Search Results (2,652)

In this study, a novel magnetic metal–organic framework (MOF) composite, Pd@UiO-66@Fe₃O₄, was successfully synthesized as a high-performance heterogeneous catalyst for the Suzuki–Miyaura cross-coupling reaction. The material was prepared by loading nano-sized carboxylated Fe₃O₄ onto UiO-66 via an in situ solvothermal method, followed by the encapsulation of Pd nanoparticles using an ultrasound-assisted dual-solvent method (DSA). Characterization results, including PXRD and TEM, confirmed that the ternary composite retains the structural integrity of UiO-66 while incorporating magnetic functionality and well-dispersed Pd active sites. The catalyst exhibited high catalytic performance for the coupling of aryl iodides and aryl boronic acids. Furthermore, the catalyst demonstrated good compatibility with the substrates examined and excellent stability. Due to the integration of carboxylated Fe₃O₄, the composite could be easily separated from the reaction mixture using an external magnet and reused for at least five cycles without a significant loss in catalytic activity. The high activity and durability are attributed to the integrated roles of the Pd nanoparticles, the porous MOF support, and the magnetic Fe₃O₄ component, which respectively provide catalytic active sites, structural stabilization/dispersion, and magnetic recoverability. Full article

Chronic wound healing disorders are closely associated with microenvironmental imbalance, while traditional dressings fail to meet dynamic therapeutic demands due to limited functionality, poor responsiveness, and lack of controlled drug release. In this study, a smart hydrogel dressing was developed by integrating curcumin/Cu²⁺ co-loaded UiO-66-NH₂ metal–organic frameworks into a dynamically cross-linked oxidized hyaluronic acid/carboxymethyl chitosan (OHA-CMCS) network via Schiff base bonding. The MOFs served as a “one-carrier-dual-function” platform, enabling simultaneous delivery of Cu²⁺ and curcumin. The resulting Cur/Cu-MOF@OHA-CMCS hydrogel exhibited a porous structure, excellent self-healing ability, injectability, and favorable rheological and mechanical properties. Additionally, it showed pH-responsive degradation behavior and sustained drug release (~71% within 7 days). The hydrogel demonstrated effective anti-bacterial activity against both Escherichia coli and Staphylococcus aureus, along with good cytocompatibility (>70% cell viability). These results highlight its potential as a multifunctional and responsive dressing for chronic wound management. Full article

The excessive use of herbicides in agricultural fields has emerged as a critical environmental concern. This study innovatively synthesized a ZIF-8@TPPa composite through a solvothermal method for the efficient removal of herbicides from aqueous environment. The material exhibited remarkable adsorption capacities for butachlor (232.56 mg/g), anilofos (188.68 mg/g), and pendimethalin (285.71 mg/g), along with excellent acid–base stability (pH 3–9), strong anti-ion interference capability, and good reusability (adsorption efficiency >80% after five cycles). The adsorption processes were well-described by the two isotherm models and the pseudo-second-order model, indicating that the dominant mechanism is a synergistic effect between monolayer chemical adsorption and multilayer physical adsorption, primarily driven by π-π stacking, hydrogen bonding, and coordination. The material maintained outstanding adsorption efficiency (>85%) in real water samples (tap water, seawater, and river water). This study not only provides a sustainable and effective strategy for herbicide remediation from aqueous environment but also expands the practical applications of MOF@COF in aqueous environment. Full article

Developing bifunctional non-noble metal electrocatalysts with high activity, stability, and cost-effectiveness is essential for large-scale sustainable water splitting, yet remains challenging. Herein, 2P-FeCoNi-MOF was synthesized via hydrothermal reaction of FeCoNi-LDH followed by phosphidation. Its layered structure, integrated with 3D nickel foam, creates a hierarchical porous architecture that increases surface area and accelerates electron transport. Synergistic effects among Fe, Co, Ni in the trimetallic phosphides, together with an amorphous carbon layer, boost catalytic performance. Moreover, superhydrophilic and superaerophobic surfaces enhance mass transfer. In 1 M KOH, 2P-FeCoNi-MOF achieves low overpotentials of 70 mV for HER and 225 mV for OER at 10 mA cm⁻², with excellent stability for 100 h at 100 mA cm⁻². For the overall water splitting, it requires only 1.54 V to reach 10 mA cm⁻² and maintains stability for 100 h at 100 mA cm⁻². Therefore, this study provides a new approach for the preparation of high-performance self-supported non-noble metal-based electrocatalysts for water splitting. Full article

