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109 Results Found

  • Article
  • Open Access
1,494 Views
16 Pages

11 January 2024

A specific method for the estimation of the induced power at the tip by an active implantable medical device (AIMD) during an MRI scan is not defined in ISO/TS 10974:2018 for the cases of devices with multiple leads or the presence of abandoned and r...

  • Case Report
  • Open Access
3 Citations
2,932 Views
9 Pages

Implantation of a Dual-Chamber Automatic Cardioverter Defibrillator in a Patient with Persistent Left Superior Vena Cava: Case Report and Brief Literature Review

  • Mihai Cristian Haba,
  • Andreea Maria Ursaru,
  • Antoniu Octavian Petriș,
  • Ștefan Eduard Popescu and
  • Nicolae Dan Tesloianu

10 December 2020

Persistence of the left superior vena cava (PLSVC) is a congenital anomaly reported in 0.3–0.5% of patients. Due to the multiple and complex anatomical variations, transvenous lead placement can become challenging. We report the case of a 47-ye...

  • Case Report
  • Open Access
462 Views
8 Pages

From Technical Pitfall to Clinical Consequences: Leadless Pacing as a Rescue Solution

  • Fulvio Cacciapuoti,
  • Ciro Mauro,
  • Flavia Casolaro,
  • Antonio Torsi,
  • Salvatore Crispo and
  • Mario Volpicelli

17 October 2025

Background and Clinical Significance: Early lead failure after dual-chamber pacemaker implantation is rare but clinically significant, particularly when associated with thromboembolic complications. Technical pitfalls at the time of implantation, suc...

  • Article
  • Open Access
9 Citations
2,218 Views
19 Pages

11 April 2023

Background: Transvenous lead extraction (TLE) should be completed, even when facing difficulties which have yet to be described. The aim was to explore unexpected TLE obstacles (the circumstances of the occurrence and influence on TLE outcome). Metho...

  • Case Report
  • Open Access
1 Citations
2,385 Views
5 Pages

Implantation of a Leadless Pacemaker after Incomplete Transvenous Lead Extraction in a 90-Year-Old Pacemaker-Dependent Patient

  • Gerald Drożdż,
  • Bruno Hrymniak,
  • Bartosz Biel,
  • Przemysław Skoczyński,
  • Wiktoria Drożdż,
  • Dorota Zyśko,
  • Waldemar Banasiak and
  • Dariusz Jagielski

Transluminal lead extraction (TLE) is a well-established procedure for the removal of damaged or infected pacing systems. Despite its high efficacy, the procedure is associated with significant risks, some of which may contribute to severe life-threa...

  • Article
  • Open Access
5 Citations
2,675 Views
10 Pages

Analysis and Hardening of SEGR in Trench VDMOS with Termination Structure

  • Yuan Wang,
  • Tao Liu,
  • Lingli Qian,
  • Hao Wu,
  • Yiren Yu,
  • Jingyu Tao,
  • Zijun Cheng and
  • Shengdong Hu

20 March 2023

Single-event gate-rupture (SEGR) in the trench vertical double-diffused power MOSFET (VDMOS) occurs at a critical bias voltage during heavy-ion experiments. Fault analysis demonstrates that the hot spot is located at the termination of the VDMOS, and...

  • Article
  • Open Access
15 Citations
4,446 Views
12 Pages

In Vitro Study of Preload Loss in Different Implant Abutment Connection Designs

  • Ana Sofia Vinhas,
  • Carlos Aroso,
  • Filomena Salazar,
  • Marta Relvas,
  • Ana Cristina Braga,
  • Blanca Ríos-Carrasco,
  • Javier Gil,
  • José Vicente Rios-Santos,
  • Ana Fernández-Palacín and
  • Mariano Herrero-Climent

14 February 2022

The stability and integrity of the abutment-implant connection, by means of a screw, is fallible from the moment the prosthetic elements are joined and is dependent on the applied preload, wear of the components and function. One of the main causes o...

  • Article
  • Open Access
21 Citations
6,806 Views
15 Pages

A Scalable Manufacturing Approach to Single Dose Vaccination against HPV

  • Shuai Shao,
  • Oscar A. Ortega-Rivera,
  • Sayoni Ray,
  • Jonathan K. Pokorski and
  • Nicole F. Steinmetz

19 January 2021

Human papillomavirus (HPV) is a globally prevalent sexually-transmitted pathogen, responsible for most cases of cervical cancer. HPV vaccination rates remain suboptimal, partly due to the need for multiple doses, leading to a lack of compliance and i...

