465 Results Found

Background: The infiltration of inflammatory cells during a kidney injury stimulates myofibroblast activation leading to kidney fibrosis. Fibroblast-specific protein 1 (FSP-1) positive cells have been reported as either myofibroblasts or monocytes du...

Background/Objectives: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and holds promise as a therapeutic strategy against cancers with elevated iron metabolism. However, many tumors evade ferroptosis throug...

Ferroptosis suppressor protein 1 (FSP1) has emerged as a critical regulator of ferroptosis, an iron-dependent form of programmed cell death with significant therapeutic potential in cancer treatment. Despite rapidly expanding research, current knowle...

Non-alcoholic fatty liver disease (NAFLD) can progress from steatosis to non-alcoholic steatohepatitis (NASH) characterized by liver inflammation, possibly leading to cirrhosis and hepatocellular carcinoma (HCC). Mice with impaired macrophage activat...

The article presents the results of tests of the tribological properties of a bearing alloy on a tin matrix (B89) after surface modification by means of friction stir processing (FSP) with a Whorl tool. The samples were processed using two tool speed...

Background: Primary lung cancer is among the cancers with the poorest prognosis, having the highest mortality rate among men and the second highest among women in Japan. While surgery is the primary treatment, advanced stages often require pharmacoth...

This present study investigated the impact of incorporating boron nitride (BN) and vanadium carbide (VC) reinforcements on various properties of friction stir processed (FSP) AA6061 alloy composites, focusing specifically on grain structure, thermal...

Ferroptosis has emerged as a promising therapeutic strategy for drug-resistant cancers; however, the molecular mechanisms governing ferroptosis susceptibility in breast cancer remain poorly defined. Here, we have investigated distinct ferroptosis res...

Background: Hepatocellular carcinoma (HCC), currently ranking as the third most lethal malignancy, poses a grave threat to human health. Ferroptosis, a form of programmed cell demise, has emerged as a promising therapeutic target in HCC treatment. In...

The large originator pharmaceutical companies need more and more new compounds for their molecule banks, because high throughput screening (HTS) is still a widely used method to find new hits in the course of the lead discovery. In the design and syn...

Numerous studies over three decades have confirmed the significant role of S100A4/FSP1 in the development of metastasis, the formation of the cellular and inflammatory components of the tumor microenvironment, and the development of fibrosis. S100A4...

In this study, Scenedesmus sp. FSP3 was cultured using a two-stage culture strategy for CO₂ fixation and lutein production. During the first stage, propylene carbonate was added to the medium, with 5% CO₂ introduced to promote the rapid growth and CO...

This work investigates the impact of friction stir processing (FSP) on the microstructure and mechanical characteristics of AA 6061 alloy and its composites, which are strengthened with boron nitride nanoparticles and vanadium carbide microparticles....

The use of a novel chrono-potentiometry method (abbreviated as “CP”) in the determination of the moisture content in wood (abbreviated as “MC”) above the FSP is a practical application of the electrical charging effect (or ECE...

The ceramic particle reinforcement process is one of the most utilized techniques to enhance the metal surface. The current investigation uses vanadium and niobium carbides to reinforce the AA6061 alloy using the friction stir process (FSP). The mech...

Human osteosarcoma (OS) is a rare tumor predominantly affecting long bones and characterized by a poor prognosis. Currently, the first line of intervention consists of the surgical resection of primary tumors combined with radiotherapy and chemothera...

Powdery mildew disease caused by Blumeria graminis f.sp. tritici (Bgt) leads to severe economic losses in bread wheat (Triticum aestivum L.). To date, only a few epigenetic modulators have been revealed to regulate wheat powdery mildew resistance. In...

Ferroptosis, a recently identified form of regulated cell death characterized by the iron-dependent accumulation of lethal lipid peroxidation, has gained increasing attention in cancer therapy. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiq...

Noble metal-TiO₂ nanohybrids, NM⁰-TiO₂, (NM⁰ = Pt⁰, Pd⁰, Au⁰, Ag⁰) have been engineered by One-Nozzle Flame Spray Pyrolysis (ON-FSP) and Double-Nozzle Flame Spray Pyrolysis (DN-FSP), by controlling the method of noble metal deposition to the TiO₂ mat...

This study investigates the impact of friction stir processing (FSP) on the deformation behavior of 1.1 mm-thick DP600 steel sheets under both static and dynamic loading scenarios, with a focus on the automotive applications of the material. During t...

In the present work, an aluminum metal matrix reinforced with (Al₂O₃) nanoparticles was fabricated as a surface composite sheet using friction stir processing (FSP). The effects of processing parameters on mechanical properties, hardness, and microst...

This study examined the impact of hybrid reinforcement particles, specifically zirconium carbide (ZrC) and tungsten carbide (WC), as well as the parameters of friction stir processing (FSP), on the microstructure, mechanical properties, and dynamic b...

Recently, the use of oxide-based nanomaterials for bio-imaging has received great attention owing to their remarkable stabilities as compared to those of conventional organic dyes. Therefore, the development of scalable methods for highly luminescent...

In the current study, a new approach for surface modification and surface hardening of aluminum alloys is developed. The method is based on the logic of in-situ reinforcing FSP strategies. The novelty of the proposed process is the application of a b...

In the present work, Aluminum Metal Matrix Surface Nano Composites (AMMSNCs) were manufactured using Friction Stir Processing (FSP). Moreover, the fabricated surface composite matrix was exposed to a different number of tool passes with different pro...

