Search Results (106)

Background: Tobacco use, and particularly cigarette smoking, is elevated among patients with substance use disorders (SUDs), resulting in health inequities. In rural and medically underserved areas (MUAs), healthcare access is limited; thus, patients with SUDs may receive care in substance use treatment centers (SUTCs) and/or medical healthcare centers (MHCs). Healthcare providers in these settings should know the importance and benefits of quitting tobacco use for patients with SUDs, as this is essential for effective cessation care. This study examined baseline provider knowledge/training receipt and knowledge gains following training in SUTCs and MHCs serving rural and MUAs of Texas, USA. Methods: From 2021 to 2024, 428 providers from 8 SUTCs and 8 MHCs completed an e-survey on tobacco knowledge and past-year training. They then completed 1 to 1.5 h of training. Knowledge gain was assessed via a 10-item test delivered pre- and post-training. Results: Pre-training knowledge and past-year training rates were low across settings; providers at SUTCs were more likely than those at MHCs to know that persons with behavioral disorders like substance misuse are 2 times more likely to smoke than the general USA population. Both groups demonstrated significant knowledge gains from training (SUTCs: 37.41% and MHCs: 45.92% increases; ps < 0.0001). Conclusions: Findings support the need for routine tobacco training in healthcare centers serving rural and MUAs of Texas. Brief educational sessions may help address provider knowledge gaps and, ultimately, strengthen cessation care and reduce tobacco-related disparities in these settings. Full article

Background and Objectives: Evidence on epilepsy surgery from Central Asia is limited, reflecting the real-world challenges of developing this service in low- and middle-income settings. We evaluated one-year seizure outcomes after resective surgery for drug-resistant focal epilepsy at a single center in Kazakhstan, and we assessed whether the use of advanced presurgical imaging was associated with seizure freedom. Materials and Methods: A retrospective cohort study was conducted, including consecutive adults who underwent curative-intent resective epilepsy surgery from 2017 to 2023. Outcomes at 12 months or more post-surgery were classified using the Engel criteria. Logistic regression was used to examine associations between the advanced presurgical diagnostic tool and achieving an Engel class I outcome. Crude and adjusted risk ratios (RRs) for not achieving Engel I were estimated using modified Poisson regression with robust SEs. Results: Among 112 patients (median age 31 years; median epilepsy duration 19 years), 76% underwent temporal lobe procedures and 71% had lobectomies. At one year, 74 patients were seizure-free (Engel II: 15.2%, III: 11.6%, IV: 7.1%). Year-to-year Engel I rates varied without a significant linear trend from 2018 to 2023. In bivariable analyses, MRI-defined atrophy (RR, 3.14) and mixed lesions (RR, 2.62) were associated with a higher risk of not achieving Engel I, whereas longer epilepsy duration was linked to a lower risk (RR, 0.97 per year). In adjusted models, predictors of not achieving Engel I included generalized tonic–clonic seizures (aRR, 1.96), atrophy (aRR, 2.98), mixed lesions (aRR, 2.45), and undergoing any advanced diagnostic test (aRR, 3.38). Longer epilepsy durations remained protective (aRR 0.95 per year). In modality-specific logistic models, fMRI use was associated with higher odds of Engel I (aOR 3.39), and MR spectroscopy was associated with lower odds (aOR 0.33). Conclusions: In this Central Asian single-center cohort, about two-thirds of adults achieved complete seizure freedom one year after resective surgery—comparable to international benchmarks. Advanced imaging modalities showed divergent associations with outcomes, likely reflecting confounding by indication. These findings support the feasibility of effective epilepsy surgery in a low-resource context and the value of targeted use of advanced imaging. Full article