The growing concern over greenhouse gas emissions has prompted the need for efficient carbon dioxide (CO₂) capture technologies. This study focuses on simulating CO₂ adsorption using a zinc-based metal–organic framework (Zn-MOF-5). The primary aim is to develop and refine a robust MATLAB-based approach for equilibrium and kinetic modelling using the Linear Driving Force (LDF) model and Langmuir isotherm, capable of accurately predicting CO₂ adsorption performance under varying operational conditions. By employing advanced computational methods, this research seeks to streamline the process design and enhance the feasibility of sustainable CO₂ capture solutions. Excel was used for statistical analysis and validation, while MATLAB R2025a was utilised for equilibrium and kinetic modelling using the LDF model and the Langmuir isotherm. The independent effects of temperature, pressure, and flow rate were evaluated using the variable effect method. The study found a significant negative association between temperature and CO₂ uptake, consistent with the exothermic nature of the adsorption process. Pressure had a significant impact on adsorption, whereas flow rate had little effect within the investigated range. The simulated CO₂ uptake (21.196 mmol/g) closely matched the experimental data (21.07 mmol/g) with a 0.59% variance, validating the model’s trustworthiness. The research shows that Zn-MOF-5 has a strong adsorption potential and that simulation tools can significantly minimise experimental costs and time. Furthermore, it underscores the potential of simulation tools to significantly reduce experimental costs and time, paving the way for more efficient and effective carbon capture solutions. This initiative not only contributes to optimising process design but also promotes sustainable practices in addressing global CO₂ emissions. By contributing to process optimisation, this study aligns with the United Nations Sustainable Development Goal (SDG) 13: Climate Action, which emphasises the urgent need for innovative solutions to combat climate change and its impacts. Furthermore, it promotes sustainable practices to address global CO₂ emissions, thereby supporting broader efforts for environmental sustainability. Full article

This study develops high-performance ammonia sensors based on composites of metal-organic frameworks (MOF-808 and MOF-818) with reduced graphene oxide (rGO). Two sensor architectures were fabricated: interdigital electrodes and silicon micropillar arrays. The MOF-808/rGO composite demonstrated superior sensing performance for 40 ppm NH₃ at room temperature, with faster response kinetics and higher sensitivity compared to pristine rGO and MOF-818/rGO. Silicon micropillar array sensors showed enhanced performance through optimized periodic arrangements, while oxygen plasma surface modification improved both sensor types. Comprehensive testing confirmed that the MOF-808/rGO sensor maintains reliable NH₃ detection at concentrations as low as 5 ppm under high humidity conditions, exhibiting excellent stability and selectivity. These findings provide valuable insights for developing advanced gas sensors for environmental monitoring applications. Full article

Metal–organic frameworks (MOFs) possess unique structural tunability, abundant coordination sites, and outstanding biosafety, rendering them highly advantageous for the development of high-performance magnetic resonance imaging (MRI) contrast agents. In light of the significant advancements in MOF-derived theranostic platforms, a comprehensive overview focusing on their classification and clinically oriented applications is urgently required. This review provides an in-depth examination of various categories of MOF-derived contrast agents, including T1, T2, dual-mode, ratiometric and 19F imaging systems, and analyzes the correlation between structural characteristics and imaging performance. Furthermore, it highlights typical MRI-guided therapeutic applications, such as those related to atherosclerosis, bacterial infections, and cancer immunotherapy. The review systematically addresses existing challenges, including issues related to biodegradability, metabolic behavior, and biosafety. It also summarizes the rational design principles for novel MOF contrast agents, aiming to facilitate their transition from fundamental research to clinical applications. Full article

Photocatalytic H₂O₂ production coupled with selective organic oxidation provides a promising strategy for simultaneously generating value-added oxidants and chemicals under mild conditions. Herein, Ni-modified defect-engineered NH₂-UiO-66 photocatalysts (Ni/UN) are constructed by introducing Ni species into a vacuum-treated NH₂-UiO-66 framework (UN). Compared with the original NH₂-UiO-66 and the defect-treated UN, Ni/UN exhibits weakened photoluminescence emission, enhanced transient photocurrent response, and reduced electrochemical impedance, indicating that the separation and transfer of photogenerated charge carriers have been improved. The band structure analysis further reveals that Ni/UN has a narrow band gap of approximately 2.52 electron volts and a slightly more negative conduction band position (−0.50 V), which is conducive to the photoinduced reduction reaction. The importance of O₂ in the photocatalytic process was demonstrated by changing the atmospheric conditions. Therefore, in the benzylalcohol system, under the oxygen atmosphere, Ni/UN achieved the highest H₂O₂ production rate of 3257 μmol g⁻¹ h⁻¹, accompanied by the continuous generation of benzaldehyde, with its content reaching 3420 μmol g⁻¹ after 60 min of irradiation. The scavenger experiment further indicates that photogenerated electrons and the active substances derived from oxygen are closely involved in the formation of H₂O₂, while the ·OH-related processes only play a limited contribution role. This study demonstrates an effective strategy for enhancing the performance of metal–organic framework (MOF)-based photocatalysts through defect engineering and metal coordination regulation, thereby achieving efficient photochemical production of hydrogen peroxide and the selective oxidation of benzyl alcohol. Full article

