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Search Results (3)

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Keywords = five and six members ring azaheterocycles

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37 pages, 6867 KiB  
Review
A Review on the Synthesis of Fluorescent Five- and Six-Membered Ring Azaheterocycles
by Gheorghita Zbancioc, Ionel I. Mangalagiu and Costel Moldoveanu
Molecules 2022, 27(19), 6321; https://doi.org/10.3390/molecules27196321 - 25 Sep 2022
Cited by 11 | Viewed by 3160
Abstract
Azaheterocycles rings with five and six members are important tools for the obtaining of fluorescent materials and fluorescent sensors. The relevant advances in the synthesis of azaheterocyclic derivatives and their optical properties investigation, particularly in the last ten years, was our main objective [...] Read more.
Azaheterocycles rings with five and six members are important tools for the obtaining of fluorescent materials and fluorescent sensors. The relevant advances in the synthesis of azaheterocyclic derivatives and their optical properties investigation, particularly in the last ten years, was our main objective on this review. The review is organized according to the size of the azaheterocycle ring, 5-, 6-membered and fused ring azaheterocycles, as well as our recent contribution on this research field. In each case, the reaction pathways with reaction condition and obtained yield, and evaluation of the optical properties of the obtained products were briefly presented. Full article
(This article belongs to the Section Organic Chemistry)
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41 pages, 22144 KiB  
Review
Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
by Dorina Amariucai-Mantu, Violeta Mangalagiu, Iustinian Bejan, Aculina Aricu and Ionel I. Mangalagiu
Pharmaceutics 2022, 14(10), 2026; https://doi.org/10.3390/pharmaceutics14102026 - 23 Sep 2022
Cited by 10 | Viewed by 2423
Abstract
Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern [...] Read more.
Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented. Full article
(This article belongs to the Special Issue Microbial Infections and Wound Healing: Medicinal-Chemistry and Technological Based Approaches)
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20 pages, 7191 KiB  
Review
Microwave Assisted Reactions of Azaheterocycles Formedicinal Chemistry Applications
by Dorina Amariucai-Mantu, Violeta Mangalagiu, Ramona Danac and Ionel I. Mangalagiu
Molecules 2020, 25(3), 716; https://doi.org/10.3390/molecules25030716 - 7 Feb 2020
Cited by 27 | Viewed by 3772
Abstract
Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles chemistry during the last decades. Five and six membered ring azaheterocycles are privileged scaffolds in modern medicinal chemistry possessing a large variety of biological activity. This review is focused on the recent [...] Read more.
Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles chemistry during the last decades. Five and six membered ring azaheterocycles are privileged scaffolds in modern medicinal chemistry possessing a large variety of biological activity. This review is focused on the recent relevant advances in the MW assisted reactions applied to azaheterocyclic derivatives and their medicinal chemistry applications from the last five years. The review is divided according to the main series of azaheterocycles, more precisely 5- and 6-membered ring azaheterocycles (with one, two, and more heteroatoms) and their fused analogues. In each case, the reaction pathways, the advantages of using MW, and considerations concerning biological activity of the obtained products were briefly presented. Full article
(This article belongs to the Special Issue Microwave Assisted Reactions: A Modern Useful Tool in Medicinal Chemistry)
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