Search Results (71)

Directive (EU) 2024/3019 updates and introduces new approaches to the collection, treatment, and discharge of urban wastewater. The directive aims to safeguard the environment and human health, reduce greenhouse gas emissions within the wastewater treatment cycle, improve energy efficiency, and foster the transition towards climate neutrality, while promoting the circular economy and the reuse of water resources. Within this framework, the reuse of treated urban wastewater emerges as a strategic lever to confront the growing challenge of water scarcity, to support circular economy principles, and to alleviate pressure on natural water reserves. This paper, starting from the European and Italian regulatory frameworks for urban wastewater management, provides an in-depth analysis of potential reuse pathways, highlighting both the advantages and the challenges associated with their application. Full article

Achieving high selectivity in the hydrogenation of CO₂ to light olefins remains challenging because of the complex reaction network and the difficulty of regulating key intermediates. Motivated by green-hydrogen-enabled power-to-chemicals pathways, we combine density functional theory (DFT) with first-principles microkinetic simulation (FPMS) to construct a quantitatively predictive reaction-energy landscape and elucidate structure–selectivity relationships. A comprehensive reaction network is established through energy-surface fitting, and steady-state rate constants are solved to capture the microkinetic competition between elementary steps. By introducing electronic density-of-states (DOS) modulation as a design variable, we directly correlate surface structural parameters with rate-controlling steps, thereby enabling targeted regulation of C–C coupling and hydrogen transfer processes. The calculated barrier for CO₂ adsorption to COOH* is 1.35 eV, while the transition state barrier for C–C coupling is 1.50 eV, corresponding to a reaction rate of 9.7 × 10³ s⁻¹; the olefin desorption rate reaches 1.7 × 10⁷ s⁻¹. Crucially, shifting the d-band center from −2.35 eV to −1.60 eV increases the C₂–C₄ olefin selectivity from 42.6% to 68.3%, establishing an actionable electronic structure lever for catalyst optimization. These results reveal the intrinsic mechanism by which surface electronic and geometric regulation governs intermediate stabilization and rate control, providing a verifiable, mechanism-based design principle for efficient CO₂-to-olefin catalysts aligned with green hydrogen deployment. Full article

As global urbanization accelerates, biophilic urbanism has emerged as a key nature-based strategy for enhancing public health. While plants are critical active agents for psychological restoration, the specific pathways through which vegetation characteristics influence human–environment interactions remain fragmented. This knowledge gap hinders the evidence-based translation of biophilic principles into actionable urban design and governance. This study conducts a systematic bibliometric analysis of 443 peer-reviewed articles (2000–2025) at the intersection of restorative landscapes, urban settings, and plant-based interventions retrieved from the Web of Science Core Collection. Employing multiple visualization tools (VOSviewer, bibliometrix, and CiteSpace), we map publication trends, international collaborations, and thematic evolution. The results demonstrate a significant shift in the field, moving beyond the validation of foundational restorative theories (e.g., ART and SRT) to a more precise, implementation-oriented framework. This shift is characterized by the operationalization of vegetation attributes as controllable design variables, increasingly relating biophilic principles to broader nature-based solutions (NbS) agendas and evidence-informed urban governance. Thematic clustering analysis identified three core knowledge domains: (1) the role of plants as active exposure agents and behavioral mediators in psychological restoration; (2) the impact of specific plant characteristics—such as canopy structure, species diversity, and seasonal variation—on therapeutic outcomes; and (3) the integration of urban green spaces into broader governance frameworks to promote health equity and inclusive well-being. Our analysis highlights that plant-based interventions are evolving from aesthetic ornaments into precision design levers for fostering human–nature interactions. This study provides a science-based foundation for developing practical design guidelines and policy frameworks, shifting biophilic urbanism toward a robust governance strategy for creating equitable, restorative, and resilient cities. Full article

