Dear Colleagues,

In the last years, chromatographic methods in Therapeutic Drug Monitoring (TDM) have undergone a rapid evolution, thanks to innovative and performing analytical instruments. Their characteristics consist in the increase of analytical performance in terms of the limits of determination and quantitation, lower sample quantity for analysis, extraction methods, interpretation of the analytical data and shorter time to the final report.

These innovative features have allowed TDM to be increasingly applied and broadly used, gaining significant advantages with respect to the choice of the more appropriate therapeutic dose, the capability of monitoring patients' adherence, and its applications in pharmacokinetic studies. Respecting these parameters is fundamental for therapy effectiveness, tolerability, and safety, which characterize the complex management of patients for whom TDM plays a fundamental role.

In agreement with the aims of Separations journal, the focus of this Special Issue is to emphasize all innovative analytical methods in TDM that can bring advantages in terms of the turn around time, the cost and the difficulty of analysis, the robustness, reproducibility, specificity, and sensitivity of the analytical method.

The scope of this Special Issue will serve as a forum for manuscripts on the following topics:

• Solid Phase Extraction methods applied to chromatographic methods
• Rapid extraction phase
• New and innovative extraction methods
• Liquid chromatography methods
• Mass spectrometric methods
• Innovative methods and advantages respect to other analytical procedure
• Validation in according to international guidelines
• Possible clinical advantage from TDM

Dr. Giacomo Luci
Prof. Dr. Antonello Di Paolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Therapeutic Drug Monitoring (TDM)
• LC-MS/MS
• Chromatographic Method
• HPLC-UV or FLD
• Drugs
• Monoclonal Antibody
• Extraction from bioloigcal matrices