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Separations
Special Issues
Application of Chromatography in Forensic Toxicology and Pharmacology
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Special Issue "Application of Chromatography in Forensic Toxicology and Pharmacology"

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Forensics/Toxins".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Fabio Vaiano
E-Mail Website
SciProfiles
Guest Editor
University of Florence | UNIFI · Dipartimento di Scienze della Salute; U.R.I.To.N. research unit
Interests: sample preparation; liquid chromatography; gas chromatography; mass spectrometry; biological matrices; drugs of abuse; new psychoactive substances; forensic toxicology; driving under the influence; DFSA
Dr. Fabrizio Carta
E-Mail Website
SciProfiles
Guest Editor
U.R.I.To.N. research unit, UNIFI · Dipartimento NEUROFARBA, University of Florence, Florence, France
Interests: medicinal chemistry; drugs; toxicology; enzymes; X-ray crystallography
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to inform you that a new Separations Special Issue has been launched, titled “Application of Chromatography in Forensic Toxicology and Pharmacology”.

Chromatography techniques have become essential for forensic toxicologists and pharmacologists, representing a mandatory requirement in many applications of these sciences. Thus, a great number of studies have been focused on the development and validation of new analytical methods with high separation efficiency and low limits of detection.

This Special Issue aims to collect the most recent advances in chromatography techniques (hyphenated or not to mass spectrometry) applied to forensic toxicology and pharmacology, useful to depict the state-of-the-art, but also providing new starting points for future advances.

Dr. Fabio Vaiano
Dr. Fabrizio Carta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liquid chromatography
  • gas chromatography
  • forensic toxicology
  • pharmacology
  • drugs of abuse
  • drugs
  • biological matrices

Published Papers (1 paper)

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Research

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Article
Determination of Lidocaine in Postmortem Whole Blood Samples after Unsuccessful Cardiopulmonary Resuscitation
by
Amvrosios Orfanidis
,
Nikolaos Raikos
,
Evdokia Brousa
,
Eleni Zangelidou
and
Orthodoxia Mastrogianni
Separations 2021, 8(8), 117; https://doi.org/10.3390/separations8080117 - 09 Aug 2021
Viewed by 283
Abstract
Forensic toxicologists often detect lidocaine in the biological fluids of the deceased, due to cardiopulmonary resuscitation (CPR) attempts prior to death. Here, we describe the development of a rapid, sensitive and robust method for the detection of lidocaine in postmortem whole blood using [...] Read more.
Forensic toxicologists often detect lidocaine in the biological fluids of the deceased, due to cardiopulmonary resuscitation (CPR) attempts prior to death. Here, we describe the development of a rapid, sensitive and robust method for the detection of lidocaine in postmortem whole blood using liquid−liquid extraction (LLE) followed by GC/MS analysis. The method showed a dynamic linear range of 100 to 6000 ng/mL with a linearity expressed by the regression coefficient (R2) and a value of 0.9947. The quantitation limit (LOQ) was found to be 0.03 ng/mL and the detection limit (LOD) 0.01 ng/mL. Recovery accuracy and repeatability were satisfactory. Finally, the method was applied to 23 real whole blood samples from cases where CPR was attempted. Blood concentrations ranged from 0.21–0.96 μg/mL. Full article
(This article belongs to the Special Issue Application of Chromatography in Forensic Toxicology and Pharmacology)
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