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Search Results (2,905)

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30 pages, 536 KB  
Article
An Attention-Driven Feature Fusion Approach for Multimodal Aspect-Based Sentiment Analysis
by Ismail Ifakir, El Habib Nfaoui, Abderrahim Zannou and Asmaa Mourhir
Big Data Cogn. Comput. 2026, 10(6), 169; https://doi.org/10.3390/bdcc10060169 (registering DOI) - 23 May 2026
Abstract
Aspect-Based Sentiment Analysis explores sentiment trends related to specific opinion aspects and holds significant commercial potential for monitoring brand reputation, understanding customer satisfaction, and personalizing recommendations. However, traditional methods rely exclusively on textual input and often struggle when the target aspect is not [...] Read more.
Aspect-Based Sentiment Analysis explores sentiment trends related to specific opinion aspects and holds significant commercial potential for monitoring brand reputation, understanding customer satisfaction, and personalizing recommendations. However, traditional methods rely exclusively on textual input and often struggle when the target aspect is not mentioned in the sentence. Multimodal Aspect-Based Sentiment Analysis addresses this limitation by incorporating both textual and visual modalities to enable more comprehensive sentiment understanding. Despite advancements in deep learning and transformer-based architectures, existing models often suffer from suboptimal modality fusion and weak aspect grounding, limiting their classification accuracy. To overcome these challenges, we propose an Attention-Driven Feature Fusion (ADFF) approach based on a three-stage hierarchical attention mechanism. First, it only fuses text and image embeddings. Second, it incorporates aspect-level features. Third, a multi-head attention layer further enhances cross-modal dependencies. The resulting representation is passed to a Long Short-Term Memory (LSTM) classifier for sentiment polarity prediction. We evaluate our model on three benchmark datasets, namely Twitter-2015, Twitter-2017, and MASAD. The experimental results demonstrate that the proposed model substantially outperforms state-of-the-art multimodal and unimodal baselines, improves both accuracy and F1-score, achieving 82.55% accuracy and 81.05% F1-score on Twitter-2015, 77.07% accuracy and 77.15% F1-score on Twitter-2017, and up to 99.67% accuracy and F1-score in the Plant domain of MASAD, where we observe consistent improvements across all seven domains. These results highlight the effectiveness and scalability of the hierarchical attention-based fusion strategy for real-world aspect-based sentiment analysis tasks. Full article
30 pages, 7666 KB  
Article
NeSy-Drop: Interpretable Dropout Prediction and Personalized Intervention via Neuro-Symbolic Graph Learning in MOOCs
by Abdennour Redjaibia, Samia Drissi, Karima Boussaha, Yacine Lafifi and Sevinç Gülseçen
Electronics 2026, 15(10), 2212; https://doi.org/10.3390/electronics15102212 - 21 May 2026
Viewed by 144
Abstract
Dropout prediction in Massive Open Online Courses (MOOCs) has been extensively studied, yet existing systems share three fundamental limitations: Accurate models are black boxes, post-hoc explanations approximate rather than faithfully represent model decisions, and predictions are rarely translated into concrete instructor actions. This [...] Read more.
