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4 Results Found

  • Article
  • Open Access
16 Citations
4,137 Views
10 Pages

Increased Production of Taxoids in Suspension Cultures of Taxus globosa after Elicitation

  • Hebert Jair Barrales-Cureño,
  • Ana C. Ramos Valdivia and
  • Marcos Soto Hernández

The objectives of this study were to investigate whether elicitors induce the production of taxoids in Taxus globosa by testing the hypothesis that the cells induce a greater accumulation of taxoids depending on the type and concentration of the elic...

  • Article
  • Open Access
10 Citations
7,601 Views
12 Pages

The Kinetic Signature of Toxicity of Four Heavy Metals and Their Mixtures on MCF7 Breast Cancer Cell Line

  • Egbe Egiebor,
  • Adam Tulu,
  • Nadia Abou-Zeid,
  • Isoken Tito Aighewi and
  • Ali Ishaque

This study evaluated the kinetic signature of toxicity of four heavy metals known to cause severe health and environmental issues—cadmium (Cd), mercury (Hg) lead (Pb) arsenic (As)—and the mixture of all four metals (Mix) on MCF7 cancer cells, in the...

  • Review
  • Open Access
171 Citations
24,497 Views
15 Pages

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

  • Paweł Lis,
  • Mariusz Dyląg,
  • Katarzyna Niedźwiecka,
  • Young H. Ko,
  • Peter L. Pedersen,
  • Andre Goffeau and
  • Stanisław Ułaszewski

15 December 2016

This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a...

  • Article
  • Open Access
1 Citations
2,115 Views
11 Pages

Quercetin Attenuates Acetaldehyde-Induced Cytotoxicity via the Heme Oxygenase-1-Dependent Antioxidant Mechanism in Hepatocytes

  • Kexin Li,
  • Minori Kidawara,
  • Qiguang Chen,
  • Shintaro Munemasa,
  • Yoshiyuki Murata,
  • Toshiyuki Nakamura and
  • Yoshimasa Nakamura

20 August 2024

It is still unclear whether or how quercetin influences the toxic events induced by acetaldehyde in hepatocytes, though quercetin has been reported to mitigate alcohol-induced mouse liver injury. In this study, we evaluated the modulating effect of q...