  • Article
  • Open Access
4,612 Views
12 Pages

Efficacy of Air-Polishing with Sodium Bicarbonate vs. Erythritol in the Decrease of the Bacterial Concentration on the Surface of Dental Implants: In Vitro Study

  • Ashley Yaressi Gómez-Rueda,
  • Myriam Angélica De La Garza-Ramos,
  • Norma Idalia Rodríguez-Franco,
  • Jesús Israel Rodríguez-Pulido,
  • Claudia Lucía Elizalde-Molina and
  • Omar Elizondo-Cantú

12 March 2025

Dental implants are recognized as one of the most effective long-term solutions for the replacement of one or multiple missing teeth, addressing both aesthetics and functionality. However, one of the leading causes of implant failure is peri-implant...

  • Case Report
  • Open Access
1 Citations
2,838 Views
8 Pages

An electrical storm (ES) is defined as the presence of at least three episodes of sustained ventricular tachycardia or ventricular fibrillation within 24 h. This patient had a previously known arterial hypertension, type II diabetes mellitus, and chr...

  • Article
  • Open Access
116 Citations
11,411 Views
15 Pages

24 January 2019

This review of literature paper was done in order to conduct a review of the literature and an assessment of the effects of titanium implant corrosion on peri-implant health and success in the oral environment. This paper evaluates and critically rev...

  • Review
  • Open Access
15 Citations
3,594 Views
11 Pages

New Horizons of Cementless Total Knee Arthroplasty

  • Giuseppe Polizzotti,
  • Alfredo Lamberti,
  • Fabio Mancino and
  • Andrea Baldini

30 December 2023

Background: Considering the increasing number of young and active patients needing TKA, orthopedic surgeons are looking for a long-lasting and physiological bond for the prosthetic implant. Multiple advantages have been associated with cementless fix...

  • Article
  • Open Access
2 Citations
1,779 Views
15 Pages

5 August 2024

The treatment of bone defects caused by disease or accidents through the use of implants presents significant clinical challenges. After clinical implantation, these materials attract and accumulate bacteria and hinder the integration of the implant...

  • Article
  • Open Access
1 Citations
1,919 Views
15 Pages

Multilevel Venous Obstruction in Patients with Cardiac Implantable Electronic Devices

  • Marek Czajkowski,
  • Anna Polewczyk,
  • Wojciech Jacheć,
  • Jarosław Kosior,
  • Dorota Nowosielecka,
  • Łukasz Tułecki,
  • Paweł Stefańczyk and
  • Andrzej Kutarski

17 February 2024

Background and Objectives: The nature of multilevel lead-related venous stenosis/occlusion (MLVSO) and its influence on transvenous lead extraction (TLE) as well as long-term survival remains poorly understood. Materials and Methods: A total of 3002...

  • Review
  • Open Access
30 Citations
12,991 Views
21 Pages

Cardiac Implantable Electronic Miniaturized and Micro Devices

  • Moshe Rav Acha,
  • Elina Soifer and
  • Tal Hasin

29 September 2020

Advancement in the miniaturization of high-density power sources, electronic circuits, and communication technologies enabled the construction of miniaturized electronic devices, implanted directly in the heart. These include pacing devices to preven...

  • Review
  • Open Access
10 Citations
5,078 Views
27 Pages

Nanomaterials for Anti-Infection in Orthopedic Implants: A Review

  • Junhao Sui,
  • Yijin Hou,
  • Mengchen Chen,
  • Zhong Zheng,
  • Xiangyu Meng,
  • Lu Liu,
  • Shicheng Huo,
  • Shu Liu and
  • Hao Zhang

21 February 2024

Postoperative implant infection is a severe complication in orthopedic surgery, often leading to implant failure. Current treatment strategies mainly rely on systemic antibiotic therapies, despite contributing to increasing bacterial resistance. In r...

  • Article
  • Open Access
21 Citations
3,233 Views
12 Pages

14 January 2021

One of the current major challenges in implant therapy is to minimize marginal bone loss around implants, since it can trigger bacterial colonization of the implant’s neck, leading to its failure. The present study aimed (1) to scientifically v...

