Search Results (8,586)

Plastic greenhouses, which account for the majority of protected horticulture facilities in East Asia, are highly susceptible to wind-induced uplift failures that can lead to severe structural and economic damage. To address this issue, this study developed a low-power and low-cost wireless monitoring system applying the concept of structural health monitoring (SHM) to greenhouse foundations. Each sensor node integrates a MEMS-based inertial measurement unit (IMU) for attitude estimation, a LoRa module for long-range alert transmission, and a microSD module for data logging, while a gateway relays anomaly alerts to users through an IP network. Uplift tests were conducted on standard steel-pipe foundations commonly used in plastic greenhouses, and the proposed sensor nodes were evaluated alongside a commercial IMU to validate attitude estimation accuracy and anomaly detection performance. Despite the approximately 30-fold cost difference, comparable attitude estimation results were achieved. The system demonstrated low power consumption, confirming its feasibility for long-term operation using batteries or small solar cells. These results demonstrate the applicability of low-cost IMUs for real-time structural monitoring of lightweight greenhouse foundations. Full article

Electric Submersible Pumps (ESPs) are widely deployed in high-flowrate wells but are constrained by frequent failures and the need for rig-based interventions. This study presents the development and field validation of a rigless cable-deployed ESP (CDESP) system designed to enhance operational uptime and reduce intervention costs. The system features a corrosion-resistant metal-jacketed power cable, an inverted ESP configuration that eliminates the motor lead extension (MLE), and a vertical cable hanger spool (VCHS) for surface integration without removing the production tree. A field trial in a high-H₂S well demonstrated successful rigless deployment using coiled tubing (CT), achieving over two years of continuous runtime. Post-retrieval inspection revealed minimal wear, validating the system’s mechanical durability and reusability. Operational performance demonstrated reduced non-productive time (NPT), enhanced safety, and cost savings, with deployment completed in under 24 h, compared to the typical 10–14 days for rig-based methods. The CDESP system’s compatibility with digital monitoring and its potential for redeployment across wells positions it as a transformative solution for offshore and mature field operations. These findings support the broader adoption of CDESP as a scalable, efficient, and safer alternative to conventional ESP systems. Full article

To address the premature corrosion failure of chromium-based coatings in harsh environments (e.g., high temperatures, chloride-containing solutions), this work systematically investigates how rare-earth (RE, i.e., Ce and La) elements regulate nitrogen (N) adsorption and diffusion behavior in Cr during the early stages of nitriding, a critical corrosion protection strategy, using first-principles density functional theory (DFT). Results show that RE preferentially occupies Cr substitutional site, increasing the Young’s modulus from 293.5 GPa (pristine Cr) to 344.9 GPa (Ce-doped) and 348.7 GPa (La-doped). Surface RE doping on Cr(110) significantly enhances N adsorption energy from −3.23 eV to −3.559/−3.645 eV (Ce-/La-doped), whereas subsurface doping slightly weakens the adsorption. Moreover, the energy barrier for N penetration into subsurface is reduced from 2.11 eV to 2.03/1.91 eV (Ce-/La-doped), thereby facilitating nitridation. Notably, RE is found to strongly trap vacancies and N atoms, leading to increased migration barriers and thus hindering their long-range transport. These findings demonstrate that RE exhibits a dual role during nitriding: promoting N incorporation at the surface while restricting its deep diffusion into the bulk. The study provides theoretical insights into the atomistic mechanisms by which RE elements modulate nitriding efficiency in Cr-based alloys, offering guidance for the design of RE-doped surface-modified coatings with improved corrosion resistance. Full article

