Search Results (16)

Convective updrafts are one of the main characteristics of convective clouds, responsible for the convective mass flux and the redistribution of energy and condensate in the atmosphere. During the early stages of their lifecycle, convective clouds experience rapid cloud-top ascent manifested by a decrease in the geostationary IR brightness temperature ($T{B}_{IR}$). Under the assumption that the convective cloud top behaves like a black body, the ascent rate of the convective cloud top can be estimated as (${\displaystyle \frac{\partial T{B}_{IR}}{\partial t}}$), and it can be used to infer the near cloud-top convective updraft. The temporal resolution of the geostationary IR measurements and non-uniform beam-filling effects can influence the convective updraft estimation. However, the main shortcoming until today was the lack of independent verification of the strength of the convective updraft. Here, Doppler radar observations from the ESCAPE and TRACER field experiments provide independent estimates of the convective updraft velocity at higher spatiotemporal resolution throughout the convective core column and can be used to evaluate the updraft velocity estimates from the IR cooling rate for limited samples. Isolated convective cells were tracked with dedicated radar (RHIs and PPIs) scans throughout their lifecycle. Radial Doppler velocity measurements near the convective cloud top are used to provide estimates of convective updrafts. These data are compared with the geostationary IR and VIS channels (from the GOES satellite) to characterize the convection evolution and lifecycle based on cloud-top cooling rates. Full article

A novel design of a proton exchange membrane electrolyzer is presented. In contrast to previous designs, the flow field plates are round and oriented horizontally with the feed water entering from a central hole and spreading evenly outward over the anode flow field in radial, interdigitated flow channels. The cathode flow field consists of a spiral channel with an outlet hole near the outside of the bipolar plate. This results in anode and cathode flow channels that run perpendicular to avoid shear stresses. The novel sealing concept requires only o-rings, which press against the electrolyte membrane and are countered by circular gaskets that are placed over the flow channels to prevent the membrane from penetrating the channels, which makes for a much more economical sealing concept compared to prior designs using custom-made gaskets. Hydrogen leaves the electrolyzer through a vertical outward pipe placed off-center on top of the electrolyzer. The electrolyzer stack is housed in a cylinder to capture the oxygen and water vapor, which is then guided into a heat exchanger section, located underneath the electrolyzer partition. The function of the heat exchanger is to preheat the incoming fresh water and condense the escape water, thus improving the efficiency. It also serves as internal phase separator in that a level sensor controls the water level and triggers a recirculation pump for the condensate, while the oxygen outlet is located above the water level and can be connected to a vacuum pump to allow for electrolyzer operation at sub-ambient pressure to further increase efficiency and/or reduce the iridium loading. Full article

The adoption of grain amaranth (Amaranthus hypochondriacus L.) as a climate-smart crop due to its hardiness and drought escape mechanisms in sub-Saharan Africa is under threat from the lack of pure seed due to contamination by weedy relatives, such as pigweed (A. hybridus L.). Due to limited land availability, proper isolation distances to attain seed purity in the small-scale farming sector are impossible. A study investigating the cross-pollination rate between grain amaranth and pigweed at distances between 3 and 150 m was conducted at three sites in Zimbabwe during the 2020/2021 and 2021/2022 rainy seasons. Grain amaranth was planted at radial distances of 3 to 150 m from the pure pigweed plot. Meteorological conditions, such as temperature and wind speed and direction, were measured during the anthesis period. The cross-pollination rate in grain amaranth was influenced by distance from the pollen source. A maximum cross-pollination rate of 12.9% was observed within a 10 m radius from the pollen donor plot, and a minimum outcrossing rate of 0.45% was recorded at 150 m. The complete removal of weedy relatives within an extrapolated distance of 325 m is recommended to maintain the genetic purity of grain amaranth in small-scale farming systems. Full article