Dropout prediction in Massive Open Online Courses (MOOCs) has been extensively studied, yet existing systems share three fundamental limitations: Accurate models are black boxes, post-hoc explanations approximate rather than faithfully represent model decisions, and predictions are rarely translated into concrete instructor actions. This paper presents NeSy-Drop, a neuro-symbolic framework that simultaneously addresses prediction, explanation, and personalized intervention routing for MOOC dropout. NeSy-Drop constructs a heterogeneous graph per course cohort encoding student–resource–assessment interactions, processed through a heterogeneous graph transformer encoder, five behavioral atom predictor MLPs, and a differentiable symbolic rule layer producing guaranteed faithful ante-hoc explanations. A three-level explainability stack provides symbolic rule chains, SHAP embedding attribution, LIME raw-feature importance, and gradient-based counterfactual prescriptions. Each at-risk student is routed to one of five concrete interventions at one of three severity levels. Evaluated on OULAD covering 32,593 students across 22 cohorts, NeSy-Drop achieves AUC of 0.961 and macro F1 of 0.8983, within 2.2% AUC of the best non-interpretable baseline under a fair evaluation protocol, while being the only system that simultaneously predicts, explains, and prescribes actions at the individual student level. Full article
(This article belongs to the Section Artificial Intelligence)
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17 pages, 1473 KB  
Review
From Traditional Risk Factors to Machine Learning Models: Advancing the Prediction of Anastomotic Leak and Other Major Complications in Colorectal Cancer Surgery
by Sophia Tsokkou, Nikolaos Konstantinididis, Ioannis Konstantinidis, Menelaos Papakonstantinou, Filippos Alexandris, Despina Tokou, Konstantia Kotsani, Dimitrios Alexandrou, Dimitrios Giakoustidis, Alexandros Giakoustidis, Vasileios Papadopoulos and Petros Bangeas
Cancers 2026, 18(10), 1668; https://doi.org/10.3390/cancers18101668 - 21 May 2026
Viewed by 166
Abstract
Background: Colorectal cancer (CRC) represents a major global health burden, accounting for roughly 10% of all newly diagnosed cancers and cancer-related deaths worldwide. According to the World Health Organization, it is the third most diagnosed malignancy and the second leading cause of cancer [...] Read more.
Background: Colorectal cancer (CRC) represents a major global health burden, accounting for roughly 10% of all newly diagnosed cancers and cancer-related deaths worldwide. According to the World Health Organization, it is the third most diagnosed malignancy and the second leading cause of cancer mortality. Postoperative complications remain a significant concern after CRC resection, occurring in up to 50% of patients and contributing to increased morbidity, mortality, prolonged hospitalization, and substantial healthcare expenditure. Artificial intelligence (AI) has emerged as a transformative tool in modern healthcare, offering advanced capabilities in predictive analytics, clinical decision support, and personalized perioperative management. Methods: This review systematically evaluates the application of AI, specifically machine learning (ML) and deep learning (DL) algorithms, in the prediction of anastomotic leak (AL) and other major postoperative complications. In this context, AI models are generally used to refine risk stratification and enhance surgical decision-making. Results: A total of 13 studies were included, encompassing 15,105 patients. Across these studies, ML and DL algorithms consistently outperformed conventional statistical models in forecasting postoperative outcomes. Conclussions: Current evidence suggests that AI has substantial potential to improve perioperative risk prediction, support intraoperative decision-making, and personalize postoperative surveillance in patients undergoing CRC surgery. Methodological limitations, including a high risk of bias, limited external validation, heterogeneous outcome definitions, and inconsistent reporting, necessitate more robust, prospective, multicenter research before widespread clinical adoption can be realized. Full article
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23 pages, 332 KB  
Article
Value Innovation in Church Administration: A Theological-Orthodox Reading of the “Blue Ocean” and the ERSC Matrix
by Doru Negricea
Religions 2026, 17(5), 620; https://doi.org/10.3390/rel17050620 - 21 May 2026
Viewed by 178
Abstract
This study proposes a theological-orthodox reinterpretation of contemporary management concepts—particularly “value innovation,” the “blue ocean strategy,” and the E.R.S.C. matrix—within the framework of church administration. Starting from the premise that such concepts cannot be directly imported into the ecclesial context without distortion, the [...] Read more.
