have been extensively studied in endocrinology and gynecology; herein, we discuss the potential of inositols in the prevention of osteoporosis, highlighting the link with bone metabolism and possible future applications. Full article

The rapid growth of Australia’s hydrogen economy highlights the pressing need for innovative regulatory strategies that address the distinct characteristics of hydrogen supply chains. This study focuses on the supply-side dynamics of the hydrogen energy sector, emphasizing the importance of tailored frameworks to ensure the safe, efficient, and reliable movement of hydrogen across the supply chain. Key areas of analysis include the regulatory challenges associated with various transportation and storage methods, particularly during long-distance transport and extended storage periods. The research identifies notable gaps and inconsistencies within the current regulatory systems across Australian states, which inhibit the development of a unified hydrogen economy. To address these challenges, the concept of Proactive Regulation for Hydrogen Supply (PRHS) is introduced. PRHS emphasizes anticipatory governance that adapts alongside technological advancements to effectively manage hydrogen transportation and storage. The study advocates for harmonizing fragmented state frameworks into a cohesive national regulatory system to support the sustainable and scalable expansion of hydrogen logistics. Furthermore, the paper examines the potential of blockchain technology to enhance safety, accountability, and traceability across the hydrogen supply chain, offering practical solutions to current regulatory and operational barriers. Full article

With the advancement of global economic restructuring and China’s economic transformation, structural employment contradictions have intensified amid increasingly competitive labor markets. The frequent occurrences of “degree devaluation” and talent “downskilling” have made perceived overqualification increasingly prevalent in organizations. This study, based on the Cognitive–Affective Personality System theory, investigates the differential mechanisms through which perceived overqualification drives approach and avoidance job crafting via cognitive and affective pathways. Data from a two-wave survey of 556 Chinese employees produced several key findings: (1) Perceived overqualification significantly enhances approach job crafting while suppressing avoidance job crafting by elevating role breadth self-efficacy (cognitive pathway), demonstrating a proactive breakthrough effect. (2) Perceived overqualification inhibits approach job crafting and exacerbates avoidance job crafting through triggering emotional exhaustion (affective pathway), revealing a passive exhaustion trap. (3) Perceived overqualification exerts a positive and significant overall indirect effect on approach job crafting through the combined mechanisms of cognitive gains from role breadth self-efficacy and affective costs from emotional exhaustion, whereas the overall indirect effect on avoidance job crafting is non-significant. (4) Idiosyncratic deals (i-deals) function as a dynamic boundary mechanism that amplifies the positive impact of role breadth self-efficacy and mitigates the negative effects of emotional exhaustion, while moderating the mediating roles of both pathways. This research develops a dual-path integrated model of perceived overqualification and job crafting by classifying job crafting categories, incorporating cognitive–affective pathways, and introducing i-deals as a contextual element. These findings respond to scholarly demands for elucidating the intricate connections between perceived overqualification and job crafting through integrative perspectives; in addition, they offer theoretical and practical insights for organizations to leverage the potential of overqualified individuals appropriately. Full article

Background/Objectives: Anterior cruciate ligament (ACL) injury is common in interaction sports and has severe physical and psychological consequences. Recent research suggests that neurocognitive factors, such as proactive inhibitory control, may influence injury risk. The present work compares the proactive inhibitory performance ability of athletes with no ACL injury and ACL-rehabilitated athletes (ACLR). Methods: This study involved 60 athletes from interaction sports (30 with no history of ACL injury and 30 ACL rehabilitated athletes). During the experimental session, participants performed an executive go–no-go task to assess proactive inhibitory control. Results: The ACLR group exhibited higher adjusted-precision response times (p = 0.011), higher inhibitory failures response times (p < 0.001), poorer accuracy (p = 0.003), and higher commission error rate (p = 0.026) than the group of athletes with no history of ACL injury. Conclusions: Athletes rehabilitated from an ACL injury show inferior performance in proactive inhibitory control, evidenced by lower accuracy and higher reaction times than athletes without a history of injury. Consequently, physiotherapists and exercise professionals should consider cognition during ACL injury rehabilitation and physical retraining before returning to sporting activity. Full article