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MDPIMDPI

11 Results Found

  • Systematic Review
  • Open Access
1 Citations
1,240 Views
11 Pages
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The Role of Immature Platelet Fraction and Reticulated Platelets in Stroke Monitoring and Outcome Prognosis: A Systematic Review

  • Alexandra Tsankof,
  • Dimitrios A. Tsakiris,
  • Lemonia Skoura,
  • Panagiota Tsiatsiou,
  • Eleftheria Ztriva,
  • Georgios Ntaios,
  • Christos Savopoulos and
  • Georgia Kaiafa
J. Clin. Med.2025, 14(13), 4760;https://doi.org/10.3390/jcm14134760

5 July 2025

Background/Objectives: Immature platelet fraction (IPF) and reticulated platelets (RPs) are biomarkers reflecting the youngest and most metabolically active platelets in circulation. RPs, a subset of immature platelets, contain residual RNA and have...

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  • Open Access
13 Pages
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Immature Platelet Fraction as a Surrogate Marker of Thrombo-Inflammation in Hospitalized COVID-19 Patients

  • Adrian Duek,
  • Alexandra Zimin,
  • Yael Hershkop,
  • Michal Cipok,
  • Amir Cohen and
  • Merav Leiba
Life2025, 15(12), 1846;https://doi.org/10.3390/life15121846

30 November 2025

Although COVID-19 is associated with significant thrombo-inflammatory complications, reliable biomarkers to guide antithrombotic therapy remain limited. Immature platelet fraction (IPF) reflects platelet turnover and may indicate heightened thromboti...

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  • Article
  • Open Access
1 Citations
1,066 Views
16 Pages
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Immature Platelet Fraction as a Sensitive Biomarker in Neonatal Sepsis: Diagnostic Performance Preceding Thrombocytopenia

  • Ilkay Er and
  • Medeni Arpa
Children2025, 12(7), 931;https://doi.org/10.3390/children12070931

15 July 2025

Background: Early and accurate diagnosis of neonatal sepsis remains a clinical challenge due to nonspecific signs and limitations of conventional biomarkers. The immature platelet fraction (IPF), a novel hematologic parameter reflecting thrombopoieti...

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  • Review
  • Open Access
18 Citations
6,897 Views
12 Pages
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Reticulated Platelets—Which Functions Have Been Established by In Vivo and In Vitro Data?

  • Muataz Ali Hamad,
  • Nancy Schanze,
  • Nicolas Schommer,
  • Thomas Nührenberg and
  • Daniel Duerschmied
Cells2021, 10(5), 1172;https://doi.org/10.3390/cells10051172

12 May 2021

Reticulated platelets (RP) are the youngest platelet fraction released into the circulation. These immature platelets have increased RNA content, a larger cell volume, more dense granules, higher levels of surface activation markers and are thought t...

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  • Article
  • Open Access
4 Citations
3,303 Views
13 Pages
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Changes in Platelet Function in Preterm Newborns with Prematurity Related Morbidities

  • Irina Franciuc,
  • Elena Matei,
  • Mariana Aschie,
  • Anca Mitroi,
  • Anca Chisoi,
  • Ionut Poinareanu,
  • Nicolae Dobrin,
  • Andreea Georgiana Stoica,
  • Traian Virgiliu Surdu and
  • Mihaela Manea
  • + 2 authors
Children2022, 9(6), 791;https://doi.org/10.3390/children9060791

27 May 2022

Platelet indices represent useful biomarkers to express the thromboembolic status, inflammatory response, and oxidative stress in preterm newborns. Our study presented platelet count and function changes in prematurity-related morbidities such as res...

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  • Open Access
485 Views
14 Pages
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The Diagnostic and Prognostic Value of Reticulated Platelets in Ischemic Stroke: Is Immature Platelet Fraction a New Biomarker?