This study proposes a theological-orthodox reinterpretation of contemporary management concepts—particularly “value innovation,” the “blue ocean strategy,” and the E.R.S.C. matrix—within the framework of church administration. Starting from the premise that such concepts cannot be directly imported into the ecclesial context without distortion, the paper argues for their “theological translation,” whereby their underlying logic is reoriented toward the service of the person, communion, and oikonomia. The analysis demonstrates that church administration cannot be understood as a neutral technical system, but as a form of diakonia, intrinsically linked to the ecclesial nature of the Church as the Body of Christ. Consequently, “value” is redefined not in utilitarian or economic terms, but as concrete good: the protection of human dignity, the strengthening of communion, the accessibility of liturgical and pastoral life, and the responsible use of resources. Within this framework, innovation is understood as a Christ-centered renewal of administrative practices, while differentiation (“blue ocean”) becomes a form of service rather than competition. The E.R.S.C. matrix is reinterpreted as an ascetical discipline of discernment, guiding administrative decisions through criteria rooted in theological anthropology and ecclesial ethics. Furthermore, the study addresses the ethical meaning of surplus, the role of transparency, the integration of virtue and competence in organizational culture, and the transformation of communication from image management into truthful witness. Ultimately, the paper argues that authentic church administration is not defined by procedural efficiency alone, but by its capacity to manifest, through structures and decisions, the love of Christ in concrete institutional life. Full article
33 pages, 895 KB  
Review
The Emerging Role of Peroxyacetic Acid in Water and Wastewater Treatment: Degradation of Pharmaceuticals, Microplastics, and Other Micropollutants
by Patrycja Zawiślak, Justyna Kapelewska, Izabela Ryza, Joanna Karpińska and Urszula Kotowska
Molecules 2026, 31(10), 1748; https://doi.org/10.3390/molecules31101748 - 20 May 2026
Viewed by 214
Abstract
Conventional wastewater treatment systems cannot effectively eliminate micropollutants such as contaminants of emerging concern (CECs). These compounds, even at trace levels, are persistent or pseudo-persistent, bioaccumulative, and potentially harmful to ecosystems and human health. Advanced oxidation processes (AOPs), based on the in situ [...] Read more.
Conventional wastewater treatment systems cannot effectively eliminate micropollutants such as contaminants of emerging concern (CECs). These compounds, even at trace levels, are persistent or pseudo-persistent, bioaccumulative, and potentially harmful to ecosystems and human health. Advanced oxidation processes (AOPs), based on the in situ generation of highly reactive oxygen species, have emerged as promising solutions. Peroxyacetic acid (PAA) has gained attention due to its strong oxidizing capacity, broad antimicrobial activity, environmentally benign by-products, and compatibility with different activation methods. This review provides an updated and integrated synthesis of recent advances in PAA-based AOPs for the degradation of major CEC groups, including pharmaceuticals, personal care products, pesticides, and industrial chemicals, as well as for the oxidative modification of microplastics (MPs). The review discusses several strategies for PAA activation and critically discusses removal efficiency, underlying mechanisms, and current limitations, emphasizing the gap between pollutant transformation and complete mineralization. Furthermore, the article highlights a key research need, which is the assessment of the toxicity of transformation products and their validation under realistic conditions. Overall, this review provides insight into the potential and challenges of PAA-based AOPs for sustainable water treatment. Full article
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13 pages, 827 KB  
Review
Integrating Artificial Intelligence into Community Health Nursing Education and Practice: Opportunities, Ethical Challenges, and Future Directions
by Bandar Alhumaidi and Talal Ali F. Alharbi
Healthcare 2026, 14(10), 1407; https://doi.org/10.3390/healthcare14101407 - 20 May 2026
Viewed by 177
Abstract
Background/Objectives: Artificial intelligence (AI) is rapidly transforming healthcare. Its integration into community health nursing—a discipline centered on population-level prevention, health promotion, and primary care in community settings—remains insufficiently explored. This narrative review examines the opportunities, ethical challenges, and future directions for integrating [...] Read more.