Background: Higher socioeconomic status (SES) is generally associated with lower engagement in health-risk behaviors, in part due to increased access to health information, preventive resources, and supportive environments. However, emerging evidence suggests that this protective pattern may not extend uniformly to all forms of substance use, including adolescent e-cigarette use, and may vary by gender. For instance, some studies have found higher rates of e-cigarette use among adolescents from higher SES backgrounds. Aim: This study examined whether the associations between family SES and tobacco use differ between girls and boys. We also explored whether these associations vary by age group. Methods: A cross-sectional survey was conducted among students (age 14–20) attending public high schools in Baltimore City. Family SES was assessed using three indicators: parental education, parental employment, and household income. Tobacco use was measured using self-reported past use of e-cigarettes and conventional cigarettes. Demographic covariates included age, sex, race/ethnicity, and household composition. Separate logistic regression models were estimated for each tobacco use outcome, adjusting for covariates. To examine subgroup differences, analyses were stratified by gender and age. Results: Higher parental education was associated with lower odds of e-cigarette use, but no SES indicators were significantly associated with conventional cigarette use. Subgroup analyses showed that the protective association of parental education against e-cigarette use was evident among girls but not boys and among older but not younger adolescents. Conclusions: These findings differ from previous studies that reported a positive association between SES and adolescent e-cigarette use. In this predominantly low-income, urban sample, higher parental education appeared to be protective for girls but not for boys. These results suggest that SES influences on tobacco use may be context- and subgroup-specific. Further research is needed to better understand how sociodemographic and contextual factors shape adolescent tobacco use behaviors. Full article

Background: Socioeconomic status (SES) significantly influences outcomes in colorectal cancer (CRC) patients, with those from low-SES backgrounds facing worse prognoses. However, living in an affluent neighborhood may mitigate some of these disparities through environmental advantages. This study investigates whether Medicaid-insured CRC patients, as a proxy for low individual SES, experience better outcomes when residing in high-SES neighborhoods. Methods: Using the National Cancer Database, we examined Medicaid CRC patients, stratifying them by neighborhood SES indicators: median household income and education level. Patients in the highest and lowest quartiles of income and education were compared. Medicaid patients from the highest-SES neighborhoods were compared to the general population. Multivariable regression models analyzed 30- and 90-day postoperative mortality, overall survival (OS), and time from diagnosis to treatment initiation and surgery. Results: CRC patients in high-income neighborhoods began treatment earlier (coefficient −1.847, p = 0.015) and exhibited improved OS (HR 0.810, p < 0.001) compared to those in low-income neighborhoods, irrespective of education level. Similarly, patients in high-education neighborhoods started treatment sooner (coefficient −3.926, p < 0.001) and had better OS (HR 0.897, p < 0.001). No differences were observed in time to surgery or postoperative mortality. Despite these advantages, Medicaid patients in high-income (HR 1.130, p < 0.001) and high-education (HR 1.209, p = 0.002) areas still had worse OS compared to non-Medicaid patients. Conclusions: Higher neighborhood SES is associated with a significant survival benefit for Medicaid CRC patients, but these patients still lag behind their non-Medicaid counterparts. Understanding the mechanisms by which neighborhood SES influences cancer outcomes could inform targeted interventions to close the survival gap. Full article

Type 2 diabetes (T2D) is a rapidly growing global health concern, projected to affect 1.3 billion people by 2050, necessitating a multidisciplinary approach. This review examines the epidemiological disparities in T2D, focusing on modifiable and nonmodifiable risk factors, socioeconomic determinants, and healthcare inequities. While genetic predisposition, age, and ethnicity contribute to T2D risk, socioeconomic status (SES) significantly mediates modifiable factors such as diet, physical activity, and access to healthcare. Lower SES is associated with poorer lifestyle choices, limited access to resources, and increased exposure to risk factors, exacerbating T2D prevalence among vulnerable populations. Geographic variations in T2D prevalence are evident, with racial and ethnic minorities and lower-income individuals being disproportionately affected in regions like the United States and Europe. The economic burden of T2D is substantial, with global healthcare expenditures reaching USD 966 billion in 2021 and projected to rise significantly, albeit with variations across different countries and health systems. Despite advancements in treatment, inequities in healthcare access persist, particularly in low- and middle-income countries, hindering optimal glycemic control and consequently contributing to preventable complications and poor health outcomes. This review highlights the critical need for targeted interventions and policy reforms to address the intersection of demographic, economic, and healthcare-related variables influencing T2D disparities. By bridging gaps in prevention, management, and treatment and accounting for the effect of SES on both modifiable and nonmodifiable risk factors, the global disease burden of T2D could be reduced and health equity could be improved. Full article

