Search Results (21)

Achillea nobilis and its subspecies (A. nobilis subsp. neilreichii and A. nobilis subsp. sipylea) have been traditionally used in various ethnomedical systems across Eurasia. However, comprehensive studies on their phytochemical composition and pharmacological properties are still insufficient. This review aims to provide a critical synthesis of current knowledge regarding the botanical characteristics, geographic distribution, traditional applications, chemical constituents, and pharmacological effects of A. nobilis A structured search was conducted using eight scientific platforms, including Scopus, PubMed, Web of Science, Google Scholar, Science.gov, ScienceDirect, JSTOR, and BASE. Keywords related to phytochemistry, pharmacology, and ethnomedicine were applied, and a total of 28,000 records were initially retrieved. After a multi-stage screening process based on inclusion and exclusion criteria, 167 peer-reviewed publications from 1952 to 2023 were selected for detailed evaluation. Findings reveal a diverse range of bioactive compounds, such as flavonoids, monoterpenes, sesquiterpenes, and sesquiterpene lactones, which demonstrate antioxidant, antimicrobial, anti-inflammatory, antinociceptive, antispasmodic, and anticonvulsant activities. Most studies have focused on aerial parts and water-based extracts, while the root chemistry and organ-specific metabolite profiles remain largely unexplored. This review highlights the therapeutic potential of A. nobilis and underscores the need for future studies using multi-omics and advanced analytical techniques to support its development in pharmaceutical and nutraceutical applications. Full article

To study the mantle structure of the North China Craton (NCC) and its tectonic implications, in particular, the evolution of the rift systems in the Trans-North China Orogen (TNCO), we used teleseismic data recorded by 250 portable seismic stations to invert for the P-wave velocity (Vp) structures of the mantle beneath the NCC. Our results show a large-scale low-Vp anomaly in the shallow mantle and high-Vp anomalies in the deeper upper mantle beneath the eastern NCC, with fine-scale high-Vp anomalies at the lithosphere–asthenosphere boundary, indicating multi-stage lithospheric delamination during the Cenozoic. In the Yan Mountains (YanM), an east–west striking high-Vp anomaly between 60 to 200 km depths and low heat flow suggest the preservation of a thick mantle root. In the TNCO, high-Vp bodies in the upper mantle and the upper part of the mantle transition zone (MTZ) are imaged. The shallower high-Vp anomaly located beneath the Shanxi–Shaanxi Rift (SSR), along with an overlying local-scale low-Vp anomaly, indicates local hot material upwelling due to lithospheric root removal. The India–Eurasia collision’s far-field effects are proposed to cause lithospheric thickening, subsequent root delamination, and the formation and evolution of the SSR. Full article

The North Caspian Basin, known for its oil and gas potential, was formed because of the evolution of the ancient Tethys Ocean and is also a result of the collision of the East European, Kazakhstania, and Siberian paleocontinents. At the beginning of the Mesozoic Era, it was a part of the northern continental margin of the Neo-Tethys, which formed Eurasia. In the Late Triassic and Early Jurassic, a major restructuring of the North Caspian sedimentary basin occurred, characterized by angular unconformity and the erosion of underlying sediments in the coastal zones of the basin. The sedimentary succession of the depression accumulating in the Mesozoic Era consisted of alternating siliciclastic and carbonate rocks. It began to form due to the destruction of the uplifts formed north and west of the East European craton and Urals, which resulted in coastal clastic material in the Triassic and Jurassic, but by the end of the Jurassic and Cretaceous, when all uplifts existing in the north of Tethys were leveled, it was mostly marine environments that contributed to the accumulation of siliciclastic and carbonate strata. The appearance of a large amount of sedimentary material towards the center of the depression, causing stress, as well as the deflection of the basement, contributed to fault tectonics and the resumption and manifestation of salt tectonics. As a result of the continuous diapirism of salt bodies during the Late Mesozoic, mini basins were formed, in which different sedimentogenesis was manifested. These processes contributed to the redistribution of hydrocarbons from the underlying pre-salt formations to the intermediate depth interval post-salt succession with Permian–Triassic and also near-surface Jurassic–Cretaceous formations. Full article

