Search Results (854)

Ensuring bacterial safety of blood transfusions remains a critical focus in medicine. We investigated a novel pathogen reduction technology utilizing nylon functionalized with synthetic dyes (nylon affinity networks) to capture and remove bacteria from plasma. In the initial screening process, we spiked phosphate buffer solution (PBS) and human plasma (1 mL each) with 10 or 100 colony forming units (cfu) of either Escherichia coli or Staphylococcus epidermidis, exposed the suspensions to affinity networks and assessed the extent of bacterial reduction using agar plate cultures as the assay output. Nineteen synthetic dyes were tested. Among these, Alcian Blue exhibited the best performance with both bacterial strains in both PBS and plasma. Next, bacterial suspensions of approximately 1 and 2 cfu/mL in 10 and 50 mL, respectively, were treated with Alcian Blue affinity networks in three sequential capture steps. This procedure resulted in complete bacterial depletion, as demonstrated by the lack of bacterial growth in the remaining fraction. The viability of the captured bacteria was confirmed by plating the post-treatment affinity networks on agar. Alcian Blue affinity networks captured and sequestered a few plasma proteins identified by liquid chromatography tandem mass spectrometry. These findings support the potential applicability of nylon affinity networks to enhance transfusion safety, although additional investigations are needed. Full article

Land use significantly influences mobility dynamics, affecting both travel behavior and mode choice. Traditional indicators such as the Floor Area Ratio, Land-Use Mix Index, and Built-up Area Ratio are widely used to describe settlement patterns; yet, they often fail to capture their functional impacts on road networks. This study introduces two complementary indicators—Settlement Ratio (SR) and Settled Area (SA)—developed through a spatial analysis framework integrating GIS data and MATLAB processing. SR offers a continuous typological profile of built-up functions along the road axis, while SA measures the percentage of anthropized land within fixed analysis windows. Applied to two Italian state roads, SS14 and SS309, in the Veneto Region, the dual-indicator approach reveals how the intensity (SR) and extent (SA) of settlement vary across different territorial contexts. In suburban segments, SR values exceeding 15–20, together with SA levels between 10% and 15%, highlight the significant spatial impact of isolated development clusters—often not evident from macro-scale observations. These findings demonstrate that the SR–SA framework provides a robust tool for analyzing land use in relation to road function. Although the study focuses on spatial structure and indicator design, future developments will explore correlations with traffic flow, speed, and crash data to support road safety analyses. Full article

This study proposes an integrated framework that combines nonlinear stochastic vibration analysis with reliability assessment to address the safety issues of cable systems under damage conditions. First of all, a mathematical model of the damaged cable is established by introducing damage parameters, and its static configuration is determined. Using the Pearl River Huangpu Bridge as a case study, the accuracy of the analytical solution for the cable’s sag displacement is validated through the finite difference method (FDM). Furthermore, a quantitative relationship between the damage parameters and structural response under stochastic excitation is developed, and the nonlinear stochastic dynamic equations governing the in-plane and out-of-plane motions of the damaged cable are derived. Subsequently, a Gaussian Radial Basis Function Neural Network (GRBFNN) method is employed to solve for the steady-state probability density function of the system response, enabling a detailed analysis of how various damage parameters affect structural behavior. Finally, the First-Order and Second-Order Reliability Method (FORM/SORM) are used to compute the reliability index and failure probability, which are further validated using Monte Carlo simulation (MCS). Results show that the severity parameter η shows the highest sensitivity in influencing the failure probability among the damage parameters. For the system of the Pearl River Huangpu bridge, an increase in the damage extent δ from 0.1 to 0.4 can reduce the reliability-based service life of by approximately 40% under fixed values of the damage severity and location, and failure risk is highest when the damage is located at the midspan of the cable. This study provides a theoretical framework from the point of stochastic vibration for evaluating the response and associated reliability of mechanical systems; the results can be applied in practice with guidance for the engineering design and avoid potential damages of suspended cables. Full article