The vulnerability of Social–Ecological Systems (SES) is a frontier research topic in the field of geography. Research on drought vulnerability has emerged as a key area of focus in the study of SES vulnerability, and it has increasingly been recognized as a critical step in formulating policies for drought prevention and mitigation. In this study, the indicator system for drought vulnerability evaluation of SES in the Three-River Headwaters Region (TRHR) was established. This paper revealed the drought vulnerability evolution process and characteristics, and key driving indicators of SES at county-town-village spatial scales in six time periods of 1990, 2000, 2010, 2015, 2020, and 2023, and predicted the drought vulnerability of SES in 2050 under two scenarios. Results indicate that the average drought vulnerability in the TRHR decreased from 0.526 in 1990 to 0.444 in 2023. Compared to 1990, among the 82 selected towns, 85.37% experienced a decline in 2023, and among the 152 selected villages, 95.39% showed a reduction in 2023. Hot spots of drought vulnerability were concentrated in the southeast of the TRHR, while cold spots were in the northwest. From 1990 to 2000, the drought vulnerability of counties and towns in the TRHR increased, but it decreased between 2000 and 2023. In 1990, Henan County exhibited the highest drought vulnerability at the county level. Waeryi Town in Jiuzhi County had the highest vulnerability among towns, while Suojia Town in Zhidoi County had the lowest. Of the 152 selected villages, 41.45% exhibited relatively high or high levels of drought vulnerability, while 23.68% showed relatively low levels. In 2023, Jiuzhi County became the most vulnerable county, with Baiyu Town in Jiuzhi County ranking highest among towns and Suojia Town in Zhidoi County remaining the least vulnerable. At the village level, 22.37% exhibited relatively high or high vulnerability, whereas 42.11% showed relatively low or low levels. Drought disaster records, the proportion of agricultural and animal husbandry output value, the proportion of grassland, the proportion of large livestock, and the per capita disposable income surface are the key factors influencing drought vulnerability in the TRHR. By 2050, under the first scenario, the average drought vulnerability of the TRHR is projected to be 0.428, indicating a medium level, while the second scenario predicts a further reduction to 0.350, representing a relatively low level. The adaptive governance strategies to mitigate drought vulnerability in the TRHR include developing an integrated drought management system; establishing an ecological management, protection, and financial support model; and so on. Overall, this paper can provide scientific references and policy recommendations for policymakers and researchers on the aspects of drought vulnerability and sustainable development of SES. Full article

Despite the global development of social enterprises (SEs) over the past three decades, how to improve sustainability remains a challenging issue for most SEs. Although SE ecosystems have been recognized as crucial determinants of SE sustainability performance in the current literature, no empirical study has comprehensively examined the relationships among them. Additionally, prior studies have demonstrated that sustainability performance might vary among SEs of different revenue structures or across different contexts, suggesting that more attention should be devoted to the complexity of the causal mechanisms determining SE sustainability performance. To address these gaps in the current literature, this paper examines the complex, divergent, and asymmetric causal links among SE ecosystems, revenue structures, and the sustainability performance of SEs in China by conducting fuzzy set qualitative comparative analysis (fsQCA) of 274 typical cases of SEs. The results revealed alternative configurations for high and low levels of sustainability performance among SEs of different revenue structures. First, the fsQCA results indicated that SE sustainability performance was not determined by the impacts of single components of SE ecosystems but rather by the combined effects of multiple elements. Second, for SEs of divergent revenue structures, causal paths leading to high or low levels of sustainability performance showed notable discrepancies in terms of both number and composition. Specifically, commercial SEs receiving income mainly from market-based earned income were more likely to achieve higher levels of social and financial sustainability because of greater adaptability to SE ecosystems and less environmental dependence. Third, the impacts of different components of SE ecosystems on sustainable performance also varied with SE revenue structures. Three categories of components—policy environment, sociocultural setting, and industrial infrastructure—made more important contributions to SE sustainability performance in both the social and financial dimensions. Full article

