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Authors = Manisha Sathe

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12 pages, 105 KiB  
Article
Synthesis and Antimalarial Evaluation of Cyclic β-Amino Acid-Containing Dipeptides
by Manisha Sathe, D. Thavaselvam, A. K. Srivastava and M. P. Kaushik
Molecules 2008, 13(2), 432-443; https://doi.org/10.3390/molecules13020432 - 18 Feb 2008
Cited by 15 | Viewed by 8101
Abstract
This paper describes an efficient synthesis and the antiparasitic evaluation ofcyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial propertiesof all these dipeptides have been evaluated in vitro against Plasmodium falciparum and invivo against Plasmodium berghai. Compounds 4.4 and 4.5 have been found [...] Read more.
This paper describes an efficient synthesis and the antiparasitic evaluation ofcyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial propertiesof all these dipeptides have been evaluated in vitro against Plasmodium falciparum and invivo against Plasmodium berghai. Compounds 4.4 and 4.5 have been found to be veryeffective in this respect, with IC50 values of 3.87 and 3.64 μg/mL in the in vitro test, while4.5 has also been found to be active in the in vivo evaluation. Full article
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11 pages, 85 KiB  
Article
Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions
by Hitendra N Karade, Manisha Sathe and M P Kaushik
Molecules 2007, 12(7), 1341-1351; https://doi.org/10.3390/12071341 - 9 Jul 2007
Cited by 104 | Viewed by 11069
Abstract
This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions. Full article
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