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Article

16 Citations

7,353 Views

8 Pages

Understanding Acid Lability of Cysteine Protecting Groups

Iván Ramos-Tomillero,
Lorena Mendive-Tapia,
Miriam Góngora-Benítez,
Ernesto Nicolás,
Judit Tulla-Puche and
Fernando Albericio

Molecules2013, 18(5), 5155-5162;https://doi.org/10.3390/molecules18055155

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6 May 2013

Cys-disulfide bonds contribute to the stabilization of peptide and protein structures. The synthesis of these molecules requires a proper protection of Cys residues, which is crucial to prevent side-reactions and also to achieve the correct Cys conne...

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Article

3 Citations

3,660 Views

8 Pages

A New Regioselective Synthesis of the Cysteine-Rich Peptide Linaclotide

Zhonghao Qiu,
Xiandong Dai,
Chongxu Fan,
Ying Cao,
Zirui Lv,
Xingyong Liang and
Fanhua Meng

Molecules2023, 28(3), 1007;https://doi.org/10.3390/molecules28031007

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19 January 2023

Linaclotide is a 14-amino acid residue peptide approved by the FDA for the treatment of irritable bowel syndrome with constipation (IBS-C), which activates guanylate cyclase C to accelerate intestinal transit. Here we show a new method for the synthe...

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