The emerging demand for water pollution control has driven a significant interest in advanced porous materials for sustainable and effective wastewater treatment technologies. Metal–organic frameworks (MOFs) have been employed as promising substrates due to their versatile properties, especially their high surface area, tunable properties, and chemical functionality. However, their practical applications are often limited by poor aqueous stability, instability during recovery, and high production costs. Lignocellulosic biomass (LCB) is an abundant, low-cost, and renewable resource, primarily composed of cellulose, hemicellulose, and lignin, offering a sustainable solution for these challenges. This review critically examines the recent advances in design and applications of LCB-MOF materials for wastewater remediation. Several synthesis strategies, including in situ growth, ex situ impregnation, and post-synthetic modification, are systematically discussed in relation to their significance in enhancing stability, recyclability, and dispersibility of MOFs. The key, structural, morphological, and physicochemical properties of these LCB-MOFs were analyzed, along with their performance in removing organic dyes and heavy metal ions. Current drawbacks in long-term stability, scalability, and real-world wastewater performance are highlighted. Overall, LCB-MOFs demonstrate a promising class of sustainable materials that align with the principles of the circular economy and green chemistry, making them ideal for next-generation wastewater remediation technologies. Full article

Asthma is a chronic, etiologically diverse lung disease that contributes to worldwide morbidity and healthcare burdens. Although bronchodilators and corticosteroids remain the cornerstones of asthma treatment, their long-term use is associated with significant side effects. Furthermore, steroid resistance in severe asthma emphasizes the need for alternative therapeutic approaches. Nanotechnology has emerged as a viable alternative to these standard approaches, allowing for targeted, prolonged, and precise drug delivery. Nanozymes, or synthetic nanomaterials that imitate natural enzyme functions, are gaining popularity among nanomedicine platforms due to their redox-regulating and immunomodulatory properties. This review provides a comprehensive overview of the present landscape of nanozyme-based treatments for asthma, with a focus on carbon-based nanozymes, while discussing MOF-derived and single-atom nanozymes in terms of their physicochemical properties and potential applicability to airway inflammatory diseases. Moreover, we look at current advancements in nanozyme-enabled drug delivery systems, their biocompatibility profiles, and potential strategies for designing nanozyme therapies according to asthma endotypes. These findings establish nanozymes as a transformational and therapeutically promising platform for next-generation asthma treatment. Full article

Rapid growth in fossil-fuel consumption has amplified the severity of global climate issues, making the deployment of renewable energy solutions increasingly imperative. Among candidate approaches, adsorption-based technologies are attractive; however, the limited adsorption capacity and kinetic performance of traditional adsorbents constrain composite-cycle efficiency and hinder large-scale implementation. In this work, we develop and evaluate a new class of composite adsorbents prepared by impregnating metal–organic frameworks (MOFs) with hygroscopic chloride salt solutions (LiCl, CaCl₂, and MgCl₂). Owing to their enhanced sorption characteristics, the resulting materials support an integrated adsorption cycle in which one device can simultaneously realize refrigeration, space heating, seawater desalination, and power generation. Under standard operating conditions, experiments demonstrate that MOF–vermiculite composites deliver a cooling coefficient of performance (COP) of 0.71, a heating COP (COP_h) of 1.30, a specific power-generation output of 27.2 kJ/kg, and a desalination yield of 0.71 g/g. Collectively, these metrics outperform the majority of previously published results, indicating that composite adsorbents can substantially improve the efficiency and practicality of renewable energy conversion systems. Full article

Cyclin-dependent kinase 1 (CDK1) is frequently upregulated in multiple cancers and plays a central role in cell cycle progression and tumorigenesis. However, whether CDK1 directly regulates the histone acetyltransferase KAT8 (also known as MOF) in non-small cell lung cancer (NSCLC) remains unclear. Here, we identify CDK1 as a kinase that directly interacts with and phosphorylates KAT8 at serine 348 (S348) and threonine 418 (T418). Mechanistically, CDK1-mediated phosphorylation, particularly at S348, enhances the interaction between KAT8 and MSL1, thereby stabilizing the MSL complex and promoting KAT8-dependent acetylation of histone H4 at lysine 16 (H4K16). Functionally, the phosphorylation-deficient mutant KAT8-S348A exhibits impaired MSL complex assembly, reduced H4K16 acetylation, and decreased NSCLC cell proliferation both in vitro and in vivo. Pharmacological inhibition of CDK1 using RO-3306 suppresses KAT8 phosphorylation and H4K16 acetylation, leading to significant tumor growth inhibition. Notably, this effect is partially rescued by re-expression of wild-type KAT8 but not by the S348A mutant, supporting a phosphorylation-dependent mechanism. Collectively, these findings define a CDK1–KAT8 signaling axis that promotes NSCLC proliferation through epigenetic regulation and suggest that targeting CDK1-dependent KAT8 phosphorylation may represent a potential therapeutic strategy for lung cancer. Full article

