Search Results (111)

Due to the limited endurance of UAVs, especially in scenarios involving large areas and dense target nodes, it is challenging for multiple UAVs to complete diverse tasks while ensuring timely execution. Toward this, we propose a cross-platform system consisting of an aircraft carrier (AC) and multiple UAVs, which makes unified task planning for included heterogeneous platforms to maximize the efficiency of the entire combat system. The carrier-based UAV swarm mission planning problem is formulated to minimize completion time and resource utilization, taking into account large-scale targets, multi-type tasks, and multi-obstacle environments. Since the problem is complex, we design a decoupled framework to simplify the solution by decomposing it into two levels: upper-level AC path planning and bottom-level multi-UAV cooperative mission planning. At the upper level, a drop point determination method and a discrete genetic algorithm incorporating improved A* (DGAIIA) are proposed to plan the AC’s path in the presence of no-fly zones and radar threats. At the bottom level, an improved differential evolution algorithm with a market mechanism (IDEMM) is proposed to minimize task completion time and maximize UAV utilization. Specifically, a dual-switching search strategy and a neighborhood-first buying-and-selling mechanism are developed to improve the search efficiency of the IDEMM. Simulation results validate the effectiveness of both the DGAIIA and IDEMM. An animation of the simulation results is available at simulation section. Full article

Mycoplasma pneumoniae, a cell wall-deficient pathogen, primarily affects children and adolescents, causing Mycoplasma pneumoniae pneumonia (MPP). Following the relaxation of non-pharmaceutical interventions (NPIs) post COVID-19, there has been a global increase in MPP cases and macrolide-resistant strains. Vaccination against M. pneumoniae is being explored as a promising approach to reduce infections, limit antibiotic misuse, and prevent the emergence of drug-resistant variants. We developed an mRNA vaccine, mRNA-SP+P1, incorporating a eukaryotic signal peptide (tissue-type plasminogen activator signal peptide) fused to the C-terminal region of the P1 protein. Targeting amino acids 1288 to 1518 of the P1 protein, the vaccine was administered intramuscularly to BALB/c mice in a three-dose regimen. To evaluate immunogenicity, we quantified anti-P1 IgG antibody titers using enzyme-linked immunosorbent assays (ELISAs) and assessed cellular immune responses by analyzing effector memory T cell populations using flow cytometry. We also tested the functional activity of vaccine-induced sera for their ability to inhibit adhesion of the ATCC M129 strain to KMB17 cells. The vaccine’s protective efficacy was assessed against the ATCC M129 strain and its cross-protection against the ST3-resistant strain. Transcriptomic analysis was conducted to investigate gene expression changes in peripheral blood, aiming to uncover mechanisms of immune modulation. The mRNA-SP+P1 vaccine induces P1 protein-specific IgG antibodies and an effector memory T-cell response in BALB/c mice. Adhesion inhibition assays demonstrated that serum from vaccinated mice attenuatesthe adhesion ability of ATCC M129 to KMB17 cells. Furthermore, three doses of the vaccine confer significant and long-lasting, though partial, protection against the ATCC M129 strain and partial cross-protection against the ST3 drug-resistant strain. Transcriptome analysis revealed significant gene expression changes in peripheral blood, confirming the vaccine’s capacity to elicit an immune response from the molecular level. Our results indicate that the mRNA-SP+P1 vaccine appears to be an effective vaccine candidate against the prevalence of Mycoplasma pneumoniae. Full article