  • Article
  • Open Access
2,246 Views
10 Pages

Clinical Outcomes of XEN45®-Stent Implantation after Failed Trabeculectomy: A Retrospective Single-Center Study

  • Constance Weber,
  • Sarah Hundertmark,
  • Michael Petrak,
  • Elisabeth Ludwig,
  • Christian Karl Brinkmann,
  • Frank G. Holz and
  • Karl Mercieca

6 February 2023

Background: The implantation of a collagen gel micro-stent (XEN45®) as a minimally invasive form of glaucoma surgery (MIGS) after a failed trabeculectomy (TE) may be an effective option with few risks. This study investigated the clinical outcome...

  • Article
  • Open Access
8 Citations
4,486 Views
14 Pages

Investigation of a Deep Brain Stimulator (DBS) System

  • Jennifer Whitestone,
  • Anmar Salih and
  • Tarun Goswami

A deep brain stimulator (DBS) device is a surgically implanted system that delivers electrical impulses to specific targets in the brain to treat abnormal movement disorders. A DBS is like a cardiac pacemaker, but instead of sending electrical signal...

  • Article
  • Open Access
9 Citations
5,793 Views
10 Pages

25 December 2023

Joint replacement arthroplasty for the treatment of thumb osteoarthritis is gaining popularity as recent studies have demonstrated better pinch and grip strength and faster rehabilitation. Our aim was to identify early complications in modern implant...

  • Review
  • Open Access
9 Citations
7,007 Views
11 Pages

Recent Advances in Myoelectric Control for Finger Prostheses for Multiple Finger Loss

  • Viritpon Srimaneepong,
  • Artak Heboyan,
  • Azeem Ul Yaqin Syed,
  • Hai Anh Trinh,
  • Pokpong Amornvit and
  • Dinesh Rokaya

14 May 2021

The loss of one or multiple fingers can lead to psychological problems as well as functional impairment. Various options exist for replacement and restoration after hand or finger loss. Prosthetic hand or finger prostheses improve esthetic outcomes a...

  • Article
  • Open Access
1 Citations
2,272 Views
15 Pages

Finite Element Analysis of Different Osseocartilaginous Reconstruction Techniques in Animal Model Knees

  • Cosmin Cosma,
  • Dragos Apostu,
  • Cristian Vilau,
  • Alexandru Popan,
  • Daniel Oltean-Dan,
  • Nicolae Balc,
  • Gheorghe Tomoaie and
  • Horea Benea

23 March 2023

Lesions of the articular cartilage are frequent in all age populations and lead to functional impairment. Multiple surgical techniques have failed to provide an effective method for cartilage repair. The aim of our research was to evaluate the effect...

  • Article
  • Open Access
1,909 Views
16 Pages

22 January 2023

Inadequate R wave amplitude (RWA) after implantable cardiac defibrillator (ICD) implantation in patients with arrhythmogenic cardiomyopathy (ACM) was suspected to relate to right ventricle impairment. However, little data-based evidence was provided...

  • Article
  • Open Access
6 Citations
3,956 Views
13 Pages

3D Printed Skull Cap and Benchtop Fabricated Microwire-Based Microelectrode Array for Custom Rat Brain Recordings

  • Dongyang Yi,
  • Jeremiah P. Hartner,
  • Brian S. Ung,
  • Harrison L. Zhu,
  • Brendon O. Watson and
  • Lei Chen

Microwire microelectrode arrays (MEAs) have been a popular low-cost tool for chronic electrophysiological recordings and are an inexpensive means to record the electrical dynamics crucial to brain function. However, both the fabrication and implantat...

  • Article
  • Open Access
4 Citations
3,189 Views
10 Pages

With more than two decades of experience and thousands of patients treated worldwide, deep brain stimulation (DBS) has established itself as an efficacious and common surgical treatment for movement disorders. However, a substantial majority of patie...

  • Article
  • Open Access
22 Citations
2,766 Views
13 Pages

Analysis of Risk Factors for Major Complications of 1500 Transvenous Lead Extraction Procedures with Especial Attention to Tricuspid Valve Damage

  • Łukasz Tułecki,
  • Anna Polewczyk,
  • Wojciech Jacheć,
  • Dorota Nowosielecka,
  • Konrad Tomków,
  • Paweł Stefańczyk,
  • Jarosław Kosior,
  • Krzysztof Duda,
  • Maciej Polewczyk and
  • Andrzej Kutarski

Background: Transvenous lead extraction (TLE) is a relatively safe procedure, but it may cause severe complications such as cardiac/vascular wall tear (CVWT) and tricuspid valve damage (TVD). Methods: The risk factors for CVWT and TVD were examined b...

