Search Results (145)

South Africa has relatively recently transitioned from a condition of legislated racial stratification to a democracy in which all South Africans now enjoy political enfranchisement. While political emancipation has been achieved, economic and social emancipation remain elusive for the majority of Black South Africans who still bear the brunt of poverty and deprivation. South Africa’s white colonial communities, having relinquished political power, continue to retain and enjoy economic and social class privileges. Despite state-driven social cohesion and nation-building initiatives, the envisaged ‘rainbow nation’ (a metaphor coined by the late Archbishop Desmond Tutu) is becoming an increasingly fragile social aspiration. Historical legacies, especially regarding white affirmation, wealth accumulation, and the imperative for economic redistribution and land reform, have become key flashpoints in contemporary South Africa. This paper addresses the issue of how South Africa’s corrective justice and affirmative action policies are re-racialised into narratives of reverse racism, white persecution, and white genocide. It examines how racial arbitrage works where whiteness is systematically re-racialised and traded for its value in a different country context. It examines how disillusioned white South Africans leverage white racial and class privilege for transnational mobility and protections, white settler-colonial receptivity and white nationhood. It draws attention to the tensions and contradictions in global asylum regimes, illuminating transnational networks of privilege and economic superpower coercion. Full article

Since the end of Apartheid in 1994, South Africa has striven to address past discrimination against members of marginalized groups such as Africans, women and LGBTQ+ individuals. Sophisticated media legislation and a vibrant civil society forged in the struggle against Apartheid ensure limited discrimination in traditional media and relatively fringe online forums. However, subtle forms of undermining signal the persistent legacy of a colonial and patriarchal past. While incidents of online racism and sexism are relatively well documented, ableism deserves more attention. Despite growing scholarship on digital discrimination, a significant research gap remains in understanding how ableist microaggressions manifest online, particularly when intersecting with race and gender. As a result of established media tropes, microaggressions against people with disabilities are somewhat naturalized and reproduced on social media, yet their intersectional dimensions—especially targeting Black women with disabilities—remain underexplored. This paper addresses this gap through a focused case study of jokes targeting Black women with disabilities in one TikTok video and the approximately 700 comments. Considering (dis)ability’s intersections with race, gender, and socio-economic status, these media texts are subjected to a critical thematic analysis. The study also problematizes the methodological challenges associated with finding, identifying, and purposively selecting such content. The analysis reveals a set of historically and contextually rooted microaggressions expressed through humor, which, as a cultural expression, is inherently covert and thus hard to detect and regulate. This research contributes to understanding how intersectional ableism operates digitally and highlights the need for nuanced approaches to identifying subtle forms of discrimination in online spaces. Full article

Physiologically based pharmacokinetic (PBPK) models allow to simulate the behaviour of compounds in diverse physiological populations. However, the categorization of individuals into distinct populations raises questions regarding the classification criteria. In previous research, simulations of the pharmacokinetics of the mycotoxin aflatoxin B1 (AFB1), were performed in the black South African population, using PBPK modeling. This study investigates the prevalence of clinical CYP450 phenotypes (CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4/5) across Sub-Saharan Africa (SSA), to determine the feasibility of defining SSA as a single population. SSA was subdivided into Central, East, South and West Africa. The phenotype data were assigned to the different regions and a fifth SSA group was composed of all regions’ weighted means. Available data from literature only covered 7.30% of Central, 56.9% of East, 38.9% of South and 62.9% of West Africa, clearly indicating critical data gaps. A pairwise proportion test was performed between the regions on enzyme phenotype data. When achieving statistical significance (p < 0.05), a Cohen’s d-test was performed to determine the degree of the difference. Next, per region populations were built using SimCYP starting from the available SSA based SouthAfrican_Population FW_Custom population, supplemented with the phenotype data from literature. Simulations were performed using CYP probe substrates in all populations, and derived PK parameters (C_max, T_max, AUC_ss and CL) were plotted in bar charts. Significant differences between the African regions regarding CYP450 phenotype frequencies were shown for CYP2B6, CYP2C19 and CYP2D6. Limited regional data challenge the representation of SSA populations in these models. The scarce availability of in vivo data for SSA regions restricted the ability to fully validate the developed PBPK populations. However, observed literature data from specific SSA regions provided partial validation, indicating that SSA populations should ideally be modelled at a regional level rather than as a single entity. The findings, emerging from the initial AFB1-focused PBPK work, underscore the need for more extensive and region-specific data to enhance model accuracy and predictive value across SSA. Full article

