This study aims to synthesize a new series of furochromone derivatives, evaluate their antimicrobial properties, and improve the permeability of potent compounds to inhibit different types of bacteria and fungi. Hence, Substituted furo[3,2-
g]chromene-6-carbonitrile (
3a,b) readily form 7-amino-5-methyl-furo [3,2-
g
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This study aims to synthesize a new series of furochromone derivatives, evaluate their antimicrobial properties, and improve the permeability of potent compounds to inhibit different types of bacteria and fungi. Hence, Substituted furo[3,2-
g]chromene-6-carbonitrile (
3a,b) readily form 7-amino-5-methyl-furo [3,2-
g]chromene-6-carbonitrile (
4a,
b) via reduction using sodium borohydride in methanol. The same compounds of (
4a,
b) were used as starting materials for the synthesis of new furochromone derivatives such as furochromeno [2,3-
d]pyrimidines,
N- (6-cyano- 5-methyl-furochromene) acetamide,
N-(6-cyano-5-methyl-furo chromene)-2-phenyl acetamide,
N- (6-cyano-5-methyl-furochromene) formimidate, furochromeno[1,2,4]triazepin-5-amine, furochrom ene-6-carboxamide, furochromeno[1,2,4]triazolopyrimidines, and furochromeno[2,3-
b]quinolin- 6-amine. The structures of the new compounds were determined using spectroscopy: Nuclear Magnetic Resonance (
1H,
13C), Mass spectra, Infrared, and elemental analysis. Molecular docking studies were conducted to investigate the binding patterns of the prepared compounds against DNA-gyrase (PDB 1HNJ). The results displayed that compounds furochromenotriazolopyrimidine (
20a,
b), furochromenoquinolin-6-amine (
21a,
b), furochromenotriazepin-amine (
9a,
b), and furo- chromenopyrimidine-amine (
19a,
b) were excellent antimicrobials.
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