African swine fever (ASF) is a lethal disease of domestic pigs that is currently challenging swine production in large areas of Eurasia. The causative agent, ASF virus (ASFV), is a large, double-stranded and structurally complex virus. The ASFV genome encodes for more than 160 proteins; however, the functions of most of these proteins are still in the process of being characterized. The ASF gene R298L, which has previously been characterized as able to encode a functional serine protein kinase, is expressed late in the virus infection cycle and may be part of the virus particle. There is no description of the importance of the R298L gene in basic virus functions such as replication or virulence in the natural host. Based on its evolution, it is proposed that there are four different phenotypes of R298L of ASFV in nature, which may have potential implications for R298L functionality. We report here that a recombinant virus lacking the R298L gene in the Georgia 2010 isolate, ASFV-G-∆R298L, does not exhibit significant changes in its replication in primary cultures of swine macrophages. In addition, when experimentally inoculated in pigs, ASFV-G-∆R298L induced a fatal form of the disease similar to that caused by the parental virulent ASFV-G. Therefore, deletion of R298L does not significantly affect virus replication and virulence in domestic pigs of the ASFV Georgia 2010 isolate. Full article

The Silk Road pattern (SRP) and circumglobal teleconnection pattern (CGT) are two well-known teleconnection patterns, representing the summer circulation variations of the Northern Hemisphere mid-latitudes, which have different definitions but are often regarded as one teleconnection pattern. In view of the distinct features of the SRP/CGT on the interannual (IA) and interdecadal (ID) timescales, the present study investigates the linkages and differences between the SRP and CGT on the two timescales, respectively. On the IA timescale, both the SRP and CGT feature a similar circumglobal wave train structure with strong and significant centers over Eurasia but show clear independence. Specifically, the SRP and CGT illustrate largely the mid-/high-latitude-related and tropics-related parts of the Northern Hemisphere upper tropospheric circulation variations, respectively. Also, the CGT shows a stronger connection to the Indian summer monsoon (ISM) heating and El Niño–Southern Oscillation than the SRP, which makes the CGT more like a tropical forcing-driven atmospheric mode and the SRP more like an internal atmospheric mode. The linkages and differences between them are associated with their asymmetrical relationship during their positive and negative phases, which are attributed mainly to the asymmetrical impact of the ISM heating/cooling on the Eurasian circulations. On the ID timescale, the SRP and CGT are characterized by a coherent two-wave train structure over Eurasia and feature a similar teleconnection pattern over Eurasia, which is associated with the Pacific Decadal Oscillation and Atlantic Multidecadal Oscillation. The present findings on their linkages and differences are helpful in understanding the variability and prediction of the SRP and CGT. Full article

Eurasia is represented by all climatic zones and various environments. A unique breed variety of farm animals has been developed in Russia, whose territory covers a large area of the continent. A total of 69 local breeds and types of dairy, wool, and meat sheep (Ovis aries) are maintained here. However, the genetic diversity and maternal origin of these local breeds have not been comprehensively investigated. In this study, we describe the diversity and phylogeny of Russian sheep breeds inhabiting different geographical regions based on the analysis of complete sequences of mitochondrial genomes (mtDNA). Complete mtDNA sequences of the studied sheep were obtained using next-generation sequencing technology (NGS). All investigated geographical groups of sheep were characterized by high haplotype (Hd = 0.9992) and nucleotide diversity (π = 0.00378). Analysis of the AMOVA results showed that genetic diversity was majorly determined by within-population differences (77.87%). We identified 128 haplotypes in all studied sheep. Haplotypes belonged to the following haplogroups: B (64.8%), A (28.9%), C (5.5%), and D (0.8%). Haplogroup B was predominant in the western part of Russia. A high level of mtDNA polymorphism in the studied groups of local sheep indicates the presence of a significant reserve of unique genotypes in Russia, which is to be explored. Full article