Background: The Lingnan region is characterized by a hot and humid climate and abundant, diverse natural resources, while the Central Plains region experiences distinct four seasons and has a rich agricultural culture. Both regions possess unique dietary traditions and preferences. This study aims to investigate the differences in dietary structure between the Lingnan region (Guangdong, Guangxi, Hainan) and the Central Plains region (Shanxi, Shaanxi, Henan) and their impact on health. Methods: Using cross-sectional survey data from the 2015–2017 China National Nutrition and Health Survey, this study selected residents aged 18 and above as the research subjects. Generalized linear models were employed to analyze differences in the intake of various food groups between the two regions, while logistic regression models were used to examine regional differences in the prevalence of obesity, hypertension, diabetes mellitus, and hyperlipidemia. Results: A total of 14,484 adults were included in this study. Lingnan participants consumed significantly more rice products, red meat, poultry, seafood, and dark-colored vegetables, while Central Plains residents had higher intakes of wheat products, other cereals, soybeans, and eggs. Lingnan exhibited lower prevalence rates of obesity (8.6% vs. 18.1%), diabetes (7.6% vs. 9.8%), and hypertension (33.0% vs. 46.9%) compared to the Central Plains, with no significant difference in hyperlipidemia prevalence. Adjusted analyses confirmed that Lingnan residents had significantly reduced risks of obesity (OR = 0.431, 95% CI: 0.388–0.479), diabetes mellitus (OR = 0.841, 95% CI: 0.744–0.950), and hypertension (OR = 0.564, 95% CI: 0.523–0.608). Conclusions: The dietary structure in the Lingnan region plays a positive role in cardiometabolic health. Further analysis of the combined effects of different foods on health could provide a scientific basis for future nutrition and health management. Full article

Evaluating the properties of single carbon fibers is crucial, as it provides parameters not only for optimizing carbon fiber production processes but also for enhancing composite material properties. In recent years, significant advancement have been made in the evaluations of the transverse compressive properties of single fibers. However, compressive testing methods for fibers in the fine size range remain limited at the commercial scale. The direct measurement of the transverse compressive properties of three domestic high-strength polyacrylonitrile-based single carbon fibers (T300 grade, T700 grade, and T800 grade) with diameters of ~5.5~6.5 μm was made possible through the use of a micro-compression tester. Transverse compressive moduli of 5.19 GPa (0.050), 5.42 GPa (0.104), and 6.63 GPa (0.120) were obtained for domestic T300-, T700- and T800-grade carbon fibers, respectively. In addition, transverse compressive strengths of 2.35 GPa (0.033), 2.65 GPa (0.041), and 2.82 GPa (0.121) were obtained for domestic T300-, T700- and T800-grade carbon fibers, respectively. It is noted that minor deviations in fiber geometry from an ideal circular cross-section may influence absolute modulus and strength values. These fibers exhibit strong anisotropy in the longitudinal and transverse directions from the fiber axis. A correlation between the transverse compressive modulus and strength was found for these fibers. These results provide critical parameters for the optimization of carbon fiber-reinforced composite designs (e.g., enhancing impact resistance in aerospace structures), offering substantial practical value to the field of materials science. Full article

In this paper, a beetle with excellent flight ability and a large folding ratio of its hind wings is selected as the biomimetic design. We mimicked the geometric patterns formed during the folding process of the hind wings to construct a deployable mechanism while calculating the sector angles and dihedral angles of the origami mechanism. In the expandable structure of thick plates, hinge-like steps are added on the thick plate to effectively avoid interference motion caused by the folding of the thick plate. The kinematic characteristics of two deployable mechanisms were characterized by ADAMS 2018 software to verify the feasibility of the mechanism design. The finite element method is used to analyze the structural performance of the deployable mechanism, and its modal response is analyzed in both unfolded and folded configurations. The aerodynamic generation of a spatially deployable wing is characterized by computational fluid dynamics (CFD) to study the vortex characteristics at different frame rates. Based on the aerodynamic parameters obtained from CFD simulation, a wavelet neural network is introduced to learn and train the aerodynamic parameters. Full article

This study proposes and numerically demonstrates a novel nonreciprocal electromagnetic metasurface by integrating a highly nonlinear liquid metamaterial (LMM) with a simple two-dimensional silicon dielectric grating. The transmission characteristics of the proposed structure were investigated using a full-vector finite-element method. We demonstrated that the proposed subwavelength-thickness metasurface achieves a transmission coefficient contrast of up to 0.96 between forward and backward propagation. Highly nonlinear LMMs, when employed as nonreciprocal media, significantly lower the radiation power needed to induce a nonlinear response compared to natural materials. Furthermore, we numerically analyzed the effects of the grating’s structural parameters, LMM thickness, and packing fraction on transmittance. The proposed design holds promise for applications in optical isolators. Full article

