Search Results (1,984)

Rapid population growth challenges governance systems, housing markets, infrastructure capacity, and social cohesion, yet it is often treated as a predictable and uniform process. This structured comparative review synthesizes four distinct rapid-growth literatures: energy boomtowns, amenity-migration destinations, gateway communities, and mega-event host towns, to examine how different growth drivers shape community resilience. Using systematic forward and backward citation tracking grounded in community theory, the review identifies recurring patterns across otherwise separate research traditions. The analysis shows that outcomes are shaped less by growth itself than by institutional and spatial conditions. Extractive boomtowns and mega-event hosts experience compressed cycles of disruption and recovery that test adaptive capacity, while amenity-migration destinations and gateway communities face sustained pressures related to housing affordability, land-use conflict, and social boundary formation. Across contexts, three interrelated dimensions of adaptive capacity consistently structure trajectories: multilevel governance coordination, housing and land-use elasticity, and the management of social equity and cohesion. The findings advance a conceptual resilience framework that interprets rapid population change as a socio-spatial shock filtered through institutional and spatial conditions, with implications for sustainable urban design, flexible infrastructure planning, and inclusive governance. Full article

This study reconceptualises marginality in China’s inter-provincial border regions as a dynamic, scale-sensitive spatial relationship rather than a static condition of underdevelopment. Using the Hubei–Henan–Anhui border area as a case study, we quantitatively assess marginality across three dimensions—production, livelihood, and ecology—based on panel data from 61 counties for 2000, 2010, and 2021. The entropy-weighted TOPSIS method is used to calculate comprehensive development indices, and geographic detector models identify key driving factors. The results show that production marginality is persistently shaped by economic level and industrial structure. Livelihood marginality exhibits a clear temporal shift: dominant drivers move from healthcare security to cultural amenities and finally to transport accessibility. Ecological marginality remains primarily determined by natural endowments such as habitat quality and ecosystem services. Theoretically, the study advances marginality analysis by integrating spatial, temporal and dimensional perspectives. Practically, it offers a diagnostic framework to support differentiated, cross-administrative governance strategies that can transform peripheral border regions into cooperative hubs. Full article

This study developed a Visitor Attraction Quality Checklist to evaluate amenity infrastructure. Seoullo 7017, an elevated linear park located in the Seoul Station area, is the study region. Drawing on the literature on urban regeneration and tourism, as well as amenity-based approaches and the quality evaluation of elevated linear parks, this study develops evaluation criteria that incorporate the physical environment and safety, accessibility and convenience, landscape and identity, and social usage and experience. By applying a longitudinal analysis, on-site qualitative evaluations were conducted between August 2017 and January 2026. The findings show that Seoullo 7017 functions well as a visitor attraction, offering high-standard safety infrastructure, cleanliness, and good esthetic value to accommodate diverse visitors. However, there is a seasonal disparity in cultural programming and limited connections to the surrounding local economy. This study also reveals that rigid planter designs, a lack of tree maintenance, and insufficient shaded areas limit spatial flexibility and visitor comfort. For Seoullo 7017 to pursue sustainability, it must refine its horticultural management, integrate with local businesses, and improve its design. The Visitor Attraction Quality Checklist serves as a longitudinal diagnostic tool for managing elevated urban linear parks as an outcome of global regeneration projects. Full article

