You are currently viewing a new version of our website. To view the old version click .

41 Results Found

  • Article
  • Open Access
13 Citations
3,346 Views
17 Pages

Porous Zirconia/Magnesia Ceramics Support Osteogenic Potential In Vitro

  • Oleg Prymak,
  • Lida E. Vagiaki,
  • Ales Buyakov,
  • Sergei Kulkov,
  • Matthias Epple and
  • Maria Chatzinikolaidou

23 February 2021

Porous zirconia (ZrO2), magnesia (MgO) and zirconia/magnesia (ZrO2/MgO) ceramics were synthesised by sintering and designated as ZrO2(100), ZrO2(75)MgO(25), ZrO2(50)MgO(50), ZrO2(25)MgO(75), MgO(100) based on their composition. The ceramic samples we...

  • Feature Paper
  • Review
  • Open Access
52 Citations
6,127 Views
20 Pages

The Potential of Magnesium Based Materials in Mandibular Reconstruction

  • Somasundaram Prasadh,
  • Vaishnavi Ratheesh,
  • Vyasaraj Manakari,
  • Gururaj Parande,
  • Manoj Gupta and
  • Raymond Wong

7 March 2019

The future of biomaterial design will rely on development of bioresorbable implant materials that completely and safely degrade in vivo after the tissues grow, without generating harmful degradation products at the targeted anatomic site. Permanent b...

  • Feature Paper
  • Review
  • Open Access
84 Citations
12,205 Views
32 Pages

A Critical Review on Metallic Glasses as Structural Materials for Cardiovascular Stent Applications

  • Mehdi Jafary-Zadeh,
  • Gideon Praveen Kumar,
  • Paulo Sergio Branicio,
  • Mohsen Seifi,
  • John J. Lewandowski and
  • Fangsen Cui

Functional and mechanical properties of novel biomaterials must be carefully evaluated to guarantee long-term biocompatibility and structural integrity of implantable medical devices. Owing to the combination of metallic bonding and amorphous structu...

  • Article
  • Open Access
2 Citations
2,038 Views
15 Pages

Surface Heparinization of a Magnesium-Based Alloy: A Comparison Study of Aminopropyltriethoxysilane (APTES) and Polyamidoamine (PAMAM) Dendrimers

  • Masoumeh Ebrahimi,
  • Atefeh Solouk,
  • Ali Davoodi,
  • Somaye Akbari,
  • Masoumeh Haghbin Nazarpak and
  • Alireza Nouri

13 December 2022

Magnesium (Mg)-based alloys are biodegradable metallic biomaterials that show promise in minimizing the risks of permanent metallic implants. However, their clinical applications are restricted due to their rapid in vivo degradation and low surface h...

  • Article
  • Open Access
1,588 Views
25 Pages

21 January 2025

This study aimed to develop a novel type of biodegradable magnesium (Mg)-based implant with enhanced biological activity through surface modification using plasma electrolytic oxidation (PEO) combined with the incorporation of rare earth ions (Eu and...

  • Article
  • Open Access
8 Citations
3,659 Views
25 Pages

In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium

  • Diana M. Vranceanu,
  • Elena Ungureanu,
  • Ionut C. Ionescu,
  • Anca C. Parau,
  • Vasile Pruna,
  • Irina Titorencu,
  • Mihaela Badea,
  • Cristina-Ștefania Gălbău,
  • Mihaela Idomir and
  • Mihaela Dinu
  • + 2 authors

Biomaterials are an important and integrated part of modern medicine, and their development and improvement are essential. The fundamental requirement of a biomaterial is found to be in its interaction with the surrounding environment, with which it...

  • Feature Paper
  • Review
  • Open Access
23 Citations
4,072 Views
17 Pages

Metals Biotribology and Oral Microbiota Biocorrosion Mechanisms

  • Nicola Contuzzi,
  • Giuseppe Casalino,
  • Antonio Boccaccio,
  • Andrea Ballini,
  • Ioannis Alexandros Charitos,
  • Lucrezia Bottalico and
  • Luigi Santacroce

During the last decades, metal-based biomaterials have been extensively explored to be used as biocompatible metals for biomedical applications, owing to their superior mechanical properties and corrosion resistance. Consequently, for long-term impla...

