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15 pages, 7923 KiB  
Technical Note
Recent Active Wildland Fires Related to Rossby Wave Breaking (RWB) in Alaska
by Hiroshi Hayasaka
Remote Sens. 2025, 17(15), 2719; https://doi.org/10.3390/rs17152719 - 6 Aug 2025
Abstract
Wildland fires are a common and destructive natural disaster in Alaska. Recent active fires in Alaska were assessed and analysed for their associated synoptic-scale climatic conditions in this study. Hotspot (HS) data from satellite observations over the past 20 years since 2004 (total [...] Read more.
Wildland fires are a common and destructive natural disaster in Alaska. Recent active fires in Alaska were assessed and analysed for their associated synoptic-scale climatic conditions in this study. Hotspot (HS) data from satellite observations over the past 20 years since 2004 (total number of HS = 300,988) were used to identify active fire-periods, and the occurrence of Rossby wave breaking (RWB) was examined using various weather maps. Analysis results show that there are 13 active fire-periods of which 7 active fire-periods are related to RWB. The total number of HSs during the seven RWB-related fire-periods was 164,422, indicating that about half (54.6%) of the recent fires in Alaska occurred under fire weather conditions related to RWB. During the RWB-related fire-periods, two hotspot peaks with different wind directions occurred. At the first hotspot peak, southwesterly wind blew from high-pressure systems in the Gulf of Alaska. In the second hotspot peak, the Beaufort Sea High (BSH) supplied strong easterly wind into Interior Alaska. It was suggested that changes in wind direction during active fire-period and continuously blowing winds from BSH may affect fire propagation. It is hoped that this study will stimulate further research into active fires related to RWBs in Alaska. Full article
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24 pages, 8377 KiB  
Article
Investigation of Wind Pressure Dynamics on Low-Rise Buildings in Sand-Laden Wind Environments
by Di Hu, Teng Zhang and Qiang Jin
Buildings 2025, 15(15), 2779; https://doi.org/10.3390/buildings15152779 - 6 Aug 2025
Abstract
To enhance the structural safety in wind-sand regions, this study employs the Euler-Lagrange numerical method to investigate the wind pressure characteristics of typical low-rise auxiliary buildings in a strong wind-blown sand environment. The results reveal that sand particle motion dissipates wind energy, leading [...] Read more.
To enhance the structural safety in wind-sand regions, this study employs the Euler-Lagrange numerical method to investigate the wind pressure characteristics of typical low-rise auxiliary buildings in a strong wind-blown sand environment. The results reveal that sand particle motion dissipates wind energy, leading to a slight reduction in average wind speed, while the increase in small-scale vortex energy enhances fluctuating wind speed. In the sand-laden wind field, the average wind pressure coefficient shows no significant change, whereas the fluctuating wind pressure coefficient increases markedly, particularly in the windward region of the building. Analysis of the skewness and kurtosis of wind pressure reveals that the non-Gaussian characteristics of wind pressure are amplified in the sand-laden wind, thereby elevating the risk of damage to the building envelope. Consequently, it is recommended that the design fluctuating wind load for envelopes and components of low-rise buildings in wind-sand regions be increased by 10% to enhance structural resilience. Full article
(This article belongs to the Section Building Structures)
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40 pages, 87429 KiB  
Article
Optimizing Urban Mobility Through Complex Network Analysis and Big Data from Smart Cards
by Li Sun, Negin Ashrafi and Maryam Pishgar
IoT 2025, 6(3), 44; https://doi.org/10.3390/iot6030044 - 6 Aug 2025
Abstract
Urban public transportation systems face increasing pressure from shifting travel patterns, rising peak-hour demand, and the need for equitable and resilient service delivery. While complex network theory has been widely applied to analyze transit systems, limited attention has been paid to behavioral segmentation [...] Read more.