Drawing on 964 field observations from typical community parks in Changsha, this study utilizes the System for Observing Play and Recreation in Communities (SOPARC) alongside Kernel Density Estimation (KDE) to quantitatively dissect the intrinsic associations between older adults’ outdoor activity patterns and micro-spatial characteristics. The findings reveal a pronounced demographic differentiation in spatial utilization. Specifically, female-dominated collective activities, such as square dancing, exhibit a profound reliance on central plazas with unobstructed sightlines to cultivate a sense of social security. Conversely, male users demonstrate a distinct preference for static social interactions, including playing chess or cards, within semi-enclosed and shaded spaces beneath a tree canopy. Beyond gender distinctions, age-related spatial anchoring is also evident. Intergenerational caregiving activities among the younger old cohort (aged 55 to 74) are exclusively concentrated around children’s playgrounds, whereas older old individuals and those with impaired mobility rely heavily on densely distributed micro-scale resting amenities. Driven by these empirical insights, this research contends that age-friendly park design must transcend generic accessibility standards, advocating instead for a “categorized spatial provision” strategy. By meticulously balancing open exhibition plazas, semi-private shaded units, and composite caregiving zones within a single park ecosystem, this approach can effectively accommodate the multifaceted health and social requirements of various older adult subgroups. Full article

In recent decades, cruise tourism has emerged as a key economic driver for port cities, while simultaneously intensifying environmental pressures and socio-spatial inequalities. Despite growing scholarly attention, research exploring how these pressures are distributed within urban contexts and how they interact with pre-existing vulnerability patterns remains scarce. This study addresses this gap by proposing a GIS-based integrated methodological framework, the Port-city Risk Integrated Spatial Method (PRISM), applied to the Mediterranean port city of Malaga, Spain. The approach combines socio-demographic indicators and data related to spatial amenities with environmental pressures from cruise ship emissions to construct an Urban Socio-Environmental Complexity Index. Emission scenarios for peak cruise days were estimated using a bottom-up methodology and spatialized through atmospheric dispersion modeling, enabling their integration with exposure, vulnerability, and urban capacity indicators. The results reveal marked intra-urban heterogeneity and highlight the emergence of cumulative risk hotspots in areas adjacent to the port and along prevailing inland dispersion corridors. This study demonstrates the potential of integrated spatial indices as decision support tools for urban planning, offering a replicable framework for other port cities facing similar tourism-driven transformations. Full article

Investments in urban parks are frequently justified not only in terms of their environmental and recreational amenities but also in terms of their potential to fuel appreciation in neighborhoods and corresponding increases in local fiscal revenues. There is a substantial body of literature indicating that proximity to parks and other forms of urban open spaces can be capitalized into surrounding residential property values; however, there is relatively limited research examining whether these effects plausibly translate into fiscal revenues that could offset the costs of urban park projects. This study seeks to address this question in the context of Chicago’s 606 Trail, a 2.7-mile elevated rail-to-trail conversion completed and opened on 6 June 2015, after a publicly disclosed investment of $95 million in the project at the time of opening. Using property transaction data and a difference-in-differences event-study approach, this study estimates the impact of park completion on surrounding residential property values and converts these amenity capitalization effects into corresponding municipal fiscal revenues. The main contribution of this paper is to demonstrate that amenity capitalization and fiscal self-financing are analytically separate outcomes, even though park completion may be associated with corresponding increases in surrounding residential property values. The study contributes a framework for evaluating substantial urban park investments by drawing on both urban amenity studies and municipal finance studies. Full article

Based on the stimulus–organism–response (S–O–R) framework, this study explored the psychological spillover mechanism through which tourism experiences in Museum Agglomeration Areas (MAAs) enhance city image and influence behavioral intentions. Structural equation modeling (SEM) based on survey data yielded several key findings. First, information visibility, content visibility, and the quality of amenities and the operational environment played critical roles in shaping tourists’ internal states, including perceived experiential value, affective response, immersion, and satisfaction. In addition, the social atmosphere emerged as an important factor in enriching these evaluations. Second, accessibility and connectivity were identified as factors that reduce friction along the visitor journey, thereby enhancing experiential continuity and immersion. Third, experiential value and immersion were found to be the primary mediators among the internal-state variables, transmitting the effects of environmental stimuli to city-level perceptions and behavioral intentions, such as revisit and recommendation intentions. These findings suggest that the competitiveness of MAAs lies not merely in spatial agglomeration itself but also in their ability to provide engaging and meaningful content, maintain safe and enjoyable operational environments, and develop integrated circulation and information systems. By conceptualizing MAAs as sites of district-scale tourism experiences, this study extends the application of the S–O–R framework to a multi-site urban cultural context and clarifies how differentiated internal states mediate the spillover from district experience to city-level perceptions and behavioral intentions. Rather than proposing a fundamentally new theoretical framework, the study offers a context-specific refinement of the organism layer and provides empirically grounded implications for design and operational strategies in culturally clustered urban districts. Full article