The Muji spring travertines, located in the Muji Basin in the eastern Pamirs Plateau, represent a typical spring deposit found on plateaus that is characterized by arid and semi-arid climatic conditions. However, its formation mechanisms remain poorly understood. This study aims to explore the recharge processes of the spring, the sedimentary environment, and the genetics of Muji spring travertines through a comparative analysis of conventional hydrochemistry, H-O stable isotope analysis of both spring and river water, and petrographic observation, as well as in situ analysis of major and trace elements present in calcite within travertines. The basin is surrounded by mountains with a topography that facilitates groundwater convergence within it. Carbonate-bearing strata are extensively developed around the basin, which serves as a crucial material foundation for travertine development. It infiltrates underground through fractures and faults, interacting with carbonate rocks to produce significant amounts of HCO₃⁻, Ca²⁺, and Mg²⁺. The observed range of isotopic compositions (δ²H, −102.27‰ to −96.43‰; δ¹⁸O, −14.90‰ to −14.36‰) in water samples suggests that their primary origin was from glacial and snowmelt sources. The concentration of HCO₃⁻ in spring water samples exhibits significant variability, with the highest value being 1646 mg·L⁻¹, which deviates significantly from the typical composition of karst groundwater. During its migration, groundwater undergoes the dissolution of gaseous CO₂ derived from deep metamorphic processes, leading to variable degrees of mixing with geothermal groundwater containing elevated concentrations of dissolved components that enhance the dissolution potential of carbonate rocks. Eventually, upwelling occurs along the Southwestern Boundary Fault of Muji, resulting in the formation of linear springs characterized by CO₂ escape. The Muji laminated travertines exhibit distinct white and dark laminae, and radial coated grains consisting of micritic and sparry layers. Chemical composition analyses reveal significant differences in the trace and rare-earth element composition, as well as the Mg/Ca ratio, of the two types of travertines. Specifically, the micritic laminae of the pisoid (Mg/Ca = 0.019; Sr = 530 × 10⁻⁶; Ba = 64.6 × 10⁻⁶) and the dark laminae of the laminated travertine (Mg/Ca = 0.014; Sr = 523 × 10⁻⁶; Ba = 48.1 × 10⁻⁶) exhibit generally higher Mg/Ca ratios and Sr, Ba contents than the neighboring sparry laminae (Mg/Ca = 0.012; Sr = 517 × 10⁻⁶; Ba = 36.6 × 10⁻⁶) and white laminae (Mg/Ca = 0.006; Sr = 450 × 10⁻⁶; Ba = 35.6 × 10⁻⁶). The development of laminated travertines and radial coated grains here is attributed to periodic changes in groundwater recharge induced by seasonal temperature fluctuations, as evidenced by the structural characteristics of the two types of travertines and the trace element analysis of different layers. Algae play a role in forming the dark laminae of laminated travertines and the micritic laminae of pisoids. Full article

Melanoma progression is a multistep evolution from a common melanocytic nevus through a radial superficial growth phase, the invasive vertical growth phase finally leading to metastatic dissemination into distant organs. Melanoma aggressiveness largely depends on the propensity to metastasize, which means the capacity to escape from the physiological microenvironment since tissue damage due to primary melanoma lesions is generally modest. Physiologically, epidermal melanocytes are attached to the basement membrane, and their adhesion/migration is under the control of surrounding keratinocytes. Thus, the epidermal compartment represents the first microenvironment responsible for melanoma spread. This complex process involves cell–cell contact and a broad range of secreted bioactive molecules. Invasion, or at the beginning of the microinvasion, implies the breakdown of the dermo-epidermal basement membrane followed by the migration of neoplastic melanocytic cells in the superficial papillary dermis. Correspondingly, several experimental evidences documented the structural and functional rearrangement of the entire tissue surrounding neoplasm that in some way reflects the atypia of tumor cells. Lastly, the microenvironment must support the proliferation and survival of melanocytes outside the normal epidermal–melanin units. This task presumably is mostly delegated to fibroblasts and ultimately to the self-autonomous capacity of melanoma cells. This review will discuss remodeling that occurs in the epidermis during melanoma formation as well as skin changes that occur independently of melanocytic hyperproliferation having possible pro-tumoral features. Full article

The paper presents the use of a supervised active learning approach for the solution of a simulation-driven design optimization (SDDO) problem, pertaining to the resistance reduction of a destroyer-type vessel in calm water. The optimization is formulated as a single-objective, single-point problem with both geometrical and operational constraints. The latter also considers seakeeping performance at multiple conditions. A surrogate model is used, based on stochastic radial basis functions with lower confidence bounding, as a supervised active learning approach. Furthermore, a multi-fidelity formulation, leveraging on unsteady Reynolds-averaged Navier–Stokes equations and potential flow solvers, is used in order to reduce the computational cost of the SDDO procedure. Exploring a five-dimensional design space based on free-form deformation under limited computational resources, the optimal configuration achieves a resistance reduction of about 3% at the escape speed and about 6.4% on average over the operational speed range. Full article

