Search Results (35)

Coalbed methane (CBM) reservoirs in southwestern China are characterized by thick, multi-layered coal sequences partitioned into several independent pressure systems by impermeable strata. Commingled production from multiple coal seams in such multi-superposed CBM systems often suffers from severe inter-layer interference, leading to suboptimal gas recovery. To address this challenge, we developed a systematic four-step optimization workflow integrating geological data screening, pressure compartmentalization analysis, and numerical reservoir simulation. The workflow identifies the key “main” coal seams and evaluates various co-production layer combinations to maximize gas recovery while minimizing negative interference. We applied this method to a CBM well (LC-C2) in the Western Guizhou–Eastern Yunnan region, which penetrates three discrete CBM pressure systems. In the case study, single-layer simulations first revealed that one seam (No. 7 + 8) contributed over 30% of the total gas potential, with a few other seams (e.g., No. 18, 13, 4, 16) providing moderate contributions and many seams yielding negligible gas. Guided by these results, we simulated five commingling scenarios of increasing complexity. The optimal scenario was to co-produce the seams from the two higher-pressure systems (a total of six seams) while excluding the low-pressure shallow seams. This optimal six-seam configuration achieved a 10-year cumulative gas production of approximately 2.53 × 10⁶ m³ (about 700 m³/day average)—roughly 75% higher than producing the main seam alone, and even about 15% greater than a scenario involving all available seams. In contrast, including all three pressure systems (ten seams) led to interference effects where the high-pressure seams dominated flow and the low-pressure seams contributed little, resulting in lower overall recovery. The findings demonstrate that more is not always better in multi-seam CBM production. By intelligently selecting a moderate number of compatible seams for co-production, the reservoir’s gas can be extracted more efficiently. The proposed quantitative optimization approach provides a practical tool for designing multi-seam CBM wells and can be broadly applied to similar geologically compartmentalized reservoirs. Full article

Vascular steal refers to the diversion of blood flow between collateral vessels that share a common inflow restricted by arterial stenosis. Blood is diverted from the high-pressure to the low-pressure, low-resistance system. Vascular steal is associated with anatomical bypass or vasodilation in the collateral network and is called “the arterial steal”. However, we have demonstrated that in the presence of an outflow gradient (e.g., intra-extracranial), blood is shunted to a lower pressure system, a phenomenon we term “venous steal”. Using Thevenin’s equivalent, we generalized the concept of venous steal to apply it to any region of the vascular system with increased outflow pressure. Both arterial steal, caused by increased collateral network conductivity, and venous steal, resulting from lower collateral outflow pressure, reduce compartment perfusion. This occurs indirectly by increasing flow and the pressure gradient across the arterial stenosis, lowering the segmental compartment perfusion pressure—the difference between post-stenotic (inflow) and compartmental (outflow) pressures. Venous steal diverts blood flow from compartments with elevated pressure, such as intracranial, subendocardial, the ischemic core, and regions of focal edema due to inflammation, trauma, or external compression. In shock and low-flow states, it contributes to regional blood flow maldistribution. Treatment of venous steal addresses inflow stenosis, increased compartmental pressure and systemic loading conditions (arterial and venous pressure) to reverse venous steal malperfusion in the ischemic regions. Full article

