Special Issue "Determination and Detoxification Strategies of Mycotoxins"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Dr. Sung-Yong Hong
E-Mail Website
Guest Editor
Department of Food and Nutrition/Department of Functional Food, Hanyang University, Seoul 04763, Korea
Interests: strategies for the biological control of mycotoxins in food and feed; monitoring and determination of levels of mycotoxins in food and feed; identification of mycotoxin synthetic pathways; mechanisms of the regulation of gene expression in mycotoxin gene clusters
Prof. Dr. Ae-Son Om
E-Mail Website
Guest Editor
Department of Food and Nutrition/Department of Functional Food, Hanyang University, Seoul 04763, Korea
Interests: strategies to control chemical and biological toxins in food and feed; determination of levels of chemical and biological toxins in food and feed; mechanisms of toxicity of chemical and biological toxins

Special Issue Information

Dear Colleagues,

 

Toxigenic fungi can grow on agricultural commodities and produce mycotoxins under warm and humid conditions. These mycotoxins occur in agricultural crops during pre-harvest and storage. The mycotoxin contamination of agricultural crops poses a serious health threat to humans and livestock, causing a variety of adverse health effects in target organs such as the liver, kidney, and nervous system. Therefore, it presents a major concern in food and feed safety.

To date, several hundred different mycotoxins have been identified, including aflatoxins, ochratoxins, fumonisins, zearalenone, trichothecenes (nivalenol, deoxynivalenol, 3-acetylnivalenol, zearalenone, T-2 toxin, and HT-2 toxin), and patulin. As the mycotoxins are chemically stable, they are not degraded during food processing.

Thus, most countries, including the European Union, the United States, and members of the Codex Alimentarius, have started to reinforce the management of mycotoxins in food and feed to set common regulatory limits for mycotoxins. In addition, great efforts in research for developing new strategies to minimize mycotoxin levels have been made, since mycotoxin contamination of food and feed causes economic losses as well as serious health problems.

The aim of this Special Issue, entitled ‘Determination and Detoxification Strategies of Mycotoxins’, is to gather recent research on the determination of levels of the major and emerging mycotoxins in food and feed, and effective strategies to eliminate or reduce their contamination, including, but not limited to, detoxification technologies such as biological and chemical degradation, and physical degradation or adsorption of mycotoxins.

 

Prof. Dr. Sung-Yong Hong
Prof. Dr. Ae-Son Om
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxins
  • determination
  • analyses
  • detoxification
  • reduction
  • biodegradation
  • chemical and physical detoxification
  • physical binding
  • fungi
  • food and feed

Published Papers (1 paper)

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Research

Article
Bacterial Enrichment Cultures Biotransform the Mycotoxin Deoxynivalenol into a Novel Metabolite Toxic to Plant and Porcine Cells
Toxins 2021, 13(8), 552; https://doi.org/10.3390/toxins13080552 - 09 Aug 2021
Viewed by 497
Abstract
The mycotoxin deoxynivalenol (DON), produced in wheat, barley and maize by Fusarium graminearum and Fusarium culmorum, is threatening the health of humans and animals. With its worldwide high incidence in food and feed, mitigation strategies are needed to detoxify DON, maintaining the [...] Read more.
The mycotoxin deoxynivalenol (DON), produced in wheat, barley and maize by Fusarium graminearum and Fusarium culmorum, is threatening the health of humans and animals. With its worldwide high incidence in food and feed, mitigation strategies are needed to detoxify DON, maintaining the nutritional value and palatability of decontaminated commodities. A promising technique is biological degradation, where microorganisms are used to biotransform mycotoxins into less toxic metabolites. In this study, bacterial enrichment cultures were screened for their DON detoxification potential, where DON and its potential derivatives were monitored. The residual phytotoxicity was determined through a bioassay using the aquatic plant Lemna minor L. Two bacterial enrichment cultures were found to biotransform DON into a still highly toxic metabolite for plants. Furthermore, a cytotoxic effect was observed on the cellular viability of intestinal porcine epithelial cells. Through liquid chromatography high-resolution mass spectrometry analysis, an unknown compound was detected, and tentatively characterized with a molecular weight of 30.0 Da (i.e., CH2O) higher than DON. Metabarcoding of the subsequently enriched bacterial communities revealed a shift towards the genera Sphingopyxis, Pseudoxanthomonas, Ochrobactrum and Pseudarthrobacter. This work describes the discovery of a novel bacterial DON-derived metabolite, toxic to plant and porcine cells. Full article
(This article belongs to the Special Issue Determination and Detoxification Strategies of Mycotoxins)
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