Preserving an accurate cell count is crucial for maintaining homeostasis. Apical extrusion, a process in which redundant cells are eliminated by neighboring cells, plays a key role in this regard. Recent studies have revealed that apical extrusion can also be triggered in cells transformed by oncogenes, suggesting it may be a mechanism through which tumor cells escape their microenvironment. In previous work, we demonstrated that p60AmotL2 modulates the E-cadherin function by inhibiting its connection to radial actin filaments. This isoform of AmotL2 is expressed in invasive breast and colon tumors and promotes invasion in vitro and in vivo. Transcriptionally regulated by c-Fos, p60AmotL2 is induced by local stress signals such as severe hypoxia. In this study, we investigated the normal role of p60AmotL2 in epithelial tissues. We found that this isoform is predominantly expressed in the gut, where cells experience rapid turnover. Through time-lapse imaging, we present evidence that cells expressing p60AmotL2 are extruded by their normal neighboring cells. Based on these findings, we hypothesize that tumor cells exploit this pathway to detach from normal epithelia and invade surrounding tissues. Full article

We are concerned with the classical approach to atomic motions in the vicinity of a wire charged by an oscillating voltage. This mechanism has been proposed to serve for trapping cold neutral atoms. We prove that, under some conditions, the atom must either collide with the wire or escape to infinity in the radial direction. The presented results for the atom–wire problem extend and complement some earlier ones in the literature. Full article

Sardas Landfill at Sabiñánigo Huesca is polluted with Dense Non-Aqueous Liquid Phases (DNAPLs) composed of a complex mixture of chlorinated organic compounds (COCs). This DNAPL was produced as liquid waste from lindane production being dumped decades ago in the unlined landfills close to the lindane factory. This DNAPL migrated by gravity through the subsurface and accumulated in the contact between the alluvial and marls layers (about 15 m b.g.l.). Seven injections of an aqueous emulsion of a biodegradable non-ionic surfactant (E-Mulse 3^®) were carried out at the most polluted areas of the Sardas alluvial. Injections were carried out between April and November 2021 using different surfactant concentrations (6.7, 20, 25 and 50 g/L), injection volumes (0.2 to 7 m³) and injection flow rates (0.08–0.85 m³/h). Injected fluids were extracted in the same well or surrounding wells, and the time elapsed between surfactant injection and extraction varied between 24 and 72 h. A total of 22 m³ were injected into the alluvial, and more than double this injected volume was extracted. Injection and extraction points were in the contact between the marls and the alluvial layer. Extracted fluid accumulated in tanks, and phases separated. DNAPL recovered here was mobilized rather than solubilized and managed as toxic waste. The aqueous supernatant was treated in a wastewater treatment plant with physicochemical treatment (including adsorption in activated carbon) before being discharged into the environment. The transport of the injected fluids was monitored by conductivity profiles using bromide (260–538 mg·L⁻¹) as a conservative tracer. High radial dispersion of the injected fluid was found. Surfactant losses by adsorption in the alluvial and absorption in DNAPL were noticed, and both surfactant and contamination did not escape from the capture zone. Monitoring since 2018 of the COCS in groundwater and the DNAPL presence in the contact between alluvial and marls layers showed a significant reduction of COCs in the treated zone with the surfactant injections. Full article

CH₄ can be separated from low-concentration coal bed methane (LCCBM) by using the hydrate-based gas separation (HBGS) method. To study the contribution of different cyclic organic compounds to the separation of CH₄ in LCCBM, an LCCBM hydrate model was constructed. Based on the Monte Carlo and molecular dynamics theory, we simulated the effect of three cyclic organic compounds—cyclopentane (CP), cyclopentanone (CP-one), and cyclopentanol (CP-ol)—on the stability of the LCCBM hydrate at P = 2 MPa, various temperatures, and discussed the structural stability of the hydrate in depth in terms of final snapshots, radial distribution function, mean square displacement, diffusion coefficient, and potential energy change. The results showed that for the CH₄-N₂ LCCMM gas mixture, CP showed the best facilitation effect compared to the other two cyclic compounds by maintaining the stability of the LCCBM hydrate well at T = 293 K. The promotion effect of CP-one is between CP and CP-ol, and when the temperature increases to T = 293 K, the oxygen atoms in the water molecule can maintain the essential stability of the hydrate structure, although the orderliness decreases significantly. Moreover, the structure of the hydrate model containing CP-ol is destroyed at T = 293 K, and the eventual escape of CH₄ and N₂ molecules in solution occurs as bubbles. The research results are important for further exploration of the mechanism of action of cyclic promoter molecules with LCCBM hydrate molecules and promoter preferences. Full article