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder caused by right heart failure leading to premature death. The TGFBR2 and BMPR-II receptors, which are members of the TGF-β receptor family, are considered promising targets for developing novel drugs in PAH. Lupeol and ψ-taraxasterol, naturally occurring triterpene molecules with proven anti-inflammatory, anti-cancer, and cardioprotective activities, hold considerable potential in the treatment of PAH. Hence, the present study aimed to evaluate the impacts of lupeol and ψ-taraxasterol isolated from Cirsium sintenisii Freyn on the TGF-β and BMP pathways, aiming to determine their therapeutic values in PAH. The effects of the compounds were extensively investigated using both in silico and wet lab experiments, including reporter assays, RT-PCR/QPCR, Western blots, and cell proliferations assays. Both lupeol and ψ-taraxasterol demonstrated interactions with the majority of components of these signaling pathways, including the TGFBR2 and BMPR-II receptors, suggesting that both compounds were capable of modulating the BMP and TGF-β pathways. Data derived from reporter assays, RT-PCR/QPCR, and Western blots demonstrated that lupeol and ψ-taraxasterol inhibited the TGF-β signaling pathway by reducing the phosphorylation of the SMAD3 protein and the expression of pai-1 transcripts. Additionally, ψ-taraxasterol enhanced BMP signaling via regulating the phosphorylation of SMAD1/5 proteins and upregulated the expression of id-1 transcripts. Finally, lupeol and ψ-taraxasterol inhibited abnormal proliferation of mutant-type (bmpr2^R899X+/-) PAMSCs stimulated with the TGF-β1 ligand with no discernible effects on wild-type cells. This is the first comprehensive report outlining the potential therapeutic effects of lupeol and ψ-taraxasterol in PAH, which may have immediate experimental and clinical applications not only in PAH but also other BMP- and TGF-β-associated disorders. Full article

Background/Objectives: Transportation is a critical social determinant of health with direct impacts on healthcare access and utilization. This study examines transportation challenges faced by low-income individuals with chronic conditions who participated in the Food as Medicine (FAM) program offered by their primary care provider and explores the strategies they employ to overcome those challenges, particularly during the COVID-19 pandemic. Methods: We conducted semi-structured interviews with 36 FAM participants from Grady Health System in Atlanta, Georgia between May 2022 and October 2023. Interviews explored their ability to access routine care, FAM, and healthy food as prescribed by their physicians and nutritionists, as well as how the COVID-19 pandemic affected their transportation challenges and solutions. Results: Participants reported various transportation barriers including long wait times, delays, cost burdens, unreliable services, and coordination failures, which contributed to missing doctor appointments and FAM attendance. To overcome those challenges, participants planned trips in advance, used multiple transportation options, relied on social networks, or reduced and sometimes forwent trips. The COVID-19 pandemic limited their accessibility to healthcare, FAM, and healthy food options by reducing business hours and disrupting transportation services. Alternatives such as telemedicine and online ordering were less utilized due to distrust, dissatisfaction, and limited digital literacy. Conclusions: Transportation barriers can substantially restrict healthcare and food access for low-income individuals managing chronic conditions, especially during public crises that may lead to service disruptions. Transportation assistance that accommodates individuals’ financial circumstances and health conditions, implemented through collaborative efforts of healthcare institutions, transportation agencies, and governments, is essential to facilitating chronic disease management and reducing health disparities. Full article

This work first analyzes the failure behaviors of P-GaN HEMTs with different gate structures (Schottky gate vs. Ohmic gate) under both forward and reverse ESD stresses. It reveals that the Schottky gate structure lacks effective electrostatic charge discharge paths, which leads to the accumulation of transient charges generated by ESD stress in the gate terminal, resulting in significant transient overvoltage and ultimately causing breakdown failure. Subsequently, the paper systematically reviews three existing unidirectional ESD protection technologies based on the P-GaN HEMT platform. While these technologies can discharge transient electrostatic charges generated by both forward and reverse ESD stresses, they operate in diode mode during reverse ESD events, exhibiting excessively low reverse triggering voltage. Furthermore, unidirectional ESD protection structures based on resistive voltage division and diode voltage division introduce substantial forward and reverse leakage currents. Finally, the article evaluates four bidirectional GaN ESD protection technologies. These bidirectional structures can likewise discharge transient charges from both forward and reverse ESD stresses. Compared to unidirectional approaches, the key advantage of bidirectional ESD protection lies in its ability to provide an appropriate reverse triggering voltage during reverse ESD events, thereby effectively clamping the reverse potential to the desired level. However, likewise, bidirectional ESD protection schemes based on resistive or diode voltage division also inevitably introduce relatively large forward and reverse leakage currents. Full article

