Special Issue "Host Cell Organelles in Viral Infections: Friends and Foes"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Daniela Ribeiro
E-Mail Website1 Website2
Guest Editor
University of Aveiro, 3810-193 Aveiro, Portugal.
Interests: virus-host interactions; viral immune evasion; innate immunity; intracellular organelles; peroxisomes; cellular proteostasis; RNA metabolism in viral infections
Dr. Markus Islinger
E-Mail Website
Guest Editor
Medical Faculty Mannheim, University of Heidelberg, Grabengasse 1, 69117 Heidelberg, Germany.
Interests: organelles; organelle interactions; peroxisomes; mitochondria; cellular metabolism; lipid metabolism

Special Issue Information

Dear colleagues,

Viruses are completely dependent on their host cells’ machinery to replicate and propagate. During infection, viruses hijack multiple host cell organelles such as the endoplasmic reticulum, mitochondria, peroxisomes, lipid droplets, Golgi complex and the nucleus to successfully achieve the formation of new virus particles. On the other hand, many of these host cell organelles are also exploited by the cellular immune system, becoming central players on the intricate virus-host interplay. 

This Special Issue aims to create a collection of state-of-the art manuscripts related to the importance of the host cell organelles in the contexts of infection by animal or plant viruses and of the cellular antiviral response. This exciting topic will stimulate discussions on, but not limited to, host cell organelles’ manipulation by viruses, host cell organelles as platforms for antiviral signaling, viral evasion from the cellular antiviral response, virus particle attachment and entry into the host cell, viral proteins’ production and maturation, virus particle formation, apoptosis as a response to viral infections, manipulation of host cell metabolism during viral infections, etc.

Dr. Daniela Ribeiro
Dr. Markus Islinger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virus
  • host cell organelles
  • antiviral signalling
  • viral evasion
  • virus particle formation

Published Papers (1 paper)

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Research

Article
Roles of the Endogenous Lunapark Protein during Flavivirus Replication
Viruses 2021, 13(7), 1198; https://doi.org/10.3390/v13071198 - 22 Jun 2021
Viewed by 574
Abstract
The endoplasmic reticulum (ER) of eukaryotic cells is a dynamic organelle, which undergoes continuous remodeling. At the three-way tubular junctions of the ER, the lunapark (LNP) protein acts as a membrane remodeling factor to stabilize these highly curved membrane junctions. In addition, during [...] Read more.
The endoplasmic reticulum (ER) of eukaryotic cells is a dynamic organelle, which undergoes continuous remodeling. At the three-way tubular junctions of the ER, the lunapark (LNP) protein acts as a membrane remodeling factor to stabilize these highly curved membrane junctions. In addition, during flavivirus infection, the ER membrane is invaginated to form vesicles (Ve) for virus replication. Thus, LNP may have roles in the generation or maintenance of the Ve during flavivirus infection. In this study, our aim was to characterize the functions of LNP during flavivirus infection and investigate the underlying mechanisms of these functions. To specifically study virus replication, we generated cell lines expressing replicons of West Nile virus (Kunjin strain) or Langat virus. By using these replicon platforms and electron microscopy, we showed that depletion of LNP resulted in reduced virus replication, which is due to its role in the generation of the Ve. By using biochemical assays and high-resolution microscopy, we found that LNP is recruited to the Ve and the protein interacts with the nonstructural protein (NS) 4B. Therefore, these data shed new light on the interactions between flavivirus and host factors during viral replication. Full article
(This article belongs to the Special Issue Host Cell Organelles in Viral Infections: Friends and Foes)
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