In the rapidly advancing era of intelligent technology, flexible strain sensors are emerging as a key component in wearable electronics. Laser-induced graphene (LIG) stands out as a promising fabrication method due to its rapid processing, environmental sustainability, low cost, and superior physicochemical properties. However, the stretchability and conformability of LIG are often limited by the substrate material, hindering its application in scenarios requiring high deformation. To address this issue, we propose a high-performance flexible and stretchable strain sensor fabricated by generating graphene on a polyimide (PI) substrate using laser induction and subsequently transferred onto a polydimethylsiloxane (PDMS). The resultant sensor demonstrates an ultra-low detection limit (0.1%), a rapid response time (150 ms), a wide strain range (40%), and retains stable performance after 1000 stretching cycles. Notably, this sensor has been successfully applied to the real-time monitoring of civil aviation test pilots during flight for the first time, enabling the accurate detection of physiological signals such as pulse, hand movements, and blink frequency. This study introduces a unique and innovative solution for the real-time health monitoring of civil aviation test pilots, with significant implications for enhancing flight safety. Full article

Flexible wearable strain sensors demonstrate promising application prospects in health monitoring, human-machine interaction, motion tracking, and the detection of human physiological signals. Although laser-induced graphene (LIG) materials have been extensively utilized in these scenarios, traditional types of LIG sensors are constrained by intrinsic limitations, including discontinuous conductive networks and electromechanical responsive hysteresis. These limitations hinder their applications in micro-strain detection scenarios. Consequently, enhancing the performance of LIG-based sensors has become a crucial priority. To address this challenge, we developed a novel MXene/LIG composite featuring optimized conductive networks and interfacial coupling effects through the systematic enhancement of LIG. The flexible strain sensor fabricated using this composite exhibits exceptional performance, including an ultra-low sheet resistance of 14.1 Ω, a high sensitivity of 20.7, a micro-strain detection limit of 0.05%, and a rapid response time of approximately 65 ms. These improvements significantly enhance electromechanical responsiveness and strain detection sensitivity. Furthermore, the sensor exhibits remarkable stability under varying tensile strains, particularly showing outstanding repeatability across 2500 cyclic tests. Notably, when applied to the pilot health monitoring scenarios, the MXene/LIG-based sensor demonstrates robust capability in detecting body movement signals such as micro-expressions and joint movements. This establishes a novel and highly effective technological solution for the real-time monitoring of pilots’ motion states during operational scenarios. Full article

The specific pathogenesis of osteoarthritis (OA) remains not fully understood. As a transmembrane heparan sulfate proteoglycan, syndecan-4 (SDC4) has been proven to play an important role in the development of OA. Notably, the extracellular domain of SDC4 can be cleaved by proteolytic enzymes, leading to the release of shed SDC4 (sSDC4), which subsequently regulates various biological processes in an autocrine or paracrine manner. This review analyzed 97 publications (1987–2025) from Pubmed and the Web of Science Core Collection using specific key words (syndecan-4, shed syndecan-4, and osteoarthritis), providing a comprehensive overview of the current research on sSDC4, including its shedding enzymes and specific cleavage sites, as well as the factors and mechanisms that influence SDC4 shedding. Furthermore, it summarizes the functions of both sSDC4 and its remaining membrane-bound domain. Finally, the roles of sSDC4 in OA are discussed to identify potential therapeutic targets and explore new strategies for the treatment of OA. Full article

