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28 pages, 808 KB  
Article
How Does Digital Transformation Drive Green Innovation? The Key Roles of Green Dynamic Capabilities and Environmental Munificence
by Renpu Liu, Mengchen Xie and Yu Li
Sustainability 2025, 17(19), 8885; https://doi.org/10.3390/su17198885 - 6 Oct 2025
Viewed by 879
Abstract
Against the backdrop of the global integration of green transformation and the digital economy, how manufacturing enterprises leverage digitalisation to drive green innovation has become a focal point for both academic and industrial sectors. Based on the Resource-Based View (RBV) and Dynamic Capabilities [...] Read more.
Against the backdrop of the global integration of green transformation and the digital economy, how manufacturing enterprises leverage digitalisation to drive green innovation has become a focal point for both academic and industrial sectors. Based on the Resource-Based View (RBV) and Dynamic Capabilities Theory (DCT), this study constructs a moderated mediation model to explore the internal mechanism through which digital transformation influences green innovation via green dynamic capabilities and examines the boundary role of environmental munificence. Questionnaire data, collected in two stages from 312 Chinese manufacturing enterprises using SPSS 27.0 and AMOS 24.0, was analysed, and the empirical results indicate that digital transformation not only directly promotes green innovation but also exerts an indirect influence through the three dimensions of green dynamic capabilities: insights into the capability of green opportunities, green resource integration, and green resource reconstruction. Furthermore, environmental munificence significantly and positively moderates the relationship between green dynamic capabilities and green innovation, suggesting that this relationship is strengthened in resource- and opportunity-rich environments. Path analysis of the three green dynamic capability dimensions reveals that back-end capabilities (resource integration and reconfiguration) have a more pronounced impact on green innovation than front-end capabilities (opportunity insights). From the dual perspectives of capability building and contextual fit, this study elucidates the mechanism and boundary conditions of digital transformation driving green innovation, enriches green innovation theory, and offers practical insights into the digital-green transformation of manufacturing enterprises. Full article
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19 pages, 757 KB  
Article
The Impact of Technological Progress and Industrial Structure Upgrading on Agricultural Economic Resilience: An Empirical Study in China
by Changyu Ren, Weizhong Liu, Tong Xiao, Alessandra Castellini and Giulia Maesano
Sustainability 2025, 17(17), 8062; https://doi.org/10.3390/su17178062 - 7 Sep 2025
Viewed by 1857
Abstract
Technological advancements are a key engine for improving productivity and are fundamental to enhancing the resilience of the agricultural economy by influencing production methods and driving structural transformation. The objective of this study is to analyze the impact of technological progress on agricultural [...] Read more.
Technological advancements are a key engine for improving productivity and are fundamental to enhancing the resilience of the agricultural economy by influencing production methods and driving structural transformation. The objective of this study is to analyze the impact of technological progress on agricultural economic resilience in China, with particular attention to (i) its direct effects on resistance, recovery, and reconstruction; (ii) its indirect effects through the upgrading of the agricultural industrial structure; and (iii) its potential nonlinear effects under different structural thresholds. To achieve this, a multidimensional evaluation framework has been developed to assess agricultural economic resilience through three distinct dimensions: resistance, recovery, and reconstruction. Using fixed effects, mediation, threshold and spatial Durbin models, we empirically analyze the impact pathways. The results suggest that technological progress significantly increases agricultural resilience, with robustness confirmed by various tests including model substitution and variable replacement. Furthermore, regional heterogeneity is evident, with the central region showing the strongest positive effect. The mediation analysis shows that modernization of industrial structure serves as an important transmission channel, while the threshold regression identifies nonlinear effects, with significant improvements occurring beyond certain structural thresholds. The results underline the importance of promoting technological innovation in agriculture, developing region-specific support measures and accelerating structural optimization to strengthen the resilience of agriculture. Full article
(This article belongs to the Section Sustainable Agriculture)
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15 pages, 471 KB  
Article
How Does Meaning-Centered Coping Influence College Students’ Mental Health? The Mediating Roles of Interdependent Self-Construal and School Connectedness
by Qin Lu, Qian Chen, Yuanhao Zhang and Zongkui Zhou
Behav. Sci. 2025, 15(7), 955; https://doi.org/10.3390/bs15070955 - 15 Jul 2025
Viewed by 1084
Abstract
Meaning-centered coping is regarded as an effective strategy for managing stress and preventing mental disorders. However, it remains unclear how it influences mental health by affecting both the self and social connection dimensions. This study investigated 856 college students through a questionnaire, examining [...] Read more.
