Special Issue "Purification of Plant Extracts"

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Purification Technology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 917

Special Issue Editor

Dr. Kazuya Murata
E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Graduate School of Medicine, Pharmaceutical Research and Technology Institute, Kindai University, Higashiosaka, Japan
Interests: separation; chemical structure analysis; physiologically active substances; machine analysis; life sciences; environmental and pharmaceutical development

Special Issue Information

Dear Colleagues,

Separation is one of the chemical reactions that occurs between compounds and solid phases and/or mobile phases. Their combinations are infinite, and every compound should be separated into single pure form. We are happy to invite papers outlining examples of compounds and their separation methods in the journal Separations.

In addition to this, plants are well recognized as one of the biggest resources of active compounds used as medicines and functional foods. There are various plants yet to be investigated for other novel compounds.

Thus, this Special Issue of Separations is focused on the purification of bioactive natural products from plant resources as well as analytical methods using various chromatography approaches, including GC and HPLC. Papers on the isolation and structural determination of novel compounds of plant origin as well as on their analytical methods are welcome for submission.

Dr. Kazuya Murata
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPLC
  • GC
  • plants
  • terpenes
  • aromatic compounds
  • polyketides
  • alkaloids
  • analytical methods

Published Papers (2 papers)

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Research

Article
Antiallergic Properties of Biflavonoids Isolated from the Flowers of Mesua ferrea Linn.
Separations 2022, 9(5), 127; https://doi.org/10.3390/separations9050127 - 18 May 2022
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Abstract
The methanolic extract from the flowers of Mesua ferrea Linn. (Calophyllaceae) showed significant hyaluronidase inhibitory activity. Following a bioassay-guided separation of the extract, two biflavonoids, viz., mesuaferrone-A (1) and mesuaferrone-B (2), were isolated, along with ten flavonoids (3 [...] Read more.
The methanolic extract from the flowers of Mesua ferrea Linn. (Calophyllaceae) showed significant hyaluronidase inhibitory activity. Following a bioassay-guided separation of the extract, two biflavonoids, viz., mesuaferrone-A (1) and mesuaferrone-B (2), were isolated, along with ten flavonoids (312), two xanthones (13 and 14), three triterpenes (1517), a phenylpropanoid (18), and five aromatics (1924). Among the isolates, 1 and 2 (IC50 = 51.1 µM and 54.7 µM, respectively) exhibited hyaluronidase inhibitory activity equivalent to that of the commercially available antiallergic agents disodium cromoglycate (64.8 μM) and ketotifen fumarate (76.5 μM). These biflavonoids (1 and 2) are 8-8″ linked dimers that are composed of naringenin (1a) or apigenin (3), with their corresponding monomers lacking inhibitory activity (IC50 > 300 μM). In addition, 1 and 2 (IC50 = 49.4 µM and 49.2 µM, respectively) inhibited the release of β-hexosaminidase, which is a marker of antigen-IgE-mediated degranulation, in rat basophilic leukemia (RBL-2H3) cells. These inhibitory activities were more potent than those of the antiallergic agents tranilast and ketotifen fumarate (IC50 = 282 μM and 158 μM, respectively), as well as one of the corresponding monomers (1a; IC50 > 100 μM). Nonetheless, these effects were weaker than those of the other monomer (3; IC50 = 6.1 μM). Full article
(This article belongs to the Special Issue Purification of Plant Extracts)
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Article
Tyrosinase Inhibitory Activity of Extracts from Prunus persica
Separations 2022, 9(5), 107; https://doi.org/10.3390/separations9050107 - 26 Apr 2022
Viewed by 376
Abstract
The demand for skin-whitening agents is high across the world, including Asian countries. An extensive screening using a tyrosinase inhibition assay was performed in order to discover novel plant materials. In our research program investigating a safe and effective agent, 50% ethanolic extracts [...] Read more.
The demand for skin-whitening agents is high across the world, including Asian countries. An extensive screening using a tyrosinase inhibition assay was performed in order to discover novel plant materials. In our research program investigating a safe and effective agent, 50% ethanolic extracts prepared from discarded parts of Prunus persica were screened for in vitro tyrosinase inhibitory activity. Among the extracts tested, twig extract showed the most potent inhibitory activity: 38% inhibition at 500 µg/mL. The investigation of active compounds in twig extract found four flavanones that acted as moderate inhibitors, including (−)-prunin, persiconin, (+)-dihydrokaempferol, and (−)-naringenin. These compounds were only observed in the twig extract following preliminary quantification by HPLC, with the following concentrations: (−)-prunin, 1.8 mg/g sample; persiconin, 0.8 mg/g sample; (+)-dihydrokaempferol, 0.8 mg/g sample; (−)-naringenin, 1.7 mg/g sample. These results suggest that twig extracts can be more useful for skin-whitening compared with other parts of the plant. In addition, a new constituent of twig extract was identified, namely isoquercitrin, which suggests that twig extract can be a potent source of flavones and flavanones. Further studies on the identification of novel compounds from twig extract are now underway in our laboratory. Full article
(This article belongs to the Special Issue Purification of Plant Extracts)
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