  • Article
  • Open Access
1 Citations
1,066 Views
32 Pages

Hyaluronan-Containing Injectable Magnesium–Calcium Phosphate Cements Demonstrated Improved Performance, Cytocompatibility, and Ability to Support Osteogenic Differentiation In Vitro

  • Natalia S. Sergeeva,
  • Polina A. Krokhicheva,
  • Irina K. Sviridova,
  • Margarita A. Goldberg,
  • Dinara R. Khayrutdinova,
  • Suraya A. Akhmedova,
  • Valentina A. Kirsanova,
  • Olga S. Antonova,
  • Alexander S. Fomin and
  • Ivan V. Mikheev
  • + 6 authors

Due to their biocompatibility, biodegradability, injectability, and self-setting properties, calcium–magnesium phosphate cements (MCPCs) have proven to be effective biomaterials for bone defect filling. Two types of MCPC powders based on the ma...

  • Article
  • Open Access
5 Citations
1,812 Views
28 Pages

Evaluation of Physiochemical and Biological Properties of Biofunctionalized Mg-Based Implants Obtained via Large-Scale PEO Process for Dentistry Applications

  • Julia Radwan-Pragłowska,
  • Łukasz Janus,
  • Tomasz Galek,
  • Ernest Szajna,
  • Aleksandra Sierakowska,
  • Karol Łysiak,
  • Mirosław Tupaj and
  • Dariusz Bogdał

An increasing number of tooth replacement procedures ending with implant failure generates a great need for the delivery of novel biomedical solutions with appropriate mechanical characteristics that would mimic natural tissue and undergo biodegradat...

  • Article
  • Open Access
7 Citations
5,072 Views
18 Pages

Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

  • Grega Popovic,
  • Nicholas C. Kirby,
  • Taylor C. Dement,
  • Kristine M. Peterson,
  • Caroline E. Daub,
  • Heather A. Belcher,
  • Martin Guthold,
  • Adam R. Offenbacher and
  • Nathan E. Hudson

19 January 2022

Fibrin forms the structural scaffold of blood clots and has great potential for biomaterial applications. Creating recombinant expression systems of fibrinogen, fibrin’s soluble precursor, would advance the ability to construct mutational libra...

  • Review
  • Open Access
237 Citations
14,612 Views
21 Pages

9 January 2012

Magnesium-Calcium (Mg-Ca) alloy has received considerable attention as an emerging biodegradable implant material in orthopedic fixation applications. The biodegradable Mg-Ca alloys avoid stress shielding and secondary surgery inherent with permanent...

  • Article
  • Open Access
22 Citations
4,588 Views
17 Pages

Biocompatibility and Immune Response of a Newly Developed Volume-Stable Magnesium-Based Barrier Membrane in Combination with a PVD Coating for Guided Bone Regeneration (GBR)

  • Larissa Steigmann,
  • Ole Jung,
  • Wolfgang Kieferle,
  • Sanja Stojanovic,
  • Annica Proehl,
  • Oliver Görke,
  • Steffen Emmert,
  • Stevo Najman,
  • Mike Barbeck and
  • Daniel Rothamel

To date, there are no bioresorbable alternatives to non-resorbable and volume-stable membranes in the field of dentistry for guided bone or tissue regeneration (GBR/GTR). Even magnesium (Mg) has been shown to constitute a favorable biomaterial for th...

  • Article
  • Open Access
2 Citations
2,359 Views
20 Pages

Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization Strategies

  • Annj Zamuner,
  • Elena Zeni,
  • Hamada Elsayed,
  • Michele Di Foggia,
  • Paola Taddei,
  • Antonella Pasquato,
  • Lucy Di Silvio,
  • Enrico Bernardo,
  • Paola Brun and
  • Monica Dettin

Hardystonite-based (HT) bioceramic foams were easily obtained via thermal treatment of silicone resins and reactive oxide fillers in air. By using a commercial silicone, incorporating strontium oxide and magnesium oxide precursors (as well as CaO and...

  • Article
  • Open Access
5 Citations
2,848 Views
13 Pages

Tuning Physicochemical Properties of a Macroporous Polysaccharide-Based Scaffold for 3D Neuronal Culture

  • Gaspard Gerschenfeld,
  • Rachida Aid,
  • Teresa Simon-Yarza,
  • Soraya Lanouar,
  • Patrick Charnay,
  • Didier Letourneur and
  • Piotr Topilko

25 November 2021

Central nervous system (CNS) lesions are a leading cause of death and disability worldwide. Three-dimensional neural cultures in biomaterials offer more physiologically relevant models for disease studies, toxicity screenings or in vivo transplantati...

