Special Issue "Advances in Hydrophilic Interaction Chromatography"
Deadline for manuscript submissions: 31 December 2022 | Viewed by 182
Interests: synthesis of stationary phases; enantioselective separations; hyphenated HPLC methods; stereostability studies by dynamic HPLC and NMR; heterogeneous organocatalysis
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Interests: synthesis of stationary phases; enantioselective separations; hyphenated HPLC methods; chirality; chiral stationary phases (CSPs); ultra-high-performance liquid chromatography (UHPLC); natural products; pharmaceuticals; biopharmaceuticals
Hydrophilic interaction liquid chromatography (HILIC) is a complementary technique to normal-phase (NP) and reversed-phase (RP) chromatography. The HILIC mode is particularly amenable in separating highly hydrophilic and amphiphilic compounds that are too polar to be retained in RP-LC and poorly charged to establish electrostatic interaction in ion-exchange chromatography. Indeed, HILIC has been successfully applied to separate small organic acids, basic drugs, and neutral and charged pharmaceuticals. In particular, exciting applications concern the analysis of carbohydrates and peptides, biological fluids, and studies concerning -omics sciences (i.e., metabolomics, peptidomics, and proteomics).
Specifically designed stationary phases are continuously developed to extend their use in these fields. However, the main drawback is their chemical stability attested by the bleeding effect, making their stability one of the most challenging in developing stationary phases for HILIC.
Due to its potential to solve many complex separation problems, HILIC is increasingly attracting much interest. This Special Issue aims to collect recent trends in the HILIC world spanning from the development of dedicated stationary phases, their characterization and use, to analytical applications in HPLC and UHPLC fields, including hyphenated LC-MS and 2D-LC techniques. In addition, fundamental and theoretical results in the elucidation of the retention mechanism are also welcome.
With this Special Issue, we hope to offer an update to the state of knowledge of hydrophilic interaction chromatography.
Prof. Dr. Alessia Ciogli
Dr. Giulia Mazzoccanti
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- stationary phases
- basic analytes
- oligopeptide analysis
- sugar separations