Meaning-centered coping is regarded as an effective strategy for managing stress and preventing mental disorders. However, it remains unclear how it influences mental health by affecting both the self and social connection dimensions. This study investigated 856 college students through a questionnaire, examining how meaning-centered coping affects their mental health (depression and anxiety). Additionally, this study explored the roles of interdependent self-construal and school connectedness as mediators in this process. The results indicate that meaning-centered coping influences mental health either via the mediation of school connectedness alone (indirect effect for depression: β = −0.08, 95% CI [−0.11, −0.04]; for anxiety: β = −0.06, 95% CI [−0.10, −0.03]) or via the sequential mediation of interdependent self-construal and school connectedness (indirect effect for depression: β = −0.08, 95% CI [−0.11, −0.05]; for anxiety: β = −0.06, 95% CI [−0.10, −0.04]). This study reveals that college students who are skilled at seeking and reconstructing their sense of meaning can effectively cope with stress and alleviate related depression and anxiety. This coping mechanism operates through perceived school connectedness or through activated interdependent self-construal followed by perceived school connectedness, subsequently reducing anxiety and depression induced by chronic stress. This study theoretically deepens the comprehension of the mechanism on meaning-centered coping, while practically, the findings provide valuable insights for educating training college students to leverage the wisdom of meaning theory to sustain their mental health in future challenges. Full article
(This article belongs to the Section Developmental Psychology)
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12 pages, 3419 KB  
Article
Graphene Oxide-Enriched Polymer: Impact on Dental Pulp Cell Viability and Differentiation
by Magdalena Vega-Quiroz, Agustin Reyes-Maciel, Christian Andrea Lopez-Ayuso, Carlos A. Jurado, Hector Guzman-Juarez, Carlos Andres Alvarez-Gayosso, Benjamin Aranda-Herrera, Abdulrahman Alshabib and Rene Garcia-Contreras
Polymers 2025, 17(13), 1768; https://doi.org/10.3390/polym17131768 - 26 Jun 2025
Viewed by 959
Abstract
Background: Reconstructing maxillofacial defects is important in dentistry, so efforts are being made to develop materials that promote cell migration and repair. Graphene oxide (GO) is used to enhance the biocompatibility of polymethylmethacrylate (PMMA) due to its nanostructure. Objective: to assess cytotoxicity, cell [...] Read more.
Background: Reconstructing maxillofacial defects is important in dentistry, so efforts are being made to develop materials that promote cell migration and repair. Graphene oxide (GO) is used to enhance the biocompatibility of polymethylmethacrylate (PMMA) due to its nanostructure. Objective: to assess cytotoxicity, cell proliferation, and differentiation of human dental pulp stem cells (hDPSC) in response to a conventional PMMA (PMMA) and polymer enriched with GO (PMMA+GO). Methods: Experiments were carried out with primary hDPSC subcultures. The PMMA and PMMA+GO were tested in direct and indirect contact. Cytotoxicity (1 day) and proliferation (3, 7, and 14 days) were evaluated with an MTT bioassay. The osteogenic, adipogenic, and chondrogenic aspects were determinate with alizarin red, oil red, and safranine. Mean values, standard deviation, and percentages were calculated; data were analyzed with Shapiro–Wilks normality and Student’s t-test. Results: The cell viability of PMMA and PMMA+GO in direct contact correspond to 90.8 ± 6.2, 149.6 ± 14.5 (1 day); 99.9 ± 7.0, 95.7 ± 6.1 (3 days); 120.2 ± 14.6, 172.9 ± 16.2 (7 days); and 102.9 ± 17.3, 95.4 ± 22.8 (14 days). For indirect contact, 77.2 ± 8.4, 99 ± 21.4 (1 day); 64.8 ± 21.6, 67.0 ± 9.6 (3 days); 91.4 ± 16.5, 142 ± 18.7 (7 days); and 63 ± 15.8, 79.1 ± 3.1 (14 days). PMMA+GO samples showed enhanced adipogenic, chondrogenic, and osteogenic aspects. Conclusions: The integration of GO into PMMA biopolymers stimulates cell proliferation and differentiation, holding great promise for future applications in the field of biomedicine. Full article
(This article belongs to the Special Issue Challenges and Opportunities of Polymer Materials in Dentistry)
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17 pages, 4968 KB  
Article
A Comparative Evaluation of Threshold Segmentation and LiDAR for Sawmill Residue Volume Estimation
by Carlos Borrego-Núñez, Juan de Dios García-Quezada, Leonardo Vásquez-Ibarra, Pablito Marcelo López-Serrano, Pedro Antonio Domínguez-Calleros, Artemio Carrillo-Parra and Jorge Luis Compeán-Aguirre
Forests 2025, 16(7), 1045; https://doi.org/10.3390/f16071045 - 22 Jun 2025
Viewed by 592
Abstract
The sawn timber production process generates up to 63% of residues during primary processing in sawmills. For this industry, the devaluation and disposal of these residues remain significant challenges; proper management requires a more accurate quantification of the volume. This study evaluates and [...] Read more.