  • Article
  • Open Access
59 Citations
4,755 Views
19 Pages

Application of Walnut Shell Biowaste as an Inexpensive Adsorbent for Methylene Blue Dye: Isotherms, Kinetics, Thermodynamics, and Modeling

  • Sabrina Farch,
  • Madiha Melha Yahoum,
  • Selma Toumi,
  • Hichem Tahraoui,
  • Sonia Lefnaoui,
  • Mohammed Kebir,
  • Meriem Zamouche,
  • Abdeltif Amrane,
  • Jie Zhang and
  • Amina Hadadi
  • + 1 author

This research aimed to assess the adsorption properties of raw walnut shell powder (WNSp) for the elimination of methylene blue (MB) from an aqueous medium. The initial MB concentration (2–50 mg/L), the mass of the biomaterial (0.1–1 g/L)...

  • Article
  • Open Access
38 Citations
3,991 Views
19 Pages

Influence of Copper-Strontium Co-Doping on Bioactivity, Cytotoxicity and Antibacterial Activity of Mesoporous Bioactive Glass

  • Akrity Anand,
  • Susanta Sengupta,
  • Hana Kaňková,
  • Anna Švančárková,
  • Ana M. Beltrán,
  • Dušan Galusek,
  • Aldo R. Boccaccini and
  • Dagmar Galusková

16 November 2022

Mesoporous bioactive glass (MBG) is an extensively studied biomaterial used for the healing of bone defects. Its biological applications can be tailored by introducing metallic ions, such as strontium (Sr) and copper (Cu), which can enhance its funct...

  • Article
  • Open Access
77 Citations
5,800 Views
13 Pages

23 January 2020

Bioactive sol-gel glasses are attractive biomaterials from both technological and functional viewpoints as they require lower processing temperatures compared to their melt-derived counterparts and exhibit a high specific surface area due to inherent...

  • Article
  • Open Access
2,303 Views
14 Pages

Applying the Alkali-Activation Method to Encapsulate Silicon Nitride Particles in a Bioactive Matrix for Augmented Strength and Bioactivity

  • Guido Manuel Olvera de la Torre,
  • Monika Tatarková,
  • Zuzana Netriová,
  • Martin Barlog,
  • Luca Bertolla,
  • Miroslav Hnatko and
  • Gianmarco Taveri

9 January 2024

The development of bioactive ceramics still poses challenges in finding a good compromise between bioactivity and mechanical robustness. Moreover, a facile, low-cost and energy-saving synthesis technique is still needed. This study concerns the synth...

  • Article
  • Open Access
6 Citations
2,201 Views
16 Pages

24 April 2022

This study aimed to evaluate the adsorptive capacity of Cr (VI) on the residues of the plantain starch extraction process in a batch system, determining the effect of temperature, initial concentration and adsorbent dose. The adsorbent was characteri...

  • Article
  • Open Access
9 Citations
2,505 Views
16 Pages

Synthesis and Characterization of Porous Forsterite Ceramics with Prospective Tissue Engineering Applications

  • Andrada Elena Alecu,
  • Gabriel-Costin Balaceanu,
  • Adrian Ionut Nicoara,
  • Ionela Andreea Neacsu and
  • Cristina Busuioc

6 October 2022

Due to the urgent need to develop and improve biomaterials, the present article proposes a new strategy to obtain porous scaffolds based on forsterite (Mg2SiO4) for bone tissue regeneration. The main objective is to restore and improve bone function,...

  • Article
  • Open Access
25 Citations
5,004 Views
17 Pages

Bioactive Composite Methacrylated Gellan Gum for 3D-Printed Bone Tissue-Engineered Scaffolds

  • Ugo D’Amora,
  • Alfredo Ronca,
  • Stefania Scialla,
  • Alessandra Soriente,
  • Paola Manini,
  • Jun Wei Phua,
  • Christoph Ottenheim,
  • Alessandro Pezzella,
  • Giovanna Calabrese and
  • Maria Grazia Raucci
  • + 1 author

19 February 2023

Gellan gum (GG) was chemically modified with methacrylic moieties to produce a photocrosslinkable biomaterial ink, hereinafter called methacrylated GG (GGMA), with improved physico-chemical properties, mechanical behavior and stability under physiolo...

  • Article
  • Open Access
3 Citations
4,132 Views
14 Pages

Study Regarding the Potential Use of a Spent Microbial Biomass in Fertilizer Manufacturing

  • Nicoleta Radu,
  • Ana Aurelia Chirvase,
  • Narcisa Babeanu,
  • Ovidiu Popa,
  • Petruta Cornea,
  • Lucia Pirvu,
  • Marinela Bostan,
  • Alexandru Ciric,
  • Endre Mathe and
  • Elena Radu
  • + 5 authors

19 February 2020

A spent biomass, which results from the biopharma industry, is stabilized and functionalized by biosorption with microelements. The efficiency of this new biomaterial was tested in two experiments: 1) In a mixture with soil to determine its effects o...

