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Keywords = (25R)-spirost-4-en-3,6-dione

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17 pages, 5398 KiB  
Article
Antiproliferative, Cytotoxic, and Apoptotic Activity of Steroidal Oximes in Cervicouterine Cell Lines
by Luis Sánchez-Sánchez, María Guadalupe Hernández-Linares, María L. Escobar, Hugo López-Muñoz, Edgar Zenteno, María A. Fernández-Herrera, Gabriel Guerrero-Luna, Alan Carrasco-Carballo and Jesús Sandoval-Ramírez
Molecules 2016, 21(11), 1533; https://doi.org/10.3390/molecules21111533 - 14 Nov 2016
Cited by 25 | Viewed by 7383
Abstract
Steroidal sapogenins have shown antiproliferative effects against several tumor cell lines; and their effects on human cancer cells are currently under study. Changes in the functionality on the steroidal structure make it possible to modify the biological activity of compounds. Herein, we report [...] Read more.
Steroidal sapogenins have shown antiproliferative effects against several tumor cell lines; and their effects on human cancer cells are currently under study. Changes in the functionality on the steroidal structure make it possible to modify the biological activity of compounds. Herein, we report the synthesis and in vitro antitumor activity of two steroidal oxime compounds on cervical cancer cells. These derivatives were synthesized from the steroidal sapogenin diosgenin in good yields. The in vitro assays show that the steroidal oximes show significant antiproliferative activity compared to the one observed for diosgenin. Cell proliferation, cell death, and the cytotoxic effects were determined in both cervical cancer cells and human lymphocytes. The cancer cells showed apoptotic morphology and an increased presence of active caspase-3, providing the notion of a death pathway in the cell. Significantly, the steroidal oximes did not exert a cytotoxic effect on lymphocytes. Full article
(This article belongs to the Special Issue Women in Organic Chemistry)
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