Objectives: This study aimed to describe the outcomes of a staged procedure combining Descemet membrane endothelial keratoplasty (DMEK) and sutureless scleral fixation (SSF) of a one-piece intraocular lens (IOL) in a case series. Co-performing endothelial keratoplasty (EK) and SSF is associated with intraoperative and postoperative complications such as graft deployment difficulties, air migration, graft detachment, and IOL opacification or tilt, all of which are evaluated in this study. Methods: This is a retrospective observational case series. Clinical data were collected from eight eyes of eight patients who underwent DMEK for endothelial failure and had previously received an SSF with one-piece IOL following complete vitrectomy. During DMEK surgery, an air leak test was conducted to check for air migration into the posterior chamber. If instability was detected, pupilloplasty was performed. Intraoperative and postoperative data, including DMEK graft unfolding time, were collected. Corrected Distance Visual Acuity (CDVA), refraction, endothelial cell density (ECD), central corneal thickness (CCT), intraocular pressure (IOP), and complications were recorded over a 12-month follow-up period. Results: We performed pupilloplasty in four patients (50%). The median CDVA improved from preoperative 0.85 logMAR (range: 0.60 to 1.00) at baseline to 0.18 logMAR (range: 0.10 to 0.70, p = 0.012) at 12 months. The median refraction value changed significantly from −1.00 to −0.50 at 12 months. The median percentage reduction in ECD after 12 months was 33.4% (range 30 to 40). The median baseline CCT was 689 μm (range: 651 to 701) at baseline visit and 541.5 μm (range: 525 to 591, p = 0.008) at 12 months. The median IOP was reduced significantly during follow-up. The median graft unfolding time was 6 min (5 to 9). One patient required rebubbling for partial detachment on postoperative day one. No complications occurred within 12 months. Conclusions: The effective compartmentalization of the anterior and posterior chambers in vitrectomized eyes with an SSF one-piece IOL and pupilloplasty can facilitate critical steps of DMEK surgery in complex eyes. Additionally, the air leak test could prove useful in identifying the need for iris-lens diaphragm reconstruction. Full article

According to the requirements of the small double-pulse solid rocket motor, a compartmentalized isolation device has been designed. This device consists of a metal diaphragm and a support frame. An experimental study and numerical simulation were used to verify the bidirectional working process of the metal diaphragm during operation of the double-pulse motor. The results show that the pressure-bearing capacity of the metal diaphragm meets the requirements under the working conditions of pulse I without affecting pulse II, because the metal diaphragm can provide insulation and flame retardancy. The metal diaphragm can be cracked in the direction of the preset V-groove in a relatively short time under the working conditions of pulse II, which allows the gas to flow to the first pulse combustion chamber normally. This indicates that the metal diaphragm can meet the requirements of bidirectional working process in dual-pulse motors. Full article

The COVID-19 pandemic has underscored the necessity of implementing non-pharmaceutical interventions such as lockdowns to mitigate the spread of infectious diseases. This study aims to model the impact of lockdown measures on the progression of an epidemic. Using a combination of compartmental models, specifically a novel delay model, we analyze the effects of varying lockdown intensities and durations on disease transmission dynamics. The results highlight that timely and stringent lockdowns can significantly reduce the peak number of infections and delay the epidemic’s peak, thereby alleviating pressure on healthcare systems. Moreover, our models demonstrate the importance of appropriate lifting of lockdowns to prevent a resurgence of cases. Analytical and numerical results reveal critical thresholds for lockdown efficacy from the epidemiological point of view, which depend on such factors as the basic reproduction number (${\Re }_0$), disease duration, and immunity waning. In the case of a single outbreak with permanent immunity, we analytically determine the optimal proportion of isolated people which minimizes the total number of infected. While in the case of temporary immunity, numerical simulations show that the infectious cases decrease with respect to the proportion of isolated people during lockdowns; as we increase the proportion of isolated people, we have to increase the duration of lockdowns to obtain periodic outbreaks. Further, we assess the influence of epidemic with or without lockdown on the economy and evaluate its economical efficacy by means of the level of population wealth. The percentage of productive individuals among isolated people influences the wealth state of the population during lockdowns. The latter increases with the rise of the former for fixed epidemic parameters. This research provides valuable insights for policymakers in designing effective lockdown strategies to control future epidemics. Full article

Treating posterior segment and retinal diseases poses challenges due to the complex structures in the eye that act as robust barriers, limiting medication delivery and bioavailability. This necessitates frequent dosing, typically via eye drops or intravitreal injections, to manage diseases, often leading to side effects with long-term use. Suprachoroidal injection is a novel approach for targeted drug delivery to the posterior segment. The suprachoroidal space is the region between the sclera and the choroid and provides a potential route for minimally invasive medication delivery. Through a more targeted delivery to the posterior segment, this method offers advantages over other routes of administration, such as higher drug concentrations, increased bioavailability, and prolonged duration of action. Additionally, this approach minimizes the risk of corticosteroid-related adverse events such as cataracts and intraocular pressure elevation via compartmentalization. This review focuses on preclinical and clinical studies published between 2019 and 2023, highlighting the potential of suprachoroidal injection in treating a variety of posterior segment diseases. However, to fully harness its potential, more research is needed to address current challenges and limitations, such as the need for technological advancements, refinement of injection techniques, and consideration of cost and accessibility factors. Future studies exploring its use in conjunction with biotech products, gene therapies, and cell-based therapies can lead to personalized treatments that can revolutionize the field of ophthalmology. Full article

Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of injury throughout the lung parenchyma that alters regional alveolar opening and collapse time constants. Such heterogeneity leads to atelectasis and repetitive alveolar collapse and expansion (RACE). The net effect is a progressive loss of lung volume with secondary ventilator-induced lung injury (VILI). Previous concepts of ARDS pathophysiology envisioned a two-compartment system: a small amount of normally aerated lung tissue in the non-dependent regions (termed “baby lung”); and a collapsed and edematous tissue in dependent regions. Based on such compartmentalization, two protective ventilation strategies have been developed: (1) a “protective lung approach” (PLA), designed to reduce overdistension in the remaining aerated compartment using a low tidal volume; and (2) an “open lung approach” (OLA), which first attempts to open the collapsed lung tissue over a short time frame (seconds or minutes) with an initial recruitment maneuver, and then stabilize newly recruited tissue using titrated positive end-expiratory pressure (PEEP). A more recent understanding of ARDS pathophysiology identifies regional alveolar instability and collapse (i.e., hidden micro-atelectasis) in both lung compartments as a primary VILI mechanism. Based on this understanding, we propose an alternative strategy to ventilating the injured lung, which we term a “stabilize lung approach” (SLA). The SLA is designed to immediately stabilize the lung and reduce RACE while gradually reopening collapsed tissue over hours or days. At the core of SLA is time-controlled adaptive ventilation (TCAV), a method to adjust the parameters of the airway pressure release ventilation (APRV) modality. Since the acutely injured lung at any given airway pressure requires more time for alveolar recruitment and less time for alveolar collapse, SLA adjusts inspiratory and expiratory durations and inflation pressure levels. The TCAV method SLA reverses the open first and stabilize second OLA method by: (i) immediately stabilizing lung tissue using a very brief exhalation time (≤0.5 s), so that alveoli simply do not have sufficient time to collapse. The exhalation duration is personalized and adaptive to individual respiratory mechanical properties (i.e., elastic recoil); and (ii) gradually recruiting collapsed lung tissue using an inflate and brake ratchet combined with an extended inspiratory duration (4–6 s) method. Translational animal studies, clinical statistical analysis, and case reports support the use of TCAV as an efficacious lung protective strategy. Full article

The development of a capnometry wristband is of great interest for monitoring patients at home. We consider a new architecture in which a non-dispersive infrared (NDIR) optical measurement is located close to the skin surface and is combined with an open chamber principle with a continuous circulation of air flow in the collection cell. We propose a model for the temporal dynamics of the carbon dioxide exchange between the blood and the gas channel inside the device. The transport of carbon dioxide is modeled by convection–diffusion equations. We consider four compartments: blood, skin, the measurement cell and the collection cell. We introduce the state-space equations and the associated transition matrix associated with a Markovian model. We define an augmented system by combining a first-order autoregressive model describing the supply of carbon dioxide concentration in the blood compartment and its inertial resistance to change. We propose to use a Kalman filter to estimate the carbon dioxide concentration in the blood vessels recursively over time and thus monitor arterial carbon dioxide blood pressure in real time. Four performance factors with respect to the dynamic quantification of the CO₂ blood concentration are considered, and a simulation is carried out based on data from a previous clinical study. These demonstrate the feasibility of such a technological concept. Full article