The sawn timber production process generates up to 63% of residues during primary processing in sawmills. For this industry, the devaluation and disposal of these residues remain significant challenges; proper management requires a more accurate quantification of the volume. This study evaluates and compares two indirect methods for estimating the volume of stacked residues: one based on image processing and the other on terrestrial LiDAR technology. Residues of Pinus spp. from a sawmill were used, with their actual volume determined using a xylometer. The image-based method, which uses threshold-based segmentation, achieved a R2 = 0.64 and RMSE = 0.006 m3. In contrast, the LiDAR-based method, which derives measurements directly from 3D reconstruction, obtained an R2 = 0.506 and RMSE = 0.009 m3. Despite these differences, ANOVA testing (p > 0.05) indicated no statistically significant differences between the methods. The results suggest that both approaches may serve as preliminary tools for forest residue quantification and provide a solid foundation for future research aimed at developing field-applicable technological solutions. Full article
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13 pages, 7037 KB  
Proceeding Paper
Ancient Science: From Effects to Ballistics Parameters
by Flavio Russo and Adriana Rossi
Eng. Proc. 2025, 96(1), 2; https://doi.org/10.3390/engproc2025096002 - 3 Jun 2025
Cited by 1 | Viewed by 637
Abstract
A well-equipped legionary army prepared to lay siege to Pompeii. Among the weapons deployed along the northern stretch of the city walls were battering rams and mobile siege towers equipped with ballistae and scorpions. The impact marks from Republican-era stone balls and dart [...] Read more.
A well-equipped legionary army prepared to lay siege to Pompeii. Among the weapons deployed along the northern stretch of the city walls were battering rams and mobile siege towers equipped with ballistae and scorpions. The impact marks from Republican-era stone balls and dart tips remain visible today between the Vesuvio and Ercolano Gates. In 2002 and 2016, the authors surveyed significant cavities using both direct and indirect methods. The collected data were then used to calculate the volume of fractured stone material. Given the hardness of the wall ashlars, ballistic parameters were quantified based on Hellenistic treatises. The results make it possible to derive dimensions for reconstructing artillery calibrated to the observed effects. Full article
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13 pages, 281 KB  
Article
Decay Estimates for a Lamé Inverse Problem Involving Source and Damping Term with Variable-Exponent Nonlinearities
by Zülal Mısır and Metin Yaman
Axioms 2025, 14(6), 424; https://doi.org/10.3390/axioms14060424 - 30 May 2025
Viewed by 409
Abstract
We investigate an inverse problem involving source and damping term with variable-exponent nonlinearities. We establish adequate conditions on the initial data for the decay of solutions as the integral overdetermination approaches zero over time within an acceptable range of variable exponents. This class [...] Read more.
