2,021 Results Found

Tuberculosis continues to be a major threat to the human population. Global efforts to eradicate the disease are ongoing but are hampered by the increasing occurrence of multidrug-resistant strains of Mycobacterium tuberculosis. Therefore, the develo...

Inflammation resolution is an active process via specialized pro-resolving mediators (SPMs) to fight invading microbes and repair tissue injury. RvD1 and RvD2 are SPMs produced from DHA during inflammation responses and show a benefit in treating inf...

The crankshaft bearing is the key component of a rotate vector (RV) reducer. However, owing to the harsh working load and restricted available space, the bearing often suffers from fatigue failure. Therefore, this study proposes a novel optimization...

Nowadays, tuberculosis is the second leading cause of death from a monopathogenic transmitted disease, only ahead of COVID-19. The role of exported repetitive protein (Erp) in the virulence of Mycobacterium tuberculosis has been extensively demonstra...

Objectives: The construction of subunit vaccines based on antigens that can induce strong cellular immunity is a widely accepted strategy to develop new tuberculosis vaccines. This study screens immunogens with potential for subunit vaccine developme...

The virulence of Mycobacterium tuberculosis (M. tuberculosis) is related to many factors, including intracellular survival, cell wall permeability, and cell envelope proteins. However, the biological function of the M. tuberculosis membrane protein R...

Mycobacterium tuberculosis has seen tremendous success as it has developed defenses to reside in host alveoli despite various host-related stress circumstances. Rv1636 is a universal stress protein contributing to mycobacterial survival in different...

The increasing emergence of Mycobacterium tuberculosis (Mtb) strains resistant to traditional anti-tuberculosis drugs has alarmed health services worldwide. The search for new therapeutic targets and effective drugs that counteract the virulence and...

Mycobacterium tuberculosis (M. tuberculosis) has developed some strategies to evade host immune responses through ubiquitination, thereby facilitating persistent mycobacterial infection. The Rv3717 protein has been identified as a peptidoglycan (PG)...

In fault diagnosis research, compound faults are often regarded as an isolated fault mode, while the association between compound faults and single faults is ignored, resulting in the inability to make accurate and effective diagnoses of compound fau...

Koala retrovirus, a recent discovery in Australian koalas, is endogenised in 100% of northern koalas but has lower prevalence in southern populations, with lower proviral and viral loads, and an undetermined level of endogenisation. KoRV has been ass...

Mycobacterium tuberculosis (Mtb) can evade antimicrobial immunity and persist within macrophages by interfering with multiple host cellular functions through its virulence factors, causing latent tuberculosis. The Rv2387 protein has been identified a...

Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However,...

The rotate vector (RV) reducer has a complex structure and highly coupled internal components. Acoustic emission (AE) signal, which is more sensitive to a weak fault, is selected for fault diagnosis of the RV reducer. The high sampling frequency and...

(1) Background: To evaluate time-dependent right ventricular (RV) performance in patients with COVID-19-associated acute respiratory distress syndrome (ARDS) undergoing intensive care (ICU) treatment. (2) Methods: This prospective observational study...

Due to their advantages of compact size, high reduction ratio, large stiffness and high load capacity, RV reducers have been widely used in industrial robots. The dynamic characteristics of RV reducers in terms of vibratory response and dynamic trans...

Menière’s disease and vestibular migraine (VM) are two common inner ear disorders whose diagnoses are based on clinical history and audiometric exams. In some cases, patients have been reporting different episodes of vertigo for years bu...

Rotate vector (RV) reducers have widely been used in high-performance precision drives for industrial robots. However, the current nonlinear dynamic studies on RV reducers are not extensive and require a deeper focus. To bridge this gap, a translatio...

RV reducers contain multi-tooth contact characteristics, with high-impact resistance and a small backlash, and are widely used in precision transmissions, such as robot joints. The main parameters affecting the transmission performance include torsio...

An electrochemically reduced graphene oxide (ERGO) electrode-based electrochemical assay was developed for rapid, sensitive, and straightforward analysis of both activity and inhibition of the endonuclease EcoRV. The procedure uses a DNA substrate de...

Mycobacterium tuberculosis (Mtb), as a typical intracellular pathogen, possesses several putative restriction–modification (R-M) systems, which restrict exogenous DNA’s entry, such as bacterial phage infection. Here, we investigate Rv2528...

This paper introduces a new hybrid model, HAR-RV-CARMA, which combines the Heterogeneous Autoregressive model for Realized Volatility (HAR-RV) with the Continuous Autoregressive Moving Average (CARMA) model. The key innovation of this study lies in t...

Tuberculosis, an infectious disease, is one of the leading causes of death worldwide. Drug-resistant tuberculosis exacerbates its threat. Despite long-term and costly treatment with second-line drugs, treatment failure rates and mortality remain high...

The cycloid gear wear of RV reducers leads to the degradation of the industrial robots’ transmission accuracy, but the degradation law with respect to the wear volume is still unclear. In this paper, a method for determining transmission error...

Bin1/Amphiphysin/Rvs (BAR) domain-containing proteins mediate fundamental cellular processes, including membrane remodeling and endocytosis. Nematode-trapping (NT) fungi can differentiate to form trapping structures through highly reorganized cell me...