The measurement of physiologic pressure helps diagnose and prevent associated health complications. From typical conventional methods to more complicated modalities, such as the estimation of intracranial pressures, numerous invasive and noninvasive tools that provide us with insight into daily physiology and aid in understanding pathology are within our grasp. Currently, our standards for estimating vital pressures, including continuous BP measurements, pulmonary capillary wedge pressures, and hepatic portal gradients, involve the use of invasive modalities. As an emerging field in medical technology, artificial intelligence (AI) has been incorporated into analyzing and predicting patterns of physiologic pressures. AI has been used to construct models that have clinical applicability both in hospital settings and at-home settings for ease of use for patients. Studies applying AI to each of these compartmental pressures were searched and shortlisted for thorough assessment and review. There are several AI-based innovations in noninvasive blood pressure estimation based on imaging, auscultation, oscillometry and wearable technology employing biosignals. The purpose of this review is to provide an in-depth assessment of the involved physiologies, prevailing methodologies and emerging technologies incorporating AI in clinical practice for each type of compartmental pressure measurement. We also bring to the forefront AI-based noninvasive estimation techniques for physiologic pressure based on microwave systems that have promising potential for clinical practice. Full article

The conceptual design of a hybrid aerial vehicle for the exploration of the upper Venus atmosphere is presented. The vehicle will float like a balloon and harvest solar energy which is stored in batteries. The neutral buoyancy reduces the energy consumption and makes the vehicle robust and durable. Energy stored in the batteries can be used for powered flight with good horizontal and vertical mobility to explore aspects of the atmosphere. The vehicle is intended to operate near 55.3 km altitude and to explore the cloud layer of the planet. The vehicle takes its inspiration from the Stingray inflatable wing by Prospective Concepts. Based on a trade study, the wing span was set to 25 m. Equations are developed for the altitude, gas and skin temperature, and skin stress during neutrally buoyant flight. To keep the equations in a simplified analytical form, the complex compartmentalized gas pockets of the vehicle are lumped into a single gas sphere. The equations take into account the volumetric expansion of the structure and the requirement that the differential pressure needs to be large enough to allow for brief periods of powered flight without significant structural deformation. An aerodynamic analysis provides the lift and drag coefficient curves and indicates that the vehicle is pitch-stable. A powered flight analysis shows that an airspeed of 30 m/s can be maintained for 31 min at 55 km and 69 min at 69 km altitude. Full article

Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve markers for renal and cardiovascular outcomes in patients with and without type 2 diabetes (T2D). To assess whether individual differences in plasma drug exposure can explain inter-individual response variation, we characterized the exposure–response relationship for two SGLT2 inhibitors on several clinical and kidney hemodynamic variables. Data were obtained from two studies, RED and RECOLAR, assessing the effects of once-daily 10 mg dapagliflozin or empagliflozin, respectively, on kidney hemodynamics in patients with T2D. Individual plasma exposure was estimated using non-compartmental analyses and exposure–response relationships were assessed using linear mixed-effects models. In 23 patients participating in RED, the dapagliflozin geometric mean apparent area under the concentration-time curve during one dosing interval at steady state (AUC_0–tau,ss) was 1153.1 µg/L*h (coefficient of variation (CV) 81.8%) and associated, per doubling, with decreases in body weight (0.29 kg, p < 0.001), systolic blood pressure (0.80 mmHg, p = 0.002), measured glomerular filtration rate (mGFR) (0.83 mL/min, p = 0.03), and filtration fraction (0.09%, p = 0.04). In 20 patients participating in RECOLOR, the empagliflozin geometric mean AUC_0–tau,ss was 2035.7 nmol/L*h (CV 48.4%) and associated, per doubling, with decreases in body weight (0.13 kg, p = 0.002), systolic blood pressure (0.65 mmHg, p = 0.045), and mGFR (0.78 mL/min, p = 0.002). To conclude, dapagliflozin and empagliflozin plasma exposure was highly variable between patients and associated with inter-individual variation in response variables. Full article

Membrane oxygenators are devices that benefit from automatic control. This is especially true for implantable membrane oxygenators—a class of wearable rehabilitation devices that show high potential for fast recovery after lung injury. We present a performance comparison for reference tracking of carbon dioxide partial pressure between three control algorithms—a classical proportional-integral (PI) controller, a modern non-linear model predictive controller, and a novel deep reinforcement learning controller. The results are based on simulation studies of an improved compartmental model of a membrane oxygenator. The compartmental model of the oxygenator was improved by decoupling the oxygen kinetics from the system and only using the oxygen saturation as an input to the model. Both the gas flow rate and blood flow rate were used as the manipulated variable of the controllers. All three controllers were able to track references satisfactorily, based on several performance metrics. The PI controller had the fastest response, with an average rise time and settling time of 1.18 s and 2.24 s and the lowest root mean squared error of 1.06 mmHg. The NMPC controller showed the lowest steady state error of 0.17 mmHg and reached the reference signal with less than 2% error in 90% of the cases within 15 s. The PI and RL reached the reference with less than 2% error in 84% and 50% of the cases, respectively, and showed a steady state error of 0.29 mmHg and 0.5 mmHg. Full article