At the end of November 2021, a large area of Puglia (an administrative region in Southern Italy) was officially nominated as new aUGGp (aspiring UNESCO Global Geopark) by the Italian National Commission of UNESCO. This area comprises the northwestern part of the Murge territory, where a Cretaceous sector of the Apulia Carbonate Platform crops out, and part of the adjacent Premurge territory, where the southwestward lateral continuation of the same platform (being flexed toward the Southern Apennines Chain) is covered by thin Plio-Quaternary foredeep deposits. The worldwide geological uniqueness of the aspiring Geopark (Murge aUGGp) is that the area is the only in situ remnant of the Adria Plate, the old continental plate almost entirely squeezed between the Africa and Eurasia Plates. In such a context, the Murge area (part of the Apulia Foreland) is a virtually undeformed sector of Adria, while other territories of the plate are and/or were involved in the subduction/collision processes. In the aspiring Geopark, the crust of Adria is still rooted to its mantle, and the Cretaceous evolution of the continent is widely recorded in the Murge area thanks to the shallow-water carbonate succession of one of the largest peri-Tethys carbonate platforms (the Apulia Carbonate Platform). The aspiring Geopark also comprises the Premurge area, which represents the outer Southern Apennines foredeep, whose Plio-Quaternary evolution is spectacularly exposed thanks to an “anomalous” regional middle-late Quaternary uplift. Despite the presence of numerous geological singularities of international importance, it would be important, from a geotourist point of view, to propose a regional framework of the geology of the aUGGp before introducing visitors to the significance of the individual geosites, whose importance could be amplified if included in the geoevolutionary context of the Murge aUGGp. Full article

Based on the analysis of Landsat satellite images over the period of 2013–2019, the number (6683) and total area (4529 km²) of giant aufeis fields (area ≥ 0.1 km²) were estimated for the territory of North-Eastern Eurasia. The contribution of aufeis runoff to river streamflow in different seasons was calculated for 58 hydrological gauges (area 523–526,000 km²). The contribution of aufeis and glaciers to water balance is compared. The aufeis resources vary from 0.4 to 4.25 km³ (or 3.7–11 mm) for individual basins of large rivers. They are at least 10.6 km³ in total or 5 mm of water depth on average for the study area. Aufeis annual runoff varies from 0.3 to 29 mm (0.1–22%, average 3.8%), with the share in winter runoff amount about 6–712% (average 112%) and the spring freshet 0.2–43% (average 7.1%). In general, the aufeis runoff exceeds the glacial runoff. The dynamics of aufeis formation are directly related to winter runoff, whose changes are observed in different parts of the cryosphere. The presented results are relevant for studying the impact of climate change on the hydrological cycle and its components in the permafrost regions of the Northern Hemisphere. Full article

Ants of the «Formica picea—F. candida» complex are widespread across Eurasia. However, it is still a matter of debate if it constitutes one or two species. In this study, we collected a sample of specimens from different parts of Eurasia, sequenced the mitochondrial cox1 and cytb genes, as well as three nuclear loci—wg, Top1, and ITS2—and analyzed the available published data. We found this complex to contain a new, yet undescribed, taxon that has a large distribution in Siberia and East Asia. Thus, the «Formica picea—F. candida» complex consists of at least three taxa with distinct distributions. Full article

