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Article

1,529 Views

13 Pages

Comprehensive Annotation and Expression Profiling of C2H2 Zinc Finger Transcription Factors across Chicken Tissues

Shuai Chen,
Jiayao Jiang,
Wenxiu Liang,
Yuchen Tang,
Renzhe Lyu,
Yun Hu,
Demin Cai,
Xugang Luo and
Mingan Sun

Int. J. Mol. Sci.2024, 25(19), 10525;https://doi.org/10.3390/ijms251910525

30 September 2024

As the most abundant class of transcription factors in eukaryotes, C2H2-type zinc finger proteins (C2H2-ZFPs) play critical roles in various biological processes. Despite being extensively studied in mammals, C2H2-ZFPs remain poorly characterized in...

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Article

15 Citations

3,559 Views

24 Pages

SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and Suppresses Prostate Cancer Growth and Migration

Takanori Eguchi,
Eva Csizmadia,
Hotaka Kawai,
Mona Sheta,
Kunihiro Yoshida,
Thomas L. Prince,
Barbara Wegiel and
Stuart K. Calderwood

Cells2022, 11(24), 3993;https://doi.org/10.3390/cells11243993

10 December 2022

Epithelial–mesenchymal transition (EMT) is a reversible cellular program that transiently places epithelial (E) cells into pseudo-mesenchymal (M) cell states. The malignant progression and resistance of many carcinomas depend on EMT activation,...

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28 Citations

5,739 Views

15 Pages

MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer

Takanori Eguchi,
Thomas L. Prince,
Manh Tien Tran,
Chiharu Sogawa,
Benjamin J. Lang and
Stuart K. Calderwood

Cancers2019, 11(6), 792;https://doi.org/10.3390/cancers11060792

8 June 2019

Cell division control 37 (CDC37) increases the stability of heat shock protein 90 (HSP90) client proteins and is thus essential for numerous intracellular oncogenic signaling pathways, playing a key role in prostate oncogenesis. Notably, elevated exp...

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7 Citations

3,377 Views

22 Pages

Stress-Inducible SCAND Factors Suppress the Stress Response and Are Biomarkers for Enhanced Prognosis in Cancers

Mona Sheta,
Kunihiro Yoshida,
Hideka Kanemoto,
Stuart K. Calderwood and
Takanori Eguchi

Int. J. Mol. Sci.2023, 24(6), 5168;https://doi.org/10.3390/ijms24065168

8 March 2023

The cell stress response is an essential system present in every cell for responding and adapting to environmental stimulations. A major program for stress response is the heat shock factor (HSF)–heat shock protein (HSP) system that maintains p...

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16 Citations

3,151 Views

18 Pages

Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues

Young-Eun Cho,
Jeong-Hee Kim,
Young-Hyun Che,
Yong-Jun Kim,
Ji-Youn Sung,
Yoon-Wha Kim,
Bong-Geun Choe,
Sun Lee and
Jae-Hoon Park

Int. J. Mol. Sci.2022, 23(16), 9302;https://doi.org/10.3390/ijms23169302

18 August 2022

Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) acts as an oncogenic transcription factor in human malignant tumors, including colon and prostate cancer. However, most of the ZKSCAN3-induced carcinogenic mechanisms remain unknown. In this...

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