Urban public transportation systems face increasing pressure from shifting travel patterns, rising peak-hour demand, and the need for equitable and resilient service delivery. While complex network theory has been widely applied to analyze transit systems, limited attention has been paid to behavioral segmentation within such networks. This study introduces a frequency-based framework that differentiates high-frequency (HF) and low-frequency (LF) passengers to examine how distinct user groups shape network structure, congestion vulnerability, and robustness. Using over 20 million smart-card records from Beijing’s multimodal transit system, we construct and analyze directed weighted networks for HF and LF users, integrating topological metrics, temporal comparisons, and community detection. Results reveal that HF networks are densely connected but structurally fragile, exhibiting lower modularity and significantly greater efficiency loss during peak periods. In contrast, LF networks are more spatially dispersed yet resilient, maintaining stronger intracommunity stability. Peak-hour simulation shows a 70% drop in efficiency and a 99% decrease in clustering, with HF networks experiencing higher vulnerability. Based on these findings, we propose differentiated policy strategies for each user group and outline a future optimization framework constrained by budget and equity considerations. This study contributes a scalable, data-driven approach to integrating passenger behavior with network science, offering actionable insights for resilient and inclusive transit planning. Full article
(This article belongs to the Special Issue IoT-Driven Smart Cities)
11 pages, 671 KiB  
Article
Impact of Mattress Use on Sacral Interface Pressure in Community-Dwelling Older Adults
by Hye Young Lee, In Sun Jang, Jung Eun Hong, Je Hyun Kim and Seungmi Park
Geriatrics 2025, 10(4), 107; https://doi.org/10.3390/geriatrics10040107 - 6 Aug 2025
Abstract
Background/Objectives: Pressure injuries are a significant concern among older adults, particularly in community-based long-term care settings where prolonged immobility is prevalent. This study aimed to identify factors influencing sacral interface pressure in community-dwelling older adults, with an emphasis on support surface usage and [...] Read more.
Background/Objectives: Pressure injuries are a significant concern among older adults, particularly in community-based long-term care settings where prolonged immobility is prevalent. This study aimed to identify factors influencing sacral interface pressure in community-dwelling older adults, with an emphasis on support surface usage and clinical risk indicators. Methods: A total of 210 participants aged 65 years and older, all receiving long-term care services in South Korea, were enrolled in this study. Sacral interface pressure was measured in the supine position using a portable pressure mapping device (Palm Q7). General characteristics, Braden Scale scores, Huhn Scale scores, and mattress usage were assessed. Data were analyzed using descriptive statistics, t-tests, chi-square tests, and logistic regression. Results: Mattress non-use was identified as the strongest predictor of elevated sacral interface pressure (OR = 6.71, p < 0.001), followed by Braden Scale scores indicating moderate risk (OR = 4.8, p = 0.006). Huhn Scale scores were not significantly associated with interface pressure. These results suggest that support surface quality and skin condition have a stronger impact on interface pressure than mobility-related risk factors. Conclusions: The findings highlight the importance of providing high-quality pressure-relieving mattresses and implementing standardized nursing assessments to reduce the risk of pressure injuries. Integrating smart technologies and expanding access to advanced support surfaces may aid in developing tailored preventive strategies for vulnerable older adults. Full article
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16 pages, 2899 KiB  
Article
The Coupling Mechanism of the Electricity–Gas System and Assessment of Attack Resistance Based on Interdependent Networks
by Qingyu Zou and Lin Yan
Eng 2025, 6(8), 193; https://doi.org/10.3390/eng6080193 - 6 Aug 2025
Abstract
Natural gas plays a critical role in integrated energy systems. In this context, the present study proposes an optimization model for the electricity–gas coupling system, grounded in the theory of interdependent networks. By integrating network topology parameters with real-time operational metrics, the model [...] Read more.