We investigate an inverse problem involving source and damping term with variable-exponent nonlinearities. We establish adequate conditions on the initial data for the decay of solutions as the integral overdetermination approaches zero over time within an acceptable range of variable exponents. This class of inverse problems, where internal terms such as source and damping are to be determined from indirect measurements, has significant relevance in real-world applications—ranging from geophysical prospecting to biomedical engineering and materials science. The accurate identification of these internal mechanisms plays a crucial role in optimizing system performance, improving diagnostic accuracy, and constructing predictive models. Therefore, the results obtained in this study not only contribute to the theoretical understanding of nonlinear dynamic systems but also provide practical insights for reconstructive analysis and control in applied settings. The asymptotic behavior and decay conditions we derive are expected to be of particular interest to researchers dealing with stability, uniqueness, and identifiability in inverse problems governed by nonstandard growth conditions. Full article
(This article belongs to the Special Issue Advances in Nonlinear Analysis and Numerical Modeling)
23 pages, 12949 KB  
Article
A Grid-Based Hierarchical Representation Method for Large-Scale Scenes Based on Three-Dimensional Gaussian Splatting
by Yuzheng Guan, Zhao Wang, Shusheng Zhang, Jiakuan Han, Wei Wang, Shengli Wang, Yihu Zhu, Yan Lv, Wei Zhou and Jiangfeng She
Remote Sens. 2025, 17(10), 1801; https://doi.org/10.3390/rs17101801 - 21 May 2025
Viewed by 1801
Abstract
Efficient and realistic large-scale scene modeling is an important application of low-altitude remote sensing. Although the emerging 3DGS technology offers a simple process and realistic results, its high computational resource demands hinder direct application in large-scale 3D scene reconstruction. To address this, this [...] Read more.
Efficient and realistic large-scale scene modeling is an important application of low-altitude remote sensing. Although the emerging 3DGS technology offers a simple process and realistic results, its high computational resource demands hinder direct application in large-scale 3D scene reconstruction. To address this, this paper proposes a novel grid-based scene-segmentation technique for the process of reconstruction. Sparse point clouds, acting as an indirect input for 3DGS, are first processed by Z-Score and a percentile-based filter to prepare the pure scene for segmentation. Then, through grid creation, grid partitioning, and grid merging, rational and widely applicable sub-grids and sub-scenes are formed for training. This is followed by integrating Hierarchy-GS’s LOD strategy. This method achieves better large-scale reconstruction effects within limited computational resources. Experiments on multiple datasets show that this method matches others in single-block reconstruction and excels in complete scene reconstruction, achieving superior results in PSNR, LPIPS, SSIM, and visualization quality. Full article
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14 pages, 6740 KB  
Article
Er:YAG Laser in QSP Modality for Treatment of Indirect Adhesive Restoration Build-Up: Surface Roughness Analysis and Morphology Assessment by Environmental Scanning Electron Microscopy (ESEM)
by Ilaria Giovannacci, Monica Mattarozzi, Fabrizio Moroni, Giuseppe Pedrazzi, Paolo Vescovi and Maria Careri
Dent. J. 2025, 13(5), 223; https://doi.org/10.3390/dj13050223 - 21 May 2025
Viewed by 620
Abstract
Background/Objectives: Sandblasting build-ups before applying the acid and adhesive significantly improves the bond strength. The aim of this study is to evaluate, for the first time, the effectiveness of an Er:YAG laser used in QSP mode to treat the surface of build-ups before [...] Read more.
Background/Objectives: Sandblasting build-ups before applying the acid and adhesive significantly improves the bond strength. The aim of this study is to evaluate, for the first time, the effectiveness of an Er:YAG laser used in QSP mode to treat the surface of build-ups before the adhesive cementation sequence. Methods: This ex vivo study was conducted on 12 intact, undecayed extracted teeth kept hydrated in NaCl 0.9% solution. A cavity was created in the center and reconstructed with composite resin (build-up). Then, samples were prepared with burs and divided into three groups: control group G1, prepared only with burs; group G2, in which surfaces were treated with a sandblaster (2.5 bar, 10 mm from composite surface, aluminum oxide, 10 s); and group G3, treated using an Er:YAG laser (QSP modality, 1 W, 10 Hz, 100 mJ). The surface roughness of the build-ups was measured using a CCI MP-L digital optical profiler (Taylor Hobson, Leicester, UK), and surface morphology was studied using the Quanta™ 250 FEG (FEI, Hillsboro, OR, USA) ESEM instrument. Results: Regarding enamel, mean surface roughness in G1 vs. G2 was not statistically significant (p = 0.968); meanwhile, differences between the Er:YAG laser group (G3) and G1 or G2 were significant (G3 vs. G1 p < 0.001; G3 vs. G2 p < 0.001). Regarding dentin, G1 vs. G2 was significant (p = 0.021); differences between G3 and G1 or G2 were extremely significant (G3 vs. G1 p < 0.001; G3 vs. G2 p < 0.001). The same trend was detected for resin. Conclusions: An Er:YAG laser in QSP mode used on the build-up surface for indirect adhesive restorations is innovative and should be investigated with further studies. However, it seems extremely effective with increased roughness, the absence of a smear layer and characteristics potentially favorable for good adhesion for all substrates (enamel, dentin, resin). Full article
(This article belongs to the Special Issue Laser Dentistry: The Current Status and Developments)
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21 pages, 2798 KB  
Article
Degradation Law of Long-Term Performance in In-Service Emulsified Asphalt Cold Recycled Mixtures
by Bingyang Wu, Shuai Wang, Ziqi Ma, Hui Zhao and Hengkang Zhu
Processes 2025, 13(5), 1561; https://doi.org/10.3390/pr13051561 - 18 May 2025
Viewed by 562
Abstract
To investigate the performance degradation of emulsified asphalt cold recycled mixtures (CRM) during service, this study selected a 10 km section of the cold recycled layer (CRL) from the Changjiu Expressway reconstruction project as the research subject. The deterioration patterns of key pavement [...] Read more.