Background/Objectives: Artificial intelligence (AI) is rapidly transforming healthcare. Its integration into community health nursing—a discipline centered on population-level prevention, health promotion, and primary care in community settings—remains insufficiently explored. This narrative review examines the opportunities, ethical challenges, and future directions for integrating AI into community health nursing education and practice. Methods: A literature search was conducted across PubMed, CINAHL, Scopus, Web of Science, and IEEE Xplore for publications between January 2017 and March 2026. The initial search yielded 612 records; after the removal of duplicates and screening of titles, abstracts, and full texts against predefined criteria, 58 sources were retained for thematic synthesis, comprising empirical studies, systematic and umbrella reviews, scoping reviews, meta-analyses, and authoritative policy documents. Screening and data extraction were performed by two reviewers, with disagreements resolved by discussion. Results: AI offers opportunities for community health nursing across four interconnected domains: clinical decision support for community-based assessments, predictive analytics for population health management, enhanced disease surveillance and outbreak detection, and personalized health education delivery. Significant challenges persist, including algorithmic bias, data privacy concerns, threats to the therapeutic nurse–client relationship, inadequate AI literacy among nursing faculty, and regulatory gaps. Most empirical evidence originates from hospital or general nursing settings; transferability to community contexts is therefore inferred rather than directly demonstrated. Conclusions: Responsible integration of AI into community health nursing requires curriculum reform, ethical governance frameworks, faculty development, equitable access, and interdisciplinary collaboration. AI should augment, not replace, the relational and culturally sensitive care that defines this discipline. Given the narrative nature of the review and the limited community-specific evidence, conclusions are framed as a vision of the AI–community health nursing interface rather than a definitive synthesis. Full article
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13 pages, 242 KB  
Article
From Virality to Value: A Bibliometric and Thematic Analysis of Engagement Metrics in Brand Storytelling on Social Media
by Andaleep Sadi Ades
Journal. Media 2026, 7(2), 108; https://doi.org/10.3390/journalmedia7020108 - 20 May 2026
Viewed by 158
Abstract
The advent of social media has transformed brand communication to put storytelling at the center of building engagement and awareness. But the role of long-term brand value in virality is an essential challenge. This paper conducts a bibliometric and thematic analysis from the [...] Read more.
The advent of social media has transformed brand communication to put storytelling at the center of building engagement and awareness. But the role of long-term brand value in virality is an essential challenge. This paper conducts a bibliometric and thematic analysis from the fields of marketing, psychology, and media studies published between 2015 and 2025, examining the correlation between narrative design and audience response, separating short-term popularity and long-term consumer appeal. The analysis was based on a structured literature review and qualitative methodological framework, using the literature sourced through Scopus, Web of Science, PsycINFO, and Google Scholar published between 2015 and 2025. Thematic coding searched for emotional tones, devices used in the narration, types of metrics, and contextual factors in inclusion and exclusion criteria. The findings indicate a divide in quantitative measures, such as likes and shares, and qualitative measures, such as sentiment and resonance stories. Story elements such as authenticity, the depth of the characters, and video-based content had a major effect on the two types of engagement. Storytelling effectiveness was also mediated by influencer participation, algorithmic interactions, and audience demographics. The results confirm that meaningful storytelling with hybrid metrics contributes to stronger brand–consumer relationships. Future studies ought to shift to predictive modeling and focus on the ability of AI to dictate personalized brand stories in diverse cultures. Full article
58 pages, 898 KB  
Article
Adoption of Artificial Intelligence in Organizational Coaching Processes
by Yanis Faquir, Arnaldo Santos and Henrique S. Mamede
AI 2026, 7(5), 175; https://doi.org/10.3390/ai7050175 - 19 May 2026
Viewed by 130
Abstract
Artificial intelligence (AI) is transforming how organizations develop human potential, offering scalable and data-driven support for coaching and capability building. This study proposes and validates a conceptual framework for integrating AI into organizational coaching processes to enhance competence development and strategic alignment. AI-supported [...] Read more.