Natural gas plays a critical role in integrated energy systems. In this context, the present study proposes an optimization model for the electricity–gas coupling system, grounded in the theory of interdependent networks. By integrating network topology parameters with real-time operational metrics, the model substantially enhances system robustness and adaptability. To quantify nodal vulnerability and importance, the study introduces two novel evaluation indicators: the Electric Potential–Closeness Fusion Indicator (EPFI) for power networks and the Pressure Difference–Closeness Comprehensive Indicator (PDCI) for natural gas systems. Leveraging these indicators, three coupling paradigms—assortative, disassortative, and random—are systematically constructed and analyzed. System resilience is assessed through simulation experiments incorporating three attack strategies: degree-based, betweenness centrality-based, and random node removal. Evaluation metrics include network efficiency and the variation in the size of the largest connected subgraph under different coupling configurations. The proposed framework is validated using a hybrid case study that combines the IEEE 118-node electricity network with a 20-node Belgian natural gas system, operating under a unidirectional gas-to-electricity energy flow model. Results confirm that the disassortative coupling configuration, based on EPFI and PDCI indicators, exhibits superior resistance to network perturbations, thereby affirming the effectiveness of the model in improving the robustness of integrated energy systems. Full article
15 pages, 316 KiB  
Article
Evaluation of Diet Quality, Physical Health, and Mental Health Baseline Data from a Wellness Intervention for Individuals Living in Transitional Housing
by Callie Millward, Kyle Lyman, Soonwye Lucero, James D. LeCheminant, Cindy Jenkins, Kristi Strongo, Gregory Snow, Heidi LeBlanc, Lea Palmer and Rickelle Richards
Nutrients 2025, 17(15), 2563; https://doi.org/10.3390/nu17152563 - 6 Aug 2025
Abstract
Background/Objectives: The aim of this study was to evaluate baseline health measurements among transitional housing residents (n = 29) participating in an 8-week pilot wellness intervention. Methods: Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, [...] Read more.
Background/Objectives: The aim of this study was to evaluate baseline health measurements among transitional housing residents (n = 29) participating in an 8-week pilot wellness intervention. Methods: Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, and health-related perceptions. Researchers analyzed data using descriptive statistics and conventional content analysis. Results: Most participants were male, White, and food insecure. Mean BMI (31.8 ± 8.6 kg/m2), waist-to-hip ratio (1.0 ± 0.1 males, 0.9 ± 0.1 females), body fat percentage (25.8 ± 6.1% males, 40.5 ± 9.4% females), blood pressure (131.8 ± 17.9/85.2 ± 13.3 mmHg), and daily step counts exceeded recommended levels. Absolute grip strength (77.1 ± 19.4 kg males, 53.0 ± 15.7 kg females) and perceived general health were below reference standards. The Healthy Eating Index-2020 score (39.7/100) indicated low diet quality. Common barriers to healthy eating were financial constraints (29.6%) and limited cooking/storage facilities (29.6%), as well as to exercise, physical impediments (14.8%). Conclusions: Residents living in transitional housing have less favorable body composition, diet, and grip strength measures, putting them at risk for negative health outcomes. Wellness interventions aimed at promoting improved health-related outcomes while addressing common barriers to proper diet and exercise among transitional housing residents are warranted. Full article
(This article belongs to the Special Issue Nutrition in Vulnerable Population Groups)
22 pages, 19937 KiB  
Article
Development and Evaluation of a Two-Dimensional Extension/Contraction-Driven Rover for Sideslip Suppression During Slope Traversal
by Kenta Sagara, Daisuke Fujiwara and Kojiro Iizuka
Aerospace 2025, 12(8), 699; https://doi.org/10.3390/aerospace12080699 - 6 Aug 2025
Abstract
Wheeled rovers are widely used in lunar and planetary exploration missions owing to their mechanical simplicity and energy efficiency. However, they face serious mobility challenges on sloped soft terrain, especially in terms of sideslip and loss of attitude angle when traversing across slopes. [...] Read more.
Wheeled rovers are widely used in lunar and planetary exploration missions owing to their mechanical simplicity and energy efficiency. However, they face serious mobility challenges on sloped soft terrain, especially in terms of sideslip and loss of attitude angle when traversing across slopes. Previous research proposed using wheelbase extension/contraction and intentionally sinking wheels into the ground, thereby increasing shear resistance and reducing sideslip. Building upon this concept, this study proposes a novel recovery method that integrates beam extension/contraction and Archimedean screw-shaped wheels to enable lateral movement without rotating the rover body. The beam mechanism allows for independent wheel movement, maintaining stability by anchoring stationary wheels during recovery. Meanwhile, the helical structure of the screw wheels helps reduce lateral earth pressure by scraping soil away from the sides, improving lateral drivability. Driving experiments on a sloped sandbox test bed confirmed that the proposed 2DPPL (two-dimensional push-pull locomotion) method significantly reduces sideslip and prevents a drop in attitude angle during slope traversal. Full article
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22 pages, 1177 KiB  
Article
An Empirical Study on the Impact of Financial Technology on the Profitability of China’s Listed Commercial Banks
by Xue Yuan, Chin-Hong Puah and Dayang Affizzah binti Awang Marikan
J. Risk Financial Manag. 2025, 18(8), 440; https://doi.org/10.3390/jrfm18080440 - 6 Aug 2025
Abstract
This paper selects 50 listed commercial banks in China from 2012 to 2023 as research samples, and employs the fixed effects model and Hansen’s threshold regression method to systematically examine the impact mechanism and non-linear characteristics of FinTech development on the profitability of [...] Read more.