The automatic detection of traffic accidents plays an increasingly vital role in advancing intelligent traffic monitoring systems and improving road safety. Leveraging computer vision techniques offers a promising solution, enabling rapid, reliable, and automated identification of accidents, thereby significantly reducing emergency response times. This study proposes an enhanced version of the YOLO11 architecture, termed YOLO11-AMF. The proposed model integrates a Mamba-Like Linear Attention (MLLA) mechanism, an Asymptotic Feature Pyramid Network (AFPN), and a novel Focaler-IoU loss function to optimize traffic accident detection performance under complex and diverse conditions. The MLLA module introduces efficient linear attention to improve contextual representation, while the AFPN adopts an asymptotic feature fusion strategy to enhance the expressiveness of the detection head. The Focaler-IoU further refines bounding box regression for improved localization accuracy. To evaluate the proposed model, a custom dataset of traffic accident images was constructed. Experimental results demonstrate that the enhanced model achieves precision, recall, mAP50, and mAP50–95 scores of 96.5%, 82.9%, 90.0%, and 66.0%, respectively, surpassing the baseline YOLO11n by 6.5%, 6.0%, 6.3%, and 6.3% on these metrics. These findings demonstrate the effectiveness of the proposed enhancements and suggest the model’s potential for robust and accurate traffic accident detection within real-world conditions. Full article

Ensuring the safe operation of Unmanned Aerial Vehicles (UAVs) is crucial for both mission-critical and safety-critical tasks. In scenarios where UAVs must track airborne targets, they need to follow the target’s path while maintaining a safe distance, even in the presence of unmodeled dynamics and environmental disturbances. This paper presents a novel collision avoidance strategy for dynamic quadrotor UAVs during target-tracking missions. We propose a safety controller that combines a learning-based Control Barrier Function (CBF) with standard sliding mode feedback. Our approach employs a neural network that learns the true CBF constraint, accounting for wind disturbances, while the sliding mode controller addresses unmodeled dynamics. This unified control law ensures safe leader-following behavior and precise trajectory tracking. By leveraging a learned CBF, the controller offers improved adaptability to complex and unpredictable environments, enhancing both the safety and robustness of the system. The effectiveness of our proposed method is demonstrated through the AirSim platform using the PX4 flight controller. Full article

Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disease that can greatly affect quality of life in middle-aged and elderly individuals. Nutritional supplements are increasingly used for KOA due to their low risk, but direct comparative evidence on their efficacy and safety remains scarce. This study aimed to systematically compare the effectiveness and safety of seven common nutritional supplements for KOA. Methods: A systematic review and network meta-analysis were conducted following PRISMA guidelines. Embase, PubMed, and the Cochrane Library were searched through December 2024 for randomized controlled trials (RCTs) evaluating use of eggshell membrane, vitamin D, Boswellia, curcumin, ginger, krill oil, or collagen, versus placebo, in adults with KOA. Primary outcomes included changes in scores for WOMAC pain, stiffness and function, and pain visual analog scale (VAS). Adverse events were also assessed. Bayesian network meta-analyses estimated ranking probabilities for each intervention. Results: In total, 39 RCTs (42 studies; 4599 patients) were included. Compared with placebo, Boswellia showed significant improvements in WOMAC pain (mean difference [MD] = 10.58, 95% CI: 6.45 to 14.78, p < 0.05), stiffness (MD = 9.47, 95% CI: 6.39 254 to 12.74, p < 0.05), function (MD = 14.00, 95% CI: 7.74 to 20.21, p < 0.05), and VAS pain (MD = 17.26, 95% CI: 8.06 to 26.52, p < 0.05). Curcumin, collagen, ginger, and krill oil also demonstrated benefits in some outcomes. No supplement was associated with increased adverse events compared to placebo. Bayesian rankings indicated Boswellia had the highest probability of being most effective for pain and stiffness, with krill oil and curcumin showing potential for function improvement. Conclusions: Nutritional supplements, particularly Boswellia, appear to be effective and well-tolerated for improving KOA symptoms and function. These results suggest that certain supplements may be useful as part of non-pharmacological KOA management. However, further large-scale, well-designed randomized controlled trials (RCTs) are needed to confirm these findings, particularly those that include more standardized dosages and formulations, as well as to evaluate their long-term efficacy. Full article