Friction stir processing (FSP) is a solid-state treating method to enhance the mechanical properties of materials by altering their microstructure. In this study, FSP was applied to the AZ91 magnesium alloy cladding layer prepared using cold metal tr...

Friction Stir Processing (FSP) has emerged as an advanced solid-state surface engineering technique for tailoring high-performance surface architectures in metal matrix composites (MMCs). By combining localized thermo-mechanical deformation with cont...

Although wire arc-directed energy deposition (WA-DED) technology demonstrates advancements in the rapid manufacturing of high-strength Al-Cu aluminum alloy components, coarse microstructures and pore defects inhibit its further development and applic...

The friction welding of tube to tube plate using an external tool (FWTPET) is widely deployed in several industrial applications, such as aerospace, automotive, and power plants. Moreover, for achieving a better tensile strength and hardness in the w...

The oxygen reduction reaction (ORR) is the rate-limiting reaction in the cathode side of fuel cells. In the quest for alternatives to Pt-electrodes as cathodes in ORR, appropriate transition metal oxide-based electrocatalysts are needed. In the prese...

NiAl bronze (NAB) alloy is prepared by using friction stir processing (FSP) technique at a tool rotation rate of 1200 rpm and a traverse speed of 150 mm/min. A post heat treatment is performed at the temperature of 675 °C. The effect of heat treatmen...

Friction stir processing (FSP) is an effective method for incorporating ceramic nanoparticles into metal matrix composites. This study investigated the effects of single and multiple additions of BN, VC, and SiC nanoparticles on the microstructure re...

Traffic signal priority is an operational technique employed for the smooth progression of a specific type of vehicle at signalized intersections. Transit signal priority is the most common type of traffic signal priority, and it has been researched...

Human–machine collaborative manufacturing plays an important role in emerging Industry 5.0 and smart manufacturing. However, addressing the conflict-free human–machine collaborative manufacturing problem (CHMCMP) is extremely challenging...

Exposure to certain chemicals can promote adipogenesis, but less is known about whether exposure to human-relevant chemical mixtures behaves similarly. Chemical concentrations from the serum of mothers enrolled in the Environmental Influences on Chil...

In the present work, we proposed a novel friction stir processing (FSP) to produce a locally reinforced aluminum matrix composite (AMC) by stirring copper-coated SiC particulate reinforcement into Al6061 alloy matrix. Electroless-plating process was...

Cell death-Inducing DNA Fragmentation Factor Alpha (DFFA)-like Effector (CIDE) proteins have emerged as lipid droplet-associated proteins that regulate fat metabolism. There are three members in the CIDE protein family—CIDEA, CIDEB, and CIDEC (...

Studies on Multi-pass Friction Stir Processing (FSP) of Fe_49.5Mn₃₀Co₁₀Cr₁₀C_0.5, a metastable dual-phase High Entropy Alloy (HEA), were carried out with the aim to systematically investigate the microstructural changes occurring during different passe...

Drug leads with a high Fsp³ index are more likely to possess desirable properties for progression in the drug development pipeline. This paper describes the development of an efficient two-step protocol to completely diastereoselectively access a die...

Flame spray pyrolysis (FSP) is an industrially scalable technology that enables the engineering of a wide range of metal-based nanomaterials with tailored properties nanoparticles. In the present review, we discuss the recent state-of-the-art advance...

In the study, the friction stir processing (FSP) method was used to modify the surface layer of a tin-based bearing alloy. The modification was aimed at extending the service life of bearings by improving their tribological properties. The results of...

The ductility enhancement of an AA7075 aluminum alloy aided by a friction stir process (FSP) and various heat treatments was investigated and compared in terms of outcome with full annealing (O). The results indicate that a big improvement in the ten...

The impact strength and surface properties of polymeric materials are of critical importance in various engineering applications. Friction stir processing (FSP) is a novel method for the fabrication of composite materials with superior mechanical pro...

Friction stir processing (FSP) has confirmed its valuable contribution to refining microstructures and the improvement of mechanical properties for Mg-Al alloys. Reference papers illustrate that post-processing aging treatments enhance hardness, but...

The control system’s point is to bring the pumping curve close to the set-point curve. That concept is essential for proper design of a pumping station. An adequate design is focused not only on selecting the total number of pumps and the type of con...

Surface composites are viable choices for various applications in the aerospace and automotive industries. Friction Stir Processing (FSP) is a promising method for fabricating surface composites. Aluminum Hybrid Surface Composites (AHSC) are fabricat...

Drug leads with a high Fsp³ index are more likely to possess desirable properties for progression in the drug development pipeline. This paper describes the first detailed NMR analysis of the borylated intermediate 3-deoxy-3-boronodiethanolamine-1,2:...

ABO₃ perovskites offer versatile photoactive nano-templates that can be optimized towards specific technologies, either by means of doping or via heterojunction engineering. SrTiO₃ is a well-studied perovskite photocatalyst, with a highly reducing co...

Friction stir welding and processing (FSW/FSP) involves severe plastic deformation of metals or polymers at high temperature around a rotating tool. The material’s flow is usually modelled by FEM using a complex combination of thermomechanical...

Gastric cancer is one of the most common cancers worldwide, and new therapeutic strategies are urgently needed. Ferroptosis is an intracellular iron-dependent cell death induced by the accumulation of lipid peroxidation, a mechanism different from co...