You are currently viewing a new version of our website. To view the old version click .
MDPIMDPI

4 Results Found

  • Article
  • Open Access
31 Citations
7,136 Views
13 Pages
Download PDF

NeoBOMB1, a GRPR-Antagonist for Breast Cancer Theragnostics: First Results of a Preclinical Study with [67Ga]NeoBOMB1 in T-47D Cells and Tumor-Bearing Mice

  • Aikaterini Kaloudi,
  • Emmanouil Lymperis,
  • Athina Giarika,
  • Simone Dalm,
  • Francesca Orlandi,
  • Donato Barbato,
  • Mattia Tedesco,
  • Theodosia Maina,
  • Marion De Jong and
  • Berthold A. Nock
Molecules2017, 22(11), 1950;https://doi.org/10.3390/molecules22111950

11 November 2017

Background: The GRPR-antagonist-based radioligands [67/68Ga/111In/177Lu]NeoBOMB1 have shown excellent theragnostic profiles in preclinical prostate cancer models, while [68Ga]NeoBOMB1 effectively visualized prostate cancer lesions in patients. We wer...

Full Article
  • Article
  • Open Access
18 Citations
2,924 Views
13 Pages
Download PDF

Imaging Properties and Tumor Targeting of 68Ga-NeoBOMB1, a Gastrin-Releasing Peptide Receptor Antagonist, in GIST Patients

  • Leonhard Gruber,
  • Clemens Decristoforo,
  • Christian Uprimny,
  • Peter Hohenberger,
  • Stefan O. Schoenberg,
  • Francesca Orlandi,
  • Maurizio Franco Mariani,
  • Claudia Manzl,
  • Maria Theresia Kasseroler and
  • Herbert Tilg
  • + 3 authors
Biomedicines2022, 10(11), 2899;https://doi.org/10.3390/biomedicines10112899

11 November 2022

Background: Gastrin-releasing peptide receptors (GRPRs) are molecular imaging targets in multiple malignancies. Recently, NeoBOMB1, a 68Ga-labelled antagonist to GRPRs, was developed for PET. Here we report the outcome of a Phase I/IIa clinical trial...

Full Article
  • Article
  • Open Access
18 Citations
4,169 Views
11 Pages
Download PDF

In Vivo Biodistribution and Efficacy Evaluation of NeoB, a Radiotracer Targeted to GRPR, in Mice Bearing Gastrointestinal Stromal Tumor

  • Christopher Montemagno,
  • Florian Raes,
  • Mitra Ahmadi,
  • Sandrine Bacot,
  • Marlène Debiossat,
  • Julien Leenhardt,
  • Jean Boutonnat,
  • Francesca Orlandi,
  • Donato Barbato and
  • Mattia Tedesco
  • + 3 authors
Cancers2021, 13(5), 1051;https://doi.org/10.3390/cancers13051051

2 March 2021

NeoB is a radiotracer targeting the gastrin-releasing peptide receptor (GRPR), a G-protein–coupled receptor expressed in various cancers. The aim of the present study was to evaluate the biodistribution and efficacy of this new therapeutic agent in G...

Full Article
  • Article
  • Open Access
2 Citations
3,367 Views
12 Pages
Download PDF

Syncretism Narrative and the Use of Material Objects within Some Neo-Pentecostal Circles in Contemporary South Africa

  • Themba Shingange
Religions2024, 15(1), 52;https://doi.org/10.3390/rel15010052

29 December 2023

African Pentecostal Christianity presents interconnectedness with African cultures, spiritualities, and religiosity in many ways. Among many other practices that demonstrate this interconnectedness is the use of material objects common within some Af...

Full Article