You are currently viewing a new version of our website. To view the old version click .

110 Results Found

  • Article
  • Open Access
3 Citations
9,131 Views
16 Pages

Centella asiatica (CICA)-derived exosomes have emerged as bioactive agents for skin rejuvenation due to their regenerative and anti-inflammatory properties. This study evaluated the safety and efficacy of a topical ampoule containing CICA-derived ext...

  • Article
  • Open Access
1,358 Views
14 Pages

Anti-Aging Efficacy of Fructosazine and Deoxyfructosazine: A Comprehensive In Vitro and In Vivo Analysis

  • Ao Yang,
  • Chunyan Ma,
  • Qiling Song,
  • Wenhui Li,
  • Shixuan Lv,
  • Xiuhan Guo,
  • Shisheng Wang,
  • Zhigang Gao,
  • Shuai Wang and
  • Qingwei Meng
  • + 1 author

As the proportion of the elderly population increases, there is an urgent need for anti-aging technologies. Since the skin is the most visibly aging organ in the human body, it is crucial to develop active ingredients to slow down skin aging. Current...

  • Article
  • Open Access
3,219 Views
25 Pages

Systematic Evaluation and Identification of Anti-Inflammatory and Anti-Aging Ginseng Peptides for Skincare Applications

  • Ze Xia,
  • Wei Liu,
  • Fanmo Zeng,
  • Sining Kang,
  • Junxiang Li,
  • Wenfei Xu,
  • Pingxiang Tang,
  • Xinyi Zheng,
  • Dandan Li and
  • Xuebin Yang
  • + 2 authors

This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that ginseng extracts containing water-soluble sma...

  • Communication
  • Open Access
17 Citations
5,670 Views
20 Pages

Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study

  • Steven P. Nisticò,
  • M. E. Greco,
  • S. Amato,
  • L. Bennardo,
  • E. Zappia,
  • E. Pignataro and
  • G. Pellacani

The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a...

  • Review
  • Open Access
4 Citations
9,670 Views
28 Pages

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology

  • Trung Quang Nguyen,
  • Thinh Van Pham,
  • Yusuf Andriana and
  • Minh Ngoc Truong

3 January 2025

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C. militaris-derived bioactive gels for applications in dermatolo...

  • Review
  • Open Access
7 Citations
19,671 Views
18 Pages

13 February 2025

With the growing demand for environmental sustainability, the cosmetics industry is increasingly turning to natural ingredients with high bioactivity and efficacy. Rice, a staple food in many cultures, particularly in Asia, is renowned for its nutrit...

  • Article
  • Open Access
7 Citations
5,085 Views
13 Pages

30 April 2024

Red rice, a variety of pigmented grain, serves dual purposes as both a food and medicinal resource. In recent years, we have witnessed an increasing interest in the dermatological benefits of fermented rice extracts, particularly their whitening and...

  • Article
  • Open Access
42 Citations
107,213 Views
12 Pages

Rice Water: A Traditional Ingredient with Anti-Aging Efficacy

  • Joana Marto,
  • Ângela Neves,
  • Lídia Maria Gonçalves,
  • Pedro Pinto,
  • Cristina Almeida and
  • Sandra Simões

The skin healing benefits of rice have been known for centuries. Rice (Oryza sativa) water is a food processing waste that can potentially be incorporated into cosmetic formulations. However, no scientific evidence supports their role in skincare pro...

  • Article
  • Open Access
3 Citations
6,695 Views
14 Pages

Clinical Tolerability and Efficacy Establishment of a New Cosmetic Treatment Regimen Intended for Sensitive Skin

  • María Vitale,
  • Maria Teresa Truchuelo,
  • Vincenzo Nobile and
  • María José Gómez-Sánchez

18 July 2024

Sensitive skin has a great impact on the quality of life of subjects. In this research, we evaluated the efficacy and tolerance of a cosmetic treatment for facial skincare, consisting of a cleanser, serum and cream. A clinical-instrumental study was...

