Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (3)

Search Parameters:
Keywords = diseases caused by TBVs

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
17 pages, 4520 KiB  
Review
The Known and Unknown of Global Tick-Borne Viruses
by Abulimiti Moming, Yuan Bai, Jun Wang, Yanfang Zhang, Shuang Tang, Zhaojun Fan, Fei Deng and Shu Shen
Viruses 2024, 16(12), 1807; https://doi.org/10.3390/v16121807 - 21 Nov 2024
Cited by 3 | Viewed by 2414
Abstract
Ticks are crucial vectors for various pathogens associated with human and animal diseases, including viruses. Nevertheless, significant knowledge gaps prevail in our understanding of tick-borne viruses (TBVs). We here examined existing studies on TBVs, uncovering 870 documented virus species across 28 orders, 55 [...] Read more.
Ticks are crucial vectors for various pathogens associated with human and animal diseases, including viruses. Nevertheless, significant knowledge gaps prevail in our understanding of tick-borne viruses (TBVs). We here examined existing studies on TBVs, uncovering 870 documented virus species across 28 orders, 55 families, and 66 genera. The discovery history, vector ticks, and hosts of TBVs, as well as the clinical characteristics of TBV-induced diseases, are summarized. In total, 176 tick species from nine tick genera were confirmed as vectors for TBVs. Overall, 105 TBVs were associated with infection or exposure to humans and animals. Of them, at least 40 were identified to cause human or animal diseases. This review addresses the current challenges associated with TBV research, including the lack of knowledge about the identification of novel and emerging TBVs, the spillover potentials from ticks to hosts, and the pathogenicity and infection mechanisms of TBVs. It is expected to provide crucial insights and references for future studies in this field, while specifically focusing on expanding surveys, improving TBV identification and isolation, and enhancing the understanding of TBV–vector–host interactions. All of these findings will facilitate the preparation for preventing and treating diseases caused by emerging and novel TBVs. Full article
(This article belongs to the Section General Virology)
Show Figures

Figure 1

25 pages, 1331 KiB  
Review
Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe
by Nariman Shahhosseini, Gary Wong, George Babuadze, Jeremy V. Camp, Onder Ergonul, Gary P. Kobinger, Sadegh Chinikar and Norbert Nowotny
Microorganisms 2021, 9(9), 1907; https://doi.org/10.3390/microorganisms9091907 - 9 Sep 2021
Cited by 79 | Viewed by 11301
Abstract
The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic [...] Read more.
The global spread of ticks and various tick-borne viruses (TBVs) suggests the possibility of new tick-borne diseases emerging. Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging TBV of the Nairoviridae family that causes serious disease that can be fatal in humans. CCHFV endemic foci can be found in Africa, Asia, the Middle East, and South-Eastern Europe, and has spread to previously unaffected regions and nations, such as Spain, over the last two decades. In this review, we discuss the current situation of CCHFV in Asia, Africa and Europe based on existing knowledge, and we discuss driving factors in the distribution and transmission of the virus, such as the spread of tick vector species and host reservoirs. Full article
(This article belongs to the Special Issue Discovery and Characterization of Novel/Emerging Viruses)
Show Figures

Figure 1

17 pages, 2152 KiB  
Article
Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans
by James G. Hyatt, Sylvain Prévost, Juliette M. Devos, Courtney J. Mycroft-West, Mark A. Skidmore and Anja Winter
Pathogens 2020, 9(11), 935; https://doi.org/10.3390/pathogens9110935 - 11 Nov 2020
Cited by 9 | Viewed by 3775
Abstract
Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue virus (DENV) is a flavivirus spread by female mosquitos of the aedes genus, but the mechanism of viral endocytosis [...] Read more.
Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue virus (DENV) is a flavivirus spread by female mosquitos of the aedes genus, but the mechanism of viral endocytosis is poorly understood at a molecular level, preventing the development of effective transmission blocking vaccines (TBVs). Recently, glycosaminoglycans (GAGs) have been identified as playing a role during initial viral attachment through interaction with the third domain of the viral envelope protein (EDIII). Here, we report a systematic study investigating the effect of a range of biologically relevant GAGs on the structure and oligomeric state of recombinantly generated EDIII. We provide novel in situ biophysical evidence that heparin and chondroitin sulphate C induce conformational changes in EDIII at the secondary structure level. Furthermore, we report the ability of chondroitin sulphate C to bind EDIII and induce higher-order dynamic molecular changes at the tertiary and quaternary structure levels which are dependent on pH, GAG species, and the GAG sulphation state. Lastly, we conducted ab initio modelling of Small Angle Neutron Scattering (SANS) data to visualise the induced oligomeric state of EDIII caused by interaction with chondroitin sulphate C, which may aid in TBV development. Full article
Show Figures

Graphical abstract

Back to TopTop