Research on reliability control for enhancing power systems under random loads holds significant and undeniable importance in maintaining system stability, performance, and safety. The primary challenge lies in determining the reliability index while optimizing system parameters. To effectively address this challenge, we developed a novel intelligent algorithm and conducted an optimal reliability assessment for a Negative Stiffness Device (NSD) seismic isolation structure incorporating fractional-order damping. This algorithm combines the Gaussian Radial Basis Function Neural Network (GRBFNN) with the Particle Swarm Optimization (PSO) algorithm. It takes the reliability function with unknown parameters as the objective function, while using the Backward Kolmogorov (BK) equation, which governs the reliability function and is accompanied by boundary and initial conditions, as the constraint condition. During the operation of this algorithm, the neural network is employed to solve the BK equation, thereby deriving the fitness function in each iteration of the PSO algorithm. Then the PSO algorithm is utilized to obtain the optimal parameters. The unique advantage of this algorithm is its ability to simultaneously achieve the optimization of implicit objectives and the solution of time-dependent BK equations.To evaluate the performance of the proposed algorithm, this study compared it with the algorithm combines the GRBFNN with Genetic Algorithm (GA-GRBFNN)across multiple dimensions, including performance and operational efficiency. The effectiveness of the proposed algorithm has been validated through numerical comparisons and Monte Carlo simulations. The control strategy presented in this paper provides a solid theoretical foundation for improving the reliability performance of mechanical engineering systems and demonstrates significant potential for practical applications. Full article

In the context of intelligent coal mine safety monitoring, an integrated prediction and early-warning method named MTGNN-Bayesian-IF-DBSCAN (Multi-Task Graph Neural Network–Bayesian Optimization–Isolation Forest–Density-Based Spatial Clustering of Applications with Noise) is proposed to address the challenges of gas concentration prediction and anomaly detection in coal mining faces. The MTGNN (Multi-Task Graph Neural Network) is first employed to model the spatiotemporal coupling characteristics of gas concentration and wind speed data. By constructing a graph structure based on sensor spatial dependencies and utilizing temporal convolutional layers to capture long short-term time-series features, the high-precision dynamic prediction of gas concentrations is achieved via the MTGNN. Experimental results indicate that the MTGNN outperforms comparative algorithms, such as CrossGNN and FourierGNN, in prediction accuracy, with the mean absolute error (MAE) being as low as 0.00237 and the root mean square error (RMSE) maintained below 0.0203 across different sensor locations (T0, T1, T2). For anomaly detection, a Bayesian optimization framework is introduced to adaptively optimize the fusion weights of IF (Isolation Forest) and DBSCAN (Density-Based Spatial Clustering of Applications with Noise). Through defining the objective function as the F1 score and employing Gaussian process surrogate models, the optimal weight combination (w_if = 0.43, w_dbscan = 0.52) is determined, achieving an F1 score of 1.0. By integrating original concentration data and residual features, gas anomalies are effectively identified by the proposed method, with the detection rate reaching a range of 93–96% and the false alarm rate controlled below 5%. Multidimensional analysis diagrams (e.g., residual distribution, 45° diagonal error plot, and boxplots) further validate the model’s robustness in different spatial locations, particularly in capturing abrupt changes and low-concentration anomalies. This study provides a new technical pathway for intelligent gas warning in coal mines, integrating spatiotemporal modeling, multi-algorithm fusion, and statistical optimization. The proposed framework not only enhances the accuracy and reliability of gas prediction and anomaly detection but also demonstrates potential for generalization to other industrial sensor networks. Full article