Since the UN Water Conference in 1977, international debates have centered on global water scarcity and achieving sustainable development. In 1995, Morocco introduced a water policy to strengthen the country’s socio-economic development through irrigated agriculture, while ensuring the long-term sustainability of water resources through integrated water resource management (IWRM). Empirical research, however, reveals decreasing groundwater levels and increasing inequalities around water access. The purpose of this article is to shed light on the challenges this policy provokes for achieving sustainable development, the limitations it faces to implement IWRM, and provide insights on how the policy is linked to the increased pressure on water resources as reported in the literature. We conducted a content analysis of ten key water policy documents and thirty-seven in-depth semi-structured interviews undertaken between 2020 and 2021 with governmental actors and inhabitants of the Middle Draa Valley (south Morocco). We found that sustainability and social-inequality problems unintendedly triggered by the policy were linked to three factors: the use of a disciplinary approach for policy formulation and its limitations to encompass the complexity of the water-related problems, the compartmentalization of government sectors hindering the development of sound solutions to water-related problems, and the neglect of social, economic, and political factors affecting actual access to water. Full article

This review is an attempt to incorporate water as a structural and thermodynamic component of biomembranes. With this purpose, the consideration of the membrane interphase as a bidimensional hydrated polar head group solution, coupled to the hydrocarbon region allows for the reconciliation of two theories on cells in dispute today: one considering the membrane as an essential part in terms of compartmentalization, and another in which lipid membranes are not necessary and cells can be treated as a colloidal system. The criterium followed is to describe the membrane state as an open, non-autonomous and responsive system using the approach of Thermodynamic of Irreversible Processes. The concept of an open/non-autonomous membrane system allows for the visualization of the interrelationship between metabolic events and membrane polymorphic changes. Therefore, the Association Induction Hypothesis (AIH) and lipid properties interplay should consider hydration in terms of free energy modulated by water activity and surface (lateral) pressure. Water in restricted regions at the lipid interphase has thermodynamic properties that explain the role of H-bonding networks in the propagation of events between membrane and cytoplasm that appears to be relevant in the context of crowded systems. Full article

The objective of this work is to innovatively apply the boundary element method (BEM) as a general modeling strategy to deal with complicated reservoir modeling problems, especially those related to reservoir heterogeneity and fracture systems, which are common challenges encountered in the practice of reservoir engineering. The transient flow behaviors of reservoirs containing multi-scale heterogeneities enclosed by arbitrarily shaped boundaries are modeled by applying BEM. We demonstrate that a BEM-based simulation strategy is capable of modeling complex heterogeneous reservoirs with robust solutions. The technology is beneficial in making the best use of geological modeling information. The governing differential operator of fluid flow within any locally homogeneous domain is solved along its boundary. The discretization of a reservoir system is only made on the corresponding boundaries, which is advantageous in closely conforming to the reservoir’s geological description and in facilitating the numerical simulation and computational efforts because no gridding within the flow domain is needed. Theoretical solutions, in terms of pressure and flow rate responses, are validated and exemplified for various reservoir–well systems, including naturally fractured reservoirs with either non-crossing fractures or crossing fractures; fully compartmentalized reservoirs; and multi-stage, fractured, horizontal wells with locally stimulated reservoir volumes (SRVs) around each stage of the fracture, etc. A challenging case study for a complicated fracture network system is examined. This work demonstrates the significance of adapting the BEM strategy for reservoir simulation due to its flexibility in modeling reservoir heterogeneity, analytical solution accuracy, and high computing efficiency, in reducing the technical gap between reservoir engineering practice and simulation capacity. Full article