In Coiled Tubing (CT) acoustic telemetry, the reliability of surface signal reception is severely challenged by the “contact dead zone” of traditional probes and complex nonstationary environmental noise. To address these issues, this paper proposes a hardware-software integrated solution for high-fidelity signal extraction. In terms of hardware, a novel pickup probe based on the micro-lever principle is developed. By utilizing a pivoted lever structure with an optimized arm ratio of 2.6 to 1 and a full pressure-balanced mechanism, the design physically overcomes the contact dead zone inherent in traditional pressure-compensating probes and effectively isolates low frequency common-mode interference through a lateral floating architecture. In terms of software, a joint denoising model combining Complete Ensemble Empirical Mode Decomposition with Adaptive Noise and wavelet thresholding is proposed. A cross-correlation coefficient criterion is introduced to adaptively screen intrinsic mode functions and eliminate residual fluid turbulence noise. Field experiments on a 1500 ft full-scale circulation loop demonstrate that the proposed probe improves the detection sensitivity of the radial breathing mode by approximately 20.6 dB compared to the baseline, while effectively eliminating stick-slip friction noise during dynamic tripping. Furthermore, the joint algorithm increases the Signal to noise Ratio by an additional 16.9 dB under typical pumping conditions of 0.5 bpm, with a normalized cross-correlation exceeding 0.96. These results verify that the proposed method effectively solves the bottleneck of weak signal detection in deep wells, providing robust technical support for CT telemetry operations. Full article

Global data center electricity demand is projected to double to 945 TWh by 2030, yet no optimization framework jointly sizes renewable generation, battery storage, hydrogen export infrastructure, and flexible computing loads within a single industrial hub. This paper develops a two-layer techno-economic workflow for an integrated renewable–hydrogen–data center hub in Yanbu Industrial City, Saudi Arabia. HOMER Pro provides baseline capacity sizing and dispatch across four scenarios; a Pyomo-based mixed-integer linear program, calibrated to within 2% of the baseline, then extends the system to include a 60 MW data center (30 MW critical, 30 MW flexible), multi-sink hydrogen allocation (domestic, ammonia, methanol), and low-grade waste heat recovery. Battery storage emerges as the dominant cost–carbon lever: its removal raises the levelized cost of electricity (LCOE) from 0.052 to 0.181 USD/kWh (+250%) and increases CO₂ emissions from 1.83 to 2763 kt/yr, a factor of 1510. The Integrated Hub reduces annualized costs by 8.2% (36.9 M USD/yr) and emissions by 28% relative to a separate-build counterfactual, driven by shared PV–battery infrastructure and hydrogen export revenues of 58.5 M USD/yr. Export demand raises the electrolyzer capacity factor from 8.65% to 24.3%, cutting the levelized cost of hydrogen from 10.5 to 6.8 USD/kg. Waste heat recovery reduces the levelized cost of heat by 17%, and co-location lowers the levelized cost of compute by 23% (from 0.055 to 0.042 USD/GPU/hr). These results provide quantitative design principles for industrial hub planners considering data center co-location in high-solar regions with hydrogen export ambitions. Full article

Psychedelic-assisted therapies (PATs) can produce rapid and sustained antidepressant effects, yet variability in response remains substantial. Identifying predictors and moderators is essential for optimising patient selection, preparation, and delivery. To map and synthesise the evidence on the predictors of antidepressant response to classic/serotonergic psychedelics administered with psychotherapeutic support in adults with depressive disorders, including treatment-resistant depression. Following PRISMA-ScR principles, we conducted a scoping review of major biomedical and psychology databases (PubMed (MEDLINE), Embase, PsycINFO, and Web of Science) and trial registries (searches September–October 2025), supplemented by reference-list screening. We included randomised trials, open-label studies, and naturalistic cohorts reporting associations between candidate predictors (baseline traits/clinical features, set/setting variables, acute in-session phenomenology, and biological measures) and validated depression outcomes. We charted study characteristics, analytic approaches (including moderation/mediation where available), and indicators of robustness (e.g., adjustment for overall intensity, preregistration, external validation). A total of 48 studies were included in the review. Across study designs, process-level features during the dosing session were the most consistent correlates of antidepressant improvement. Greater emotional breakthrough, mystical/unitive experiences, and ego dissolution-linked reappraisal/insight generally predicted larger and more durable symptom reductions, whereas anxiety-dominant or dysphoric states tended to attenuate benefit, often independent of overall subjective intensity. Set and setting—particularly a stronger therapeutic alliance and music experienced as resonant—predicted both the emergence of therapeutically salient acute experiences and downstream clinical gains. Baseline moderators showed smaller and mixed effects: PTSD comorbidity sometimes weakened trajectories; extensive prior psychedelic exposure was associated with smaller incremental gains; demographics were typically uninformative. Converging biological findings associated better outcomes with markers consistent with increased neural flexibility and plasticity (e.g., less segregated network dynamics; EEG indices), alongside peripheral changes implicating neurotrophic, inflammatory, and HPA axis pathways. Current evidence suggests that antidepressant response in PATs is driven less by static patient characteristics and more by what occurs during dosing and how the context shapes that experience. Optimising preparation, alliance, and music; facilitating emotional breakthrough and meaning making; and mitigating anxious dysregulation are actionable levers. Future trials should harmonise measures, pre-specify and validate moderators/mediators, intensively sample in-session experience and physiology, and report benefits and harms more consistently. Full article

