Special Issue "Scorpion Toxins"
Deadline for manuscript submissions: closed (15 December 2013)
Prof. Dr. Max Goyffon
Muséum National d'Histoire Naturelle, FRE 3206, USM 505, 57 rue Cuvier, Paris, France
Prof. Dr. Jean-Nicolas Tournier
Host-Pathogen Interactions Laboratory, Institut de Recherche Biomédicale des Armées, BP 73, 91223 Brétigny-sur-Orge cedex, France
Bacterial Toxi-Infection Pathogenesis Laboratory, Institut Pasteur, 25 rue du docteur Roux, 75725 Paris cedex 15, France
Phone: +33 145 688 304
Interests: microbial toxins in host pathogen interactions; cell cytoskeleton; toxins and immune system; MAP kinases; adeylate cyclase; toxins and cell signaling; anthrax toxins
Because of their physiological characteristics, scorpions can be considered laboratory animals in the study of specific problems not only medical (envenomings) but also pharmaco-toxicologic or environmental (resistance to environmental stresses such as radioresistance, or resistance to bacterial infections, epidemiology). Indeed, the scorpion lifetime is long, several years for the larger species, and their breeding is easy. These aspects will be reflected in a series of articles sorted by specialties which provide the widest vision on problems that can be approached using this model. The following topics will shed light on the offered interest research on scorpions:
(i) venoms: in the family Buthidæ, the most important in number (40% species) and the medically most important, the venom composition is usually simple, poor in enzymes. The venom toxins essentially act on membrane ionic channels of excitable cells (neuromuscular system) and their structure is based on a basic model also present in the defensins. The study of toxins acting on sodium channels have led to the discovery of two specific binding sites and require a study of potassium and sodium membrane receptors as well as a comparative study with defensins.
(ii) these toxins involve also inflammatory systemic reactions of great medical interest: release of cytokins and neuromediators, transient myocardial injury, hypertension.
(iii) from a public health point of view, epidemiology is an important issue, as the large majority of the target of severe or lethal poisonings is constituted children and young adolescents. There is also an urban scorpionism of an unusual type in venomous animals, as some dangerous scorpion species are parthenogenetic (genus Tityus, South America). Besides, the value of the serotherapy which developed largely after the antiophidian serotherapy is currently challenged and deserves a specific focus. The possibility of producing efficient recombinant antibodies with a high neutralizing power is more advanced for scorpions than other venomous animals.
With its content this Special Issue involving a wide range of specialists is aimed at the wider public.
Prof. Dr. Max Goyffon
Prof. Dr. Jean-Nicolas Tournier
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).
- scorpion venoms
- ionic channels
Article: The Effects of a Chactoid Scorpion Venom and Its Purified Toxins on Rat Blood Pressure and Mast Cells Histamine Release
Toxins 2013, 5(8), 1332-1342; doi:10.3390/toxins5081332
Received: 23 May 2013; in revised form: 25 June 2013 / Accepted: 18 July 2013 / Published: 29 July 2013| Download PDF Full-text (667 KB) | View HTML Full-text | Download XML Full-text
Toxins 2014, 6(3), 796-815; doi:10.3390/toxins6030796
Received: 13 December 2013; in revised form: 16 January 2014 / Accepted: 18 January 2014 / Published: 26 February 2014| Download PDF Full-text (531 KB) | Download XML Full-text
Article: Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity
Toxins 2014, 6(3), 816-829; doi:10.3390/toxins6030816
Received: 4 December 2013; in revised form: 30 December 2013 / Accepted: 20 January 2014 / Published: 26 February 2014| Download PDF Full-text (1589 KB) | Download XML Full-text
Article: Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure
Toxins 2014, 6(3), 892-913; doi:10.3390/toxins6030892
Received: 12 December 2013; in revised form: 24 January 2014 / Accepted: 17 February 2014 / Published: 28 February 2014| Download PDF Full-text (1306 KB) | Download XML Full-text
Last update: 26 February 2014