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Keywords = lobocatalens A–G

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12 pages, 1952 KiB  
Article
Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
by Jiarui Zhang, Huixue Ma, Shuangshuang Jin, Xuehuan Liu, Lei Li, Zhaonan Liu, Guoqiang Li and Pinglin Li
Mar. Drugs 2023, 21(4), 223; https://doi.org/10.3390/md21040223 - 30 Mar 2023
Cited by 5 | Viewed by 2341
Abstract
Seven new lobane diterpenoids, namely, lobocatalens A–G (17), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among [...] Read more.
Seven new lobane diterpenoids, namely, lobocatalens A–G (17), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line. Full article
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