To investigate the performance degradation of emulsified asphalt cold recycled mixtures (CRM) during service, this study selected a 10 km section of the cold recycled layer (CRL) from the Changjiu Expressway reconstruction project as the research subject. The deterioration patterns of key pavement performance indicators—including the Pavement Condition Index (PCI), Riding Quality Index (RQI), Rutting Depth Index (RDI), and Pavement Structure Strength Index (PSSI)—were analyzed in relation to cumulative equivalent axle loads over a 7-year service period. Concurrently, comparative evaluations were conducted on the mechanical properties, water stability, high-temperature performance, low-temperature crack resistance, and fatigue characteristics between in-service and laboratory-prepared emulsified asphalt CRM. The results demonstrate that after seven years of service, the emulsified asphalt cold recycled pavement maintained excellent performance levels, with PCI, RQI, RDI, and PSSI values of 92.6 (excellent), 90.1 (excellent), 88.5 (good), and 93.4 (excellent), respectively. Notably, while the indirect tensile strength and unconfined compressive strength of the CRL increased with prolonged service duration, other performance metrics—including the tensile strength ratio, shear strength, fracture work, and fracture energy—exhibited an initial improvement followed by gradual deterioration. Additionally, increased traffic loading during service led to a reduction in the residual fatigue life of the CRM. Interestingly, the study observed a temporary improvement in the fatigue performance of CRM during the service period. This phenomenon can be attributed to three key mechanisms: (1) continued cement hydration, (2) secondary hot compaction effects, and (3) diffusion and rejuvenation between fresh and aged asphalt binders. These processes collectively contributed to the partial recovery of aged asphalt strength, thereby improving both the mechanical properties and overall road performance of the CRM. The findings confirm that cold recycled pavements exhibit remarkable durability and maintain a high service level over extended periods. Full article
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22 pages, 10265 KB  
Article
Signal-to-Noise Ratio Model and Imaging Performance Analysis of Photonic Integrated Interferometric System for Remote Sensing
by Chuang Zhang, Yan He and Qinghua Yu
Remote Sens. 2025, 17(9), 1484; https://doi.org/10.3390/rs17091484 - 22 Apr 2025
Viewed by 1683
Abstract
Photonic integrated interferometric imaging systems (PIISs) provide a compact solution for high-resolution Earth observation missions with stringent size, weight, and power (SWaP) constraints. As an indirect imaging method, a PIIS exhibits fundamentally different noise response characteristics compared to conventional remote sensing systems, and [...] Read more.