CRISPR/Cas systems have transformed molecular medicine, yet the field still lacks principled guidance on when transient editing suffices versus when sustained exposure through in vivo viral delivery is necessary and how to keep prolonged exposure safe. Notably, EDIT-101 was designed for a permanent edit in post-mitotic photoreceptors with lifelong Cas9 persistence. This review addresses this gap by defining the biological and therapeutic conditions that drive benefit from extended Cas activity while minimizing risk. We will (i) examine relationships between expression window and efficacy across Cas9/Cas12/Cas13 modalities, (ii) identify genome-wide off-target liabilities alongside orthogonal assays, and (iii) discuss controllable, self-limiting, and recallable editor platforms. By separating durable edits from persistent nuclease exposure, and by providing validated control levers, this work establishes a generalizable framework for safe, higher-efficacy CRISPR medicines. Furthermore, we highlight key studies in cell lines, murine models, non-human primates, and humans that examine the long-term effects of sustained expression of CRISPR/Cas systems and discuss the safety and efficacy of such approaches. Current evidence demonstrates promising therapeutic outcomes with manageable safety profiles, although there is a need for continued monitoring as CRISPR/Cas therapies are increasingly applied in clinical contexts and therapies are developed for broader clinical applications. Full article

This study examines how Empowering (EL), Responsible (RL), and Ethical Leadership (EtL) relate to employees’ perceptions of Decent Work (DW) in a Portuguese public university, using the Job Demands–Resources (JD-R) framework. DW, defined by dignity, equity, and security, was assessed across seven dimensions. A total of 226 faculty, researchers, and staff completed validated measures of EL, RL, EtL, and DW. Results showed moderate to strong positive correlations between leadership styles and DW, especially for Fundamental Principles and Values at Work (DW1), Fulfilling and Productive Work (DW3), and Health and Safety (DW7). EL displayed the strongest associations with fairness, inclusion, and psychological safety, while RL and EtL were more closely linked to accountability and ethical climate. Analyses by role and education revealed systematic asymmetries, with leaders and highly educated employees reporting more favorable experiences. High intercorrelations among leadership styles (r ≈ 0.87–0.90) suggest an integrated values-based leadership pattern. In contrast, weaker associations with structural dimensions such as workload and social protection highlight the limits of leadership influence on DW. These findings advance research on DW in higher education and underscore leadership development as a lever for institutional justice and well-being. Full article

Rapid development and scale expansion of cities are the core characteristics of the urbanization process, which effectively promote the formation of agglomeration economies, infrastructure sharing, and social mobility improvement. However, it also brings various negative effects such as unequal public services, traffic congestion, and environmental pollution. The principle of isobenefit urbanism proposes that walking accessibility of various service facilities is an important indicator for measuring whether a city is livable, fair, and sustainable. This study specifically examines the impacts of environmental factors on the implementation of isobenefit urbanism in the central urban area of Beijing, a megacity. By obtaining open-source data and performing ArcGIS (10.8.1) analysis, using 183 blocks in Beijing’s core area, we normalized Strava pedestrian heat by road area and regressed it on 12 built environment indicators. The final model (R = 0.650, R² = 0.422, and adjusted R² = 0.381) identifies five significant predictors: block area (β = 0.215, p = 0.001) and average building height (β = 0.299, p = 0.012) are positively associated with walking heat, while building density (β = −0.235, p = 0.003), intersection density (β = −0.321, p < 0.001), and average distance to bus stop (β = −0.196, p = 0.003) are negatively associated. Land use mix and facility supply show positive but nonsignificant effects after controls. These estimates provide actionable levers for isobenefit urbanism in megacity cores. Full article