This paper selects 50 listed commercial banks in China from 2012 to 2023 as research samples, and employs the fixed effects model and Hansen’s threshold regression method to systematically examine the impact mechanism and non-linear characteristics of FinTech development on the profitability of commercial banks. The key findings are summarized as follows: (1) FinTech significantly undermines the overall profitability of commercial banks by reshaping the competitive landscape of the industry and intensifying the technology substitution effect. This is primarily reflected in the reduction in traditional interest income and the erosion of market share in intermediary business. (2) Heterogeneity analysis indicates that large state-owned banks and joint-stock banks experience more pronounced negative impacts compared to small and medium-sized banks. (3) Additional research findings reveal a significant single-threshold effect between FinTech and bank profitability, with a critical value of 4.169. When the development level of FinTech surpasses this threshold, its inhibitory effect diminishes substantially, suggesting that after achieving a certain degree of technological integration, commercial banks may partially alleviate external competitive pressures through synergistic effects. This study offers crucial empirical evidence and theoretical support for commercial banks to develop differentiated technology strategies and for regulatory authorities to design dynamically adaptable policy frameworks. Full article
(This article belongs to the Section Financial Technology and Innovation)
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20 pages, 5378 KiB  
Article
Machine Learning-Based Approach for CPTu Data Processing and Stratigraphic Analysis
by Helena Paula Nierwinski, Arthur Miguel Pereira Gabardo, Ricardo José Pfitscher, Rafael Piton, Ezequias Oliveira and Marieli Biondo
Metrology 2025, 5(3), 48; https://doi.org/10.3390/metrology5030048 - 6 Aug 2025
Abstract
Cone Penetration Tests with pore pressure measurements (CPTu) are widely used in geotechnical site investigations due to their high-resolution profiling capabilities. However, traditional interpretation methods—such as the Soil Behavior Type Index (Ic)—often fail to capture the internal heterogeneity typical of [...] Read more.
Cone Penetration Tests with pore pressure measurements (CPTu) are widely used in geotechnical site investigations due to their high-resolution profiling capabilities. However, traditional interpretation methods—such as the Soil Behavior Type Index (Ic)—often fail to capture the internal heterogeneity typical of mining tailings deposits. This study presents a machine learning-based approach to enhance stratigraphic interpretation from CPTu data. Four unsupervised clustering algorithms—k-means, DBSCAN, MeanShift, and Affinity Propagation—were evaluated using a dataset of 12 CPTu soundings collected over a 19-year period from an iron tailings dam in Brazil. Clustering performance was assessed through visual inspection, stratigraphic consistency, and comparison with Ic-based profiles. k-means and MeanShift produced the most consistent stratigraphic segmentation, clearly delineating depositional layers, consolidated zones, and transitions linked to dam raising. In contrast, DBSCAN and Affinity Propagation either over-fragmented or failed to identify meaningful structures. The results demonstrate that clustering methods can reveal behavioral trends not detected by Ic alone, offering a complementary perspective for understanding depositional and mechanical evolution in tailings. Integrating clustering outputs with conventional geotechnical indices improves the interpretability of CPTu profiles, supporting more informed geomechanical modeling, dam monitoring, and design. The approach provides a replicable methodology for data-rich environments with high spatial and temporal variability. Full article
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21 pages, 3336 KiB  
Article
A Computerized Analysis of Flow Parameters for a Twin-Screw Compressor Using SolidWorks Flow Simulation
by Ildiko Brinas, Florin Dumitru Popescu, Andrei Andras, Sorin Mihai Radu and Laura Cojanu
Computation 2025, 13(8), 189; https://doi.org/10.3390/computation13080189 - 6 Aug 2025
Abstract
Twin-screw compressors (TSCs) are widely used in various industries. Their performance is influenced by several parameters, such as rotor profiles, clearance gaps, operating speed, and thermal effects. Traditionally, optimizing these parameters relied on experimental methods, which are costly and time-consuming. However, advancements in [...] Read more.