  • Article
  • Open Access
7 Citations
3,513 Views
16 Pages

Micro-carriers, thanks to high surface/volume ratio, are widely studied as mesenchymal stem cell (MSCs) in vitro substrate for proliferation at clinical rate. In particular, Ca-alginate-based biomaterials (sodium alginate crosslinked with CaCl2) are...

  • Article
  • Open Access
38 Citations
5,127 Views
16 Pages

Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing

  • Alejandro Hernández-Sosa,
  • Rosa Ana Ramírez-Jiménez,
  • Luis Rojo,
  • Fouzia Boulmedais,
  • María Rosa Aguilar,
  • Miryam Criado-Gonzalez and
  • Rebeca Hernández

30 May 2022

3D printing is an emerging and powerful technique to create shape-defined three-dimensional structures for tissue engineering applications. Herein, different alginate–cellulose formulations were optimized to be used as printable inks. Alginate...

  • Article
  • Open Access
5 Citations
2,892 Views
19 Pages

Hydrogels are intensively investigated biomaterials due to their useful physicochemical and biological properties in bioengineering. In particular, naturally occurring hydrogels are being deployed as carriers for bio-compounds. We used two approaches...

  • Article
  • Open Access
11 Citations
2,321 Views
12 Pages

25 June 2023

Functionality based on the biological activity of sorghum such as antioxidant activity is known worldwide for its excellence. In this study, we investigated the reactive oxygen species (ROS) scavenging activity, total phenolic and flavonoid contents,...

  • Article
  • Open Access
2 Citations
1,843 Views
21 Pages

Cocoa Pod Husk Valorization Through Rhizopus stolonifer Solid-State Fermentation: Enhancement in Antioxidant Activity

  • Patrick Barros Tiburcio,
  • Dão Pedro de Carvalho Neto,
  • Carlos Ricardo Soccol and
  • Adriane Bianchi Pedroni Medeiros

Cocoa pod husk (CPH), a significant agricultural byproduct of cocoa production, presents an opportunity for sustainable valorization through biotechnological methods. This study aimed to enhance the nutritional, antioxidant, and therapeutic propertie...

  • Article
  • Open Access
12 Citations
4,102 Views
18 Pages

A Milled Microdevice to Advance Glia-Mediated Therapies in the Adult Nervous System

  • Juan S. Peña,
  • Denise Robles,
  • Stephanie Zhang and
  • Maribel Vazquez

31 July 2019

Neurodegenerative disorders affect millions of adults worldwide. Neuroglia have become recent therapeutic targets due to their reparative abilities in the recycling of exogenous neurotoxins and production of endogenous growth factors for proper funct...

  • Article
  • Open Access
5 Citations
2,039 Views
19 Pages

21 February 2024

Water scarcity and contamination have emerged as critical global challenges, requiring the development of effective and sustainable solutions for the treatment of contaminated water. Recently, functionalized polymer biomaterials have garnered signifi...

  • Feature Paper
  • Review
  • Open Access
36 Citations
5,852 Views
21 Pages

1 February 2022

This mini-review provides coverage of chitosan-based adsorbents and their modified forms as sustainable solid-phase extraction (SPE) materials for precious metal ions, such as gold species, and their complexes in aqueous media. Modified forms of chit...

  • Article
  • Open Access
21 Citations
3,998 Views
16 Pages

Because of limited self-healing ability, the treatment of articular cartilage defects is still an important clinical challenge. Hydrogel-based biomaterials have broad application prospects in articular cartilage repair. In this study, gelatin methacr...

  • Review
  • Open Access
512 Views
21 Pages

10 September 2025

The global issues of resource depletion and environmental pollution have led to increased interest in a circular bioeconomy focusing on converting renewable biomass into functional biomaterials. This article explores the transformative potential of h...

  • Article
  • Open Access
22 Citations
5,051 Views
19 Pages

Advanced Ga2O3/Lignin and ZrO2/Lignin Hybrid Microplatforms for Glucose Oxidase Immobilization: Evaluation of Biosensing Properties by Catalytic Glucose Oxidation

  • Artur Jędrzak,
  • Tomasz Rębiś,
  • Maria Kuznowicz,
  • Agnieszka Kołodziejczak-Radzimska,
  • Jakub Zdarta,
  • Adam Piasecki and
  • Teofil Jesionowski

9 December 2019

In this study, novel Ga2O3/lignin and ZrO2/lignin hybrid materials were obtained and used as supports for the adsorption of the enzyme glucose oxidase (GOx). A biosensor system based on the hybrid supports was then designed to determine the concentra...