To address the challenge of repairing the damage to concrete box girder bridge piers on mountainous highways caused by falling rocks, this paper proposes an active underpinning technique that integrates a “井”-shaped cap system, graded preloading of the foundation, and synchronized beam body correction. The technique utilizes lateral beam preloading (to eliminate the inelastic deformation of the new pile foundation) and longitudinal beam connections (to form overall stiffness). The method involves building temporary and permanent support systems in stages. Through the two-stage temporary support system transition, the removal and in situ reconstruction of the old piers, a smooth transition from the pier–beam consolidation system to the basin-type bearing system is achieved while simultaneously performing precise correction of beam torsion. The structural safety during the construction process was verified through finite element simulations and dynamic monitoring. Monitoring results show that the beam torsion recovery effect is significant (maximum lift of 5.2 mm/settlement of 7.9 mm), and the pier strain (−54.5~−51.3 με) remains within a controllable range. Before the bridge was opened to traffic, vehicle load and impact load tests were conducted. The actual measured strength and vertical stiffness of the main beam structure meet the design requirements, with relative residual deformation less than 20%, indicating that the structure is in good, elastic working condition. The vehicle running and braking dynamic coefficients (μ = 0.058~0.171 and 0.103~0.163) are both lower than the theoretical value of 0.305. The study shows that this technique enables the rapid and safe repair of bridge piers and provides important references for similar engineering projects. Full article

Objectives: This study investigated regional dietary patterns and their association with hypertensive dyslipidemia multimorbidity among older Chinese adults. Methods: Data from 13,809 individuals (aged ≥ 65 years) were extracted from the 2015–2017 China Nutrition and Health Surveillance. Hypertensive dyslipidemia multimorbidity was defined as concurrent hypertension and dyslipidemia. Four dietary patterns were identified via exploratory factor analysis using 3-day 24 h dietary records. Results: Four dietary patterns were extracted: traditional southern, diverse, high oil and salt, and animal oil–other animal meat–coarse grain pattern. The national prevalence of hypertensive dyslipidemia multimorbidity was 31.9%, with significant regional variation (highest in North China: 36.4%; lowest in Central China: 27.9%; p < 0.0001). Regional dietary dominance included: the traditional southern pattern in South China (75.9%); the traditional southern (35.8%) and diversified (28.8%) patterns in East China; animal oil–other animal meat–coarse grain (38.4%) and traditional southern (37.9%) patterns in Southwest China; high oil and salt (36.8%) and traditional southern (25.9%) in Central China; diversified (47.7%) and high oil and salt (26.3%) patterns in North China; high oil and salt (44.9%) and diversified (37.9%) patterns in Northwest China; and the diversified (46.9%) pattern in Northeast China. In the highest scoring group of the animal oil–other animal meat–coarse grain pattern, the risk of hypertensive dyslipidemia multimorbidity was 1.179 times greater compared with the lowest scoring group (Q4 vs. Q1, OR = 1.179, 95% CI: 1.032–1.316, p < 0.001). Region-specific analyses highlighted: increased risks with the traditional southern pattern in South/East China (Q4 vs. Q1, OR = 2.080, 95% CI: 1.036–4.175, p < 0.001) and (Q4 vs. Q1, OR = 1.734, 95% CI: 1.052–2.859, p < 0.001); protective effects of the diversified pattern in Northwest China (Q4 vs. Q1, OR = 0.377, 95% CI: 0.173–0.824, p < 0.001); elevated risks with the high oil and salt pattern in Central/North China (Q4 vs. Q1, OR = 2.343, 95% CI: 1.107-4.955, p < 0.001) and (Q4 vs. Q1, OR = 1.837, 95% CI: 1.019–3.312, p < 0.001); and higher risks with the animal oil–other animal meat–coarse grain pattern in Southwest China (Q4 vs. Q1, OR = 2.009, 95% CI: 1.004–4.021, p < 0.001). Conclusions: In conclusion, dietary patterns among elderly Chinese are diversified and should be optimized based on local food resources to control hypertensive dyslipidemia multimorbidity. Full article

The highly selective and sensitive determination of pesticide residues in food is critical for human health protection. Herein, the specific selectivity of molecularly imprinted polymers (MIPs) was proposed to construct an electrochemical sensor for the detection of carbendazim (CBD), one of the famous broad-spectrum fungicides, by combining with the synergistic effect of bioelectrocatalysis and nanocomposites. Gold nanoparticle-reduced graphene oxide (AuNP-rGO) composites were electrodeposited on a polished glassy carbon electrode (GCE). Then the MIP films were electropolymerized on the surface of the nanolayer using CBD as the template molecule and o-phenylenediamine (OPD) as the monomer. The detection sensitivity of CBD on the heterogeneous structure films was greatly amplified by AuNP-rGO composites and the bioelectrochemical oxidation of glucose, which was catalyzed by glucose oxidase (GOD) with the help of mediator in the underlying solution. The developed sensor showed high selectivity, good reproducibility, and excellent stability towards CBD with the linear range from 2.0 × 10⁻⁹ to 7.0 × 10⁻⁵ M, and the limit of detection (LOD) of 0.68 nM (S/N = 3). The expected system would provide a new idea for the development of simple and sensitive molecularly imprinted electrochemical sensors (MIESs). Full article