Artificial intelligence (AI) is transforming how organizations develop human potential, offering scalable and data-driven support for coaching and capability building. This study proposes and validates a conceptual framework for integrating AI into organizational coaching processes to enhance competence development and strategic alignment. AI-supported coaching in this research is treated as an emerging organizational technology whose potential organizational value depends less on model capability and more on governance design, decision rights, and auditable evaluation outputs. Following a mixed-methods, multi-phase design, the research combined a Systematic Literature Review (SLR) with the construction of a layered design architecture in which OSCAR serves as the primary coaching-process scaffold, complemented by KSA for competency specification, Situational Leadership for adaptive guidance, and KPIs for monitoring and governance. The framework structures AI-supported coaching across 10 interrelated phases, from contextual anchoring to review and measurement, while preserving iterative re-entry to earlier phases whenever review evidence, contextual change, or insufficient progress makes adjustment necessary. Prototyping demonstrated feasibility and coherence across models, while the focus group provided qualitative expert feedback on the framework’s clarity, governance needs, and perceived usefulness for competence development. At this stage, however, the KPI structures generated by the framework and the descriptive comparison across AI tools should be interpreted as prototype-level outputs rather than as empirically validated performance measures or evidence of added value over baseline approaches. Because the evaluation relied on two fictional prototyping scenarios and a small expert-oriented focus group (n = 6), the findings should be interpreted as evidence of prototype demonstration and qualitative refinement rather than of real-world effectiveness or organizational impact. The study also does not include a control group or comparison with traditional human coaching, so the added value of the AI-supported framework over alternative coaching arrangements remains a question for future empirical testing. Findings suggest that AI can usefully support organizational coaching by personalizing dialogue, structuring reflection, and generating auditable development artefacts, provided ethical safeguards and human oversight remain integral. The research contributes a preliminarily validated, ethics-informed, and governance-aware framework for AI adoption in organizational coaching and offers practical insights for embedding AI-enabled development in learning organizations. Full article
12 pages, 3791 KB  
Article
Pathway-Specific Effects of Oral Corticosteroids on Eosinophilic Inflammation and Tissue Remodeling in Chronic Rhinosinusitis with Nasal Polyps
by Kamil Radajewski, Paweł Burduk, Małgorzata Wierzchowska, Paulina Antosik, Jakub Jóźwicki, Jakub Burduk and Dariusz Grzanka
Int. J. Mol. Sci. 2026, 27(10), 4565; https://doi.org/10.3390/ijms27104565 - 19 May 2026
Viewed by 144
Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease characterized by heterogeneous phenotypes and endotypes, necessitating personalized therapeutic strategies. Precision medicine approaches integrating molecular biomarkers may improve treatment selection and disease stratification. In this prospective controlled study, we investigated the tissue-level [...] Read more.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease characterized by heterogeneous phenotypes and endotypes, necessitating personalized therapeutic strategies. Precision medicine approaches integrating molecular biomarkers may improve treatment selection and disease stratification. In this prospective controlled study, we investigated the tissue-level immunohistochemical effects of oral corticosteroids (OCSs) and topical steroids on the expression of periostin, eotaxin, interleukin-4 (IL-4), transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) in nasal polyp tissue. Sixty-five patients eligible for endoscopic sinus surgery (ESS) were enrolled and divided into two groups: Group 1 (n = 42) received topical steroids combined with oral prednisone (40 mg/day for 7 days preoperatively), whereas Group 2 (n = 23) received topical steroids alone. Immunohistochemical analysis demonstrated a significant reduction in periostin and eotaxin expression in both epithelial and stromal compartments following OCS therapy, accompanied by increased TGF-β expression. No significant differences were observed in IL-4 or TNF-α expression. These findings indicate that short-term OCSs selectively modulate molecular pathways associated with eosinophilic inflammation and tissue remodeling in CRSwNP, supporting biomarker-driven precision medicine strategies. Full article
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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16 pages, 2816 KB  
Article
Occluded Person Re-Identification Method Based on Pedestrian Background Decoupling Transformer
by Xinting Li, Yuheng Chen, Yuchen Wu, Yuchong Liang, Yi Cao, Qingcheng Liu and Chengsheng Yuan
Mathematics 2026, 14(10), 1725; https://doi.org/10.3390/math14101725 - 17 May 2026
Viewed by 233
Abstract
As urbanization picks up pace and the public demand for security keeps climbing, video surveillance systems have emerged as a vital tool for maintaining social stability and safeguarding public safety. Person Re-Identification (Re-ID), as one of the core technologies in intelligent monitoring, mainly [...] Read more.
