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Keywords = graphene–hydroxyapatite hybrid bioscaffolds

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12 pages, 5292 KiB  
Article
Mechanically Robust 3D Graphene–Hydroxyapatite Hybrid Bioscaffolds with Enhanced Osteoconductive and Biocompatible Performance
by Weibo Xie, Fuxiang Song, Rui Wang, Shenglin Sun, Miao Li, Zengjie Fan, Bin Liu, Qiangqiang Zhang and Jizeng Wang
Crystals 2018, 8(2), 105; https://doi.org/10.3390/cryst8020105 - 23 Feb 2018
Cited by 20 | Viewed by 4788
Abstract
In this paper, we describe three-dimensional (3D) hierarchical graphene–hydroxyapatite hybrid bioscaffolds (GHBs) with a calcium phosphate salt electrochemically deposited onto the framework of graphene foam (GF). The morphology of the hydroxyapatite (HA) coverage over GF was controlled by the deposition conditions, including temperature [...] Read more.
In this paper, we describe three-dimensional (3D) hierarchical graphene–hydroxyapatite hybrid bioscaffolds (GHBs) with a calcium phosphate salt electrochemically deposited onto the framework of graphene foam (GF). The morphology of the hydroxyapatite (HA) coverage over GF was controlled by the deposition conditions, including temperature and voltage. The HA obtained at the higher temperature demonstrates the more uniformly distributed crystal grain with the smaller size. The as-prepared GHBs show a high elasticity with recoverable compressive strain up to 80%, and significantly enhanced strength with Young’s modulus up to 0.933 MPa compared with that of pure GF template (~7.5 kPa). Moreover, co-culture with MC3T3-E1 cells reveals that the GHBs can more effectively promote the proliferation of MC3T3-E1 osteoblasts with good biocompatibility than pure GF and the control group. The superior performance of GHBs suggests their promising applications as multifunctional materials for the repair and regeneration of bone defects. Full article
(This article belongs to the Special Issue Graphene Mechanics)
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