Photonic integrated interferometric imaging systems (PIISs) provide a compact solution for high-resolution Earth observation missions with stringent size, weight, and power (SWaP) constraints. As an indirect imaging method, a PIIS exhibits fundamentally different noise response characteristics compared to conventional remote sensing systems, and its imaging performance under practical operational scenarios has not been thoroughly investigated. The primary objective of this paper is to evaluate the operational capabilities of PIISs under remote sensing conditions. We (1) establish a signal-to-noise-ratio model for PIISs with balanced four-quadrature detection, (2) analyze the impacts of intensity noise and turbulent phase noise based on radiative transfer and turbulence models, and (3) simulate imaging performance with WorldView-3-like parameters. The results of the visibility signal-to-noise ratio (SNR) analysis demonstrate that the system’s minimum detectable fringe visibility is inversely proportional to the reciprocal of the sub-aperture intensity signal-to-noise ratio. When the integration time reaches 100 ms, the minimum detectable fringe visibility ranges between 102 and 103 (at 10 dB system efficiency). Imaging simulations demonstrate that recognizable image reconstruction requires integration times exceeding 10 ms for 10 cm baselines, achieving approximately 25 dB PSNR and 0.8 SSIM at 100 ms integration duration. These results may provide references for potential applications of photonic integrated interferometric imaging systems in remote sensing. Full article
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23 pages, 11199 KB  
Article
Transformation of Internal Thoracic Structures of Callobruchus maculatus (Coleoptera: Bruchidae) from Larva to Adult
by Sipei Liu, Xiaokun Liu, Lijie Zhang, Xieshuang Wang, Xinying Zhang, Le Zong, Wenjie Li, Zhengzhong Huang, Xin Liu and Siqin Ge
Insects 2025, 16(3), 324; https://doi.org/10.3390/insects16030324 - 19 Mar 2025
Cited by 1 | Viewed by 1155
Abstract
Callobruchus maculatus is a major quarantine pest of stored legumes in China. As a holometabolous insect, it lives inside the bean it burrows into in both its larval and pupal stages. This study utilized micro-CT and 3D reconstruction to document thoracic morphological transformation [...] Read more.
Callobruchus maculatus is a major quarantine pest of stored legumes in China. As a holometabolous insect, it lives inside the bean it burrows into in both its larval and pupal stages. This study utilized micro-CT and 3D reconstruction to document thoracic morphological transformation during larval and pupal stages. The multi-peak fitting of cranial width was applied to determine larval instars. The results indicate that the first-instar larvae bore into beans using prothoracic muscles and those connecting the head to the mesothorax. The second-instar larva possessed the highest number of thoracic muscles, likely correlating with peak boring activity. The prepupa and the initial pupa exhibited minimal musculature, suggesting larval muscle degradation prior to pupation. Muscles unique to prepupae might homologize with indirect flight muscles in pupae, implying that adult flight capability is determined in the final larval stage. The muscles of both larvae and pupae undergo changes in attachment site, shape and curvature throughout development. At the same time, changes also occur in the larval cuticle and pupal endoskeleton. During the larval stage, muscle growth and degradation occur simultaneously, influencing muscle volume. In the pupal stage, the progressive increase in both absolute and relative thoracic muscle volumes prepare the weevil for movement after emergence. Meanwhile, the other thoracic organs, including the gut, air sacs and nerves, also change during development. Full article
(This article belongs to the Section Insect Physiology, Reproduction and Development)
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12 pages, 6685 KB  
Article
Volume Restoration in Mid-Facial Aging: A Quantitative Evaluation of the Efficacy of Hyaluronic Acid Gel Injections—The Imperative to Optimize the Injection Volume Based on Anatomical Considerations
by Alberto Diaspro and Giuseppe Sito
Surgeries 2025, 6(1), 21; https://doi.org/10.3390/surgeries6010021 - 11 Mar 2025
Viewed by 4071
Abstract
Background: The attractiveness of the central area (the so-called mid-face area or middle third) has a strong impact on the observer, and the treatment of aging in this area is therefore considered a key component in facial rejuvenation. A standardized photographic and three-dimensional [...] Read more.