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global public health challenge with a significant impact on human life. The current study aims to provide a comprehensive analysis of the magnitude of dyslipidemia and the factors associated with elevated LDL-C levels among Black South Africans with T2DM. Methods: This was a cross-sectional study conducted in a tertiary hospital. Blood samples for glycated hemoglobin (HbA1c) and lipid profile were collected from the study participants and analyzed using Siemens Atellica™ analyzer. The data was entered into Microsoft excel and analyzed using SPSS version 24. Bivariate and multivariate logistic regression was employed to identify variables significantly associated with the outcomes, with a p-value  ≤  0.05 and a 95% confidence interval. Results: A total of 194 study participants with T2DM were recruited in the study. The overall prevalence of dyslipidemia was 90.72%. Of those with dyslipidemia, 40.9% had an isolated dyslipidemia, 39.7% had a combined dyslipidemia and 19.3% had atherogenic dyslipidemia. Significant factors associated with elevated levels of LDL-C included age, non-adherence to treatment (NAT) and duration. However, after multivariate analysis, NAT was found to be an independent associated factor with elevated levels of LDL-C (AOR: 4.596; 95% CI: 0.177–2.874; p = 0.027). Conclusions: Our study found that dyslipidemia is highly prevalent among Black South African patients with T2DM at a tertiary hospital, despite the use of lipid-lowering therapy. NAT was significantly associated with elevated levels of LDL-C. However, it is important to note that the study employed a cross-sectional design, conducted at a single hospital, which may impair the generalizability of the findings. Full article

Mamba (Dendroaspis species) snakebites are critical medical emergencies across sub-Saharan Africa. Envenomings can result in the rapid onset of complex neurotoxic symptoms, often leading to high rates of mortality without timely intervention with antivenom. The ancestral state of mambas is the green coloured, forest dwelling type, with the tan/grey coloured, savannah dwelling D. polylepis (Black Mamba) representing a derived state both ecologically and morphologically. However, it has not been tested whether these changes are paralleled by changes in venom biochemistry or if there are differential molecular evolutionary patterns. To fill these knowledge gaps, this study evaluated the neurotoxic effects of all Dendroaspis species venoms using the chick biventer cervicis nerve-muscle preparation, assessed the neutralizing efficacy of three antivenoms commercially available in Africa, and reconstructed the molecular evolutionary history of the toxin types to ascertain whether some were unique to particular species. All Dendroaspis venoms demonstrated potent flaccid-paralysis due to postsynaptic neurotoxicity. The only exception was D. angusticeps venom, which conversely exhibited spastic-paralysis due to presynaptic/synaptic neurotoxicity characterised by potentiation of acetylcholine presynaptic release and sustained synaptic activity of this neurotransmitter. Antivenom efficacy varied significantly. All three antivenoms neutralized to some degree the flaccid-paralysis postsynaptic effects for all species, with D. viridis venom being the best neutralized, and this pattern extended to all the antivenoms. However, neutralisation of flaccid-paralysis postsynaptic effects unmasked spastic-paralysis presynaptic/synaptic neurotoxicity within non-angusticeps venoms. Spastic-paralysis presynaptic effects were poorly neutralized for all species by all antivenoms, consistent with prior clinical reports of poor neutralisation of spastic-paralytic effects. Geographic variation in D. polylepis venom was evident for the relative neutralisation of both spastic-paralysis presynaptic/synaptic and flaccid-paralysis postsynaptic/synaptic neurotoxic pathophysiological effects, with differential neutralization capabilities noted between the Kenyan and South African populations studied. Molecular phylogenetic analyses confirmed spastic-paralysis and flaccid- paralysis toxins to be a trait that emerged in the Dendroaspis last common ancestor, with all species sharing all toxin types. Therefore, differences in venoms’ pathophysiological actions between species are due to differential expression of toxin isoforms rather than the evolution of species-specific novel toxins. Our findings highlight the synergistic nature of flaccid-paralysis postsynaptic and spastic-paralysis presynaptic/synaptic toxins, while contributing significant clinical and evolutionary knowledge of Dendroaspis venoms. These data are crucial for the continued development of more effective therapeutic interventions to improve clinical outcomes and for evidence-based design of clinical management strategies for the envenomed patient. Full article