Twin-screw compressors (TSCs) are widely used in various industries. Their performance is influenced by several parameters, such as rotor profiles, clearance gaps, operating speed, and thermal effects. Traditionally, optimizing these parameters relied on experimental methods, which are costly and time-consuming. However, advancements in computational tools, such as Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA), have revolutionized compressor analysis. This study presents a CFD analysis of a specific model of a TSC in a 5 male/6 female lobe configuration using the SolidWorks Flow Simulation environment—an approach not traditionally applied to such positive displacement machines. The results visually present internal flow trajectories, fluid velocities, pressure distributions, temperature gradients, and leakage behaviors with high spatial and temporal resolution. Additionally, torque fluctuations and isosurface visualizations revealed insights into mechanical loads and flow behavior. The proposed method allows for relatively easy adaptation to different TSC configurations and can also be a useful tool for engineering and educational purposes. Full article
(This article belongs to the Special Issue Advances in Computational Methods for Fluid Flow)
17 pages, 1766 KiB  
Article
The Effects of the Red River Jig on the Wholistic Health of Adults in Saskatchewan
by Nisha K. Mainra, Samantha J. Moore, Jamie LaFleur, Alison R. Oates, Gavin Selinger, Tayha Theresia Rolfes, Hanna Sullivan, Muqtasida Fatima and Heather J. A. Foulds
Int. J. Environ. Res. Public Health 2025, 22(8), 1225; https://doi.org/10.3390/ijerph22081225 - 6 Aug 2025
Abstract
The Red River Jig is a traditional Métis dance practiced among Indigenous and non-Indigenous Peoples. While exercise improves physical health and fitness, the impacts of cultural dances on wholistic health are less clear. This study aimed to investigate the psychosocial (cultural and mental), [...] Read more.
The Red River Jig is a traditional Métis dance practiced among Indigenous and non-Indigenous Peoples. While exercise improves physical health and fitness, the impacts of cultural dances on wholistic health are less clear. This study aimed to investigate the psychosocial (cultural and mental), social, physical function, and physical fitness benefits of a Red River Jig intervention. In partnership with Li Toneur Nimiyitoohk Métis Dance Group, Indigenous and non-Indigenous adults (N = 40, 39 ± 15 years, 32 females) completed an 8-week Red River Jig intervention. Social support, cultural identity, memory, and mental wellbeing questionnaires, seated blood pressure and heart rate, weight, pulse-wave velocity, heart rate variability, baroreceptor sensitivity, jump height, sit-and-reach flexibility, one-leg and tandem balance, and six-minute walk test were assessed pre- and post-intervention. Community, family, and friend support scores, six-minute walk distance (553.0 ± 88.7 m vs. 602.2 ± 138.6 m, p = 0.002), jump, leg power, and systolic blood pressure low-to-high-frequency ratio increased after the intervention. Ethnic identity remained the same while affirmation and belonging declined, leading to declines in overall cultural identity, as learning about Métis culture through the Red River Jig may highlight gaps in cultural knowledge. Seated systolic blood pressure (116.5 ± 7.3 mmHg vs. 112.5 ± 10.7 mmHg, p = 0.01) and lower peripheral pulse-wave velocity (10.0 ± 2.0 m·s−1 vs. 9.4 ± 1.9 m·s−1, p = 0.04) decreased after the intervention. Red River Jig dance training can improve social support, physical function, and physical fitness for Indigenous and non-Indigenous adults. Full article
(This article belongs to the Special Issue Improving Health and Mental Wellness in Indigenous Communities)
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15 pages, 1541 KiB  
Communication
Effect of Non-Thermal Treatments of Clear Apple Juice on Exogenous Pectinases
by Alberto Zavarise, Alema Puzović, Andres Felipe Moreno Barreto, Dario Pavon Vargas, Manfred Goessinger, Maja Mikulič Petkovšek, Massimiliano Rinaldi, Christian Haselmair-Gosch, Luca Cattani and Heidi Halbwirth
Beverages 2025, 11(4), 113; https://doi.org/10.3390/beverages11040113 - 6 Aug 2025
Abstract
Pulsed electric field (PEF) and high-pressure processing (HPP) are non-thermal treatments, developed to ensure preservation of food products whilst maintaining taste and valuable nutrients. In this study, we investigated their potential for the inactivation of 3 commercial exogenous pectinases (polygalacturonase, pectin transeliminase, pectin [...] Read more.