Orthohantaviruses are zoonotic pathogens that play a significant role in public health. These viruses can cause haemorrhagic fever with renal syndrome in Eurasia. In the Republic of Kazakhstan, the first human cases were registered in the year 2000 in the West Kazakhstan region. Small mammals can be reservoirs of orthohantaviruses. Previous studies showed orthohantavirus antigens in wild-living small mammals in four districts of West Kazakhstan. Clinical studies suggested that there might be further regions with human orthohantavirus infections in Kazakhstan, but genetic data of orthohantaviruses in natural foci are limited. The aim of this study was to investigate small mammals for the presence of orthohantaviruses by molecular biological methods and to provide a phylogenetic characterization of the circulating strains in Kazakhstan. Small mammals were trapped at 19 sites in West Kazakhstan, four in Almaty region and at seven sites around Almaty city during all seasons of 2018 and 2019. Lung tissues of small mammals were homogenized and RNA was extracted. Orthohantavirus RT-PCR assays were applied for detection of partial S and L segment sequences. Results were compared to published fragments. In total, 621 small mammals from 11 species were analysed. Among the collected small mammals, 2.4% tested positive for orthohantavirus RNA, one sample from West Kazakhstan and 14 samples from Almaty region. None of the rodents caught in Almaty city were infected. Sequencing parts of the small (S) and large (L) segments specified Tula virus (TULV) in these two regions. Our data show that geographical distribution of TULV is more extended as previously thought. The detected sequences were found to be split in two distinct genetic clusters of TULV in West Kazakhstan and Almaty region. TULV was detected in the common vole (Microtus arvalis) and for the first time in two individuals of the forest dormouse (Dryomys nitedula), interpreted as a spill-over infection in Kazakhstan. Full article

The origin of the man on Earth is directly associated with the determination of directions of the flow distribution of the ancient man dispersal to adjacent territories. In such studies, mainly landscape and climatological changes are traditionally considered. We suggest that along with the above factors, regional tectonic-geodynamic factors played a dominant role in the character of dispersal. The considered African-Levantine-Caucasian region is one of the most geologically complex regions of the world, where collisional and spreading processes of geodynamics converge. For the first time, we determined an essential influence of the Akchagylian hydrospheric maximum (about 200 m above the mean sea level) limiting the early dispersal of hominins from Africa to Eurasia. We propose that the Levantine Corridor emerged after the end of the Akchagylian transgression and landscape forming in the Eastern Mediterranean. This corridor location was formed by the movements between the Dead Sea Transform and the boundary of the carbonate platform of the Mesozoic Terrane Belt. Further landscape evolution was largely determined by the geodynamic behavior of the deep mantle rotating structure occurring below the central part of the region under study. All the mentioned events around and in the Levantine Corridor have been studied in detail on the basis of the combined geodynamic, paleogeographic, and paleomagnetic analyses performed in northern Israel (Carmel Uplift and Galilee Plateau). Careful studies of the Evron Quarry geological section indicate that it is unique for the dating of marine and continental archaeological sequences and sheds light on the early dispersal of hominins along the Levantine Corridor. Full article

Lake level is a sensitive integral indicator of climate change on regional scales, especially in enclosed endorheic basins. Eurasia contains the largest endorheic zone with several large terminal lakes, whose water levels recently underwent remarkable variations. To address the patterns of these variations and their links to the climate change, we investigated the variability of levels in 15 lakes of three neighboring endorheic regions—Central Asia, Tibetan Plateau, and Mongolian Plateau. Satellite altimetry revealed a heterogeneous pattern among the regions during 1992–2018: lake levels increased significantly in Central Asia and the Tibetan Plateau but decreased on the Mongolian Plateau. The shifts to the increasing trend were detected since 1997 in Central Asia, since 1998 in the southern part of the Tibetan Plateau, and since 2005 in its northern part. The shift in air temperatures around 1997 and the precipitation shifts around 1998 and 2004 contributed to the trend’s turning points, with precipitation being the major contributor to the heterogeneous pattern of lake levels. Our findings reveal the linkage of the heterogeneous pattern of lake levels to climatic factors in the endorheic basins, providing a further understanding of the hydrological regime in the Eurasian endorheic zone and its sensitivity to climate change. Full article

