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Article

8 Citations

3,339 Views

20 Pages

Activity-Guided Characterization of COX-2 Inhibitory Compounds in Waltheria indica L. Extracts

Michael Termer,
Christophe Carola,
Andrew Salazar,
Cornelia M. Keck,
Juergen Hemberger and
Joerg von Hagen

Molecules2021, 26(23), 7240;https://doi.org/10.3390/molecules26237240

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29 November 2021

Inflammation is the body’s response to infection or tissue injury in order to restore and maintain homeostasis. Prostaglandin E2 (PGE-2) derived from arachidonic acid (AA), via up-regulation of cyclooxygenase-2 (COX-2), is a key mediator of inf...

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Article

1 Citations

1,281 Views

16 Pages

Integrated Management of Bacterial Wilt and Root-Knot Nematode Diseases in Pepper: Discovery of Phenazine-1-Carboxamide from Pseudomonas aeruginosa W-126

Shuai Wang,
Yifan Wang,
Youzhi Yao,
Wenzhuo Li,
Zhan Hu,
Dong Li and
Ranfeng Sun

Int. J. Mol. Sci.2025, 26(7), 3335;https://doi.org/10.3390/ijms26073335

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3 April 2025

Ralstonia solanacearum is an important pathogen causing bacterial wilt in pepper (Capsicum annuum L.). The concurrent infection of R. solanacearum and root-knot nematodes (Meloidogyne spp.) exacerbates the severity of bacterial wilt in pepper. Utiliz...

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Article

6 Citations

2,646 Views

15 Pages

Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of Waltheria indica

Feifei Liu,
Sudipta Mallick,
Timothy J. O’Donnell,
Ruxianguli Rouzimaimaiti,
Yuheng Luo,
Rui Sun,
Marisa Wall,
Supakit Wongwiwatthananukit,
Abhijit Date and
Dane Kaohelani Silva
+ 2 authors

Molecules2022, 27(10), 3270;https://doi.org/10.3390/molecules27103270

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19 May 2022

Seven new coumarinolignans, walthindicins A–F (1a, 1b, 2–5, 7), along with five known analogs (6, 8–11), were isolated from the roots of Waltheria indica. The structures of the new compounds are determined by detailed nuclear magnet...

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