Background: Malaria remains a public health challenge in low- and middle-income countries (LMICs). Despite gains from strategies like Insecticide-Treated Nets (ITNs) and Intermittent Preventive Treatment during pregnancy (IPTp), significant socioeconomic inequalities persist, particularly among pregnant women and children under five. This study analyzed temporal and socioeconomic inequalities in malaria prevention in sub-Saharan Africa (SSA). Methods: Nationally representative Demographic Health Surveys from 10 SSA countries (Mozambique, Burkina Faso, Tanzania, Côte d’Ivoire, Madagascar Kenya, Rwanda, Nigeria, Uganda, and Cameroon) were used, comparing two time periods. Changes in ITN use by pregnant women and children under five, as well as IPTp coverage, were assessed. Inequalities based on socioeconomic status (SES) and residence were analyzed using the Erreygers Normalized Concentration Index and Theil index. Results: The results revealed significant variability in ITN use and IPTp coverage within countries. Eight countries showed improvements in ITN use during pregnancy, with Nigeria seeing a 173.9% increase over five years. Burkina Faso and Tanzania consistently reported high ITN use (~87%) in children under five. IPTp coverage increased in all countries except Kenya. Decomposition using the Theil index indicated that within-group inequalities, particularly based on SES and residence, were the primary drivers of disparities. Conclusions: To ensure progress toward universal health coverage, malaria prevention programs must prioritize vulnerable populations and be continuously evaluated. Full article

Objectives: To assess the association of the COVID-19 pandemic with an uptake rate and screening interval between two screening rounds in colorectal cancer screening program (CRCSP) and identify the disproportionate correlation of socioeconomic status (SES) factors. Methods: An analysis was performed on aggregated screening and SES data at the area level in Flanders, Belgium, during 2018–2022. The screening uptake rate was the percentage of people returning self-test results within 40 days after invitation, and the screening interval was the number of days between current and previous screening. Differences in uptake rate and screening interval before and during COVID-19 were categorized into 10 quantiles, and determinants were evaluated using quantile regression models. Results: Significant change was seen from March to August 2020. The areas with the greatest decrease in uptake rate and screening interval had low population density, and areas with the greatest increase in screening interval had the highest income and percentage of home ownership. In regression analysis, more people living alone (β = −0.09), lower income (β = 0.10), and a higher percentage of home ownership (β = −0.06) were associated with a greater decrease in uptake rate. Areas with lower population density (β = −0.75), fewer people of Belgian nationality (β = −0.11), and higher income (β = 0.42) showed greater increases in screening interval. Conclusions: During the COVID-19 pandemic, people in areas with low SES were less likely to participate in screening, whereas people in areas with high SES were more likely to delay participation. A tailored invitation highlighting benefits of CRCSP is needed for people with low SES to improve uptake. Timely warnings could help people who delay participation adhere to screening intervals. Full article

Objective: Renal cell carcinoma (RCC) is a rare but severe and aggressive pediatric malignancy. While incidence is uncommon, survival is relatively low with respect to acute lymphocytic leukemia (ALL), AML, lymphoma, ependymoma, glioblastoma, and Wilms Tumor. The pediatric renal cell carcinoma (pRCC) incidence, cumulative incidence (period prevalence), and mortality vary by health disparities’ indicators, namely sex, race, ethnicity, age at tumor diagnosis, and social determinants of health (SDHs) as well as Epigenomic Determinants of Health (EDHs). However, studies are unavailable on some pRCC risk determinants, such as area of residence and socio-economic status (SES). The current study aimed at assessing the temporal trends, cumulative incidence, household median income, urbanity, mortality, and pRCC survival differentials. Materials and Methods: A retrospective cohort design was utilized to examine the event-free survival of children (0–19) with RCC using the Surveillance Epidemiology and End Result Data, 1973–2015. While the time-dependent variable, namely survival months, was utilized, we assessed the predictors of pRCC survival, mainly sex, age at diagnosis, education, insurance status, income, and tumor grade, as prognostic factors. In examining the joint effect of area of residence and race, as an exposure function with time in survival, we utilized the Cox proportional hazard model, while the annual percent change was assessed using a generalized linear model, implying a weighted average. Results: Between 1973 and 2015, there were 174 cases of pRCC, of whom 49 experienced mortality (28.2%). The pRCC cumulative incidence tends to increase with advancing age. A significant survival differential was observed between black/AA children with RCC and their white counterparts. Compared with white children, black/AA children were almost three times as likely to die, hazard ratio (HR) = 2.90, 95% CI = 1.56–5.31, p = 0.001. A survival differential was observed in sex, with males presenting with a 21% increased likelihood of dying, HR = 1.21; 95% CI, 0.69–2.11. In the metropolitan area, the risk of dying was almost three times as likely among black/AA children compared to their white counterparts, HR = 2.78; 95% CI, 1.45–5.43, while in the urban area, the risk of dying was almost four times as likely among black/AA children compared to their white counterparts, HR = 4.18; 95% CI, 0.84–20.80. After controlling for age, sex, education, and insurance, the risk of dying increased amongst black/AA children in metropolitan areas, adjusted HR (aHR) = 3.37, 99% CI = 1.35–8.44. In the urban area, after adjustment for age, sex, and insurance, there was an increased risk of dying for black/AA children, compared with their white counterparts with pRCC, aHR = 8.87, 99% CI = 2.77–28.10. Conclusion: pRCC indicates an increased trend in males and age at diagnosis between 10 and 14, as well as a survival disadvantage among black/AA children, compared with their white counterparts. Additionally, urbanity significantly influences the racial differences in survival. These data are suggestive of the conjoined effect of environment and race in pRCC survival, indicative of further assessment of gene–environment interaction (epigenomics) in incidence, mortality, and survival in pRCC. Full article

