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Special Issue "Toxins Secretion and Translocation"
Deadline for manuscript submissions: closed (31 May 2019).
Prof. Dr. Holger Barth E-Mail
Institut für Pharmakologie und Toxikologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany
Phone: ++49 731 500 65503
Fax: +49 731 50065502
Interests: bacterial protein toxins; actin; Rho-GTPases; macrophages; cellular uptake and intracellular membrane transport of bacterial toxins; interaction of bacterial toxins with host cell chaperones; bacterial toxins as Molecular Trojan Horses for drug delivery
Dr. Panagiotis Papatheodorou E-Mail
Institut für Pharmazeutische Biotechnologie, Universität Ulm, Institut für Pharmakologie und Toxikologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany
Interests: Clostridium difficile, clostridial toxin, bacterial toxin, toxin receptor, toxin uptake
Exotoxins are proteins that are produced and secreted by living bacteria. The exotoxins must be transported across one membrane in the case of Gram-positive and across two membranes in case of Gram-negative bacteria by sophisticated mechanisms in order to be released from the producing bacteria and to exhibit their cytotoxic effects on target cells. AB-type exotoxins act inside their target cells, i.e. the proteins must again cross at least one membrane barrier. To this end, AB-toxins hijack protein trafficking pathways and mechanisms of their host cells, incuding the endocytic machinery and in some cases also host cell chaperone macheries to deliver their enzymatically active (A) subunit into the cytosol. The intracellular trans-membrane transport of many toxins includes pore formation in cell membranes, which serve as translocation channels for the enzyme subunits of the toxins. This Special Issue will focus on the molecular mechanisms underlying the transport of protein toxins across membrane barriers. This includes trans-membrane transport during toxin secretion from the producing organisms, as well as the intracellular trans-membrane transport of toxins in mammalian target cells.Prof. Dr. Holger Barth
Dr. Panagiotis Papatheodorou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bacterial exotoxins
- membrane transport
- toxin secretion
- trans-membrane pores
- toxin translocation in host cells