  • Article
  • Open Access
1,100 Views
23 Pages

Structural and Functional Profiling of Water-Extracted Polypeptides from Periplaneta americana: A Multifunctional Cosmetic Bioactive Agent with Antioxidative and Anti-Inflammatory Properties

  • Xinyu Sun,
  • Zhengyang Zhang,
  • Jingyao Qu,
  • Deyun Yao,
  • Zeyuan Sun,
  • Jingyi Zhou,
  • Jiayuan Xie,
  • Mingyang Zhou,
  • Xiaodeng Yang and
  • Ling Wang

Low-molecular-weight polypeptides (<3 kDa) were prepared from Periplaneta americana via enzymatic hydrolysis and ultrafiltration, yielding 3.53 ± 0.01 mg/g of peptide-rich extract. The extract was primarily composed of peptides, proteins, p...

  • Review
  • Open Access
4 Citations
15,857 Views
50 Pages

A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications

  • Sofia Neonilli A. Papadopoulou,
  • Elena A. Anastasiou,
  • Theodora Adamantidi,
  • Anna Ofrydopoulou,
  • Sophia Letsiou and
  • Alexandros Tsoupras

15 January 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to the observed high percentage of the worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its...

  • Review
  • Open Access
48 Citations
10,515 Views
22 Pages

With the increasing demand for natural and safe products in cosmetics, algae with their diverse and valuable bioactive compounds are gaining vital importance. Until now, cosmetics have focused mainly on the use of freshwater and marine algae. However...

  • Review
  • Open Access
22 Citations
7,098 Views
21 Pages

Grape By-Products in Sustainable Cosmetics: Nanoencapsulation and Market Trends

  • Maria Leonor Castro,
  • João Paulo Ferreira,
  • Manuela Pintado,
  • Oscar L. Ramos,
  • Sandra Borges and
  • Sara Baptista-Silva

11 August 2023

The largest human organ, the skin, serves a variety of essential functions including protection, preservation of water and electrolytes, regulation of body temperature, and fat storage. Its maintenance and preservation are supported by cosmetic produ...

  • Review
  • Open Access
24 Citations
6,811 Views
28 Pages

In recent years, numerous reports have described bioactive peptides (biopeptides)/hydrolysates produced from various food sources. Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g.,...

  • Article
  • Open Access
1 Citations
3,687 Views
19 Pages

Natural Mineral Water–Plant Extract Combinations as Potential Anti-Aging Ingredients: An In Vitro Evaluation

  • Carolina P. Gomes,
  • Ana S. Oliveira,
  • Joana Rolo,
  • Tayse F. F. da Silveira,
  • Rita Palmeira de Oliveira,
  • Maria José Alves,
  • Paula Plasencia and
  • Ana Palmeira de Oliveira

Natural mineral waters (NMWs) and plant extracts have long been valued for their therapeutic properties and skin benefits. This study investigated, in vitro, the role of five Portuguese NMWs (A-E), combined with plant extracts from five species (Ficu...

  • Article
  • Open Access
2 Citations
6,768 Views
16 Pages

A 28-Day Pilot Study of the Effects on Facial Skin Hydration, Elasticity, and Texture of a Centella asiatica Extracellular Vesicle-Based Skin Care Formulation

  • Tsong-Min Chang,
  • Chung-Chin Wu,
  • Huey-Chun Huang,
  • Ji-Ying Lu,
  • Ching-Hua Chuang,
  • Pei-Lun Kao,
  • Wei-Hsuan Tang,
  • Luke Tzu-Chi Liu,
  • Wei-Yin Qiu and
  • Ivona Percec
  • + 2 authors

28 August 2025

Extracellular vesicles (EVs) from the traditional medicinal herb Centella asiatica (Cica) represent a novel category of botanical actives with potential dermatological benefits, yet their clinical effects in cosmetic applications remain unexplored. T...