Background: Magnetic resonance spectroscopic imaging (MRSI) offers valuable metabolic information for assessing brain tumor progression and therapeutic response, but its performance in rodent models is often hindered by the low signal-to-noise ratio (SNR) and spatially heterogeneous spectral quality, particularly in peripheral voxels. These issues reduce the number of usable spectra available for quantitative and classifier-based analyses. To address this, we implemented a multi-voxel MRSI-semiLASER sequence—widely recommended in clinical practice—on a 7T Bruker Biospec system running ParaVision 5.1 to improve spectral homogeneity in mouse brain tumor studies. Results: Compared with the vendor CSI-PRESS sequence, MRSI-semiLASER produced more uniform spectra across the grid and achieved up to a 1.2-fold SNR increase in murine glioma, enabling a 20% reduction in slice thickness without compromising spectral quality. Importantly, the sequence produced a substantial gain in the proportion of spectra amenable to analysis, particularly in outer grid voxels that frequently fail with CSI-PRESS. The implemented MRSI-semiLASER sequence and instructions are openly available to the community. Conclusions: MRSI-semiLASER improves spectral homogeneity, increases the proportion of usable spectra, and supports higher spatial detail. These technical improvements may enhance data yield per subject and may facilitate future applications such as more robust pattern recognition workflows and greater data efficiency in longitudinal studies, although such aspects were not evaluated here. Full article

In this article, we present a new approximate solution for blood nanofluid having gold nanoparticles as it flows near a stretching porous cylinder in fractal space. A Casson non-Newtonian magneto-bio-nanofluid flowing through a porous medium is considered a potential application in chemotherapy for eradicating cancer cells. Without the need for the nonperturbative approach, the proposed solution uses an alternative approach to dealing with nonlinear problems. This approach transforms the nonlinear cubic jerk model resulting from the simplification of the governing fractional partial differential equations into an equivalent linear formula. This approach is known as highly efficient linear approximation (HELA) or non-perturbation technique (NPT), and this represents a significant advancement over traditional perturbation methods in the analysis of non-linear systems. As a robust mathematical approach, it excels at handling a wide range of coefficient values, particularly in cases of clear nonlinearity. This study also utilized the masking technique simultaneously with HELA, which played a crucial role, as they simplify the complex dynamics of the system, making it more amenable to analysis. The numerical solution by the Runge–Kutta fourth-order (RK-4) method integrated with a shooting technique compared favorably with graphs drawn for the analytical solution from the proposed strategy HELA. The current results show that an increase in the fractal factors enhances the resistance to fluid motion, leading to a suppression of the velocity field. Physically, this often relates to the complexity of the medium or the fractal nature of the transport process, where higher fractal dimensions or factors can lead to slower diffusion or flow rates, like the role of porous media. Therefore, the current study has significant implications in the promotion of nanotechnology fields in medicine, particularly the use of gold nanoparticles in chemotherapy for the eradication of cancerous cells. Full article