This article examines the xenophobic orientation of social media reactions, as captured in mainstream South African media, around the Miss South Africa 2024 case of Chidimma Adetshina. It will perform a decolonial interrogation of the South African digital public’s reaction to Adetshina’s participation in and eligibility for the pageant. It will also unpack how xenophobia—defined as the fear or hatred of foreigners—is evident in the backlash that encapsulated Adetshina’s story. The xenophobic utterances that circulated on social media platforms such as X and across different digital media outlets suggest an intriguing intra-black component that is intertwined with the three dimensions of coloniality: power, knowledge and being. The concept of coloniality is understood as the lingering impact of inequalities and power dynamics resulting from the colonial encounter long after the end of administrative and historical colonialism and serves as this article’s theoretical framework. It draws on the work of several decolonial scholars to identify and explore how coloniality presents itself in the Adetshina case. The research objectives are to examine how xenophobic sentiments reflect the coloniality of power, knowledge and, specifically, the coloniality of being. The methodology includes an open, flexible combination of content and textual analysis of online media articles from major news outlets operating within the South African mediasphere. This inquiry found that there is a link between the tension-filled xenophobic reactions to Adetshina’s Miss SA 2024 case and the legacy of exploitation and oppression inherited from South Africa’s still-difficult-to-navigate colonial and apartheid eras. This investigation also found complicated hierarchies between different types of humanity—indicative of the most pervasive dimension, in this case, the coloniality of being. Full article

Background: Recreational running is a globally popular activity known for its physical and mental health benefits, including stress reduction and improved quality of life. However, many recreational runners lack structured guidance, increasing their risk of lower limb injuries, often linked to variations in foot posture. Although African populations are well known for their endurance running abilities, limited research has examined their foot biomechanics and injury risk. This study addresses this gap by investigating foot posture and structure among African male recreational runners in South Africa. Methods: A cross-sectional, quantitative design was employed. Data were collected using structured data collection sheets, capturing demographic information, Foot Posture Index (FPI) scores, and Three-Dimensional (3D) foot scans. FPI provided a clinical evaluation of foot posture, while 3D foot scans delivered precise structural measurements. The aim was to describe and compare the foot posture characteristics and bilateral load distribution patterns in this population, using the Foot Posture Index (FPI) and 3D foot scanning as complementary assessment tools. Results: Findings showed agreement between FPI and 3D foot scan results, with both tools identifying a high prevalence of flexible flat feet among participants. Each method captured unique aspects of foot posture: FPI offered a qualitative overview, while 3D scans provided detailed, quantitative insights. This dual-assessment approach supports the value of using complementary methods in clinical and sports settings. Conclusions: This study suggests that integrating FPI and 3D scanning enhances the accuracy of foot posture assessments. Despite limitations such as a moderate sample size, the findings support personalized clinical interventions and footwear design tailored to the unique biomechanics of Black African male runners. Full article

Refugees are forced to flee their countries of origin due to factors beyond their control, and expect to find safety, peace, freedom, and have their basic needs met. Most engage in entrepreneurial activities to make a living. However, some refugees experience xenophobic attacks in host nations. Guided by the Social Identity Theory (SIT) to explore the phenomenon of xenophobic attacks against refugees in Atteridgeville, South Africa, this paper describes the factors contributing to xenophobic attacks against them. Participants were selected using the snowball sampling technique. Data were collected from 10 refugee entrepreneurs using one-on-one interviews guided by a semi-structured interview schedule. Data were analysed using thematic data analysis. The findings revealed the political and socio-economic factors behind the refugees’ exodus from their country of origin. In trying to better their lives, refugees encounter several bureaucratic challenges when formalising their asylum and refugee status in South Africa. The study established that xenophobic attacks on refugee entrepreneurs were influenced by numerous factors, including jealousy, hatred of foreigners, unemployment, and lack of job opportunities for young black South Africans. In addition, poverty and crime were identified as factors responsible for exacerbating xenophobic attacks. Based on the findings of this study, the social work profession has a pellucid and pivotal role to play in addressing the individual, group, community, systemic, institutional, and structural level factors responsible for xenophobic attacks on refugee entrepreneurs in Atteridgeville. The study recommends that further studies focus on designing multi-disciplinary and multi-sectoral measures for addressing xenophobic attacks against refugee entrepreneurs. Full article