  • Article
  • Open Access
6 Citations
3,958 Views
20 Pages

Acheta domesticus: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications

  • Kankanit Yeerong,
  • Panuwan Chantawannakul,
  • Songyot Anuchapreeda,
  • Thomas Rades,
  • Anette Müllertz and
  • Wantida Chaiyana

Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared...

  • Article
  • Open Access
22 Citations
5,946 Views
24 Pages

Cosmetic Application of Cyanobacteria Extracts with a Sustainable Vision to Skincare: Role in the Antioxidant and Antiaging Process

  • Janaína Morone,
  • Graciliana Lopes,
  • João Morais,
  • Jorge Neves,
  • Vítor Vasconcelos and
  • Rosário Martins

2 December 2022

Nature-based and sustainably sourced cosmetics have been dominating the area of skincare products worldwide. Due to their antioxidant and antiaging properties, compounds from cyanobacteria, such as carotenoids and phycobiliproteins, may replace synth...

  • Review
  • Open Access
15 Citations
5,961 Views
27 Pages

22 August 2024

For centuries, mushrooms have been used as a component of skincare formulations. Environmental stresses and a modern lifestyle expose the skin to accelerated aging. To slow down this process, natural anti-aging skincare ingredients are being sought....

  • Article
  • Open Access
101 Citations
53,231 Views
18 Pages

Trends in the Use of Botanicals in Anti-Aging Cosmetics

  • Marta Salvador Ferreira,
  • Maria Catarina Magalhães,
  • Rita Oliveira,
  • José Manuel Sousa-Lobo and
  • Isabel Filipa Almeida

11 June 2021

Botanical ingredients have been used for thousands of years in skincare for their convenience as well as the diversity and abundance in compounds with biological activity. Among these, polyphenols and especially flavonoids have gained increasing prom...

  • Article
  • Open Access
25 Citations
11,618 Views
16 Pages

Phenolic Compounds from Leaves and Flowers of Hibiscus roseus: Potential Skin Cosmetic Applications of an Under-Investigated Species

  • Luana Beatriz dos Santos Nascimento,
  • Antonella Gori,
  • Andrea Raffaelli,
  • Francesco Ferrini and
  • Cecilia Brunetti

10 March 2021

The use of plant extracts in skin-care cosmetics is a modern trend due to their richness in polyphenols that act as anti-aging molecules. Hibiscus roseus is a perennial species naturalized in Italy, with beautiful soft pink flowers; its phenolic comp...

  • Article
  • Open Access
2 Citations
4,988 Views
24 Pages

The growing demand for natural anti-aging ingredients necessitates scientific validation of traditional cosmetic materials. Multani Mitti (MM), a clay widely used in South Asian traditional skincare, lacks comprehensive chemical and biological charac...

  • Article
  • Open Access
15 Citations
5,516 Views
12 Pages

Effect of Sodium Hyaluronate on Antioxidant and Anti-Ageing Activities in Caenorhabditis elegans

  • Qianmin Lin,
  • Bingbing Song,
  • Yingxiong Zhong,
  • Huan Yin,
  • Ziyu Li,
  • Zhuo Wang,
  • Kit-Leong Cheong,
  • Riming Huang and
  • Saiyi Zhong

26 March 2023

As an acidic polysaccharide, the formation of Hyaluronic acid (HA) is typically Sodium Hyaluronate (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH...

  • Article
  • Open Access
3,910 Views
23 Pages

Unlocking Nature’s Anti-Aging Secrets: The Potential of Natural Mineral Waters Combined with Plant Extracts in Cosmetics

  • Ana Rita Gama,
  • Carolina P. Gomes,
  • Cátia Caetano,
  • Ana Sofia Oliveira,
  • Joana Rolo,
  • Lillian Barros,
  • Paula Plasencia,
  • Juliana Garcia,
  • Daniela Correia and
  • Maria José Alves
  • + 3 authors

Skin aging is influenced by intrinsic and extrinsic factors, leading to structural changes in the skin. Current anti-aging cosmetic trends emphasize innovative natural ingredients, including plant extracts, thermal waters, and botanical hydrolats. Th...