Study Design: Retrospective chart review. Objective: Socioeconomic status (SES) greatly impacts one’s health status and the type of trauma that a patient experiences due to increased risk of exposure and varying availability of resources to treat emergent conditions. There is a need for large-scale databases of pediatric facial trauma to identify discrepancies in occurrence and identify risk factors. Methods: This retrospective examination uses a multi-center database to evaluate pediatric facial trauma patients (n = 644) visiting Atrium Heath Wake Forest Baptist (AHWFB) hospital from 2020 to 2022. Data collected included demographic information, past medical and surgical history, trauma history, interventions, and long-term outcomes such as scarring, deformities, and sensory or motor deficits. The number of incidents for each zip code surrounding AHWFB was compared with SES data including unemployment rate, mean household income, and poverty level. Results: Thirty-five percent of patients sustained a high-energy injury, and 65% sustained a low-energy injury. Within the surrounding counties of AHWFB, there were more incidents of pediatric facial trauma in areas with greater rates of poverty (p = 0.006). Additionally, there were more incidents due to high-energy injuries in areas with lower income (p = 0.044) and more poverty (p = 0.002). Specifically, motor vehicle accidents were more common in areas with lower income (p = 0.017) and more poverty (p = 0.001). Conclusions: These findings in the central Piedmont region of North Carolina are consistent with previous research of SES’s effect on health inequalities and serve as evidence of the need to take steps to prevent pediatric facial trauma in areas of low SES. Full article

Cardiovascular disease (CVD) poses a significant health burden, particularly among individuals of low socioeconomic status (SES) in low- and middle-income countries (LMICs). This study evaluates the clinical effectiveness of cardiac rehabilitation (CR) in addressing CVD outcomes among very low-SES patients in Colombia. Data from participants enrolled in a CR program in Colombia between 2022 and 2023 were analyzed retrospectively. Measures included heart-healthy behaviors, physical/psychological outcomes, and quality of life assessed at 18, 36, and 60 sessions. Significant improvements were observed in exercise capacity, psychological well-being, and quality of life metrics throughout the CR program. However, barriers to CR attendance and the critical need for expanded program availability remain evident, particularly in LMIC settings like Colombia. In conclusion, structured CR programs demonstrate substantial benefits for very low-SES individuals in a LMIC country, highlighting the urgent need for increased program accessibility and equitable healthcare provision to optimize cardiovascular health outcomes. Full article

