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Keywords = apallic syndrome

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7 pages, 2237 KiB  
Case Report
Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease
by Stefan M. Golaszewski, Bettina Wutzl, Axel F. Unterrainer, Cristina Florea, Kerstin Schwenker, Vanessa N. Frey, Martin Kronbichler, Frank Rattay, Raffaele Nardone, Larissa Hauer, Johann Sellner and Eugen Trinka
Diagnostics 2020, 10(5), 309; https://doi.org/10.3390/diagnostics10050309 - 15 May 2020
Cited by 1 | Viewed by 8321
Abstract
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old [...] Read more.
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations. Full article
(This article belongs to the Special Issue Brain Imaging/Neuroimaging)
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