  • Article
  • Open Access
31 Citations
8,128 Views
20 Pages

Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy

  • Xinchao Zhang,
  • Siyuan Chen,
  • Dan Luo,
  • Dan Chen,
  • Hong Zhou,
  • Shuting Zhang,
  • Xuan Chen,
  • Wangwang Lu and
  • Wei Liu

17 March 2023

Due to the stratum corneum barrier, resveratrol is difficult to be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there is a lack of systematic studies on the efficacy of resveratrol in human skin, especial...

  • Article
  • Open Access
4 Citations
2,411 Views
16 Pages

A Cocktail-Based Formula for the Design of Nanosized Cosmeceuticals as Skincare and Anti-Age Products

  • Ines Castangia,
  • Federica Fulgheri,
  • Matteo Perra,
  • Gianluigi Bacchetta,
  • Laura Fancello,
  • Francesco Corrias,
  • Iris Usach,
  • Josè Esteban Peris,
  • Maria Letizia Manca and
  • Maria Manconi

4 September 2023

Nasco and Bovale grape pomace extracts, alone or in association, were loaded in nanoemulsions tailored for cosmetic application, using Kolliphor®RH40 (kolliphor) as the synthetic surfactant, Olivem®1000 (olivem) as the natural one, and lecith...

  • Article
  • Open Access
5 Citations
8,086 Views
13 Pages

2 November 2021

Skincare is very critical in preventing aging and skin trouble, which is difficult to recover if progressed. However, the development of effective anti-aging solutions is still on the horizon. The purpose of this study was to evaluate the functional...

  • Review
  • Open Access
7 Citations
5,633 Views
39 Pages

An Outlook on Platinum-Based Active Ingredients for Dermatologic and Skincare Applications

  • Shining Li,
  • Yizhou Liu,
  • Ying Wu,
  • Lu Ren,
  • Yongjie Lu,
  • Shuji Yamaguchi,
  • Qipeng Lu,
  • Chuangang Hu,
  • Dongcui Li and
  • Naisheng Jiang

2 August 2024

Platinum-based materials exhibit a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and pro-collagen synthesis properties, making them particularly useful for various biomedical applications. This revi...

  • Review
  • Open Access
11 Citations
25,948 Views
30 Pages

Use of Exosomes for Cosmetics Applications

  • Luis Jesús Villarreal-Gómez,
  • Sergio Origel-Lucio,
  • Daniela Alejandra Hernández-Hernández and
  • Graciela Lizeth Pérez-González

This study addresses a significant gap in the clinical validation and standardization of exosome-based applications within the domains of cosmetics and regenerative medicine. Despite offering a thorough overview of the potential therapeutic benefits...

  • Article
  • Open Access
2 Citations
8,500 Views
13 Pages

Peptides, composed of 2–50 amino acids, have gained attention in anti-aging treatments due to their high safety, low irritation, and cost-effective production. This study aimed to evaluate the anti-wrinkle efficacy of Tetrapeptide-68, derived f...

  • Article
  • Open Access
18 Citations
13,969 Views
14 Pages

Anti-Aging, Anti-Acne, and Cytotoxic Activities of Houttuynia cordata Extracts and Phytochemicals Analysis by LC-MS/MS

  • Santi Phosri,
  • Kanokwan Kiattisin,
  • Aekkhaluck Intharuksa,
  • Raveeporn Janon,
  • Tanat Na Nongkhai and
  • Tinnakorn Theansungnoen

7 December 2022

Although many biological properties of Houttuynia cordata have been found, its anti-aging and anti-acne effects have not yet been investigated. This study was aimed to evaluate the in vitro anti-aging and anti-acne activities of H. cordata extracts a...