Left-sided congestive heart failure (CHF) is a common cause of acute respiratory distress in cats, and echocardiographic assessment of left atrial (LA) size is an important test to differentiate it from respiratory diseases that cause similar clinical signs. Furosemide, a potent loop diuretic, is the first-line therapy for cardiogenic pulmonary edema, but its effect on LA size has not been systematically investigated in cats. Some dyspneic cats are referred after having received high doses of furosemide by the referring veterinarian without prior point-of-care ultrasound (POCUS). This can make the diagnosis of CHF challenging. If furosemide significantly reduces left atrial size, it could potentially lead to misdiagnosis, by erroneously categorizing these cats as not having CHF. This prospective, observational multicenter study enrolled 25 cats with acute left-sided CHF. Point-of-care ultrasound was used to assess LA to aortic ratio (LA:Ao) and maximal LA diameter (LAD) at admission and three hours after furosemide administration. Significant reductions were observed in LA:Ao (2.48 ± 0.35 to 2.17 ± 0.40; p < 0.001), LAD (21.0 ± 2.8 mm to 18.4 ± 3.2 mm; p < 0.001), and respiratory rate (64 ± 30 to 40 ± 14 breaths/min; p < 0.001). Normalization of respiratory rate occurred in 50% of cats, while normalization of maximum LAD occurred in 32%. One cat achieved normalization of LA:Ao. We found that furosemide induced rapid reduction in LA size and respiratory rate in cats with left-sided CHF. Clinicians should be aware that severe LA dilation can be absent in referred dyspneic cats that had already received furosemide. Full article

The mechanical performance of cast iron is strongly governed by the morphology of its graphite phase, yet establishing a quantitative link between microstructure and macroscopic properties remains a challenge. In this study, a three-dimensional finite element method (FEM)-based micromechanical framework is proposed to analyze and predict the mechanical behavior of cast iron with representative graphite morphologies, spheroidal and flake graphite. Realistic representative volume elements (RVEs) are reconstructed based on experimental microstructural characterization and literature-based X-ray computed tomography data, ensuring geometric fidelity and statistical representativeness. Cohesive zone modeling (CZM) is implemented at the graphite/matrix interface and within the graphite phase to simulate interfacial debonding and brittle fracture, respectively. Full-field simulations of plastic strain and stress evolution under uniaxial tensile loading reveal that spheroidal graphite promotes uniform deformation, delayed damage initiation, and enhanced ductility through effective stress distribution and progressive plastic flow. In contrast, flake graphite induces severe stress concentration at sharp tips, leading to early microcrack nucleation and rapid crack propagation along the flake planes, resulting in brittle-like failure. The simulated stress–strain responses and failure modes are consistent with experimental observations, validating the predictive capability of the model. This work establishes a microstructure–property relationship in multiphase alloys through a physics-informed computational approach, demonstrating the potential of FEM-based modeling as a powerful tool for performance prediction and microstructure-guided design of cast iron and other heterogeneous materials. Full article

The coronary no-reflow phenomenon remains a daunting and unresolved barrier during percutaneous coronary procedures, especially for acute coronary syndrome. Despite successful epicardial artery patency restoration, decreased microvascular perfusion leads to unfavorable outcomes such as ventricular remodeling, progression of heart failure, and increased mortality. This review provides a new, integrative informative perspective by combining multifactorial pathophysiology, which includes systemic inflammation, thrombogenicity, ischemia–reperfusion injury, and distal embolization, with advances in diagnostic imaging, such as cardiac magnetic resonance and computed tomography. Therapeutic options, including antithrombotic regimes, vasodilators, and mechanical adjuncts, are evaluated in the context of developing debates and unmet clinical needs. Importantly, we provide feasible future directions for artificial intelligence-based predictive modeling and targeted microvascular treatments. This comprehensive review fills a significant gap, aiming to inform personalized approaches and improve both short- and long-term outcomes in this high-risk patient population. Full article

The mechanical deterioration of Mg alloys during degradation significantly impairs their service performance as biomaterial implants. In the present study, the degradation behavior of a Mg-6Zn-0.5Cu alloy was systematically examined through electrochemical measurements and immersion tests, while the mechanical integrity was assessed via tensile tests under different immersion periods. The results revealed a severe loss in mechanical properties was disproportionate to the corrosion rate. After 7 days’ immersion, the ultimate tensile strength (UTS) and elongation to failure (EL) decreased by 34.4% and 60.1%, respectively, while the corrosion rate was 0.11 mm/y based on the weight loss. This severe mechanical deterioration was primarily caused by pronounced localized corrosion, which induced aggravated local stress concentration at corrosion sites, promoting microcracks initiation and leading to premature fracture of the alloy. Full article