As is the case for many lizards, leopard geckos (Eublepharis macularius) can self-detach a portion of their tail to escape predation, and then regenerate a replacement complete with a spinal cord. Previous research has shown that endogenous populations of neural stem/progenitor cells (NSPCs) reside within the spinal cord of the original tail. In response to tail loss, these NSPCs are activated and contribute to regeneration. Here, we investigate whether similar populations of NSPCs are found within the spinal cord of the trunk (body). Using a long-duration 5-bromo-2′-deoxyuridine pulse-chase experiment, we determined that a population of cells within the ependymal layer are label-retaining following a 20-week chase. Tail loss does not significantly alter rates of ependymal cell proliferation within the trunk spinal cord. Ependymal cells of the trunk spinal cord express SOX2 and represent at least two distinct cell populations: radial glial-like (glial fibrillary acidic protein- and Vimentin-expressing) cells; and neuronal-like (HuCD-expressing) cells. Taken together, these data demonstrate that NSPCs of the trunk spinal cord closely resemble those of the tail and support the use of the tail spinal cord as a less invasive proxy for body spinal cord injury investigations. Full article

According to general relativity (GR), a universe with a cosmological constant $\Lambda$, like ours, is trapped inside an event horizon, $r<\sqrt{3/\Lambda }$. What is outside? We show, using Israel (1967) junction conditions, that there could be a different universe outside. Our universe looks like a black hole for an outside observer. Outgoing radial null geodesics cannot escape our universe, but incoming photons can enter and leave an imprint on our CMB sky. We present a picture of such a fossil record from the analysis of CMB maps that agrees with the black hole universe predictions but challenges our understanding of the origin of the primordial universe. Full article

The director fields adopted by nematic liquid crystals (LCs) that are confined by the surface to form long, thin droplets are investigated using polarising optical microscopy. Samples are produced by de-wetting of the LC on a surface patterned with alternating high-surface energy and low-surface energy stripes of 10–30 μm width. The droplets obtained are expected to adopt a profile which is that of a longitudinal section of a cylinder and, as this suggests, the director fields observed are variants in the case where the LC is constrained in a cylindrical capillary or fibre. Hence, when there is normal anchoring at the air interface, the textures observed are related to the well-known escaped radial texture (for the nematic LC mixture E7) or plane polar texture (for the LC mixture MLC6609). More surprising is the observation that the nematic LC mixture MLC7023, which is anchored in a planar or tilted manner at the air interface, also gives what appears to be an escaped radial director field. As an exploration of the possibility of using these systems in creating sensors, the effects of adding a chiral dopant and of adding water to the substrates are also investigated. Full article

Root exudates accumulate as a radial gradient around the root, yet little is known about variability at the individual root level. Vertical gradients in soil properties are hypothesized to cause greater accumulation of exudates in deeper soil through hindering diffusion, increasing sorption, and decreasing mineralization. To this end, a single root exudation model coupling concentration specific exudation and depth dependent soil properties was developed. The model was parameterized for a peatland ecosystem to explore deposition to the methanogen community. Numerical experiments indicate that exudates accumulated to a greater extent in deeper soil, albeit the effect was solute specific. Rhizosphere size for glucose doubled between the 10 and 80 cm depths, while the rhizoplane concentration was 1.23 times higher. Root influx of glucose increased from 1.431 to 1.758 nmol cm⁻¹ hr⁻¹, representing a recapture efficiency gain of 15.74% (i.e., 69.06% versus 84.8%). Driven by increased root influx, overall net exudation rates of select sugars and amino acids varied by a factor two. Model sensitivity analysis revealed that soil depth and root influx capability are key determinants of the rhizoplane concentration and subsequently net exudation, which determines whether effluxed compounds escape the root oxic shell and are available to the methanogen community. Full article

Electromagnetic rays travel on curved paths under the influence of gravity. When a dispersive optical medium is included, these trajectories are frequency-dependent. In this work we consider the behaviour of rays when a spherically symmetric, luminous compact object described by the Schwarzschild metric is surrounded by an optically thin shell of plasma supported by radiation pressure. Such levitating atmospheres occupy a position of stable radial equilibrium, where radiative flux and gravitational effects are balanced. Using general relativity and an inhomogeneous plasma we find the existence of a stable circular orbit within the atmospheric shell for low-frequency rays. We explore families of bound orbits that exist between the shell and the compact object, and identify sets of novel periodic orbits. Finally, we examine conditions necessary for the trapping and escape of low-frequency radiation. Full article