Pulsed electric field (PEF) and high-pressure processing (HPP) are non-thermal treatments, developed to ensure preservation of food products whilst maintaining taste and valuable nutrients. In this study, we investigated their potential for the inactivation of 3 commercial exogenous pectinases (polygalacturonase, pectin transeliminase, pectin esterase) commonly used in juice processing for clarification of juices. The inactivation of these enzymes after processing is mandatory by European law. Clear apple juice was treated with both non-thermal processing methods, as well as with thermal pasteurization as the standard method. For HPP, 3 pressures (250, 450, and 600 MPa) and different holding times (from 2 to 12 min) were tested. For PEF, 3 electric field intensities (10, 13, and 15 kV/cm) and different specific energy values (from 121 to 417 kJ/kg). Standard thermal pasteurization resulted in a complete inactivation of all tested pectinases. HPP treatment only showed marginal effects on polygalacturonase and pectin transeliminase at the highest pressure and holding times, which are beyond levels used in industrial settings. For PEF, dependence upon high electric field strength and specific energy values was evident; however, here too, the effect was only moderate at the levels attainable within the scope of this study. Assuming a continued linear relationship, usable results could be achieved in an industrial setting, albeit under more extreme conditions. Full article
(This article belongs to the Section Beverage Technology Fermentation and Microbiology)
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14 pages, 5143 KiB  
Article
An Efficient Finite Element Model to Predict the Mechanical Response of Metallic-Reinforced Pressure Vessels
by Ana Lucía León Razo, Miguel Ernesto Gutierrez Rivera, Carlos Enrique Valencia Murillo, Elias Rigoberto Ledesma Orozco and Israel Martinez Ramirez
Hydrogen 2025, 6(3), 55; https://doi.org/10.3390/hydrogen6030055 - 6 Aug 2025
Abstract
In the design of pressure vessels for hydrogen storage, the durability and robustness of the designs are tested by using experimental methods, numerical simulations, or both. However, in the initial design phase, it is widely known that using numerical simulation tools reduces the [...] Read more.
In the design of pressure vessels for hydrogen storage, the durability and robustness of the designs are tested by using experimental methods, numerical simulations, or both. However, in the initial design phase, it is widely known that using numerical simulation tools reduces the cost of performing experiments; therefore, models that provide accurate and reliable results must be developed. This work presents an axisymmetric finite element model to predict the mechanical response of reinforced wire pressure vessels of type II. The main contribution of the present model is the use of equivalent properties and a minor number of contact elements to simulate the behavior of the wire reinforcement, which reduces the computational effort compared to a model with a solid-based mesh. The accuracy of the proposed model is tested against solid elements with very good agreement and experimental results with reasonable agreement. A parametric study was conducted to test the influence of the number of layers of reinforcement, and it was concluded that there is a limit to increasing the number of layers, which does not increase the vessel’s strength considerably, but it does with its mass. Full article
(This article belongs to the Special Issue Advances in Hydrogen Production, Storage, and Utilization)
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20 pages, 640 KiB  
Article
Digital Innovation and Cost Stickiness in Manufacturing Enterprises: A Perspective Based on Manufacturing Servitization and Human Capital Structure
by Wei Sun and Xinlei Zhang
Sustainability 2025, 17(15), 7115; https://doi.org/10.3390/su17157115 - 6 Aug 2025
Abstract
This paper examines the effect of digital innovation on cost stickiness in manufacturing firms, focusing on the underlying mechanisms and contextual factors. Using data from Chinese A-share listed manufacturing firms from 2012 to 2023, we find that, first, for each one-unit increase in [...] Read more.