  • Article
  • Open Access
6 Citations
3,395 Views
15 Pages

Biomanufacturing Biotinylated Magnetic Nanomaterial via Construction and Fermentation of Genetically Engineered Magnetotactic Bacteria

  • Junjie Xu,
  • Shijiao Ma,
  • Haolan Zheng,
  • Bo Pang,
  • Shuli Li,
  • Feng Li,
  • Lin Feng and
  • Jiesheng Tian

Biosynthesis provides a critical way to deal with global sustainability issues and has recently drawn increased attention. However, modifying biosynthesized magnetic nanoparticles by extraction is challenging, limiting its applications. Magnetotactic...

  • Article
  • Open Access
7 Citations
2,905 Views
16 Pages

1 February 2023

Calcium phosphate nanoparticles are highly biocompatible and biodegradable in bone regeneration. On the other hand, strontium and magnesium enhance the formation of bone. The substitution of calcium by strontium and magnesium is an efficient way to i...

  • Article
  • Open Access
22 Citations
2,861 Views
17 Pages

Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications: Fabrication, Structural, Electrical, and Biological Analysis

  • Imen Hammami,
  • Sílvia Rodrigues Gavinho,
  • Ana Sofia Pádua,
  • Isabel Sá-Nogueira,
  • Jorge Carvalho Silva,
  • João Paulo Borges,
  • Manuel Almeida Valente and
  • Manuel Pedro Fernandes Graça

Implantology is crucial for restoring aesthetics and masticatory function in oral rehabilitation. Despite its advantages, certain issues, such as bacterial infection, may still arise that hinder osseointegration and result in implant rejection. This...

  • Article
  • Open Access
649 Views
24 Pages

10 September 2025

Gellan gum (GG) is a promising biomaterial due to its biocompatibility, tunable gelation, and modifiability. This study investigates the influence of triple crosslinking mechanisms—thermal gelation, UV-induced covalent crosslinking, and ionic c...

  • Article
  • Open Access
19 Citations
3,415 Views
15 Pages

The Effect of Microcosm Biofilm Decontamination on Surface Topography, Chemistry, and Biocompatibility Dynamics of Implant Titanium Surfaces

  • Vanessa Sousa,
  • Nikos Mardas,
  • Dave Spratt,
  • Iman A. Hassan,
  • Nick J. Walters,
  • Víctor Beltrán and
  • Nikolaos Donos

2 September 2022

Since the inception of dental implants, a steadily increasing prevalence of peri-implantitis has been documented. Irrespective of the treatment protocol applied for the management of peri-implantitis, this biofilm-associated pathology, continues to b...

  • Article
  • Open Access
7 Citations
2,872 Views
14 Pages

Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications

  • Nurkhuzaiah Kamaruzaman,
  • Mh Busra Fauzi,
  • Yasuhiko Tabata and
  • Salma Mohamad Yusop

18 April 2023

Wound contracture, which commonly happens after wound healing, may lead to physical distortion, including skin constriction. Therefore, the combination of collagen and elastin as the most abundant extracellular matrix (ECM) skin matrices may provide...

  • Review
  • Open Access
26 Citations
4,487 Views
33 Pages

Selective Laser Melting and Spark Plasma Sintering: A Perspective on Functional Biomaterials

  • Ramin Rahmani,
  • Sérgio Ivan Lopes and
  • Konda Gokuldoss Prashanth

16 October 2023

Achieving lightweight, high-strength, and biocompatible composites is a crucial objective in the field of tissue engineering. Intricate porous metallic structures, such as lattices, scaffolds, or triply periodic minimal surfaces (TPMSs), created via...

  • Article
  • Open Access
11 Citations
3,641 Views
24 Pages

Novel Electroactive Mineralized Polyacrylonitrile/PEDOT:PSS Electrospun Nanofibers for Bone Repair Applications

  • Frederico Barbosa,
  • Fábio F. F. Garrudo,
  • Ana C. Marques,
  • Joaquim M. S. Cabral,
  • Jorge Morgado,
  • Frederico Castelo Ferreira and
  • João C. Silva

25 August 2023

Bone defect repair remains a critical challenge in current orthopedic clinical practice, as the available therapeutic strategies only offer suboptimal outcomes. Therefore, bone tissue engineering (BTE) approaches, involving the development of biomime...