This paper argues that Black women are represented in online political advertisements during South African election campaigns. Through the qualitative online research approach, this paper deploys a purposive sample of 30 online political advertisements of the African National Congress (ANC), Democratic Alliance (DA), and Economic Freedom Fighters (EFF) from the national, provincial, and local government 2009 and 2024 elections cycles. This paper deploys an Africana Womanist Approach as both a theoretical and analytical framework to interrogate underlying visual rhetoric concerning how Black women are depicted in the sampled online political advertisements, particularly in the framework of post-apartheid South Africa. Findings revealed that Black women are consistently portrayed in the ANC, DA, and EFF advertisements as maternal figures, labourers, marginalised individuals, and iconic of anti-apartheid activists’ inequality since the 1994 transition. Nevertheless, it was also found that Black women continue to be seen as emblems of poverty and underdevelopment, despite the political promises of change. This paper advances understanding as to how perspectives on Africana women shape the visual framing of political messages in the South Africa online campaign environment, demonstrating how these representations can be aligned to produce cultural and political communication strategies. Full article

The violent dispossession of land in South Africa disrupted more than just homes—it severed Black South Africans from a sacred, ancestral connection to land as a source of identity, belonging, and spiritual dwelling. This article examines how forced removals displaced not only bodies but also histories, memories, and the deep-rooted sense of ikhaya (home). Rooted in the concept of endleleni (being on the road/along the road), this study explores how amaXhosa navigate the in-between journey of landlessness and homecoming. Using indigenous storytelling methodology, it reveals how land is not merely for shelter or sustenance but is intricately tied to birth, the umbilical cord, and death, making its reclamation a fight for existence itself. Full article

Rivers are recognized as significant pathways and transportation for microplastics (MPs), an emerging contaminant, to aquatic environments. However, there is limited evidence on how riverine reservoirs influence MPs transport. To fill this gap and provide baseline empirical data and insights to South African context, the current study assessed the seasonal variation in MP densities from sediments collected upstream, within the reservoir, and downstream of the Vondo Reservoir along the Mutshindudi River. We hypothesised that MP densities would be highest within the reservoir, due to the lack of constant flow that would otherwise transport accumulated particles downriver. Additionally, we expected the cool–dry season to be associated with the highest MP densities. As expected, high MP densities were observed within the reservoir (117.38–277.46 particles kg⁻¹ dwt) when compared to the downstream (72.63–141.50 particles kg⁻¹ dwt) and upstream (28.81–91.63 particles kg⁻¹ dwt) sites of the reservoir. The cool–dry season (91.63–277.46 particles kg⁻¹ dwt) exhibited the highest MP densities compared to the hot–wet season (28.81–141.50 particles kg⁻¹ dwt). However, MP densities downstream the reservoir were higher during the hot–wet season (141.50 ± 24.34 particles kg⁻¹ dwt) compared to the cool–dry season (72.63 ± 48.85 particles kg⁻¹ dwt). The most dominant MP particles identified were white, transparent, and black fibres/filaments composed primarily of polypropylene (PP) and polyethylene (PE). This suggests diverse sources of MP particles. No significant correlations were found between water parameters and MP densities across sampling sites and seasons, indicating a widespread and context-independent presence of MPs. These findings contribute to MP studies in freshwater environments and further reinforce the role of sediments as sink for MPs and suggest that riverine reservoirs similar to dams can trap MPs, which may then be remobilized downstream during high-flow periods. Importantly, the results of this study can support local municipalities in implementing targeted plastic pollution mitigation strategies and public awareness campaigns, particularly because the Vondo Reservoir serves as a critical water resource for surrounding communities. Full article