Unexpected machine failures in industrial environments lead to high maintenance costs, unplanned downtime, and safety risks. This study proposes a proactive predictive model using a hybrid of eXtreme Gradient Boosting (XGBoost) and Neural Networks (NN) to forecast machine failures. A synthetic dataset capturing recent breakdown history and time since last failure was used to simulate industrial scenarios. To address class imbalance, SMOTE and class weighting were applied, alongside a focal loss function to emphasize difficult-to-classify failures. The XGBoost model was tuned via GridSearchCV, while the NN model utilized ReLU-activated hidden layers with dropout. Evaluation using stratified 5-fold cross-validation showed that the NN achieved an F1-score of 0.7199 and a recall of 0.9545 for the minority class. XGBoost attained a higher PR AUC of 0.7126 and a more balanced precision–recall trade-off. Sample predictions demonstrated strong recall (100%) for failures, but also a high false positive rate, with most prediction probabilities clustered between 0.50–0.55. Additional benchmarking against Logistic Regression, Random Forest, and SVM further confirmed the superiority of the proposed hybrid model. Model interpretability was enhanced using SHAP and LIME, confirming that recent breakdowns and time since last failure were key predictors. While the model effectively detects failures, further improvements in feature engineering and threshold tuning are recommended to reduce false alarms and boost decision confidence. Full article

Detection of surface defects can significantly elongate mechanical service time and mitigate potential risks during safety management. Traditional defect detection methods predominantly rely on manual inspection, which suffers from low efficiency and high costs. Some machine learning algorithms and artificial intelligence models for defect detection, such as Convolutional Neural Networks (CNNs), present outstanding performance, but they are often data-dependent and cannot provide guarantees for new test samples. To this end, we construct a detection model by combining Mask R-CNN, selected for its strong baseline performance in pixel-level segmentation, with Conformal Risk Control. The former evaluates the distribution that discriminates defects from all samples based on probability. The detection model is improved by retraining with calibration data that is assumed to be independent and identically distributed (i.i.d) with the test data. The latter constructs a prediction set on which a given guarantee for detection will be obtained. First, we define a loss function for each calibration sample to quantify detection error rates. Subsequently, we derive a statistically rigorous threshold by optimization of error rates and a given guarantee significance as the risk level. With the threshold, defective pixels with high probability in test images are extracted to construct prediction sets. This methodology ensures that the expected error rate on the test set remains strictly bounded by the predefined risk level. Furthermore, our model shows robust and efficient control over the expected test set error rate when calibration-to-test partitioning ratios vary. Full article

Traffic congestion poses a significant challenge to modern urban environments, impacting both driver satisfaction and road safety. This paper investigates the effectiveness of a smart traffic light system (STL), a solution developed under the Intelligent Transportation System (ITS) initiative by the Ministry of Works Malaysia, to address these issues in Malaysia. The system integrates a network of sensors, AI-enabled cameras, and Automatic Number Plate Recognition (ANPR) technology to gather real-time data on traffic volume and vehicle classification at congested intersections. This data is utilized to dynamically adjust traffic light timings, prioritizing traffic flow on heavily congested roads while maintaining safety standards. To evaluate the system’s performance, a comprehensive study was conducted at a selected intersection. Traffic patterns were automatically analyzed using camera systems, and the performance of the STL was compared to that of traditional traffic signal systems. The average travel time from the start to the end intersection was measured and compared. Preliminary findings indicate that the STL significantly reduces travel times and improves overall traffic flow at the intersection, with average travel time reductions ranging from 7.1% to 28.6%, depending on site-specific factors. While further research is necessary to quantify the full extent of the system’s impact, these initial results demonstrate the promising potential of STL technology to enhance urban mobility and more efficient and safer roadways by moving beyond traditional traffic signal functionalities. Full article