  • Fatih Cemal Tekin,
  • Osman Lütfi Demirci,
  • Emin Fatih Vişneci,
  • Abdullah Enes Ataş,
  • Hasan Hüseyin Kır,
  • Hasan Basri Yıldırım,
  • Çiğdem Damla Deniz,
  • Demet Acar,
  • Said Sami Erdem and
  • Mehmet Gül
Medicina2025, 61(10), 1887;https://doi.org/10.3390/medicina61101887

21 October 2025

Background and Objectives: Ongoing efforts to develop early diagnostic tools for Acute Ischemic Stroke (AIS) point out the advantages of accessible biomarkers such as Immature Platelet Fraction (IPF). This is particularly important for emergency depa...

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  • Review
  • Open Access
8 Citations
5,148 Views
22 Pages
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Platelets as a Gauge of Liver Disease Kinetics?

  • Sheng-Hung Chen,
  • Shih-Chang Tsai and
  • Hsiu-Chen Lu
Int. J. Mol. Sci.2022, 23(19), 11460;https://doi.org/10.3390/ijms231911460

28 September 2022

A multitude of laboratory and clinical interferences influence the utility of platelet-based diagnostic indices, including immature platelet fraction, in longitudinal monitoring and prognostication of patients with chronic liver disease (CLD). The co...

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  • Article
  • Open Access
4 Citations
2,507 Views
11 Pages
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Platelet microRNAs as Potential Novel Biomarkers for Antiplatelet Therapy with P2Y12 Inhibitors and Their Association with Platelet Function

  • Karolina Gumiężna,
  • Adrian Bednarek,
  • Grażyna Sygitowicz,
  • Agata Maciejak-Jastrzębska,
  • Piotr Baruś,
  • Jaromir Hunia,
  • Dominika Klimczak-Tomaniak,
  • Janusz Kochman,
  • Marcin Grabowski and
  • Mariusz Tomaniak
J. Clin. Med.2024, 13(1), 63;https://doi.org/10.3390/jcm13010063

22 December 2023

Introduction: Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) require dual antiplatelet therapy (DAPT). However, the response to treatment can vary considerably. Certain platelet microRNAs (miRs) are su...

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  • Open Access
24 Citations
5,702 Views
17 Pages
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Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers

  • Michael Hardy,
  • Sarah Lessire,
  • Sultan Kasikci,
  • Justine Baudar,
  • Maité Guldenpfennig,
  • Adrien Collard,
  • Jean-Michel Dogné,
  • Bernard Chatelain,
  • Hugues Jacqmin and
  • Thomas Lecompte
  • + 1 author
J. Clin. Med.2020, 9(8), 2515;https://doi.org/10.3390/jcm9082515

4 August 2020

Platelet count, indices (mean volume, young—immature platelet fraction) and aggregation are widely used laboratory parameters to investigate primary hemostasis. We performed a systematic, thorough evaluation of the influence of the time-interva...

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  • Article
  • Open Access
7 Citations
2,714 Views
13 Pages
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Plasma Fibrinogen Independently Predicts Hypofibrinolysis in Severe COVID-19

  • Diana Schrick,
  • Margit Tőkés-Füzesi,
  • Barbara Réger and
  • Tihamér Molnár
Metabolites2021, 11(12), 826;https://doi.org/10.3390/metabo11120826

30 November 2021

High rates of thrombosis are present in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Deeper insight into the prothrombotic state is essential to provide the best thromboprophylaxis care. Here, we aimed to explore associ...

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  • Article
  • Open Access
1 Citations
2,668 Views
13 Pages
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Complete Blood Counts and Research Parameters in the Detection of Myelodysplastic Syndromes

  • Eloísa Urrechaga,
  • Mónica Fernández and
  • Urko Aguirre
Diagnostics2024, 14(13), 1322;https://doi.org/10.3390/diagnostics14131322

21 June 2024

The diagnosis of Myelodysplastic syndromes (MDS) is frequently challenging, especially in terms of the distinction from the other non-neoplastic causes of cytopenia. Currently, it is based on the presence of peripheral blood cytopenias, peripheral bl...

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