Background: The attractiveness of the central area (the so-called mid-face area or middle third) has a strong impact on the observer, and the treatment of aging in this area is therefore considered a key component in facial rejuvenation. A standardized photographic and three-dimensional analysis was conducted in this observational study to determine the outcome of volumetric restoration procedures of the mid-face area with HA injection, providing an objective, repetitive, and reliable evaluation of this facial rejuvenation technique. Methods: In total, 47 patients were treated with two types of HA-based dermal fillers, and calibrated, stereoscopic images of the face were taken with volume reconstruction and analysis software performed before (t0), 45 days after HA implantation (t1), and at the check-up after the end of follow-up (t2). Results: In total, 39 out of 47 patients completed the study, which showed an overall volume restoration of 4.46 ± 1.34 mL at 45 days (t0–t1) after HA implantation, maintaining a value of 1.23 ± 0.68 mL at the end of the 318-day follow-up (t0–t2). Conclusions: The results of this study indicate that rejuvenation of the mid-facial region through volumetric restoration with an HA filler leads to an indirect volumetric effect that is clinically more significant than the actual injected volume and equally long-lasting. Full article
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32 pages, 11054 KB  
Article
Reconstructing the Magnetic Field in an Arbitrary Domain via Data-Driven Bayesian Methods and Numerical Simulations
by Georgios E. Pavlou, Vasiliki Pavlidou and Vagelis Harmandaris
Computation 2025, 13(2), 37; https://doi.org/10.3390/computation13020037 - 5 Feb 2025
Cited by 1 | Viewed by 923
Abstract
Inverse problems are prevalent in numerous scientific and engineering disciplines, where the objective is to determine unknown parameters within a physical system using indirect measurements or observations. The inherent challenge lies in deducing the most probable parameter values that align with the collected [...] Read more.
Inverse problems are prevalent in numerous scientific and engineering disciplines, where the objective is to determine unknown parameters within a physical system using indirect measurements or observations. The inherent challenge lies in deducing the most probable parameter values that align with the collected data. This study introduces an algorithm for reconstructing parameters by addressing an inverse problem formulated through differential equations underpinned by uncertain boundary conditions or variant parameters. We adopt a Bayesian approach for parameter inference, delineating the establishment of prior, likelihood, and posterior distributions, and the subsequent resolution of the maximum a posteriori problem via numerical optimization techniques. The proposed algorithm is applied to the task of magnetic field reconstruction within a conical domain, demonstrating precise recovery of the true parameter values. Full article
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11 pages, 1989 KB  
Systematic Review
A Meta-Analysis of First-Line Treatments for Unresectable Pleural Mesothelioma: Indirect Comparisons from Reconstructed Individual Patient Data of Six Randomized Controlled Trials
by Andrea Messori, Sabrina Trippoli, Eugenia Piragine, Sara Veneziano and Vincenzo Calderone
Cancers 2025, 17(3), 503; https://doi.org/10.3390/cancers17030503 - 3 Feb 2025
Cited by 2 | Viewed by 1736
Abstract
Background: In unresectable pleural mesothelioma, pemetrexed+cisplatin as first line is considered the standard of care, but novel treatments have been recently proposed. Methods: Our objective was to compare, albeit indirectly, the results of randomized controlled trials on overall survival (OS). The IPDfromKM method [...] Read more.
Background: In unresectable pleural mesothelioma, pemetrexed+cisplatin as first line is considered the standard of care, but novel treatments have been recently proposed. Methods: Our objective was to compare, albeit indirectly, the results of randomized controlled trials on overall survival (OS). The IPDfromKM method was employed for reconstruct individual patient data (IPD) from the graphs of Kaplan–Meier curves. Cox statistics was run to estimate hazard ratios (HRs). Results: After a literature search on Medline (via PubMed) and Scopus databases, six randomized controlled trials were identified in which five new treatments (nivolumab plus ipilimumab, bevacizumab plus pemetrexed plus cisplatin, chemotherapy plus pembrolizumab, ONCOS-102 plus pemetrexed plus cisplatin/carboplatin and cediranib plus pemetrexed+cisplatin with maintenance with cediranib) were evaluated. In five trials, pemetrexed plus cisplatin was the standard of care given to the control arms. Nivolumab plus ipilimumab, bevacizumab plus pemetrexed plus cisplatin and chemotherapy plus pembrolizumab showed a significantly better OS compared with controls. ONCOS-102 plus pemetrexed plus cisplatin/carboplatin did not significantly improve OS. In contrast, OS worsened with cisplatin alone and with cediranib plus pemetrexed+cisplatin with maintenance with cediranib. Discussion: Our analysis indicates that, in patients with unresectable pleural mesothelioma, three of the five novel treatments provided a significant survival benefit compared with the standard of care. Further research is needed to confirm the OS benefit found in our analysis with some treatments, whereas cisplatin alone and cediranib plus pemetrexed+cisplatin with maintenance with cediranib do not seem to deserve further research. Full article
(This article belongs to the Special Issue Research on Clinical Treatment of Mesothelioma)
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