As urbanization picks up pace and the public demand for security keeps climbing, video surveillance systems have emerged as a vital tool for maintaining social stability and safeguarding public safety. Person Re-Identification (Re-ID), as one of the core technologies in intelligent monitoring, mainly aims to accurately match pedestrian identities across cameras without overlapping fields of view. However, in practical applications, occlusion remains a primary challenge that severely degrades Re-ID performance. Especially in high-density crowds, pedestrians are often partially or completely obscured by other objects or individuals, resulting in incomplete image information and impaired feature representation, which significantly reduces recognition accuracy and reliability. Aiming at the problems of excessive reliance on external pose estimation models and asymmetric information matching in occluded Re-ID, this paper proposes a transformer-based pedestrian background decoupling network. The algorithm achieves foreground–background separation and multi-scale feature matching through the synergy of three modules. Meanwhile, a two-stage training strategy is adopted: the first stage optimizes the decoupling module to ensure clean feature separation, while the second stage jointly fine-tunes the correlation module to enhance matching accuracy. Extensive experimental results show that the proposed algorithm outperforms existing methods. Full article
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27 pages, 824 KB  
Review
The Architecture of AI-Mediated Learning: A Three-Layer Framework
by Arash Javadinejad and Maedeh Davari
Appl. Sci. 2026, 16(10), 4991; https://doi.org/10.3390/app16104991 - 16 May 2026
Viewed by 206
Abstract
Artificial intelligence (or AI) is rapidly transforming digital learning environments, reshaping how educational processes are organized, how knowledge is produced, and how learning is evaluated. Despite a growing body of research on AI in education, existing studies often examine technological, pedagogical, and ethical [...] Read more.
Artificial intelligence (or AI) is rapidly transforming digital learning environments, reshaping how educational processes are organized, how knowledge is produced, and how learning is evaluated. Despite a growing body of research on AI in education, existing studies often examine technological, pedagogical, and ethical dimensions in isolation, leaving a lack of integrative frameworks capable of explaining how AI restructures learning environments as a whole. This study addresses this gap by proposing a three-layer conceptual framework that models AI-mediated learning environments through the interaction of efficiency, pedagogy, and ideology. The framework conceptualizes AI integration as a system of interdependent processes: the efficiency layer captures the optimization of educational activities through automation and data-driven personalization; the pedagogical layer explains how AI reshapes learning processes, feedback cycles, and learner strategies; and the ideological layer examines the normative assumptions embedded within AI systems, including issues of epistemic authority, linguistic norms, and algorithmic bias. Drawing on a structured synthesis of recent empirical research across domains such as generative AI tools, automated feedback systems, intelligent tutoring systems, and AI-supported assessment, the study demonstrates how these dimensions interact to structure contemporary digital learning environments and generate both affordances and tensions. The main theoretical contribution lies in advancing a system-level analytical framework that moves beyond tool-specific approaches and enables a more integrated understanding of AI in education. In practical terms, the framework provides educators and policymakers with a lens to critically evaluate AI integration, supporting more informed decisions on assessment design, sustainable learning practices, and inclusive digital education. Full article
27 pages, 2148 KB  
Review
Wearable Biosensors for Continuous Monitoring of Chronic Kidney Disease: Materials, Biofluids, and Digital Health Integration
by Anupamaa Sivasubramanian, Shankara Narayanan and Gymama Slaughter
Biosensors 2026, 16(5), 287; https://doi.org/10.3390/bios16050287 - 15 May 2026
Viewed by 274
Abstract
Chronic kidney disease (CKD) is a progressive and irreversible disorder affecting over 850 million individuals globally and is associated with significant morbidity, mortality, and healthcare burden. Conventional diagnostic approaches rely on intermittent laboratory measurements, including serum creatinine, estimated glomerular filtration rate (eGFR), and [...] Read more.