Metal–organic frameworks (MOFs) show great potential for post-combustion carbon capture, yet their practical application is often constrained by challenges such as powder handling difficulties, limited structural stability during shaping processes, and performance degradation under high-humidity conditions. In this study, Mg-gallate was structured into millimeter-sized Mg-gallate/CA composite beads via the ionotropic gelation method, and then a hydrophobic layer of vinyltrimethoxysilane (VTMS) was constructed on the bead surface by chemical vapor deposition. The synthesized Mg-gallate/CA and V-Mg-gallate/CA are characterized by XRD, FT-IR, and other techniques, and their CO₂ adsorption behavior, adsorption–desorption kinetics, breakthrough performance, and cyclic stability are systematically evaluated. At 298 K and 0.1 bar, the CO₂ adsorption capacity of Mg-gallate/CA reached 94.2% of that of Mg-gallate powder. The microporous–microporous hierarchical structure constructed by the ionotropic gelation method improved the CO₂ capture efficiency of the composite beads by 16.7% at 0.1 bar. V-Mg-gallate/CA maintained a high dynamic CO₂ adsorption capacity of 2.87 mmol/g for a 10 vol.% CO₂/90 vol.% N₂ gas mixture at 298 K under 80% RH, corresponding to 2.04 times the capacity of Mg-gallate/CA, and retained 98.8% of its initial adsorption capacity at 0.1 bar after 10 cycles. Combining ionotropic gelation shaping with surface hydrophobic modification represents an effective strategy for developing MOF-based adsorbents suitable for post-combustion CO₂ capture. Full article

Metal-organic frameworks (MOFs), particularly ELM-11, are promising sorbents for CO₂ capture due to their gate-opening phenomenon and excellent reusability. Since actual exhaust gases contain impurities such as NO₂, in this study, the effect of NO₂ on the CO₂ sorption performance of ELM-11 was investigated. ELM-11 was exposed to 1000 ppm NO₂ for varying durations, ranging from short to long, and subsequent CO₂ sorption was evaluated using several methods: gravimetric analysis (TG-DTA), volumetric analysis (sorption isotherms), FT-IR spectroscopy (to detect chemical bond changes), TG-MS (to analyze decomposition products), and PXRD (to observe structural changes). The TG-DTA results indicated that long-term NO₂ exposure (e.g., 20 h) generally reduced CO₂ sorption, whereas short-term exposure (3 h) could enhance it. This finding was supported by volumetric sorption isotherm measurements. FT-IR and TG-MS analyses revealed that NO₂ underwent both physical and chemical sorption in small amounts, with chemical sorption occurring through reactions with Cu²⁺ ions. Consequently, 20 h of NO₂ exposure resulted in approximately a 6 or 10% reduction in CO₂ recovery capacity. However, since the degradation was only 6 or 10% despite exposure to a relatively high concentration of NO₂ (1000 ppm), these results suggest that ELM-11 exhibits high resistance to NO₂, making it suitable for practical applications. Full article

Minimally invasive thread lifting has emerged as an effective strategy for soft tissue repositioning and facial rejuvenation; however, currently used absorbable threads generally lack intrinsic antimicrobial functionality, which may increase the risk of postoperative infection. Here, we report a biodegradable antibacterial lifting thread based on a nanocellulose/MOF composite system. The thread was fabricated via a green wet-spinning strategy using carboxymethylated cellulose nanofibrils (CCNF, prepared with cellulose derived from Astragalus residue) and sodium alginate (SA) as the structural matrix, while tetracycline hydrochloride-loaded ZIF-8 nanoparticles were incorporated to provide sustained antibacterial activity. The resulting antibacterial CCNF/SA thread (AB-CCNF/SA) exhibited a uniform morphology and a tensile strength of 80 MPa. The porous ZIF-8 carriers enabled efficient drug loading and controlled release, providing effective antibacterial activity against Staphylococcus aureus and Escherichia coli. Meanwhile, the composite threads showed favorable biodegradability, with approximately 45% degradation within 56 days, together with excellent cytocompatibility as demonstrated by fibroblast viability above 90%. In vivo studies further revealed inflammatory responses comparable to those of commercial collagen threads, confirming the good biocompatibility of the system. Overall, this work establishes a strategy for integrating nanocellulose structural materials with MOF-enabled antibacterial drug delivery, providing a multifunctional platform that combines mechanical support, biodegradability, and sustained antibacterial activity for minimally invasive soft tissue lifting and related biomedical implant applications. Full article