  • Case Report
  • Open Access
1 Citations
979 Views
9 Pages

Giant Cyst of Dermis-Fat Graft in a Child with MRSA—Case Report

  • Biljana Kuzmanović Elabjer,
  • Mirjana Bjeloš,
  • Ana Ćurić,
  • Daliborka Miletić and
  • Mladen Bušić

2 April 2025

Background/Objectives: This case report presents a unique case of multiple postoperative complications, including sterile silicone implant extrusion, symblepharon formation, and the development of a giant cyst, following extensive multimodal chemothe...

  • Case Report
  • Open Access
5 Citations
3,806 Views
7 Pages

Hardware-Related Skin Erosion in Deep Brain Stimulation for Parkinson’s Disease: How Far Can We Go? An Illustrative Case Report

  • Pietro Zeppa,
  • Marco Fraccalvieri,
  • Chiara Fronda,
  • Enrico Lo Bue,
  • Laura Rizzi,
  • Virginia Caliendo and
  • Michele Maria Lanotte

15 December 2022

Skin erosion is a hardware-related complication commonly described after deep brain stimulation (DBS). Hardware exposure is often associated with the development of infection that can lead to implant removal. However, in selected cases, it is possibl...

  • Article
  • Open Access
2 Citations
11,271 Views
25 Pages

24 November 2024

Background/Objectives: Female infertility due to unexpected causes exhibits a great challenge for both clinicians and women who are trying to conceive. The present clinical case series study aimed to evaluate the efficacy of multiple wavelengths of r...

  • Article
  • Open Access
8 Citations
2,466 Views
11 Pages

Conventional and Digital Impressions for Fabrication of Complete Implant-Supported Bars: A Comparative In Vitro Study

  • Samanta N. V. Vieira,
  • Matheus F. Lourenço,
  • Rodrigo C. Pereira,
  • Esdras C. França,
  • Ênio L. Vilaça,
  • Rodrigo R. Silveira and
  • Guilherme C. Silva

4 June 2023

Obtaining accurate models and well-fitting prostheses during the fabrication of complete implant-supported prostheses has been a significant challenge. Conventional impression methods involve multiple clinical and laboratory steps that can lead to di...

  • Case Report
  • Open Access
1 Citations
3,355 Views
18 Pages

A Combined Use of Custom-Made Partial Pelvic Replacement and Proximal Femur Megaprosthesis in the Treatment of Severe Bone Loss after Multiple Total Hip Arthroplasty Revisions

  • Michele Fiore,
  • Azzurra Paolucci,
  • Renato Zunarelli,
  • Marta Bortoli,
  • Andrea Montanari,
  • Andrea Pace,
  • Lorenzo Di Prinzio,
  • Stefania Claudia Parisi,
  • Roberto De Cristofaro and
  • Massimiliano De Paolis
  • + 1 author

24 October 2023

Hip arthroplasty failures (either septic or aseptic) often require multiple revisions, thus leading to severe bone defects. The most common reconstruction methods do not allow the management of severe defects. For this reason, in recent years, techni...

  • Communication
  • Open Access
7 Citations
3,634 Views
7 Pages

O-Arm Navigated Frameless and Fiducial-Less Deep Brain Stimulation

  • David Krahulík,
  • Martin Nevrlý,
  • Pavel Otruba,
  • Jan Bardoň,
  • Lumír Hrabálek,
  • Daniel Pohlodek,
  • Petr Kaňovský and
  • Jan Valošek

27 September 2020

Object: Deep brain stimulation (DBS) is a very useful procedure for the treatment of idiopathic Parkinson’s disease (PD), essential tremor, and dystonia. The authors evaluated the accuracy of the new method used in their center for the placing...

  • Technical Note
  • Open Access
930 Views
10 Pages

Continuous Compression Implants in Foot and Ankle Surgery: Tips and Tricks

  • Konstantinos Tsikopoulos,
  • Konstantinos Sidiropoulos,
  • Dimitrios Kitridis,
  • Constantinos Loizou and
  • Alisdair Felstead

16 May 2025

Background: Continuous Compression Implants (CCIs) are low-profile implants made of nitinol and titanium. They offer multiple benefits in comparison to plate and screw fixation for foot and ankle indications, and they are designed in such a way that...