  • Review
  • Open Access
6 Citations
3,778 Views
18 Pages

5 February 2025

This review examines existing studies on wheat bran extracts (WBEs) to provide an overview of their functional properties, including antioxidant and enzyme-inhibitory activities, highlighting their potential as natural alternatives for applications i...

  • Review
  • Open Access
19 Citations
9,021 Views
17 Pages

Exploring Olive Pomace for Skincare Applications: A Review

  • Raquel Rodrigues,
  • Rita C. Alves and
  • Maria Beatriz P. P. Oliveira

16 February 2023

The cosmetic industry is continuously searching for new active ingredients in an effort to attend to consumer demands which, in recent years, are focused on more natural and environmentally friendly products, obtained from sustainable resources. Neve...

  • Article
  • Open Access
1,024 Views
25 Pages

Objectives: Sialic acid (SA), a naturally occurring compound abundantly found in birds’ nests, holds immense promise for skincare applications owing to its remarkable biological properties. However, its low bioavailability, poor stability, and...

  • Article
  • Open Access
557 Views
18 Pages

Insights into Thai and Foreign Hemp Seed Oil and Extracts’ GC/MS Data Re-Analysis Through Learning Algorithms and Anti-Aging Properties

  • Suthinee Sangkanu,
  • Thanet Pitakbut,
  • Sathianpong Phoopha,
  • Jiraporn Khanansuk,
  • Kasemsiri Chandarajoti and
  • Sukanya Dej-adisai

31 October 2025

This study successfully established a novel discriminative model that distinguishes between Thai and foreign hemp seed extracts based on gas chromatography/mass spectrometry (GC/MS) metabolic profiling combined with machine learning algorithms such a...

  • Review
  • Open Access
45 Citations
10,979 Views
17 Pages

18 October 2013

Fullerene medicine is a new but rapidly growing research subject. Fullerene has a number of desired structural, physical and chemical properties to be adapted for biological use including antioxidants, anti-aging, anti-inflammation, photodynamic ther...

  • Review
  • Open Access
2 Citations
8,247 Views
20 Pages

Cosmeceuticals for Anti-Aging: Mechanisms, Clinical Evidence, and Regulatory Insights—A Comprehensive Review

  • Orsola Crespi,
  • François Rosset,
  • Valentina Pala,
  • Cristina Sarda,
  • Martina Accorinti,
  • Pietro Quaglino and
  • Simone Ribero

17 September 2025

Products with biologically active ingredients have emerged as a powerful category within the skincare and anti-aging sectors. Bridging the gap between pharmaceuticals and cosmetics, they offer therapeutic benefits supported by scientific evidence whi...

  • Systematic Review
  • Open Access
13 Citations
14,541 Views
26 Pages

Thanaka (H. crenulata, N. crenulata, L. acidissima L.) is a common tree in Southeast Asia used by the people of Myanmar to create their distinctive face makeup meant for daily sun protection and skincare. Moreover, it is used as a traditional remedy...

  • Review
  • Open Access
6 Citations
4,232 Views
24 Pages

Comprehensive Insight into Cutaneous Application of Hemp

  • Ana Žugić,
  • Milica Martinović,
  • Vanja Tadić,
  • Miloš Rajković,
  • Gordana Racić,
  • Ivana Nešić and
  • Anamarija Koren

Known for its natural bio-compounds and therapeutic properties, hemp is being utilized in the development of skin products. These products offer a wide range of applications and benefits in the fields of natural bio-compounds, pharmaceutical technolo...

  • Article
  • Open Access
10 Citations
7,658 Views
16 Pages

20 November 2024

Panax ginseng (Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investig...