Chronic kidney disease (CKD) is a progressive and irreversible disorder affecting over 850 million individuals globally and is associated with significant morbidity, mortality, and healthcare burden. Conventional diagnostic approaches rely on intermittent laboratory measurements, including serum creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin, which provide limited temporal resolution and fail to capture dynamic physiological changes. Recent advances in wearable biosensing technologies offer new opportunities for continuous, non-invasive monitoring of biochemical and physiological markers relevant to renal function. This review provides a comprehensive analysis of wearable biosensors for CKD monitoring, focusing on sensing mechanisms (electrochemical, optical, and field-effect transistor), biofluid interfaces (sweat, interstitial fluid, and saliva), and materials engineering strategies enabling flexible, high-performance devices. Emphasis is placed on biofluid transport dynamics, analytical performance across sampling matrices, and system-level integration with wireless communication and digital health platforms. Key challenges limiting clinical translation, including biofouling, enzymatic instability, and variability in biofluid composition, are examined—alongside emerging solutions such as antifouling interfaces, synthetic recognition elements, and multimodal sensing architectures. Finally, regulatory pathways and the role of artificial intelligence in digital nephrology are discussed. This review highlights the potential of wearable biosensors to transform CKD management through continuous monitoring, early detection, and personalized therapeutic intervention. Full article
(This article belongs to the Special Issue AI/ML-Enabled Biosensing: Shaping the Future of Disease Detection)
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16 pages, 750 KB  
Review
Role of Artificial Neural Networks in Optimizing Bioconversion of Antiretroviral Drugs: A Review
by Nelson T. Tsotetsi, Ndiwanga F. Rasifudi, Beauty Magage and Lukhanyo Mekuto
BioMedInformatics 2026, 6(3), 30; https://doi.org/10.3390/biomedinformatics6030030 - 15 May 2026
Viewed by 219
Abstract
Antiretroviral drugs (ARVDs) remain the cornerstone of HIV/AIDS management, but their therapeutic efficacy and safety are highly influenced by bioconversion processes such as hepatic metabolism and enzymatic transformation. Variability in metabolic pathways, mediated by cytochrome P450 enzymes and other liver-based systems, contributes to [...] Read more.
Antiretroviral drugs (ARVDs) remain the cornerstone of HIV/AIDS management, but their therapeutic efficacy and safety are highly influenced by bioconversion processes such as hepatic metabolism and enzymatic transformation. Variability in metabolic pathways, mediated by cytochrome P450 enzymes and other liver-based systems, contributes to interindividual differences in drug response, toxicity, and resistance. Recent advances in artificial intelligence, particularly artificial neural networks (ANNs), offer promising tools for modeling and optimizing these complex bioconversion processes. ANNs are capable of learning nonlinear relationships from high-dimensional datasets, making them ideal for predicting the pharmacokinetic parameters, enzyme–substrate interactions, and metabolic stability of ARVDs. This review explores the emerging role of ANNs in understanding and optimizing the metabolic transformation of antiretroviral agents. Key applications are discussed, including prediction of drug–enzyme interactions, in silico modeling of hepatic clearance, and simulation of enzyme kinetics. The integration of molecular descriptors, omics data, and clinical parameters into ANN models allows for improved prediction accuracy and personalized therapy. Furthermore, ANN-based tools can aid in early-stage drug development by identifying metabolic liabilities and guiding structural modifications to enhance metabolic stability. Despite their potential, challenges such as data scarcity, model interpretability, and standardization remain. Future research should focus on hybrid models combining ANN with mechanistic pharmacokinetics, the incorporation of real-world patient data, and validation against experimental outcomes. Overall, ANNs represent a powerful approach to optimizing ARVDs bioconversion, with the potential to improve efficacy, reduce toxicity, and support the development of next-generation antiretroviral therapies Full article
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14 pages, 1408 KB  
Article
Beyond Learning-by-Hiring: Conceptualizing the Micro-Foundations of Knowledge-Centric Recruitment
by József Blaskó, Zoltán Baracskai and Tibor Dőry
Systems 2026, 14(5), 560; https://doi.org/10.3390/systems14050560 - 15 May 2026
Viewed by 164
Abstract
This conceptual article introduces knowledge-centric recruitment (KCR) as a distinct dynamic capability that reframes recruitment and post-hire socialization as strategic knowledge-development activities. (1) Background: Unlike conventional vacancy-driven approaches, KCR is a proactive process through which firms deliberately access and import external organizational capabilities [...] Read more.