In this study, the J-integral method was used to evaluate the fracture toughness (J_Q) of the isolation layer at the top of SA508-III-309L/308L-316L dissimilar metal welded joints (DMWJs) of a pressure vessel. Tests were carried out at varying temperatures, from room temperature to 320 °C, to study the mechanism underlying temperature effects on unstable crack propagation. The results show that failure occurs in the middle position of the weld isolation layer of the welded joint at all test temperatures. The J_Q of the inner diameter of the joint decreases with increased temperature, with a maximum decrease of 31.8%. The analysis shows that the lath ferrite structure in the isolation layer provides a favorable path for crack propagation. The increase in temperature enlarges the difference in thermal expansion between SA508-III steel and the isolation layer, making it easier for second-phase particles in the isolation layer to induce crack initiation and propagation, thus reducing the J_Q of the steel. In addition, at high temperatures, the dislocation density of the isolation layer, the deformation resistance of the material, and the difference in the yield ratio of the joint weld all decrease, which is not conducive to the redistribution of the stress field at the tip of the fatigue crack, leading to further reduction in the J_Q. Full article

In deep coal mines characterized by high temperature, high humidity, high-salinity water, and elevated ground stress, stress corrosion cracking (SCC) of bolts is widespread, causing frequent instability of roadway surrounding rock and hindering long-term stability. This study systematically examines the failure characteristics of anchorage materials in highly corrosive roadways and clarifies the effects of deep-mine temperature and humidity on material corrosion. Long-term corrosion tests on bolts reveal changes in mechanical properties and macroscopic morphology and elucidate the intrinsic mechanisms of SCC. The results show that with the increase in corrosion time, the yield strength, ultimate load and elongation of the anchor rod decrease by up to 11.8%, 13.6%, and 7.08%, respectively. Under high stress, localized corrosion pits form on bolt surfaces, rupturing the oxide film and initiating rapid anodic dissolution and cathodic hydrogen evolution. Interaction between corroded surfaces and microcracks produced by internal impurities leads to progressive damage accumulation and ultimate fracture of the bolts. These findings provide guidance for corrosion protection of coal mine roadway support materials and for improving the long-term performance of roadway supports. Full article

Ischemic stroke remains one of the most catastrophic diseases in neurology, in which, due to a disturbance in the cerebral blood flow, the brain is acutely deprived of its oxygen and glucose oligomer, which in turn rapidly leads to energetic collapse and progressive cellular death. There is now increasing evidence that this type of stroke is not simply a type of ‘oxidative stress’ but rather a programmable loss-of-redox homeostasis, within which electron flow and the balance of oxidants/reductants are cumulatively displaced at the level of the single molecule and at the level of the cellular area. The advances being made in cryo-electron microscopy, lipidomics, and spatial omics are coupled with the introduction of a redox code produced by the interaction of the couples NADH/NAD⁺, NADPH/NADP⁺, GSH/GSSG, BH₄/BH₂, and NO/SNO, which determine the end results of the fates of the neurons, glia, endothelium, and pericytes. Within the mitochondria, pathophysiological events, including reverse electron transport, succinate overflow, and permeability transition, are found to be the first events after reperfusion, while signals intercommunicating via ER–mitochondria contact, peroxisomes, and nanotunnels control injury propagation. At the level of the tissue, events such as the constriction of the pericytes, the degradation of the glycocalyx, and the formation of neutrophil extracellular traps underlie microvascular failure (at least), despite the effective recanalization of the vessels. Systemic influences such as microbiome products, oxidized lipids, and free mitochondrial DNA in cells determine the redox imbalance, but this generally occurs outside the brain. We aim to synthesize how the progressive stages of ischemic injury evolve from the cessation of flow to the collapse of the cell structure. Within seconds of injury, there is reverse electron transport (RET) through mitochondrial complex I, with bursts of superoxide (O₂•⁻) and hydrogen peroxide (H₂O₂) being produced, which depletes the stores of superoxide dismutase, catalase, and glutathione peroxidase. Accumulated succinate and iron-induced lipid peroxidation trigger ferroptosis, while xanthine oxidase and NOX2/NOX4, as well as uncoupled eNOS/nNOS, lead to oxidative and nitrosative stress. These cascades compromise the function of neuronal mitochondria, the glial antioxidant capacity, and endothelial–pericyte integrity, leading to the degradation of the glycocalyx with microvascular constriction. Stroke, therefore, represents a continuum of redox disequilibrium, a coordinated biochemical failure linking the mitochondrial metabolism with membrane integrity and vascular homeostasis. Full article