Background and scope: The late Villafranchian large mammal age (~2.0–1.2 Ma) of the Early Pleistocene is a crucial interval of time for mammal/hominin migrations and faunal turnovers in western Eurasia. However, an accurate chronological framework for the Balkans and adjacent territories is still missing, preventing pan-European biogeographic correlations and schemes. In this article, we report the first detailed chronological scheme for the late Villafranchian of southeastern Europe through a comprehensive and multidisciplinary dating approach (biochronology, magnetostratigraphy, and cosmogenic radionuclides) of the recently discovered Lower Pleistocene vertebrate site Tsiotra Vryssi (TSR) in the Mygdonia Basin, Greece. Results: The minimum burial ages (1.88 ± 0.16 Ma, 2.10 ± 0.18 Ma, and 1.98 ± 0.18 Ma) provided by the method of cosmogenic radionuclides indicate that the normal magnetic polarity identified below the fossiliferous layer correlates to the Olduvai subchron (1.95–1.78 Ma; C2n). Therefore, an age younger than 1.78 Ma is indicated for the fossiliferous layer, which was deposited during reverse polarity chron C1r. These results are in agreement with the biochronological data, which further point to an upper age limit at ~1.5 Ma. Overall, an age between 1.78 and ~1.5 Ma (i.e., within the first part of the late Villafranchian) is proposed for the TSR fauna. Conclusions: Our results not only provide age constraints for the local mammal faunal succession, thus allowing for a better understanding of faunal changes within the same sedimentary basin, but also contribute to improving correlations on a broader scale, leading to more accurate biogeographic, palaeoecological, and taphonomic interpretations. Full article

Ips typographus Linnaeus, 1758, the most important pest of Norway spruce (Picea abies Linnaeus, 1753) from Eurasia has damaged, in the last decades, a large area of forest in Romania. Associations between beetles and their symbiotic fungi are well known compared to beetle-mite relationships. The objectives of the study are to determine: (i) the diversity of mites species associated with I. typographus in a local outbreak from Central Romania; (ii) the mite’s preferences concerning the body parts of their carriers; and (iii) how phoresy changes during seasonal flight activity of the host. A total of 7896 adult I. typographus were analyzed and six mite species (both adults and immature stages) were found: Dendrolaelaps quadrisetus Berlese,1920, Proctolaelaps fiseri Samsinak, 1960, Trichouropoda polytricha Vitzthum, 1923, Histiostoma piceae Scheucher, 1957, Uroobovella ipidis Vitzthum, 1923, and Uroobovella vinicolora Vitzthum, 1926. Most mites were observed under the carriers’ elytra (46.8%), while 26.7% and 25.8% were seen on the thorax and elytral declivities, respectively. Mite phoresy peaked in the spring corresponding to the dispersal flight of the carrier. A smaller peak in phoresy occurred in the summer during the second beetle generation. Full article

H10, H11 and H12 (H10–H12) subtypes of the avian influenza virus (AIV) are associated with waterfowl. Although these subtypes of AIV are infrequently detected in nature, they can undergo reassortment with other AIV subtypes. Few H10–H12 subtypes of AIV have been isolated from wild birds in China. In this study, 12 AIV isolates of H10–H12 subtypes were identified via routine surveillance of wild birds in Shanghai, China from 2016 to 2019, including two H10, three H11 and seven H12 isolates. Sequence and phylogenetic analyses revealed that the genomic segments of the 12 isolates are highly diverse. These 12 isolates are closely related to those in the Eurasian lineage and share a high degree of sequence identity with those from wild birds and domestic ducks in countries in the East Asian–Australasian Flyway, including Japan, Korea, Bangladesh, Vietnam and China. However, parts of the genomic segments of two H12N2 isolates (NH112319-H12N2 and NH101807-H12N2) belong to the North American lineage, suggesting intercontinental reassortment among H12 AIVs in Eurasia and North American. To better understand the ecological and phylodynamic features of H10–H12 subtypes in wild birds, a large-scale surveillance of AIVs in wild birds is warranted. Full article