Surface ozone is a pollutant linked to higher risks of cardiopulmonary diseases with long-term exposure. Timely forecasting of ozone levels helps authorities implement preventive measures to protect public health and safety. However, few studies have been able to reliably provide long-term hourly ozone forecasts due to the complexity of ozone’s diurnal variations. To address this issue, this study constructs a hybrid prediction model integrating improved complete ensemble empirical mode decomposition with adaptive noise (ICEEMDAN), bi-directional long short-term memory neural network (BiLSTM), and the persistence model to forecast the hourly ozone concentrations for the next continuous 36 h. The model is trained and tested at the Wanshouxigong site in Beijing. The ICEEMDAN method decomposes the ozone time series data to extract trends and obtain intrinsic mode functions (IMFs) and a residual (Res). Fourier period analysis is employed to elucidate the periodicity of the IMFs, which serves as the basis for selecting the prediction model (BiLSTM or persistence model) for different IMFs. Extensive experiments have shown that a hybrid model of ICEEMDAN, BiLSTM, and persistence model is able to achieve a good performance, with a prediction accuracy of R² = 0.86 and RMSE = 18.70 µg/m³ for the 36th hour, outperforming other models. Full article

This article presents an analysis on natural gas heating in residential areas, focusing on two primary systems: (1) local heating, where piped gas is delivered directly to individual dwellings equipped with autonomous gas boilers, and (2) district heating, where gas or an alternative fuel powers a central heating plant, and the generated heat is distributed to buildings via a thermal network. The choice between these systems should first consider safety and environmental factors, followed by the urban characteristics of the settlement. In particular, building typology—such as size, function, and spatial configuration—and urban topology, referring to the relative positioning of buildings, play a crucial role. For example, very tall buildings often exclude the use of piped gas due to safety concerns, whereas in other cases, economic efficiency becomes the determining factor. To support decision-making, a comparative cost analysis is conducted, assessing the required infrastructure for both systems, including pipelines, boilers, and associated components. The study identifies representative residential building types in selected urban areas of Serbia and Czechia that are suitable for either heating approach. Additionally, the article examines the broader energy context in both countries, with emphasis on recent developments in the natural gas sector and their implications for urban heating strategies. Full article

Food fermentation is driven by microbial interactions. This article reviews the types of microbial interactions during food fermentation, the research strategies employed, and their impacts on the quality of fermented foods. Microbial interactions primarily include mutualism, commensalism, amensalism, and competition. Based on these interaction patterns, the safety, nutritional composition, and flavor quality of food can be effectively improved. Achieving precise control of fermented foods’ qualities via microbial interaction remains a critical challenge. Emerging technologies such as high-throughput sequencing, cell sorting, and metabolomics enable the systematic analysis of core microbial interaction mechanisms in complex systems. Using synthetic microbial communities and genome-scale metabolic network models, complicated microbial communities can be effectively simplified. In addition, regulatory targets of food quality can be precisely identified. These strategies lay a solid foundation for the precise improvement of fermented food quality and functionality. Full article

Ammonia, as a toxic and corrosive gas, is widely present in industrial emissions, agricultural activities, and disease biomarkers. Detecting ammonia is of vital importance to environmental safety and human health. Sensors based on MXene have become an effective means for detecting ammonia gas due to their unique hierarchical structure, adjustable surface chemical properties, and excellent electrical conductivity. This study reviews the latest progress in the use of MXene and its composites for the low-temperature detection of ammonia gas. The strategies for designing MXene composites, including heterojunction engineering, surface functionalization, and active sites, are introduced, and their roles in improving sensing performance are clarified. These methods have significantly improved the ability to detect ammonia, offering high selectivity, rapid responses, and ultra-low detection limits within the low-temperature range. Successful applications in fields such as industrial safety, food quality monitoring, medical diagnosis, and agricultural management have demonstrated the multi-functionality of this technology in complex scenarios. The challenges related to the material’s oxidation resistance, humidity interference, and cross-sensitivity are also discussed. This study aims to briefly describe the reasonable design based on MXene sensors, aiming to achieve real-time and energy-saving environmental and health monitoring networks in the future. Full article