Background: Hypertensive disorders of pregnancy (HDPs) are a major cause of maternal morbidity and mortality worldwide. Very little progress has been made in reducing HDP-related maternal deaths in low- and middle-income countries (LMICs), including South Africa, over the past decade. Aim: The aim of this study was to describe maternal deaths arising from HDPs at tertiary/quaternary hospital in Johannesburg, South Africa, with specific focus on maternal characteristics, management, timing of death, causes, and avoidable factors and to use the information to inform clinical practice. Methods: We conducted a retrospective review of patient clinical records covering the period 1 January 2015 to 31 December 2018. Data on maternal demographic and pregnancy characteristics, management, causes, and timing of death were extracted from the clinical records and transferred into a Microsoft Excel^® Spreadsheet and analysed using descriptive statistics. Results: During the study period, 70 maternal deaths were recorded, of which 23 (32.8%) were due to HDP-related complications. The majority of the maternal deaths, 20 (86.9%), occurred during the postpartum period, predominantly affecting Black African women, 23 (100%), with a median age of 27 years. Notably, 18 (78.2%) of the deceased had booked early and attended antenatal care (ANC). Eclampsia emerged as the most common final cause of death. Key avoidable factors included non-adherence to established protocols, particularly failure to initiate aspirin prophylaxis in at-risk women, as well as incorrect or inadequate administration of antihypertensive therapy and magnesium sulphate (MgSO₄) prophylaxis. Conclusions: HDP-related maternal deaths are largely preventable. They primarily result from poor quality of care due to a lack of adherence to evidence-based protocol. Full article

Participation in science, technology, engineering, and mathematics (STEM) fields is crucial, as these fields present an opportunity for individuals to overcome socio-economic adversities such as unemployment and poverty. In South Africa, access to STEM education has improved in recent years, partly due to the availability of study grants for learners interested in these fields. However, evidence shows that women remain underrepresented in STEM fields. Gender stereotypes, bullying, and pay disparities are cited as some of the contributing factors. Despite these overwhelming challenges, female learners are increasingly pursuing STEM education. Guided by the resilience theory, we explored the factors motivating female learners to enroll in STEM fields at a public secondary school level in South Africa. The research adopted the snowball sampling technique to recruit learners attending a public secondary school in South Africa. Due to COVID-19-related restrictions in 2022, the research data was collected through telephonic one-on-one interviews. The findings revealed that access to competitive employment opportunities, impactful careers, personal growth, and financial independence were some factors sparking the female learners’ interest in STEM. However, the learners experienced gender stereotypes and discrimination, which made them doubt their abilities to thrive in STEM education/fields. To cope with the complexities of STEM, the learners relied on their caregivers for emotional support, and they attended extra lessons and tutorials offered by the education system. The findings highlight the need for the government to prioritize support programs for female learners who must continuously fight rejection in STEM fields. Full article

Background and Objectives: Growing evidence suggests a strong relationship between hypertension and cancer, which can increase the risk of poor prognosis. However, data regarding mortality related to cancer and hypertension are limited. Our study aims to analyze the mortality trends related to cancer and hypertension in the United States from 1999 to 2023. Materials and Methods: A retrospective observational analysis was conducted using mortality data for the adult U.S. population from 1999 to 2023, retrieved from the CDC WONDER database using death certificates. Age-adjusted mortality rates (AAMRs) were calculated, and annual percentage changes (APCs) were analyzed using JoinPoint Regression. Results: From 1999 to 2023, a total of 1,406,107 deaths related to cancer and hypertension were recorded in the United States. The AAMR increased from 12.59 in 1999 to 35.49 in 2023. Males had a higher mortality rate compared to women throughout the study period (AAMR; 30.3 vs. 20.4). Non-Hispanic (NH) Black Americans, or African Americans had the highest mortality rates, followed by NH white, Hispanic or Latino groups, and other NH groups. The highest AAMR was observed in the South, followed by the Midwest, the Northeast, and the West. Rural areas had higher mortality rates compared to urban areas. Conclusions: Cancer- and hypertension-related mortality rates have consistently increased in the United States from 1999 to 2023, particularly affecting males, NH Black Americans, the southern region, and rural areas. The trends highlight the need for targeted prevention, including early screening, lifestyle changes, and treatment adherence. Full article

The stigma and invisibility surrounding mental health often lead to alienation and reinforce societal misconceptions. This paper examines how the concept of inxeba elingaphakathi (the invisible wound) in isiXhosa encapsulates the emotional and psychological pain frequently overlooked in mental health discussions, particularly among Black South African women. Employing an Indigenous storytelling methodology, the study explores how social community caregiving can illuminate these hidden wounds and challenge prevailing stigma. By analyzing the societal factors shaping mental health perceptions, this research advocates for a culturally grounded approach to healing and belonging. Full article