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Article

4 Citations

1,196 Views

30 Pages

Short Synthesis of Structurally Diverse N-Acylhomoserine Lactone Analogs and Discovery of Novel Quorum Quenchers Against Gram-Negative Pathogens

Marina Porras,
Dácil Hernández and
Alicia Boto

Int. J. Mol. Sci.2025, 26(4), 1775;https://doi.org/10.3390/ijms26041775

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19 February 2025

Quorum quenchers are emerging as an alternative to conventional antimicrobials, since they hinder the development of virulence or resistance mechanisms but without killing the microorganisms, thus, reducing the risk of antimicrobial resistance. Many...

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Article

9 Citations

4,931 Views

17 Pages

Novel Bifunctional Acylase from Actinoplanes utahensis: A Versatile Enzyme to Synthesize Antimicrobial Compounds and Use in Quorum Quenching Processes

Lara Serrano-Aguirre,
Rodrigo Velasco-Bucheli,
Begoña García-Álvarez,
Ana Saborido,
Miguel Arroyo and
Isabel de la Mata

Antibiotics2021, 10(8), 922;https://doi.org/10.3390/antibiotics10080922

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29 July 2021

Many intercellular communication processes, known as quorum sensing (QS), are regulated by the autoinducers N-acyl-l-homoserine lactones (AHLs) in Gram-negative bacteria. The inactivation of these QS processes using different quorum quenching (QQ) st...

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Article

19 Citations

7,165 Views

9 Pages

Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters

Stephanie Forschner-Dancause,
Emily Poulin and
Susan Meschwitz

Molecules2016, 21(8), 971;https://doi.org/10.3390/molecules21080971

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25 July 2016

Traditional therapeutics to treat bacterial infections have given rise to multi-drug resistant pathogens, which pose a major threat to human and animal health. In several pathogens, quorum sensing (QS)—a cell-cell communication system in bacteria—con...

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