Stick–slip piezoelectric actuators are widely used in high-precision positioning systems, yet their performance is limited by backward motion during the slip stage. Although the effects of preload force, driving voltage, and driving frequency have been extensively examined, the specific influence of mover mass and its coupling with these parameters remains insufficiently understood. This study aims to clarify the mass-dependent stepping behavior of stick–slip actuators and to provide guidance for structural design. A compact stick–slip actuator incorporating a lever-type amplification mechanism is developed. Its deformation amplification capability and structural reliability are verified through motion principle analysis, finite element simulations, and modal analysis. A theoretical model is formulated to describe the inverse dependence of backward displacement on the mover mass. Systematic experiments conducted under different mover masses, preload forces, voltages, and frequencies demonstrate that the mover mass directly affects stepping displacement and interacts with input conditions to determine motion linearity and backward-slip suppression. Light movers exhibit pronounced backward motion, whereas heavier movers improve smoothness and stepping stability, although excessive mass slows the dynamic response. These results provide quantitative insight into mass-related dynamic behavior and offer practical guidelines for optimizing the performance of stick–slip actuators in precision motion control. Full article

Climate change education (CCE) is increasingly recognized as a key lever for responding to the climate crisis, yet its implementation in schools often remains fragmented and weakly transformative. This review synthesizes international research on CCE in secondary education, focusing on four interconnected domains: students’ social representations of climate change (SRCC), curricular frameworks, teaching practices and teacher professional development, and emerging pathways towards transformative, justice-oriented CCE. A narrative review of empirical and theoretical studies reveals that students’ SRCC are generally superficial, fragmented and marked by persistent misconceptions, psychological distance and low perceived agency. Curricular frameworks tend to locate climate change mainly within natural sciences, reproduce deficit-based and behaviorist models and leave social, political and ethical dimensions underdeveloped. Teaching practices remain predominantly transmissive and science-centered, while teachers report limited training, time and institutional support, especially for addressing the affective domain and working transdisciplinarily. At the same time, the literature highlights promising directions: calls for an “emergency curriculum” and deeper curricular environmentalization, the potential of socio-scientific issues and complexity-based approaches, narrative and arts-based strategies, school gardens and community projects, and growing attention to emotions, hope and climate justice. Drawing on a narrative and integrative review of empirical and theoretical studies, the article identifies recurrent patterns and gaps in current CCE research and outlines priorities for future inquiry. The review argues that bridging the knowledge–action gap in schools requires aligning curriculum, pedagogy and teacher learning around four key principles—climate justice, collective agency, affective engagement and global perspectives—and outlines implications for policy, practice and research to support more transformative and socially just CCE. Full article

Historic department stores are an underexamined lever for circular, low-carbon urban transition. This study tests whether Langston’s Adaptive Reuse Potential (ARP) can be applied retrospectively and how contextual readiness shapes the timing of interventions. Using the Renoma Department Store in Wroclaw, Poland (1930–2025), we reconstruct five adaptive phases and combine expert scoring of seven obsolescence dimensions (O1–O7) with a Readiness index covering finance, governance/approvals, use commitment, delivery/supply chain, and policy priority. Decision windows are interpreted via a WAIT–PREPARE–GO lens. Results show that peaks in ARP and Readiness aligned with major reinvestments—post-war reconstruction, socialist modernisation, and post-EU-accession renewal—while the original steel frame retained high structural reserves, indicating that timing was driven more by institutional and economic conditions than by technical decay. We propose ARP as an interpretive lens for circular regeneration and show that the Readiness index clarifies feasibility and risk. The combined ARP × Readiness approach yields a replicable, phase-sensitive diagnosis of adaptive capacity and intervention timing, contributing evidence to circular city practice and aligning with New European Bauhaus principles of sustainability, inclusion, and quality of place. Full article