Urban areas are increasingly exposed to water-related challenges, including flood risk and water scarcity, amplified by climate change, population growth, and extensive soil sealing. Addressing these pressures requires integrated stormwater management (SWM) strategies that balance hydraulic, environmental, and social objectives. This study introduces a novel, replicable Key Performance Indicator (KPI)-based assessment framework for 36 green–blue and grey sustainable stormwater management systems (SWMSs), designed to enable cross-typology, multiscale comparison. Six KPIs, encompassing flood regulation, water consumption, water quality, air quality, environmental amenity, and biodiversity potential, are derived through a critical synthesis and harmonisation of the literature and complemented with new parameters and sub-parameters to address existing methodological gaps. The framework structures evaluations into six analytical tables and one summary table, ensuring transparent, systematic, and comparative assessment of heterogeneous solutions. Application to a pilot project in Rome demonstrates how integrating KPI evaluation with parametric hydraulic modelling provides actionable insights for solution selection. It also facilitates identification of potential synergies between performance dimensions, enhancing its value as a decision-support tool in preliminary design. Overall, the study demonstrates the research value of multi-scalar, performance-based approaches for urban water planning, highlights the transferability of resilient stormwater strategies in climate-sensitive contexts, and identifies promising avenues for future research, including multi-sectoral integration, trade-off analysis, and cross-platform application. Full article

Chandipura virus (CHPV) is a neurotropic rhabdovirus associated with recurrent outbreaks of acute encephalitis in children and a high case fatality rate, particularly in India. Despite its public health relevance, the host molecular processes governing CHPV infection and disease progression remain poorly defined. To address this gap, we conducted a time-resolved transcriptomic analysis to characterize host responses to CHPV infection and to explore host-directed therapeutic opportunities. Human HEK293T cells were infected with CHPV, followed by RNA sequencing (RNA-seq) at 6, 12, 18, and 24 h post infection (hpi). Transcriptome profiling revealed a temporally ordered host response. At 6 hpi, CHPV infection was dominated by strong activation of innate immune and inflammatory pathways, including interferon-stimulated genes and cytokine signaling. Antiviral responses persisted at 12 hpi, accompanied by suppression of metabolic and translational processes, indicating a shift in host cellular priorities. By 18 hpi, metabolic reprogramming—particularly involving lipid and sphingolipid metabolism—was observed alongside altered immune signaling, consistent with viral exploitation of host cellular machinery. At 24 hpi, repression of genes involved in chromatin organization, RNA processing, spliceosome assembly, and ribosome biogenesis reflected a global transcriptional shutdown associated with cytopathic effects. Integration of temporal transcriptomic signatures enabled identification of host pathways amenable to pharmacological targeting. Selected host-directed compounds were evaluated in vitro and exhibited antiviral activity against CHPV in a neuronal cell line. Collectively, this study provides the first time-resolved transcriptomic landscape of CHPV infection in human cells and identifies host-targeted strategies relevant for antiviral development. Full article

Background/Objectives: The goal of this study was to characterize changes in autofluorescence of epithelial cells obtained from saliva stains that occur with time and investigate the potential for these changes to serve as time-since-deposition (TSD) signatures for this sample type. Methods: Saliva from 50 individuals was used to create 208 deposits that were aged between one day and nine months. Autofluorescence profiles of individual cells were obtained from each sample using imaging flow cytometry (IFC) and analyzed across nine different emission channels ranging between 435 nm and 800 nm. Results: Results showed strong evidence for linear increases in autofluorescence intensity when epithelial cells from a single donor deposit were measured over time (12 of 14 donors r ≥ 0.9). When autofluorescence profiles from all 50 donors were combined into a single time series, variation in autofluorescence intensity was observed between individual deposits with the same TSD. This inter-contributor variation decreased the overall strength of the linear relationship (r = 0.83) and yielded residual errors of ~8 days for samples that were actually 1 day old and ~82 days for samples that were over 180 days old using a linear regression model. Although this approach may not currently be amenable to estimating TSD to the day with high accuracy, clear, non-overlapping differences in autofluorescence intensity were still observed between certain time intervals, e.g., saliva deposits that were aged for 1 day compared to saliva deposits that were aged for more than 120 days. Conclusions: This suggests that cellular autofluorescence signatures have the potential to be probative when hypotheses for sample deposition involve disparate time intervals or as a screening tool for identifying which samples are most likely relevant to the crime in question based on their deposition time. Full article

