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  • Article
  • Open Access
1 Citations
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16 Pages

Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits

  • Dalia Nemanić,
  • Petra Šoštarić,
  • Patrik Meglić,
  • Ivica Matak and
  • Lidija Bach-Rojecky

14 March 2025

Botulinum toxin type A (BoNT-A) induces a bilateral analgesic effect following unilateral injection in rodent bilateral or mirror pain models. This occurs either by indirect plasticity-related actions, or by the toxin’s direct central action in...