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Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids
- Juncheng Lu,
- Elena N. Atochina-Vasserman,
- Devendra S. Maurya,
- Muhammad Irhash Shalihin,
- Dapeng Zhang,
- Srijay S. Chenna,
- Jasper Adamson,
- Matthew Liu,
- Habib Ur Rehman Shah and
- Honey Shah
- + 9 authors
Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and io...