  • Article
  • Open Access
2 Citations
2,828 Views
15 Pages

The Diagnostic Yield of Implantable Loop Recorders Stratified by Indication: A “Real-World” Single-Center Experience

  • Lorenzo Pistelli,
  • Andrea Di Cori,
  • Matteo Parollo,
  • Marco Torre,
  • Federico Fiorentini,
  • Valentina Barletta,
  • Mario Giannotti Santoro,
  • Gino Grifoni,
  • Antonio Canu and
  • Luca Segreti
  • + 3 authors

7 February 2025

Background/Objectives: Implantable loop recorders (ILRs) are widely used for the diagnosis of unexplained syncope, palpitations, and cryptogenic stroke. While ILRs demonstrate clinical utility, data on their diagnostic yield and value in real-world s...

  • Article
  • Open Access
9 Citations
2,840 Views
10 Pages

Treatment of Fracture-Related Infection after Pelvic Fracture

  • Viola Freigang,
  • Nike Walter,
  • Markus Rupp,
  • Moritz Riedl,
  • Volker Alt and
  • Florian Baumann

27 September 2023

Background: The management of pelvic fractures is a significant challenge. Surgical site infection can result in the need for revision surgery, cause functional impairment, and lead to a prolonged length of stay and increased treatment costs. Althoug...

  • Review
  • Open Access
10 Citations
3,438 Views
15 Pages

Refractory Takayasu’s Arteritis with Severe Coronary Involvement—Case Report and Literature Review

  • Claudia Oana Cobilinschi,
  • Elena Grădinaru,
  • Ioana Săulescu,
  • Nicolae Cârstea,
  • Simona Caraiola,
  • Andra Rodica Bălănescu and
  • Daniela Opriș-Belinski

29 June 2023

This report presents the case of a female patient diagnosed with Takayasu arteritis from childhood, with severe, refractory coronary involvement, leading to two acute coronary syndromes and multiple anginous episodes. Consequently, the patient suffer...

  • Article
  • Open Access
5 Citations
2,615 Views
16 Pages

29 January 2024

Silicon nanowires (SiNWs) are emerging as versatile components in the fabrication of sensors for implantable medical devices because of their exceptional electrical, optical, and mechanical properties. This paper presents a novel top-down fabrication...

  • Article
  • Open Access
4 Citations
5,287 Views
10 Pages

Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty

  • Cherry W. Y. Sun,
  • Lawrence C. M. Lau,
  • Jason P. Y. Cheung and
  • Siu-Wai Choi

29 March 2024

Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, incl...

  • Feature Paper
  • Review
  • Open Access
36 Citations
6,042 Views
35 Pages

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

  • Huiliang Cao,
  • Shichong Qiao,
  • Hui Qin and
  • Klaus D. Jandt

The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the nu...

  • Communication
  • Open Access
629 Views
7 Pages

Minimizing Permanent Pacemaker Implantation After TAVR: Current Strategies, Monitoring Pathways, and Future Directions

  • Alfonso Reyes Mitre,
  • Hector Lopez de la Garza,
  • Claudio Espada Guerreiro,
  • Dahyr Olivas Medina,
  • Erick Marlon Avila Gil,
  • Pablo Juan Salvadores,
  • José Antonio Baz Alonso,
  • Andres Iñiguez Romo and
  • Victor Alfonso Jimenez Diaz

30 October 2025

Transcatheter aortic valve replacement (TAVR) has evolved over the last two decades into a cornerstone therapy for patients with severe symptomatic aortic stenosis. This therapy was initially reserved for those at high or prohibitive surgical risk bu...

  • Article
  • Open Access
2,763 Views
14 Pages

Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus

  • Yuxi Sun,
  • Tatiana Boyko,
  • Owen Marecic,
  • Danielle Struck,
  • Randall K. Mann,
  • Tom W. Andrew,
  • Michael Lopez,
  • Xinming Tong,
  • Stuart B. Goodman and
  • Fan Yang
  • + 3 authors

3 August 2023

Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of orthopedic surgeries. While the role of skeletal stem cells (SSCs) in bone formation and repair is...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,660 Views
14 Pages

Clinical versus Dental Laboratory Survey Regarding Modern Fixed Implant Supported Prosthetic in Romania

  • Luminita Oancea,
  • Eugenia Panaitescu,
  • Mihai Burlibasa and
  • Catalin Gagiu

4 January 2022

(1) Background: The success of prosthetic treatment with implant support depends on the combined effort of the team doctor-technician, each of them being responsible for the validation of execution stages. (2) Methods: we composed an online questionn...