This paper examines the effect of digital innovation on cost stickiness in manufacturing firms, focusing on the underlying mechanisms and contextual factors. Using data from Chinese A-share listed manufacturing firms from 2012 to 2023, we find that, first, for each one-unit increase in the level of digital technology, the cost stickiness index of enterprises decreases by an average of 0.4315 units, primarily through digital process innovation and digital business model innovation, whereas digital product innovation does not exhibit a statistically significant impact. Second, manufacturing servitization and the optimization of human capital structure are identified as key mediating mechanisms. Digital innovation promotes servitization by transitioning firms from product-centric to service-oriented business models, thereby reducing fixed costs and improving resource flexibility. It also optimizes human capital by increasing the proportion of high-skilled employees and reducing labor adjustment costs. Third, the effect of digital innovation on cost stickiness is found to be heterogeneous. Firms with high financing constraints benefit more from the cost-reducing effects of digital innovation due to improved resource allocation efficiency. Additionally, mid-tenure executives are more effective in leveraging digital innovation to mitigate cost stickiness, as they balance short-term performance pressures with long-term strategic investments. These findings contribute to the understanding of how digital transformation reshapes cost behavior in manufacturing and provide insights for policymakers and firms seeking to achieve sustainable development through digital innovation. Full article
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23 pages, 406 KiB  
Systematic Review
Advances in Bidirectional Therapy for Peritoneal Metastases: A Systematic Review of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Combined with Systemic Chemotherapy
by Manuela Robella, Marco Vitturini, Andrea Di Giorgio, Matteo Aulicino, Martin Hubner, Emanuele Koumantakis, Felice Borghi, Paolo Catania, Armando Cinquegrana and Paola Berchialla
Cancers 2025, 17(15), 2580; https://doi.org/10.3390/cancers17152580 - 6 Aug 2025
Abstract
Background: Peritoneal metastases (PM) represent a common and challenging manifestation of several gastrointestinal and gynecologic malignancies. Bidirectional treatment—combining Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with systemic chemotherapy—has emerged as a strategy to enhance locoregional control while maintaining systemic coverage. Objective: This systematic [...] Read more.
Background: Peritoneal metastases (PM) represent a common and challenging manifestation of several gastrointestinal and gynecologic malignancies. Bidirectional treatment—combining Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with systemic chemotherapy—has emerged as a strategy to enhance locoregional control while maintaining systemic coverage. Objective: This systematic review aimed to analyze the study design, characteristics, and timing of the treatments administered—including the type of systemic chemotherapy, intraperitoneal agents used in PIPAC, and interval between administrations—as well as the clinical outcomes, safety profile, and overall methodological quality of the available literature on bidirectional treatment for peritoneal metastases. Methods: A systematic literature search was conducted across the PubMed, Embase, and Cochrane Library databases up to April 2025. Studies were included if they reported clinical outcomes of patients undergoing bidirectional treatment. Data extraction focused on survival, response assessment (PRGS, PCI), adverse events, systemic and intraperitoneal regimens, treatment interval, and study methodology. Results: A total of 22 studies involving 1015 patients (742 treated with bidirectional therapy) were included. Median overall survival ranged from 2.8 to 19.6 months, with the most favorable outcomes observed in gastric and colorectal cancer cohorts. PRGS improvement after multiple PIPAC cycles was reported in >80% of evaluable cases. High-grade adverse events (CTCAE ≥ 3) occurred in up to 17% of patients in most studies, with only one study reporting treatment-related mortality. However, methodological quality was generally moderate, with considerable heterogeneity in treatment protocols, response criteria, systemic regimens, and toxicity attribution. Conclusions: Bidirectional therapy with PIPAC and systemic chemotherapy appears to be a feasible and potentially effective strategy for selected patients with peritoneal metastases. Despite encouraging outcomes, definitive conclusions are limited by the retrospective nature and heterogeneity of available studies. Prospective standardized trials are needed to confirm efficacy, clarify patient selection, and optimize treatment protocols. Full article
(This article belongs to the Section Cancer Therapy)
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