Special Issue "Cyanotoxin Toxicokinetics and Dynamics"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Marine and Freshwater Toxins".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Dr. Daniel R. Dietrich
E-Mail Website
Guest Editor
Human & Environmental Toxicology, Faculty of Biology, University of Konstanz, Universitätsstraße 10, 78464 Konstanz, Germany
Interests: natural toxins; mycotoxins; cyanobacterial toxins; mechanisms of toxicity; endocrine disruption; human microfluidic kidney systems; renal toxicity and carcinogenesis; environmental and human risk assessment

Special Issue Information

Dear Colleagues

The WHO recently published new guidelines on cyanotoxins in conjunction with human health hazards. The basis for these new guidelines is a recently released profound book, Toxic Cyanobacteria in Water: A Guide to Their Public Health Consequences, Monitoring and Management, edited by Ingrid Chorus and Martin Welker. However, when reading the various articles on cyanotoxins, specifically microcystins, it becomes painfully clear that we have still very little understanding of the toxicokinetics and dynamics of these toxins. Especially in case of the microcystins, with the currently >280 different congeners, toxicokinetic and dynamic knowledge in human cell systems, but also in cells of other organisms, will provide a much more solid basis for potential exposure and effect modeling and thus downstream human health hazard and risk assessment. Therefore, this Special Issue of Toxins is specifically addressed at gathering state-of-the-art techniques and knowledge with regard to cyanotoxin kinetics (incl. intracellular competitive metabolic and conjugation kinetics) and dynamics in vivo and in vitro, in silico approaches to mitigate the required testing of a huge number of unavailable congeners (as would be the case with microcystins), new  molecules that allow to trace and tag cyanotoxins and/or their metabolites of conjugates within cells and tissues to support current knowledge of kinetics and dynamics, analytical tools capable to verify true in situ exposures, and finally models that could characterize the impact of various quantities of one single cyanotoxin or the impact of mixtures of microcystin congeners in cellular systems or whole organisms. The overall goal of all contributions to this Special Issue of Toxins is to provide the most recent information, while identifying knowledge gaps and new approaches in reaching a more profound and databased hazard and risk assessment for cyanotoxins than is currently available.

Prof. Dr. Daniel Dietrich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxicokinetics
  • toxicodynamics
  • intracellular concentrations
  • cyanotoxins
  • microcystin congeners
  • cyanotoxin conjugates
  • hazard assessment
  • risk assessment
  • prediction modeling

Published Papers

This special issue is now open for submission.
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