  • Review
  • Open Access
14 Citations
4,803 Views
15 Pages

The Molecular Link between Obesity and the Endometrial Environment: A Starting Point for Female Infertility

  • Francesca Gonnella,
  • Fani Konstantinidou,
  • Marisa Donato,
  • Daniela Maria Pia Gatta,
  • Alessia Peserico,
  • Barbara Barboni,
  • Liborio Stuppia,
  • Warren B. Nothnick and
  • Valentina Gatta

Female infertility constitutes a growing health problem in developing countries and could be associated with several possible causes including reproductive disorders, congenital malformations, infections and hormonal dysfunction. Nonetheless, a serie...

  • Article
  • Open Access
657 Views
13 Pages

Prosthetic joint infections (PJIs) pose significant challenges, often requiring multiple surgeries that lead to soft tissue loss, dead space, and fibrosis. Wound breakdown increases the risk of polymicrobial infection and treatment failure. The verti...

  • Case Report
  • Open Access
3 Citations
2,332 Views
4 Pages

Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection

  • Panteleimon E. Papakonstantinou,
  • Victoria Georgiadou,
  • Grigorios Doumanis,
  • Vasiliki Bistola,
  • Joseph Papaparaskevas,
  • Gerasimos Filippatos and
  • Sotirios Xydonas

11 April 2023

Coxiella burnetii is one of the most common causes of blood culture-negative infective endocarditis (IE). However, only a few cases of cardiac implantable electronic devices (CIED) infection have been reported in the literature. Herein, we present a...

  • Article
  • Open Access
1 Citations
2,458 Views
19 Pages

The Design of a Low Noise, Multi-Channel Recording System for Use in Implanted Peripheral Nerve Interfaces

  • Shamin Sadrafshari,
  • Benjamin Metcalfe,
  • Nick Donaldson,
  • Nicolas Granger,
  • Jon Prager and
  • John Taylor

30 April 2022

In the development of implantable neural interfaces, the recording of signals from the peripheral nerves is a major challenge. Since the interference from outside the body, other biopotentials, and even random noise can be orders of magnitude larger...

  • Article
  • Open Access
16 Citations
3,515 Views
15 Pages

Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension

  • Mark Lipphardt,
  • Hassan Dihazi,
  • Jens-Holger Maas,
  • Ann-Kathrin Schäfer,
  • Saskia I. Amlaz,
  • Brian B. Ratliff,
  • Michael J. Koziolek and
  • Manuel Wallbach

22 September 2020

(1) Background: Arterial hypertension (HTN) is one of the most relevant cardiovascular risk factors. Nowadays multiple pharmaceutical treatment options exist with novel interventional methods (e.g., baroreflex activation therapy (BAT)) as a last reso...

  • Review
  • Open Access
1,064 Views
31 Pages

Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies

  • Vamsi Krishna Murthy Ginjupalli,
  • Jean-Baptiste Reisqs,
  • Michael Cupelli,
  • Mohamed Chahine and
  • Mohamed Boutjdir

13 November 2025

Myotonic Dystrophy Type 1 (DM1) is a complex multisystemic genetic disorder caused by CTG repeat expansions in the DMPK gene, leading to RNA toxicity and widespread splicing defects. These splicing abnormalities affect multiple systems, including the...

  • Article
  • Open Access
11 Citations
1,764 Views
14 Pages

LECOM (Lead Extraction COMplexity): A New Scoring System for Predicting a Difficult Procedure

  • Wojciech Jacheć,
  • Dorota Nowosielecka,
  • Bettina Ziaja,
  • Anna Polewczyk and
  • Andrzej Kutarski

8 December 2023

(1) Background: Transvenous lead extraction (TLE) can become far more complex when unanticipated difficulties arise. The aim was to develop a simple scoring system that allows for the prediction of the difficulty and complexity of this significant pr...

  • Case Report
  • Open Access
6 Citations
3,730 Views
7 Pages

Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report

  • Sofia Apostolidou,
  • Theresa Harbauer,
  • Peter Lasch,
  • Daniel Biermann,
  • Maja Hempel,
  • Marc Lütgehetmann,
  • Susanne Pfefferle,
  • Jochen Herrmann,
  • André Rüffer and
  • Konrad Reinshagen
  • + 7 authors

Critical Coronavirus disease 2019 (COVID-19) developed in a 7-year-old girl with a history of dystrophy, microcephaly, and central hypothyroidism. Starting with gastrointestinal symptoms, the patient developed severe myocarditis followed by progressi...

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