The long-term success of composite restorations largely depends on the performance of dental adhesives at the adhesive–tooth interface. Despite ongoing improvements, secondary caries remains the leading cause of restoration failure, primarily due to the adhesive layer’s susceptibility to hydrolytic degradation, bacterial invasion, and limited biological functionality. This review provides a comprehensive overview of recent advances in bioactive dental adhesives for preventing recurrent caries, focusing on their mechanisms of action, material performance, therapeutic functions, and clinical potential. Bioactive adhesives combine durable bonding with biofunctional benefits, including remineralization, antimicrobial activity, enzymatic inhibition, and support for tissue regeneration. By integrating these properties, they enhance both the durability of the adhesive interface and oral health. Recent strategies include the incorporation of ion-releasing fillers such as calcium phosphate and bioactive glass, antimicrobial monomers such as MDPB and quaternary ammonium methacrylates, enzymatic inhibitors, and hydrolytically stable resin matrices. Together, these components strengthen the adhesive interface and provide biologically active effects to prevent recurrent caries. Although in vitro findings are promising, challenges remain, including limited long-term clinical data, the absence of standardized evaluation protocols, and barriers to clinical translation. Addressing these gaps is essential to ensure predictable clinical outcomes. Bioactive dental adhesives represent a paradigm shift in restorative dentistry, evolving from passive bonding agents to multifunctional therapeutic materials. By combining structural durability with biological protection, they hold significant potential to prevent recurrent caries and improve the long-term success of composite restorations. Full article

Background/Objectives: Heart Failure (HF) remains a leading cause of hospitalization and mortality worldwide, representing a significant burden on patients and healthcare systems. Despite advances in pharmacological and device-based therapies, readmission rates remain high and traditional monitoring approaches often fail to detect early physiological deterioration. This review examines the clinical utility and implementation challenges of remote hemodynamic monitoring in HF, highlighting its role in improving patient outcomes and guiding precision care. Method: A comprehensive narrative review was conducted using PubMed, Scopus, and Web of Science databases to identify peer-reviewed English-language studies published in the past ten years. Results: Monitoring hemodynamic status is essential for preventing HF readmissions, as elevated filling pressures often precede symptoms. Previous studies suggest that traditional methods may be less effective in detecting early changes, which could contribute to delays in initiating treatment. Remote monitoring offers continuous, individualized assessment and has shown potential to reduce hospitalizations, though its effectiveness varies across populations and settings. Telemonitoring primarily targets patients at higher risk of hospitalization, such as those classified as New York Heart Association(NYHA) class III and individuals with comorbidities that exacerbate HF. Remote hemodynamic monitoring presents notable clinical advantages, although its widespread adoption faces several challenges (i.e., the invasiveness of some monitoring systems; limited patient adherence due to technical complexity or cognitive and physical barriers; difficulties associated with comorbidities; variability in the efficacy of monitoring strategies across populations; difficulties faced by healthcare teams in managing and interpreting large volumes of real-time data; cost-effectiveness issues related to devices and infrastructure costs). Addressing these limitations will be essential to fully understanding the potential of remote monitoring in HF care. Conclusions: Remote hemodynamic monitoring enables early detection of physiological deterioration in HF, allowing timely interventions that reduce hospitalizations and improve outcomes. Emerging evidence suggests that, in contrast to traditional approaches, this method has the potential to support more personalized, data-driven care. Integrating biopsychosocial, gender, and intersectional perspectives further aligns this strategy with precision medicine, enhancing its effectiveness and equity in clinical practice. Despite promising recent advances, further research is essential to broaden the scientific evidence base and to enhance support for clinical decision-making. Full article