The prevalence of foodborne diseases has raised concerns due to the potential transmission of zoonotic bacterial pathogens through meat products. The objective of this study was to determine the occurrence and antimicrobial resistance (AMR) profiles of pathogenic bacteria in cooked donkey meat products from Beijing. Twenty-one cooked donkey meat samples were collected from different delis, subjected to homogenization, and analyzed for bacterial contamination. Molecular identification was performed through polymerase chain reaction (PCR) amplification and sequencing targeting the 16S rDNA gene. The antimicrobial susceptibility of the isolates was evaluated using the disk diffusion method. A total of forty bacterial isolates were identified, with Proteus mirabilis being the predominant species, followed by Klebsiella pneumoniae and Novosphingobium. Both Proteus mirabilis and Klebsiella pneumoniae exhibited high levels of resistance to several antibiotics, including penicillin, ampicillin, and erythromycin. This study’s findings underscore the public health risk posed by antimicrobial-resistant foodborne pathogens and emphasize the necessity for enhanced food safety surveillance within the One Health context. Full article

Background: The serotype 2 oral poliovirus vaccine (OPV2) can revert to regain wild-type neurovirulence and spread, causing the emergence of vaccine-derived poliovirus (VDPV2) and immunodeficiency-related vaccine-derived polioviruses (iVDPVs). In the United States, testing carried out by the CDC of type II iVDPV (iVDPV2) with human immune serum from the vaccine has shown that the presence of the virus poses a threat to eradication efforts. Methods: We analyzed the major neutralization sites of VP1, VP2, and VP3 of the iVDPV using bioinformatics techniques and homology modeling (SWISS-MODEL). The three amino acid residues 679, 680, and 141 of the P1 region changed, which had an impact on the spatial conformation of the viral-neutralizing site. We tested polio-vaccinated human sera and rabbit anti-Sabin II polyantibodies against a panel of iVDPV pseudoviruses. Results: The results demonstrated that the serum’s capacity to neutralize mutant pseudoviruses diminished when amino acid substitutions were introduced into the P1 encapsidated protein, particularly when 141 and 679 were mutated together. This study emphasizes the significance of continually monitoring individuals who are known to be immunocompromised and maintaining high vaccination rates in OPV-using communities. Full article

1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) is the main phenolic active ingredient in Paeoniae Radix Alba, which is commonly used for the treatment of osteoporosis (OP). PGG is a potent natural antioxidant, and its effects on OP remain unknown. This study aimed to investigate the effects of PGG on promoting bone formation and explore its estrogen receptor (ER)-related mechanisms. A hydrogen peroxide-induced osteoblast apoptosis model was established in MC3T3-E1 cells. The effects of PGG were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, alkaline phosphatase (ALP) staining, RT-qPCR, and Western blot methods. Furthermore, a prednisolone-induced zebrafish OP model was employed to study the effects in vivo. ER inhibitors and molecular docking methods were used further to investigate the interactions between PGG and ERs. The results showed that PGG significantly enhanced cell viability and decreased cell apoptosis by restoring mitochondrial function, attenuating reactive oxygen species levels, decreasing the mitochondrial membrane potential, and enhancing ATP production. PGG enhanced ALP expression and activity and elevated osteogenic differentiation. PGG also promoted bone formation in the zebrafish model, and these effects were reversed by ICI182780. These results provide evidence that the effects of PGG in alleviating apoptosis and promoting bone formation may depend on ERs. As such, PGG is considered a valuable candidate for treating OP. Full article