This study aims to identify and critically compare multi-stakeholder frameworks and collaborative approaches for sustainable destination development. A comprehensive literature review was carried out, examining the most relevant frameworks published between 2014 and mid-2025. This study compares frameworks and collaborative approaches grounded in a real-life context, examining their operational mechanisms, foundational principles, and the adaptive perspectives tailored to specific destinations. The research questions were developed using the SPIDER tool, and the literature review was conducted using sources from various databases. Seventy-eight articles were included and typologically classified as applied, conceptual, and empirical. To deepen comparison, six focal cases were assessed in a five-criterion matrix. Three typical destination settings were presented and describe how frameworks are configured across contexts. The findings reflect a maturity scale, with empirical cases presenting a more comprehensive overview in relation to the criteria of the matrix. The discussion takes place through the identification of barriers and challenges of frameworks’ implementation and the introduction of two practical design levers, as an interpretive contribution, that are identified as mechanisms that go beyond the framework for upgrading the quality of implementation. The study contributes to the broader discussion on sustainable development and offers useful recommendations for future research in destination management. Full article

Transmetalation, the exchange of metal ions between coordination complexes and biomolecules, has emerged as a powerful design lever in cancer metallopharmacology. Using thiosemicarbazones (TSCs) as a unifying case study, we show how redox-inert carrier states such as zinc(II) or gallium(III) can convert in situ into redox-active copper(II) or iron(III/II) complexes within acidic, metal-rich lysosomes. This conditional activation localizes reactive oxygen species (ROS) generation and iron deprivation to tumor cells. We critically compare redox-active and redox-inert states, delineating how steric and electronic tuning, backbone rigidity, and sulfur-to-selenium substitution govern exchange hierarchies and kinetics. We further map downstream consequences for metal trafficking, lysosomal membrane permeabilization, apoptosis, and ferroptosis. Beyond TSCs, iron(III)-targeted transmetalation from titanium(IV)-chelator “chemical transferrin mimetics” illustrates a generalizable Trojan horse paradigm. We conclude with translational lessons, including mitigation of hemoprotein oxidation via steric shielding, stealth zinc(II) prodrugs, and dual-chelator architectures and outline biomarker, formulation, and imaging strategies that de-risk clinical development. Collectively, these insights establish transmetalation as a central therapeutic principle. We also highlight open challenges such as quantifying in-cell exchange kinetics, predicting speciation under non-equilibrium conditions, and rationally combining these agents with existing therapies. Full article

The aviation industry requires a series of actions that will transform its current status, aiming for sustainable operations. Aviation’s end-of-life stream is a pivotal lever for circularity, yet current dismantling and recycling practices leave significant value unrealized. Circular Economy could be considered as a transformational approach to the aviation industry and address its environmental and economic challenges, meeting sustainability principles. This study conducts a PRISMA-guided qualitative systematic review across academic and industry sources to synthesize regulations, technologies, and economics of aircraft decommissioning. It aims to quantify material recovery potential and environmental gains at the aircraft level and assess technology readiness and cost drivers for metals, polymers, and composites. Findings indicate that optimized decommissioning enables high-value part reuse and substantial material recovery (notably aluminum), with associated lifecycle greenhouse-gas avoidance at the aircraft scale. However, high costs, weak regulations, and limited recycling technologies hinder adoption. Results show that optimized dismantling and certified part-reuse pathways can recover up to 85–90% of total aircraft mass, with potential CO₂-emission avoidance of 25–35 t per narrow-body aircraft compared with landfill disposal. Metal recycling technologies (TRL 8–9) already achieve high yields, whereas polymer and composite recycling remain limited (TRL 5–6) by purity and certification barriers. A comparative assessment of EU, US, and Asia–Pacific regulations identifies enforcement and infrastructure gaps hindering implementation. The study introduces an integrated CE roadmap for aviation comprising (i) standards-aligned design-for-disassembly and digital traceability, (ii) accredited MRO-to-reuse networks, and (iii) performance-based policy incentives. Full article