Background: This study aimed to analyze the relationship between socioeconomic status (SES), poverty rate, and the prevalence of overweight/obesity or obesity in children and adolescents aged 2–14. Methods: Parents or guardians reported the weight and height of participants, used to calculate body mass index (BMI) and BMI z-scores according to the International Obesity Task Force standards. Participants were categorized into “overweight/obesity” and “no overweight/obesity” and further into “obesity” and “no obesity”. The rate of poverty rate was determined using data from the National Statistics Institute of Spain, defining it as the percentage of people with income below 60% of the national median. SES was based on the head of household’s occupation and categorized into low, medium, and high levels. Results: Adjusted multilevel models showed participants with medium or high SES had lower odds of overweight/obesity compared to those with low SES (medium SES: odds ratio [OR]: 0.63, 95% confidence interval [CI]: 0.54–0.73; high SES: OR: 0.59, 95% CI: 0.49–0.70). Participants in the high-poverty group had higher odds of having overweight/obesity (OR: 1.40, 95% CI: 1.13–1.74) compared to the low-poverty group. Conclusions: The study highlights significant socioeconomic disparities in childhood overweight/obesity, emphasizing the potential impact of SES and poverty on health outcomes in Spanish children and adolescents. Full article

Background: Socioeconomic status (SES) plays a crucial role in blood pressure (BP) control. SES may influence BP control through obesity indices, such as body mass index (BMI) and waist circumference (WC). This study aimed to understand the relationships between SES and BP control in the elderly hypertensive population, and to determine whether BMI and WC mediate the relationship between SES and BP control. Methods: The study was conducted in Jia County, Henan Province, China, from 1 July to 31 August 2023. The 18,963 hypertensive people over 65 years old who were included in the National Basic Public Health Service Program were investigated. The study utilized questionnaire surveys to collect data on participants’ demographic characteristics, disease history, lifestyle behaviors, antihypertensive medication, and measured height, weight, and blood pressure. SES was indexed by participants’ self-reported educational level, family income, and occupation, and categorized into low, medium, and high groups by using latent category analysis (LCA). Logistic regression models were used to analyze the associations between SES and BP control. Obesity indicators, represented by BMI and WC, were included in mediation models to examine the indirect effects of BMI/WC on the association between SES and BP control. Results: The mean age of 17,234 participants was 73.4 years and 9888 (57.4%) of the participants were female. The LCA results indicated the number of participants in low SES, middle SES, and high SES groups were 7760, 8347, and 1127, respectively. Compared with the low SES group, the odds ratios (ORs) and 95% confidence intervals (CIs) for the association of BP control with middle SES and high SES were 1.101 (1.031, 1.175), and 1.492 (1.312, 1.696). This association was similarly found in the subsequent subgroup analyses (p < 0.05). Compared with low SES, our findings further suggested that BMI (indirect effects: 95% CIs: −0.004–−0.001; p < 0.001) and WC (indirect effects: 95% CIs: −0.003–−0.001; p = 0.020) play a suppressing role in the association between high SES and BP control. Conclusions: Our study indicated that the elderly hypertensive population with high SES may have a better result for BP control. However, we found that BMI/WC plays a suppressing role in this association. This indicated that despite the better BP control observed in elderly hypertensive populations with high SES, BMI and WC might undermine this beneficial relationship. Therefore, implementing strategies for obesity prevention is an efficient way to maintain this beneficial association between high SES and BP control. Full article

Background: Chronic Kidney Disease (CKD) is a complex health condition that interacts significantly with socioeconomic determinants, particularly income status and education. This study developed a simple indicator of socioeconomic status (SES), which is composed of income status and education in CKD patients, and evaluated its impact on health outcomes in this population. Methods: This study was conducted on 561 CKD patients, stages 2–5. The composite SES score was developed by combining the regression coefficients of income and education as predictors of the study endpoint in a multivariable Cox model, normalizing these coefficients to derive weights, and then using these weights to calculate an individual percentage score based on each person’s income and education. The composed SES indicator was internally validated through bootstrap analysis. Over a median follow-up time of 36 months, we tracked all-cause death and non-fatal cardiovascular events. Results: Both lack of income (p = 0.020) and low educational level (p = 0.034) were independently related to the combined endpoint. Based on these covariates‘ regression coefficients, a composite socioeconomic score considering income and educational level was generated. In a Cox regression model, a 10% increase in this composite risk score entailed a 25% increase in the hazard ratio (HR) of the combined endpoint [HR (10% increase): 1.25], and the internally validated 95% CI ranged from 1.14 to 1.41 (p < 0.001). Conclusions: This study underscores the significant impact of a simple, bootstrap-validated composite SES indicator on CKD patients’ health outcomes. These findings highlight the importance of considering education and socioeconomic factors in managing and treating CKD patients and inform future research and policy considerations for this population. Full article