As a core component of industrial robots, the transmission accuracy life (TAL) of rotary vector (RV) reducers constitutes a primary factor determining the high-precision operation of robotic systems. However, current life evaluation methods for RV re...

Mycobacterium tuberculosis represents an ancient deadly human pathogen that can survive and multiply within macrophages. The effectors are key players for the successful pathogenesis of this bacterium. M. tuberculosis open reading frame (ORF) Rv0341,...

Mycobacterium tuberculosis, which causes tuberculosis, is one of the leading infectious agents worldwide with a high rate of mortality. Following aerosol inhalation, M. tuberculosis primarily infects the alveolar macrophages, which results in a host...

The isolation and characterization of the lignan meso-dihydroguaiaretic acid (MDGA) from Larrea tridentata and its activity against Mycobacterial tuberculosis has been demonstrated, but no information regarding its mechanism of action has been docume...

We observed high-resolution optical spectra of 11 RV Tauri stars without IR excess, with the primary goal of searching for chemical depletion patterns. Using equivalent widths of absorption lines, we calculated the photospheric parameters and chemica...

Intense exposure to UVB radiation incites excessive production of reactive oxygen species (ROS) and inflammation. The resolution of inflammation is an active process orchestrated by a family of lipid molecules that includes AT-RvD1, a specialized pro...

Rv3852 is a unique nucleoid-associated protein (NAP) found exclusively in Mycobacterium tuberculosis (Mtb) and closely related species. Although annotated as H-NS, we showed previously that it is very different from H-NS in its properties and is dist...

Background: Acute pulmonary embolism (PE) is a critical condition where the timely and accurate assessment of right ventricular (RV) dysfunction is important for patient management. Given the limited availability of echocardiography in emergency depa...

Tuberculosis (TB) is a major global health threat despite its virtual elimination in developed countries. Issues such as drug accessibility, emergence of multidrug-resistant strains, and limitations of the current BCG vaccine highlight the urgent nee...

The crankshaft is one of the core components of a Rotate Vector (RV) reducer. The fatigue life of the RV reducer is severely hindered by fatigue failure on the eccentric cylindrical surface of the crankshaft. The hardness gradients and residual stres...

The rotation error is the most important quality characteristic index of a rotate vector (RV) reducer, and it is difficult to accurately optimize the design of a RV reducer, such as the Taguchi type, due to the many factors affecting the rotation err...

The widely administered tuberculosis (TB) vaccine, Bacillus Calmette-Guerin (BCG), is the only licensed vaccine, but has highly variable efficiency against childhood and pulmonary TB. Therefore, the BCG prime-boost strategy is a rational solution for...

The mechanical and tribological behavior of eccentric bearings is crucial for the performance of a RV reducer. By combining the finite element model (FEM) and the elastohydrodynamic lubrication (EHL) method, a comprehensive model for the cylindrical...

High titres of rotavirus-specific maternal antibodies may contribute to lower rotavirus vaccine efficacy in low- and middle-income countries (LMICs). RV3-BB vaccine (G3P[6]) is based on a neonatal rotavirus strain that replicates well in the newborn...

With the rapid development of the electronics industry, the scale of the global Internet of Things (IoT) industry has shown an exponential growth trend in recent years. The huge demand for IoT equipment makes low cost an important indicator for the s...

The Mycobacterium tuberculosis (M. tb) genome encodes a large number of hypothetical proteins, which need to investigate their role in physiology, virulence, pathogenesis, and host interaction. To explore the role of hypothetical protein Rv0580c, we...

The thin-walled rings of the RV reducer main bearings are prone to structural elastic deformation, which can significantly change the bearing mechanical characteristics. According to the actual assembly state of the RV reducer, the simulation model o...

This paper addresses the unclear bearing force of an RV reducer shaft by establishing a transmission model and analyzing the force situation of each component. Three force models for the crank support bearing, swivel arm bearing, and main bearing are...

Elucidation of the mechanism of action of compounds with cellular bioactivity is important for progressing compounds into future drug development. In recent years, phenotype-based drug discovery has become the dominant approach to drug discovery over...

MmpL (mycobacterial membrane protein large) proteins are integral membrane proteins that have been implicated in the biosynthesis and/or transport of mycobacterial cell wall lipids. Given the cellular location of these proteins, however, it is unclea...

This paper proposes a new method for predicting rotation error based on improved grey wolf–optimized support vector regression (IGWO-SVR), because the existing rotation error research methods cannot meet the production beat and product quality...

The present study aims to determine the Rapid Visual Screening (RVS) basic scores for four representative Unreinforced Masonry (URM) and their corresponding Confined Masonry (CM) buildings. Two types of analysis were carried out on the finite element...

Tuberculosis is a highly lethal bacterial disease worldwide caused by Mycobacterium tuberculosis (Mtb). Caespitate is a phytochemical isolated from Helichrysum caespititium, a plant used in African traditional medicine that shows anti-tubercular acti...

There are many factors affecting the assembly quality of rotate vector reducer, and the assembly quality is unstable. Matching is an assembly method that can obtain high-precision products or avoid a large number of secondary rejects. Selecting suita...

This study highlights hyperspectral infrared observations from the Marine-Atmospheric Emitted Radiance Interferometer (M-AERI) collected as part of the Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) deploymen...