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Keywords = capnosane-type macrocyclic diterpenes

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Article
Six Undescribed Capnosane-Type Macrocyclic Diterpenoids from South China Sea Soft Coral Sarcophyton crassocaule: Structural Determination and Biological Evaluation
by Hanyang Peng, Yanbo Zeng, Hao Wang, Wenjun Chang, Huiqin Chen, Fengjuan Zhou, Haofu Dai and Xiachang Wang
Mar. Drugs 2023, 21(12), 645; https://doi.org/10.3390/md21120645 - 18 Dec 2023
Cited by 6 | Viewed by 2470
Abstract
Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A–F (16) and one related known analog pavidolide D (7) were isolated from Sarcophyton crassocaule, a soft coral collected off the Nansha Islands, in the South China Sea. Their complete [...] Read more.
Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A–F (16) and one related known analog pavidolide D (7) were isolated from Sarcophyton crassocaule, a soft coral collected off the Nansha Islands, in the South China Sea. Their complete structures, relative configurations and absolute configurations were established through comprehensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) and single-crystal X-ray diffraction. Sarcocrassolins D (4) and E (5) showed inhibitory activity against lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW264.7 cells with IC50 values of 76.8 ± 8.0 μM and 93.0 ± 3.8 μM, respectively. Full article
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