This conceptual article introduces knowledge-centric recruitment (KCR) as a distinct dynamic capability that reframes recruitment and post-hire socialization as strategic knowledge-development activities. (1) Background: Unlike conventional vacancy-driven approaches, KCR is a proactive process through which firms deliberately access and import external organizational capabilities embodied in senior professionals—termed knowledge-hires—from rival organizations. These knowledge-hires embody tacit, socio-cognitive building blocks of capabilities developed through involvement in their prior employers’ routines and practices. (2) Methods: This article develops a micro-foundational model of KCR comprising four interrelated processes: external capability scanning and prioritization, identification of target capabilities and knowledge-hires, evaluation through the novel lens of contextual capability fit, and expectations of adaptation during onboarding. (3) Results: Contextual capability fit integrates complementary and supplementary quality with knowledge distance to enable firms to forecast both the strategic value of inbound capabilities and the hire’s expected socialization difficulty. (4) Conclusions: The primary theoretical contribution lies in advancing the learning-by-hiring literature by shifting the focus from passive knowledge diffusion to deliberate, calculative capability acquisition. By integrating insights from the knowledge-based view, person–organization fit, absorptive capacity, and strategic recruitment, the KCR model offers a coherent micro-foundational framework for transforming employee mobility into a source of sustained competitive advantage. Full article
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12 pages, 755 KB  
Review
Novel Approaches to the Management of Myelodysplastic Syndromes: The Roles of Artificial Intelligence and Oxidative Stress Biomarkers
by Ioannis Tsamesidis, Georgios Drillis, Sotirios Varlamis, Niki Smaragdaki, Philippos Klonizakis, Maria Dimou, Konstantinos Liapis, Georgios Vrahiolias, Eleni Andreadou, Stella Mitka, Maria Chatzidimitriou, Ioannis Kotsianidis, Petros Skepastianos, Anastasios G. Kriebardis and Ilias Pessach
Hematol. Rep. 2026, 18(3), 33; https://doi.org/10.3390/hematolrep18030033 - 15 May 2026
Viewed by 151
Abstract
Objectives: Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, genomic instability, and a high risk of progression to acute myeloid leukemia. Oxidative stress (OS) has emerged as a central factor in MDS pathophysiology, contributing to [...] Read more.
Objectives: Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, genomic instability, and a high risk of progression to acute myeloid leukemia. Oxidative stress (OS) has emerged as a central factor in MDS pathophysiology, contributing to DNA damage, altered cellular signaling, and disease progression. Recent advances in artificial intelligence (AI) and machine learning (ML) offer a transformative approach for integrating multidimensional datasets including oxidative stress markers, hematologic parameters, and molecular profiles to enhance diagnosis, prognostication, and therapeutic monitoring in MDS. Methods: A comprehensive literature search was conducted in PubMed and Scopus, using the keywords “OS biomarkers,” “AI,” and “MDS’’. Results: Modified redox biomarkers can be correlated with oxidative imbalance and disease progression. ML models such as neural networks, decision trees, and support vector machines effectively capture complex relationships among redox biomarkers, enhancing risk stratification and prediction of treatment response. AI-driven proteomic analyses further revealed OS-related protein signatures linked to MDS pathophysiology. Overall, AI and ML enable the transformation of multidimensional OS data into clinically actionable tools for personalized management in MDS. Conclusions: Integrating biomarker research with AI-based analytics holds promise for advancing personalized diagnostics, prognostication, and therapeutic strategies in MDS, paving the way toward precision medicine. Full article
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