Climate change has adversely affected grain production and quality of canola, the second-largest oilseed crop, which contributes 13–16% of total vegetable oil. Multiple biotic and abiotic stresses significantly limit canola production due to rapid climate change, and conventional breeding alone is insufficient to meet global demand. Therefore, several advanced biotechnologies have been developed to cope with this change. Among these, genetic modification, gene editing, and RNA interference are particularly significant for rapid cultivar development in a cost-effective, efficient, and convenient way. Recent findings in gene editing applications have revealed “prospective sites”, highlighting regions amenable to precise editing without compromising canola plant growth or development. Pan-genome analyses have further guided gene editing target selection, enabling the validation of key stress-resilience genes across diverse canola cultivars, while the CRISPR-epigenetic regulatory connection enables targeted control of gene expression and trait modulation. A hypothetical application of genomic selection is also suggested, which could complement gene editing to accelerate the development of superior cultivars. Accordingly, this review focuses on the latest studies of genetic modification, gene editing, and RNA interference to strengthen canola resilience under rapid climate change and discusses the major concerns. Taken together, these genome-editing strategies offer precise approaches for improving biotic and abiotic stress tolerance, although careful consideration of both off-target effects and regulatory compliance remains essential for their practical implementation in canola improvement. Full article

Place-based approaches have gained significant attention as a means of addressing entrenched disadvantage through collaborative, locally responsive service delivery, yet implementation has yielded mixed results and the systemic factors that facilitate or impede inter-organisational collaboration remain inadequately understood. This study applied participatory systems mapping as part of a systemic inquiry to identify leverage points for place-based integrated service delivery in the City of Casey, an outer-metropolitan municipality in Melbourne, Australia. Twenty-one representatives from the Casey Futures Partnership engaged in group model building workshops, co-producing a causal loop diagram containing 33 factors and 104 directional connections. The resulting map was analysed using a blended analytical approach combining network metrics with the Action Scales Model. Funding availability and criteria emerged as the most central factor within the system, while belief-level factors, including territorial behaviour and resource and collaboration mindset, were found to be substantially shaped by upstream structural conditions. Factors combining network influence with deeper system positioning and amenability to local action included awareness of community needs and priorities, trust and willingness to collaborate from funders, inter-organisational communication, and advocacy effectiveness. The findings support multi-level place-based approaches that address underlying beliefs and structural conditions alongside operational improvements. Full article

Background/Objectives: Tenosynovial giant cell tumor (TGCT), historically referred to as pigmented villonodular synovitis (PVNS), is a rare proliferative synovial disorder that most commonly affects the knee and may lead to progressive joint damage. Surgical synovectomy remains the mainstay of treatment, although recurrence remains a concern, particularly in diffuse disease. The purpose of this study was to evaluate functional outcomes and recurrence following arthroscopic synovectomy with selective open excision for TGCT of the knee. Methods: This retrospective case series included patients treated surgically for TGCT of the knee at a single tertiary orthopaedic center between 2003 and 2023. The extended study period may have introduced variability in surgical technique and perioperative management due to evolving clinical practice. All patients underwent arthroscopic synovectomy, with open excision performed when necessary to address posterior or extra-articular disease not amenable to complete arthroscopic resection. Functional outcomes and knee range of motion were evaluated preoperatively and at final follow-up. Recurrence and complications were recorded. Results: A total of 43 patients were included with a mean follow-up of 8.1 years. Diffuse TGCT was present in 32 patients (74%), while 11 patients (26%) had localized disease. Arthroscopic synovectomy was performed in all cases, with additional open excision required in 10 patients. Functional scores and range of motion improved significantly at final follow-up (p < 0.001). Disease recurrence occurred in 8 patients (18.6%), all with diffuse disease, and was treated with revision arthroscopic synovectomy. Conclusions: Arthroscopic synovectomy with selective open excision when required was associated with significant improvement in functional outcomes and knee range of motion. Disease recurrence occurred in 18.6% of patients and exclusively in those with diffuse disease, emphasizing the need for careful postoperative surveillance. Full article