Special Issue "Herpes Virus Fusion and Entry"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Doina Atanasiu
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Guest Editor
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: herpes Viruses; glycoproteins; entry; fusion; neutralization; monoclonal antibodies
Dr. Tina M. Cairns
E-Mail
Guest Editor
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Special Issue Information

Dear colleagues,

Herpesviridae comprise a large family of enveloped DNA viruses with a unifying ability to establish a latent infection in their host. Though tropism differs, all herpesviruses have the same core fusion machinery that consists of three virus-encoded glycoproteins, gB and a heterodimer of gH and of gL. Studies of herpesviruses in each of the three subfamilies (i.e., alpha, beta, and gamma) have shown that each one embellishes on the core fusion machinery with additional proteins that may serve as receptor-binding proteins or are needed for entry into specific cell types. Solution of the structures of gB and gH/gL of herpes simplex virus, varicella zoster virus, Epstein-Barr virus, human cytomegalovirus and pseudorabies virus provided insight into the way these viral glycoproteins executed fusion of the viral and cellular membranes.

This Special Issue invites both updated reviews and original research articles on topics relating to the contribution of viral glycoproteins to signaling, penetration, fusion, immune escape, and vaccine development.

Dr. Doina Atanasiu

Dr. Tina M. Cairns

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • herpes virus
  • glycoproteins
  • virus entry
  • virus-cell fusion
  • membrane fusion
  • virus-cell interactions
  • receptor binding proteins
  • structure
  • neutralization

Published Papers (1 paper)

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Research

Article
Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes
Viruses 2021, 13(8), 1512; https://doi.org/10.3390/v13081512 - 31 Jul 2021
Viewed by 592
Abstract
Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of multiple cancers in immunocompromised patients including two lymphoproliferative disorders associated with KSHV infection of B lymphocytes. Despite many years of research into the pathogenesis of KSHV associated diseases, basic questions related to KSHV molecular [...] Read more.
Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of multiple cancers in immunocompromised patients including two lymphoproliferative disorders associated with KSHV infection of B lymphocytes. Despite many years of research into the pathogenesis of KSHV associated diseases, basic questions related to KSHV molecular virology remain unresolved. One such unresolved question is the cellular receptors and viral glycoproteins needed for KSHV entry into primary B lymphocytes. In this study, we assess the contributions of KSHV glycoprotein H (gH) and the cellular receptor DC-SIGN to KSHV infection in tonsil-derived B lymphocytes. Our results show that (1) neither KSHV-gH nor DC-SIGN are essential for entry into any B cell subset, (2) DC-SIGN does play a role in KSHV entry into tonsil-derived B cells, but in all B cell subtypes alternative entry mechanisms exist, (3) KSHV-gH can participate in KSHV entry into centrocytes via a DC-SIGN independent entry mechanism, and (4) in the absence of KSHV-gH, DC-SIGN is required for KSHV entry into centrocytes. Our results provide a first glimpse into the complexity of KSHV entry in the lymphocyte compartment and highlight that multiple subset-dependent entry mechanisms are employed by KSHV which depend upon multiple cellular receptors and multiple KSHV glycoproteins. Full article
(This article belongs to the Special Issue Herpes Virus Fusion and Entry)
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