  • Article
  • Open Access
1 Citations
7,759 Views
13 Pages

Antioxidants (including Vitamin C, ferulic acid, and phloretin) are among the compounds used in skincare products. The purpose of this study was to evaluate the effect of a combination containing L-ascorbic acid, ferulic acid, and phloretin. The deli...

  • Review
  • Open Access
33 Citations
6,392 Views
23 Pages

Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects

  • Sarah Bouzroud,
  • Ezzouhra El Maaiden,
  • Mansour Sobeh,
  • Nawal Merghoub,
  • Hassan Boukcim,
  • Lamfeddal Kouisni and
  • Youssef El Kharrassi

11 January 2023

Plants are the main source of bioactive compounds that can be used for the formulation of cosmetic products. Plant extracts have numerous proven health benefits, among which are anti-ageing and skin-care properties. However, with the increased demand...

  • Article
  • Open Access
3 Citations
9,772 Views
14 Pages

The Role of Cacao Powder in Enhancing Skin Moisture and Reducing Wrinkles: A 12-Week Clinical Trial and In Vitro Study

  • Sang Gyu Lee,
  • Ngoc Ha Nguyen,
  • Young In Lee,
  • Inhee Jung,
  • In Ah Kim,
  • Hyunsook Jang,
  • Hoyeon Shin and
  • Ju Hee Lee

6 November 2024

Skin aging is driven by a combination of internal and external mechanisms, with ultraviolet (UV) radiation being a prominent external factor contributing to photoaging. Photoaging manifests through several signs, including decreased skin hydration, d...

  • Review
  • Open Access
26 Citations
10,794 Views
31 Pages

4 February 2024

The pursuit for better skin health, driven by collective and individual perceptions, has led to the demand for sustainable skincare products. Environmental factors and lifestyle choices can accelerate skin aging, causing issues like inflammation, wri...

  • Article
  • Open Access
59 Citations
8,668 Views
12 Pages

The leaves of loquat (Eriobotrya japonica) possess high medicinal value and have been used as traditional medicines. However, there are no evidence-based studies on the skin-care effects of E. japonica leaves. To explore new biological activities of...

  • Article
  • Open Access
2,509 Views
21 Pages

This study aims to provide a comprehensive evaluation of the bioactive compounds present in honeysuckle flower (Lonicera japonica Thunb.) extract (HSF) and their remarkable antioxidant activity. A docking simulation was performed to clarify the bindi...

  • Review
  • Open Access
61 Citations
25,315 Views
15 Pages

Chlorogenic Acids and Caffeine from Coffee By-Products: A Review on Skincare Applications

  • Raquel Rodrigues,
  • Maria Beatriz Prior Pinto Oliveira and
  • Rita Carneiro Alves

Upcycling is a modern trend in the cosmetic sector, focusing on by-products reuse and waste reduction. Consumers are more aware of the origin of cosmetic products and their environmental impact, promoting the upcycling phenomenon. Converting these ra...

  • Review
  • Open Access
3,489 Views
26 Pages

Officinal Plants as New Frontiers of Cosmetic Ingredients

  • Annabella Vitalone,
  • Lucia D’Andrea,
  • Antonella Di Sotto,
  • Alessandra Caruso and
  • Rita Parente

In recent years, cosmetic science has adopted a more integrative approach to skincare, in which sensory experience and psychophysical well-being are increasingly valued. In this context, plant-derived ingredients, particularly those from officinal sp...

  • Review
  • Open Access
46 Citations
16,917 Views
36 Pages

27 February 2022

Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to...

  • Review
  • Open Access
12 Citations
26,210 Views
14 Pages

The Biological Role of Dead Sea Water in Skin Health: A Review

  • Daoxin Dai,
  • Xiaoyu Ma,
  • Xiaojuan Yan and
  • Xijun Bao

19 January 2023

Applying natural mineral water to skin care is a popular tendency and many cosmetics products based on thermal spring water have been developed. The special location and environmental conditions provide Dead Sea water (DSW) with unique ion compositio...

of 3