Special Issue "The Fate of Drugs under LC-MS/MS Analysis—Drug Metabolism, Pharmacometabolomics and Chemoproteomics"

Dear Colleagues,

Drug metabolism studies are of paramount importance in all phases of drug development. The use of liquid chromatography–tandem mass spectrometry approaches has continuously allowed for the identification of drug metabolites, which has contributed not only to a clear definition of the drug metabolic fate, but also to the identification of possible reactive metabolites that may be present at the onset of adverse drug reactions. To fulfill the ultimate goal of structure identification, liquid chromatography coupled to either low-resolution (LR) or high-resolution (HR) mass spectrometers is a first choice for routine structural studies. Tandem mass spectrometry (MS² and above) allows for the univocal structural elucidation of metabolites with no limitation to the number of ions, particularly when coupled to high-scan-rate instruments in either data-dependent or data-independent modes; thus, the complete cellular composition of drugs can be identified, clarifying the pharmacometabolomic and the chemoproteomic changes caused by drugs.

With this Special Issue, we hope to create a forum for discussion on the latest developments in LC-MS/MS studies, focusing on the metabolic fate of drugs both from a technological point of view and from a chemistry and biological chemistry perspective.

Dr. Gonçalo J. Justino
Dr. Maria da Conceição Oliveira
Prof. Dr. Paula Guedes de Pinho
Guest Editors

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• drug metabolism
• mass spectrometry
• LC-MS/MS methods
• drug toxicity
• metabolic profiling
• pharmacometabolomics
• chemoproteomics